Published in J Mol Biol on October 16, 2007
Structural insight into potent broad-spectrum inhibition with reversible recyclization mechanism: avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC β-lactamases. Antimicrob Agents Chemother (2013) 1.45
Evolutionary trajectories of beta-lactamase CTX-M-1 cluster enzymes: predicting antibiotic resistance. PLoS Pathog (2010) 1.26
Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. Antimicrob Agents Chemother (2009) 1.20
Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. Antimicrob Agents Chemother (2008) 0.97
Molecular basis for the catalytic specificity of the CTX-M extended-spectrum β-lactamases. Biochemistry (2014) 0.90
Distant and new mutations in CTX-M-1 beta-lactamase affect cefotaxime hydrolysis. Antimicrob Agents Chemother (2011) 0.87
Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems. Antimicrob Agents Chemother (2011) 0.87
Residues Distal to the Active Site Contribute to Enhanced Catalytic Activity of Variant and Hybrid β-Lactamases Derived from CTX-M-14 and CTX-M-15. Antimicrob Agents Chemother (2015) 0.85
Characterization of the inhibitor-resistant SHV β-lactamase SHV-107 in a clinical Klebsiella pneumoniae strain coproducing GES-7 enzyme. Antimicrob Agents Chemother (2011) 0.83
One ring to rule them all: Current trends in combating bacterial resistance to the β-lactams. Protein Sci (2016) 0.82
Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1. Antimicrob Agents Chemother (2010) 0.81
Comparative Characterization of CTX-M-64 and CTX-M-14 Provides Insights into the Structure and Catalytic Activity of the CTX-M Class of Enzymes. Antimicrob Agents Chemother (2016) 0.79
A Structure-Based Classification of Class A β-Lactamases, a Broadly Diverse Family of Enzymes. Clin Microbiol Rev (2016) 0.78
Characterization of two new CTX-M-25-group extended-spectrum β-lactamase variants identified in Escherichia coli isolates from Israel. PLoS One (2012) 0.78
Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative. J Med Chem (2014) 0.77
Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials. Antibiotics (Basel) (2016) 0.77
Noncovalent complexes of an inactive mutant of CTX-M-9 with the substrate piperacillin and the corresponding product. Antimicrob Agents Chemother (2011) 0.77
Characterization of the Global Stabilizing Substitution A77V and Its Role in the Evolution of CTX-M β-Lactamases. Antimicrob Agents Chemother (2015) 0.76
Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil. Antimicrob Agents Chemother (2015) 0.75
bla CTX-M-152, a Novel Variant of CTX-M-group-25, Identified in a Study Performed on the Prevalence of Multidrug Resistance among Natural Inhabitants of River Yamuna, India. Front Microbiol (2016) 0.75
High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A β-lactamase, PenL. Sci Rep (2016) 0.75
The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation. Biochemistry (2017) 0.75
Predicting allosteric mutants that increase activity of a major antibiotic resistance enzyme. Chem Sci (2017) 0.75
ZINC--a free database of commercially available compounds for virtual screening. J Chem Inf Model (2005) 16.75
Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science (2009) 13.87
Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature (2010) 11.24
Predicting new molecular targets for known drugs. Nature (2009) 9.71
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell (2011) 7.32
Association between body-mass index and risk of death in more than 1 million Asians. N Engl J Med (2011) 6.89
Relating protein pharmacology by ligand chemistry. Nat Biotechnol (2007) 6.61
Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A (2008) 6.42
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J Med Chem (2002) 5.67
Benchmarking sets for molecular docking. J Med Chem (2006) 5.57
Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study. Lancet (2010) 5.12
High-throughput assays for promiscuous inhibitors. Nat Chem Biol (2005) 4.32
A specific mechanism of nonspecific inhibition. J Med Chem (2003) 3.93
Large-scale prediction and testing of drug activity on side-effect targets. Nature (2012) 3.88
Prediction of protein-ligand interactions. Docking and scoring: successes and gaps. J Med Chem (2006) 3.85
Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs. J Mol Biol (2002) 3.71
Structure-based activity prediction for an enzyme of unknown function. Nature (2007) 3.65
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease. Neurology (2012) 3.58
Health Effects of Arsenic Longitudinal Study (HEALS): description of a multidisciplinary epidemiologic investigation. J Expo Sci Environ Epidemiol (2006) 3.53
Overcoming mutation-based resistance to antiandrogens with rational drug design. Elife (2013) 3.49
Identification and prediction of promiscuous aggregating inhibitors among known drugs. J Med Chem (2003) 3.44
LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages. J Cell Biol (2005) 3.11
Functional stoichiometry of the unitary calcium-release-activated calcium channel. Proc Natl Acad Sci U S A (2008) 3.07
Structure of the protein phosphatase 2A holoenzyme. Cell (2006) 3.07
Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol (2008) 2.98
A high-throughput screen for aggregation-based inhibition in a large compound library. J Med Chem (2007) 2.97
A model binding site for testing scoring functions in molecular docking. J Mol Biol (2002) 2.94
Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study. Am J Epidemiol (2006) 2.93
Directory of useful decoys, enhanced (DUD-E): better ligands and decoys for better benchmarking. J Med Chem (2012) 2.86
Does Helicobacter pylori protect against asthma and allergy? Gut (2008) 2.67
All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci U S A (2004) 2.67
ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours. Nature (2010) 2.65
Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action. Cell Metab (2007) 2.63
Arsenic exposure and toxicology: a historical perspective. Toxicol Sci (2011) 2.63
A detergent-based assay for the detection of promiscuous inhibitors. Nat Protoc (2006) 2.58
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proc Natl Acad Sci U S A (2011) 2.58
ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer Res (2012) 2.51
Structure-based discovery of beta2-adrenergic receptor ligands. Proc Natl Acad Sci U S A (2009) 2.48
Avian-origin influenza A(H7N9) infection in influenza A(H7N9)-affected areas of China: a serological study. J Infect Dis (2013) 2.47
Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh. Am J Clin Nutr (2006) 2.41
Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model. J Am Coll Cardiol (2013) 2.38
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci (2006) 2.30
Predicting absolute ligand binding free energies to a simple model site. J Mol Biol (2007) 2.19
Deconstructing fragment-based inhibitor discovery. Nat Chem Biol (2006) 2.19
Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Cancer Epidemiol Biomarkers Prev (2007) 2.17
Androgen receptor signaling regulates DNA repair in prostate cancers. Cancer Discov (2013) 2.15
Automated docking screens: a feasibility study. J Med Chem (2009) 2.14
Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment. Acta Neuropathol (2010) 2.12
Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B. J Med Chem (2002) 2.10
Ligand discovery from a dopamine D3 receptor homology model and crystal structure. Nat Chem Biol (2011) 2.10
Generation of functional hemangioblasts from human embryonic stem cells. Nat Methods (2007) 2.06
Quantitative hepatic CT perfusion measurement: comparison of Couinaud's hepatic segments with dual-source 128-slice CT. Eur J Radiol (2012) 2.06
Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J (2007) 2.04
In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green. Med Phys (2003) 2.02
Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation. Gut (2013) 1.93
Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. Mol Cell (2008) 1.93
Quantifying the relationships among drug classes. J Chem Inf Model (2008) 1.92
Structural bases of stability-function tradeoffs in enzymes. J Mol Biol (2002) 1.91
Arsenic and cardiovascular disease. Toxicol Sci (2008) 1.90
Correlates of circulating 25-hydroxyvitamin D: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol (2010) 1.90
Kinase inhibitors: not just for kinases anymore. J Med Chem (2003) 1.90
Predicting ligand binding affinity with alchemical free energy methods in a polar model binding site. J Mol Biol (2009) 1.90
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell (2006) 1.88
Associations of body mass index, smoking, and alcohol consumption with prostate cancer mortality in the Asia Cohort Consortium. Am J Epidemiol (2015) 1.87
The Enzyme Function Initiative. Biochemistry (2011) 1.87
NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores. J Cell Biol (2007) 1.85
Identification of a variety of Staphylococcus species by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol (2009) 1.84
Two-axis MEMS Scanning Catheter for Ultrahigh Resolution Three-dimensional and En Face Imaging. Opt Express (2007) 1.82
Predicting substrates by docking high-energy intermediates to enzyme structures. J Am Chem Soc (2006) 1.81
An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation. J Am Chem Soc (2002) 1.81
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase. J Med Chem (2008) 1.81
Microarray analysis of chitin elicitation in Arabidopsis thaliana. Mol Plant Pathol (2002) 1.80
Hierarchical docking of databases of multiple ligand conformations. Curr Top Med Chem (2005) 1.79
Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors. J Am Chem Soc (2008) 1.74
Testing a flexible-receptor docking algorithm in a model binding site. J Mol Biol (2004) 1.73
Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents. Med Res Rev (2012) 1.72
Structure-based discovery of A2A adenosine receptor ligands. J Med Chem (2010) 1.71
Information decay in molecular docking screens against holo, apo, and modeled conformations of enzymes. J Med Chem (2003) 1.70
Structure-based discovery of a novel, noncovalent inhibitor of AmpC beta-lactamase. Structure (2002) 1.70
Complete genome sequence of Crohn's disease-associated adherent-invasive E. coli strain LF82. PLoS One (2010) 1.69
Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer. Cancer Res (2009) 1.68
Promiscuous aggregate-based inhibitors promote enzyme unfolding. J Med Chem (2009) 1.68
Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell (2008) 1.67
Rapid context-dependent ligand desolvation in molecular docking. J Chem Inf Model (2010) 1.66
Hypertonic saline up-regulates A3 adenosine receptor expression of activated neutrophils and increases acute lung injury after sepsis. Crit Care Med (2008) 1.66
Quantifying biogenic bias in screening libraries. Nat Chem Biol (2009) 1.66
A pharmacological organization of G protein-coupled receptors. Nat Methods (2013) 1.65
Prevalence of arsenic exposure from drinking water and awareness of its health risks in a Bangladeshi population: results from a large population-based study. Environ Health Perspect (2006) 1.65
Blood arsenic as a biomarker of arsenic exposure: results from a prospective study. Toxicology (2006) 1.64
Gelsolin regulates cardiac remodeling after myocardial infarction through DNase I-mediated apoptosis. Circ Res (2009) 1.63
Lung cancer risk in white and black Americans. Ann Epidemiol (2003) 1.63
Herd behavior in a complex adaptive system. Proc Natl Acad Sci U S A (2011) 1.62
Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studies. Am J Clin Nutr (2013) 1.61
Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J (2009) 1.61
Protein-protein docking with multiple residue conformations and residue substitutions. Protein Sci (2002) 1.61
Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity. Hepatology (2012) 1.61
Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. BMC Cancer (2008) 1.61
Analytical evaluation of the VITROS 5600 Integrated System in a pediatric setting and determination of pediatric reference intervals. Clin Biochem (2010) 1.61