Multifarious determinants of cytokine receptor signaling specificity.

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Published in Adv Immunol on January 01, 2014

Authors

Ignacio Moraga1, Jamie Spangler1, Juan L Mendoza1, K Christopher Garcia2

Author Affiliations

1: Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, California, USA; Program in Immunology, Stanford University School of Medicine, Stanford, California, USA.
2: Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, California, USA; Program in Immunology, Stanford University School of Medicine, Stanford, California, USA. Electronic address: kcgarcia@stanford.edu.

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Yeast surface display for screening combinatorial polypeptide libraries. Nat Biotechnol (1997) 6.88

Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med (2005) 6.59

Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science (2006) 6.38

Interferons at age 50: past, current and future impact on biomedicine. Nat Rev Drug Discov (2007) 6.33

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Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol (2008) 5.86

New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol (2009) 5.57

Super-resolution fluorescence microscopy. Annu Rev Biochem (2009) 5.47

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Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling. Nat Methods (2006) 5.25

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A. Science (1996) 5.19

A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell (1992) 4.96

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The biology of interleukin-2. Annu Rev Immunol (2008) 4.77

Complex modulation of cell type-specific signaling in response to type I interferons. Immunity (2006) 4.48

Interleukin-10: new perspectives on an old cytokine. Immunol Rev (2008) 3.94

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. Proc Natl Acad Sci U S A (1985) 3.74

Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell (2008) 3.72

Interleukin-13 in asthma pathogenesis. Immunol Rev (2004) 3.69

Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. Cell (1990) 3.67

Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science (1991) 3.24

IL-12 family cytokines: immunological playmakers. Nat Immunol (2012) 3.12

Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins. Science (1995) 3.10

Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science (1999) 3.03

Erythropoietin receptor activation by a ligand-induced conformation change. Science (1999) 2.98

Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature (1987) 2.94

Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies. Proc Natl Acad Sci U S A (1980) 2.88

High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries. J Mol Biol (2007) 2.88

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science (2003) 2.87

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A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor beta-chain. Biochem Biophys Res Commun (1989) 2.77

Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor. Nature (1995) 2.74

Small peptides as potent mimetics of the protein hormone erythropoietin. Science (1996) 2.70

Interleukin-4 and interleukin-13 signaling connections maps. Science (2003) 2.69

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Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature (1998) 2.65

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science (2005) 2.64

Signaling through the hematopoietic cytokine receptors. Annu Rev Immunol (1995) 2.61

Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages. J Immunol (2004) 2.58

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. Cell (1991) 2.49

Rational design of potent antagonists to the human growth hormone receptor. Science (1992) 2.45

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr Opin Immunol (2011) 2.44

Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell (2011) 2.39

Homodimerization and constitutive activation of the erythropoietin receptor. Proc Natl Acad Sci U S A (1992) 2.29

Structural biology of shared cytokine receptors. Annu Rev Immunol (2009) 2.27

An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation. Nat Struct Biol (1998) 2.24

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J (1993) 2.18

Haemopoietic receptors and helical cytokines. Immunol Today (1990) 2.15

Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation. J Biol Chem (2006) 2.15

The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol Cell (2001) 2.10

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IFNgamma signaling-does it mean JAK-STAT? Cytokine Growth Factor Rev (2008) 2.06

Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain. Proc Natl Acad Sci U S A (2001) 2.00

Mutational switch of an IL-6 response to an interferon-gamma-like response. Proc Natl Acad Sci U S A (2002) 1.96

Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells. J Immunol (1988) 1.94

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Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion. J Immunol (2001) 1.93

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Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor. J Biol Chem (2004) 1.87

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Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol (2005) 1.83

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell (2008) 1.83

Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med (2008) 1.83

Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta. Mol Cell Biol (2006) 1.82

Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proc Natl Acad Sci U S A (2008) 1.81

The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction. Trends Endocrinol Metab (1999) 1.79

The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression. EMBO J (2003) 1.75

IFNalpha/beta promotes cell survival by activating NF-kappa B. Proc Natl Acad Sci U S A (2000) 1.74

The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif. Mol Cell (2001) 1.72

Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis. J Biol Chem (2001) 1.71

Engineering epidermal growth factor for enhanced mitogenic potency. Nat Biotechnol (1996) 1.68

Hematopoietic receptor complexes. Annu Rev Biochem (1996) 1.67

Covering a broad dynamic range: information processing at the erythropoietin receptor. Science (2010) 1.65

Interleukin-4 and interleukin-13: their similarities and discrepancies. Int Rev Immunol (1998) 1.60

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Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments. Mol Biol Cell (2001) 1.54

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The structure of interleukin-2 complexed with its alpha receptor. Science (2005) 1.53

Dimerization of the extracellular domain of the erythropoietin (EPO) receptor by EPO: one high-affinity and one low-affinity interaction. Biochemistry (1996) 1.52

Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15. J Biol Chem (1995) 1.52

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25. Proc Natl Acad Sci U S A (2010) 1.50

gp130 at the nexus of inflammation, autoimmunity, and cancer. J Leukoc Biol (2010) 1.48

Activation and inhibition of erythropoietin receptor function: role of receptor dimerization. Mol Cell Biol (1994) 1.47

Mechanistic diversity of cytokine receptor signaling across cell membranes. Sci STKE (2004) 1.42

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol (2012) 1.41

The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor. Proc Natl Acad Sci U S A (1997) 1.40

Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nat Immunol (2004) 1.39

Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Mol Cell (2003) 1.38

Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation. Immunol Rev (2012) 1.38

NFkappaB negatively regulates interferon-induced gene expression and anti-influenza activity. J Biol Chem (2006) 1.38