Published in Curr Top Microbiol Immunol on January 01, 2007
Interferon-stimulated genes: a complex web of host defenses. Annu Rev Immunol (2014) 3.47
Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol (2009) 3.05
Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell (2011) 2.39
Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression. PLoS Pathog (2008) 1.94
USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response. PLoS One (2011) 1.60
Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expression. Hepatology (2014) 1.46
Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment. Cancer Cell (2017) 1.44
Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation. Immunol Rev (2012) 1.38
Siglec-H protects from virus-triggered severe systemic autoimmunity. J Exp Med (2016) 1.37
IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus. J Immunol (2009) 1.33
Evolutionary genetic dissection of human interferons. J Exp Med (2011) 1.32
Inborn errors of anti-viral interferon immunity in humans. Curr Opin Virol (2011) 1.31
Type I interferon drives tumor necrosis factor-induced lethal shock. J Exp Med (2009) 1.25
Receptor density is key to the alpha2/beta interferon differential activities. Mol Cell Biol (2009) 1.22
Temporal and spatial resolution of type I and III interferon responses in vivo. J Virol (2010) 1.18
Type I interferon and systemic lupus erythematosus. J Interferon Cytokine Res (2011) 1.18
IL-28B/IFN-lambda 3 drives granzyme B loading and significantly increases CTL killing activity in macaques. Mol Ther (2010) 1.12
Hope and fear for interferon: the receptor-centric outlook on the future of interferon therapy. J Interferon Cytokine Res (2013) 1.07
Multifaceted activities of type I interferon are revealed by a receptor antagonist. Sci Signal (2014) 1.04
IFN-α subtypes: distinct biological activities in anti-viral therapy. Br J Pharmacol (2013) 1.02
Inflammatory signaling compromises cell responses to interferon alpha. Oncogene (2011) 0.96
Selective Blockade of Interferon-α and -β Reveals Their Non-Redundant Functions in a Mouse Model of West Nile Virus Infection. PLoS One (2015) 0.95
Human metapneumovirus inhibits IFN-β signaling by downregulating Jak1 and Tyk2 cellular levels. PLoS One (2011) 0.94
Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1. PLoS Pathog (2011) 0.94
Loss of mandibular lymph node integrity is associated with an increase in sensitivity to HSV-1 infection in CD118-deficient mice. J Immunol (2009) 0.92
Simian immunodeficiency virus infection in the brain and lung leads to differential type I IFN signaling during acute infection. J Immunol (2011) 0.91
IFN-ε is constitutively expressed by cells of the reproductive tract and is inefficiently secreted by fibroblasts and cell lines. PLoS One (2013) 0.91
Role of novel type I interferon epsilon in viral infection and mucosal immunity. Mucosal Immunol (2012) 0.90
Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor. J Biol Chem (2011) 0.90
TNF-α Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism. PLoS Pathog (2015) 0.89
Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling. J Cell Biol (2015) 0.88
Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies. Proc Natl Acad Sci U S A (2012) 0.87
Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury. EMBO Mol Med (2014) 0.87
Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide. J Exp Med (2016) 0.87
The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases. Gene (2015) 0.87
Ubiquitination-mediated regulation of interferon responses. Growth Factors (2012) 0.86
Tyrosine phosphorylation of protein kinase D2 mediates ligand-inducible elimination of the Type 1 interferon receptor. J Biol Chem (2011) 0.86
Innate immune signaling and regulation in cancer immunotherapy. Cell Res (2016) 0.86
Intermolecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric reverse-protonation and two-dimensional NOESY. Biochemistry (2010) 0.85
Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types. Front Immunol (2014) 0.85
Antiviral Activities of Different Interferon Types and Subtypes against Hepatitis E Virus Replication. Antimicrob Agents Chemother (2016) 0.84
Identification and characterization of the interferon-beta-mediated p53 signal pathway in human peripheral blood mononuclear cells. Immunology (2009) 0.84
Interferon induction by RNA viruses and antagonism by viral pathogens. Viruses (2014) 0.84
TYK2 kinase activity is required for functional type I interferon responses in vivo. PLoS One (2012) 0.84
Live cell micropatterning reveals the dynamics of signaling complexes at the plasma membrane. J Cell Biol (2014) 0.84
Epstein-Barr virus IL-10 engages IL-10R1 by a two-step mechanism leading to altered signaling properties. J Biol Chem (2012) 0.83
Enhanced production of human influenza virus in PBS-12SF cells with a reduced interferon response. Hum Vaccin Immunother (2015) 0.83
Multifarious determinants of cytokine receptor signaling specificity. Adv Immunol (2014) 0.83
Prominent amphibian (Xenopus laevis) tadpole type III interferon response to the frog virus 3 ranavirus. J Virol (2015) 0.82
Antagonizing interferon-mediated immune response by porcine reproductive and respiratory syndrome virus. Biomed Res Int (2014) 0.82
Mutant p53 attenuates the anti-tumorigenic activity of fibroblasts-secreted interferon beta. PLoS One (2013) 0.82
The JAK-STAT pathway and hematopoietic stem cells from the JAK2 V617F perspective. JAKSTAT (2012) 0.82
Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression. Cell Rep (2016) 0.82
Reactive oxygen species and IRF1 stimulate IFNα production by proximal tubules during ischemic AKI. Am J Physiol Renal Physiol (2013) 0.82
Human metapneumovirus antagonism of innate immune responses. Viruses (2012) 0.81
Role of type I interferon receptor signaling on NK cell development and functions. PLoS One (2014) 0.81
Enhanced in vivo efficacy of a type I interferon superagonist with extended plasma half-life in a mouse model of multiple sclerosis. J Biol Chem (2014) 0.81
NMR mapping of the IFNAR1-EC binding site on IFNalpha2 reveals allosteric changes in the IFNAR2-EC binding site. Biochemistry (2010) 0.81
Fine Tuning of a Type 1 Interferon Antagonist. PLoS One (2015) 0.79
Plasmacytoid dendritic cells: development, functions, and role in atherosclerotic inflammation. Front Physiol (2014) 0.79
A Model to Explain How the Bacille Calmette Guérin (BCG) Vaccine Drives Interleukin-12 Production in Neonates. PLoS One (2016) 0.79
ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system. Oncotarget (2016) 0.78
Differential activity of type I interferon subtypes for dendritic cell differentiation. PLoS One (2013) 0.77
Defective trained immunity in patients with STAT-1-dependent chronic mucocutaneaous candidiasis. Clin Exp Immunol (2015) 0.77
Kinetic analysis of cytokine-mediated receptor assembly using engineered FC heterodimers. Protein Sci (2013) 0.77
Interferon-β Mediates Signaling Pathways Uniquely Regulated in Hepatic Stellate Cells and Attenuates the Progression of Hepatic Fibrosis in a Dietary Mouse Model. J Interferon Cytokine Res (2015) 0.77
Recruitment of histone deacetylase 3 to the interferon-A gene promoters attenuates interferon expression. PLoS One (2012) 0.77
Nuclear transit of the intracellular domain of the interferon receptor subunit IFNaR2 requires Stat2 and Irf9. Cell Signal (2008) 0.76
Type I Interferons Control Proliferation and Function of the Intestinal Epithelium. Mol Cell Biol (2016) 0.76
Eliminative signaling by Janus kinases: role in the downregulation of associated receptors. J Cell Biochem (2014) 0.76
A potent in vivo anti-tumor efficacy of novel recombinant type I interferon. Clin Cancer Res (2016) 0.76
Interferon alpha bioactivity critically depends on Scavenger receptor class B type I function. Oncoimmunology (2016) 0.75
Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation. J Invest Dermatol (2016) 0.75
Interferon Beta and Interferon Alpha 2a Differentially Protect Head and Neck Cancer Cells from Vesicular Stomatitis Virus-Induced Oncolysis. J Virol (2015) 0.75
Binding of interferon reduces the force of unfolding for interferon receptor 1. PLoS One (2017) 0.75
Endotoxin tolerance in monocytes can be mitigated by α2-interferon. J Leukoc Biol (2015) 0.75
Matrix Metalloproteinase 9 Facilitates Hepatitis B Virus Replication through Binding with Type I Interferon (IFN) Receptor 1 To Repress IFN/JAK/STAT Signaling. J Virol (2017) 0.75
Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications. Oncoimmunology (2017) 0.75
Total chemical synthesis of human interferon alpha-2b via native chemical ligation. J Pept Sci (2015) 0.75
Chemical Reaction Network Theory elucidates sources of multistability in interferon signaling. PLoS Comput Biol (2017) 0.75
Regulating STING in health and disease. J Inflamm (Lond) (2017) 0.75
Innate Immune Basis for Rift Valley Fever Susceptibility in Mouse Models. Sci Rep (2017) 0.75
Proteomics informed by transcriptomics for characterising differential cellular susceptibility to Nelson Bay orthoreovirus infection. BMC Genomics (2017) 0.75
Dynamic Modulation of Binding Affinity as a Mechanism for Regulating Interferon Signaling. J Mol Biol (2017) 0.75
A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell (1992) 4.96
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. Science (1994) 4.07
Rational design of faster associating and tighter binding protein complexes. Nat Struct Biol (2000) 3.03
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6. EMBO J (1995) 2.52
The modular architecture of protein-protein binding interfaces. Proc Natl Acad Sci U S A (2004) 2.48
Characterization of the relA1 mutation and a comparison of relA1 with new relA null alleles in Escherichia coli. J Biol Chem (1989) 2.46
The nucleotide sequence and characterization of the relA gene of Escherichia coli. J Biol Chem (1988) 2.45
Protein-protein recognition: crystal structural analysis of a barnase-barstar complex at 2.0-A resolution. Biochemistry (1994) 2.38
Chemolithoautotrophic metabolism of anaerobic extremely thermophilic archaebacteria. Nature (1983) 2.38
Electrostatic enhancement of diffusion-controlled protein-protein association: comparison of theory and experiment on barnase and barstar. J Mol Biol (1998) 2.13
Rat transthyretin (prealbumin). Molecular cloning, nucleotide sequence, and gene expression in liver and brain. J Biol Chem (1985) 1.87
Subcellular control of Rac-GTPase signalling by magnetogenetic manipulation inside living cells. Nat Nanotechnol (2013) 1.82
Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. J Biol Chem (1996) 1.78
Causative and susceptibility genes for Alzheimer's disease: a review. Brain Res Bull (2003) 1.76
Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex. Nature (1988) 1.67
A case study in ontology library construction. Artif Intell Med (1995) 1.60
Thermodynamics of the interaction of barnase and barstar: changes in free energy versus changes in enthalpy on mutation. J Mol Biol (1997) 1.59
Evaluation of direct and cooperative contributions towards the strength of buried hydrogen bonds and salt bridges. J Mol Biol (2000) 1.59
Expression of the genes coding for the Escherichia coli integration host factor are controlled by growth phase, rpoS, ppGpp and by autoregulation. Mol Microbiol (1994) 1.56
Transcriptional regulation of plasma protein synthesis during inflammation. J Biol Chem (1986) 1.55
Predicting the rate enhancement of protein complex formation from the electrostatic energy of interaction. J Mol Biol (1999) 1.53
Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons. Mol Cell Biol (1991) 1.52
The proption of the incorporation of leucine into albumin to that into totaprotein in rat liver and hepatoma Morris 5123 TC. Eur J Biochem (1969) 1.50
The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha. Oncogene (1999) 1.44
Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction. J Biol Chem (1995) 1.41
The acute phase response of plasma protein synthesis during experimental inflammation. J Biol Chem (1982) 1.41
Bronchioloalveolar lung carcinomas: K-ras mutations are constant events in the mucinous subtype. J Pathol (1996) 1.40
The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor. Proc Natl Acad Sci U S A (1997) 1.40
Association between cigarette smoking and FHIT gene alterations in lung cancer. Cancer Res (1997) 1.39
Binding hot spots in the TEM1-BLIP interface in light of its modular architecture. J Mol Biol (2006) 1.34
New insights into the mechanism of protein-protein association. Proteins (2001) 1.32
Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2. J Mol Biol (1999) 1.31
New structural and functional aspects of the type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interface. J Biol Chem (2000) 1.29
The folding pathway of a protein at high resolution from microseconds to seconds. Proc Natl Acad Sci U S A (1997) 1.29
Biophysical characterization of the interaction of the beta-lactamase TEM-1 with its protein inhibitor BLIP. Biochemistry (1999) 1.28
A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling. Proc Natl Acad Sci U S A (2000) 1.27
Amplification and excision of integrated polyoma DNA sequences require a functional origin of replication. Cell (1984) 1.26
The secretion of serum protein and the synthesis of albumin and total protein in regenerating rat liver. J Biol Chem (1971) 1.26
Reduced expression of INT-6/eIF3-p48 in human tumors. Int J Oncol (2001) 1.26
Regulation of polyomavirus late promoter activity by viral early proteins. J Virol (1986) 1.26
Mutational and structural analysis of the binding interface between type I interferons and their receptor Ifnar2. J Mol Biol (1999) 1.26
Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex. Proc Natl Acad Sci U S A (2004) 1.25
Pharmacokinetics of gatifloxacin and interaction with an antacid containing aluminum and magnesium. Antimicrob Agents Chemother (1999) 1.24
Experimental assignment of the structure of the transition state for the association of barnase and barstar. J Mol Biol (2001) 1.24
Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking. Proc Natl Acad Sci U S A (2001) 1.23
p53 alterations are predictive of chemoresistance and aggressiveness in ovarian carcinomas: a molecular and immunohistochemical study. Br J Cancer (1997) 1.21
Structure and expression of the rat transthyretin (prealbumin) gene. J Biol Chem (1988) 1.21
Thyroxine transport to the brain: role of protein synthesis by the choroid plexus. Endocrinology (1993) 1.20
Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem (1998) 1.19
Exon skipping mutations in collagen VI are common and are predictive for severity and inheritance. Hum Mutat (2008) 1.18
The cerebral expression of plasma protein genes in different species. Comp Biochem Physiol B Biochem Mol Biol (1995) 1.18
The Janus kinase family of protein tyrosine kinases and their role in signaling. Cell Mol Life Sci (1999) 1.15
Messenger RNA activities of four acute phase proteins during inflammation. FEBS Lett (1983) 1.14
Rat choroid plexus specializes in the synthesis and the secretion of transthyretin (prealbumin). Regulation of transthyretin synthesis in choroid plexus is independent from that in liver. J Biol Chem (1986) 1.13
Interferon alpha inhibits a Src-mediated pathway necessary for Shigella-induced cytoskeletal rearrangements in epithelial cells. J Cell Biol (1998) 1.12
Gene expression in regenerating and acute-phase rat liver. Am J Physiol (1990) 1.11
The synthesis and secretion of rat transferrin. J Biol Chem (1979) 1.09
Diploid/triploid mosaicism: further delineation of the phenotype. Am J Med Genet (1994) 1.08
[Status of the development of electron spin resonance measurement for the detection of irradiated food]. Z Ernahrungswiss (1992) 1.08
Negative regulation of type I interferon signaling: facts and mechanisms. Cell Mol Biol (Noisy-le-grand) (2006) 1.07
p53 mutations and histological type of invasive breast carcinoma. Cancer Res (1993) 1.06
The ratio of albumin synthesis to total protein synthesis in normal rat liver, in host liver, and in Morris hepatoma 9121. Cancer Res (1970) 1.06
Dissection of multi-protein complexes using mass spectrometry: subunit interactions in transthyretin and retinol-binding protein complexes. Proteins (1998) 1.06
p53 alterations in non-small cell lung cancers correlate with metastatic involvement of hilar and mediastinal lymph nodes. Cancer Res (1993) 1.05
p21 RNA and protein expression in non-small cell lung carcinomas: evidence of p53-independent expression and association with tumoral differentiation. Oncogene (1996) 1.05
Endothelium and the brain in CNS lupus. Lupus (2003) 1.05
High prealbumin and transferrin mRNA levels in the choroid plexus of rat brain. Biochem Biophys Res Commun (1985) 1.04
IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells. FEBS Lett (1996) 1.03
Activation of the protein tyrosine kinase tyk2 by interferon alpha/beta. Eur J Biochem (1994) 1.03
Exploring the relationship between timing of menarche and eating disorder symptoms in Black and White adolescent girls. Int J Eat Disord (2001) 1.02
Cyclin-D1-gene amplification and expression in breast carcinoma: relation with clinicopathologic characteristics and with retinoblastoma gene product, p53 and p21WAF1 immunohistochemical expression. Int J Cancer (1997) 1.02
Thyroxine transport in choroid plexus. J Biol Chem (1987) 1.02
A comparison of portal and systemic venous drainage in porcine renal allografts. Br J Surg (1972) 1.01
mdm2 gene alterations and mdm2 protein expression in breast carcinomas. J Pathol (1995) 1.01
Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. J Biol Chem (1997) 1.01
The distribution of albumin precursor protein and albumin in liver. Biochem Biophys Res Commun (1976) 1.00
Lack of secretion of serum protein by transplanted rat hepatomas. Cancer Res (1966) 1.00
Computational redesign of a protein-protein interface for high affinity and binding specificity using modular architecture and naturally occurring template fragments. J Mol Biol (2008) 1.00
The receptor interaction region of Tyk2 contains a motif required for its nuclear localization. J Biol Chem (2001) 0.99
Embryonic soluble HLA-G as a marker of developmental potential in embryos. Hum Reprod (2004) 0.99
A rat serum glycoprotein whose synthesis rate increases greatly during inflammation. J Biol Chem (1979) 0.98
The use of social networking to explore knowledge and attitudes toward organ donation in Italy. Minerva Anestesiol (2012) 0.97
mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations. Diagn Mol Pathol (1995) 0.95
The Archaebacterium Thermofilum pendens Represents, a Novel Genus of the Thermophilic, Anaerobic Sulfur Respiring Thermoproteales. Syst Appl Microbiol (1983) 0.95
Perforation of the rectum by a Smith-Petersen nail. J Trauma (1982) 0.95
Transthyretin expression in the rat brain: effect of thyroid functional state and role in thyroxine transport. Brain Res (1993) 0.95
Rat ceruloplasmin. Molecular cloning and gene expression in liver, choroid plexus, yolk sac, placenta, and testis. J Biol Chem (1987) 0.95
FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations. J Pathol (1998) 0.95
A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region. Genomics (1999) 0.94
A calorimetric study of the thermal stability of barstar and its interaction with barnase. Biochemistry (1995) 0.94
Analysis of ligand binding to receptors by competition kinetics. Application to muscarinic antagonists in rat brain cortex. J Biol Chem (1985) 0.93
Carcinogen induced asynchronous replication of polyoma DNA is mediated by a trans-acting factor. Carcinogenesis (1986) 0.93
Unusual small supernumerary marker chromosome (sSMC) 9 in a Klinefelter patient. Cytogenet Genome Res (2005) 0.93
Lectin-binding sites in normal human testis. Andrologia (1989) 0.93
Differences in activity between alpha and beta type I interferons explored by mutational analysis. J Biol Chem (1998) 0.92
Mitochondrial enzymes in human serum: comparative determinations of glutamate dehydrogenase and mitochondrial aspartate aminotransferase in healthy persons and patients with chronic liver diseases. Clin Chem (1985) 0.92
Postsurgical medical treatment of advanced endometriosis: results of a randomized clinical trial. Am J Obstet Gynecol (1994) 0.92
Deletion of the origin of replication impairs the ability of polyomavirus DNA to transform cells and to form tandem insertions. J Virol (1984) 0.91
Down-modulation of type 1 interferon responses by receptor cross-competition for a shared Jak kinase. J Biol Chem (2001) 0.91