Hepatic tissue engineering: from transplantation to customized cell-based liver directed therapies from the laboratory.

PubWeight™: 1.18‹?› | Rank: Top 10%

🔗 View Article (PMC 3823472)

Published in J Cell Mol Med on November 16, 2007

Authors

Henning C Fiegel1, Peter M Kaufmann, Helge Bruns, Dietrich Kluth, Raymund E Horch, Joseph P Vacanti, Ulrich Kneser

Author Affiliations

1: Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany. henning.fiegel@medizin.uni-leipzig.de

Articles citing this

Maintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels. Tissue Eng Part A (2010) 1.50

Evaluation of blood vessel ingrowth in fibrin gel subject to type and concentration of growth factors. J Cell Mol Med (2008) 0.96

Liver bioengineering: current status and future perspectives. World J Gastroenterol (2012) 0.95

Tissue engineering using autologous microcirculatory beds as vascularized bioscaffolds. FASEB J (2008) 0.90

T17b murine embryonal endothelial progenitor cells can be induced towards both proliferation and differentiation in a fibrin matrix. J Cell Mol Med (2009) 0.89

Preparation and characterization of chitosan/galactosylated hyaluronic acid scaffolds for primary hepatocytes culture. J Mater Sci Mater Med (2009) 0.88

Regression and persistence: remodelling in a tissue engineered axial vascular assembly. J Cell Mol Med (2009) 0.87

Decellularization and cell seeding of whole liver biologic scaffolds composed of extracellular matrix. J Clin Exp Hepatol (2014) 0.84

Hair organ regeneration via the bioengineered hair follicular unit transplantation. Sci Rep (2012) 0.83

Profiling the impact of medium formulation on morphology and functionality of primary hepatocytes in vitro. Sci Rep (2013) 0.83

Ethical issues in cellular and molecular medicine and tissue engineering. J Cell Mol Med (2008) 0.81

Influence of chitosan nanofiber scaffold on porcine endogenous retroviral expression and infectivity in pig hepatocytes. World J Gastroenterol (2011) 0.80

Improvement of carbon tetrachloride-induced acute hepatic failure by transplantation of induced pluripotent stem cells without reprogramming factor c-Myc. Int J Mol Sci (2012) 0.80

Future of bioartificial liver support. World J Gastrointest Surg (2009) 0.79

Cell patterning for liver tissue engineering via dielectrophoretic mechanisms. Sensors (Basel) (2014) 0.78

Changes of anabolic processes at the cellular and molecular level in chronic wounds under topical negative pressure can be revealed by transcriptome analysis. J Cell Mol Med (2011) 0.77

Hepatic stem cells: A viable approach for the treatment of liver cirrhosis. World J Stem Cells (2015) 0.77

Cell therapeutic options in liver diseases: cell types, medical devices and regulatory issues. J Mater Sci Mater Med (2011) 0.76

Liver Cell Culture Devices. Cell Med (2010) 0.75

In utero hepatocellular transplantation in rats. Clin Dev Immunol (2013) 0.75

Cellularized biosynthetic microhydrogel polymers for intravascular liver tissue regeneration therapy. Tissue Eng Part A (2014) 0.75

Use an alginate scaffold-bone marrow stromal cell (BMSC) complex for the treatment of acute liver failure in rats. Int J Clin Exp Med (2015) 0.75

Cellular Transplantation for Liver Diseases. Gastroenterology Res (2008) 0.75

Modifying three-dimensional scaffolds from novel nanocomposite materials using dissolvable porogen particles for use in liver tissue engineering. J Biomater Appl (2012) 0.75

A PET-compatible tissue bioreactor for research, discovery, and validation of imaging biomarkers and radiopharmaceuticals: system design and proof-of-concept studies. J Nucl Med (2013) 0.75

Three-dimensional culture in a microgravity bioreactor improves the engraftment efficiency of hepatic tissue constructs in mice. J Mater Sci Mater Med (2014) 0.75

Articles cited by this

High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J Cell Biol (1969) 20.26

Tissue engineering. Science (1993) 19.65

Infection in organ-transplant recipients. N Engl J Med (1998) 6.49

Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells. FASEB J (1999) 4.22

The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg Gynecol Obstet (1973) 3.84

Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med (1998) 3.77

Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. J Cell Biol (1996) 3.13

The mass isolation of whole cells from rat liver. Science (1953) 3.06

The enzymatic preparation of isolated intact parenchymal cells from rat liver. J Cell Biol (1967) 2.70

Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure. Gastroenterology (1988) 2.60

Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood (2005) 2.60

Endothelialized microvasculature based on a biodegradable elastomer. Tissue Eng (2005) 2.23

Endothelialized networks with a vascular geometry in microfabricated poly(dimethyl siloxane). Biomed Microdevices (2004) 1.97

Tissue engineering of bone: the reconstructive surgeon's point of view. J Cell Mol Med (2006) 1.93

Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: hepatocytes cultured in a sandwich configuration. FASEB J (1996) 1.90

Switching from differentiation to growth in hepatocytes: control by extracellular matrix. J Cell Physiol (1992) 1.79

Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure. Ann Surg (2004) 1.79

Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type. Exp Cell Res (1983) 1.68

Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes. Science (1986) 1.61

Long-term engraftment of hepatocytes transplanted on biodegradable polymer sponges. J Biomed Mater Res (1997) 1.51

Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver. Ann Surg (1994) 1.46

Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop. Tissue Eng (2006) 1.40

Clinical extracorporeal hybrid liver support--phase I study with primary porcine liver cells. Xenotransplantation (2003) 1.35

Morphology and function of isolated hepatocytes transplanted into rat spleen. Transplantation (1979) 1.33

Autonomously vascularized cellular constructs in tissue engineering: opening a new perspective for biomedical science. J Cell Mol Med (2007) 1.31

Development of a bioartificial liver: properties and function of a hollow-fiber module inoculated with liver cells. Hepatology (1993) 1.23

Stem cell biology, hormone/matrix synergies and liver differentiation. Curr Opin Cell Biol (1990) 1.20

The Hepatix extracorporeal liver assist device: initial clinical experience. Artif Organs (1994) 1.17

A new approach to tissue engineering of vascularized skeletal muscle. J Cell Mol Med (2006) 1.15

A new procedure for the removal of protein bound drugs and toxins. ASAIO J (1994) 1.11

Inducing hepatic differentiation of human mesenchymal stem cells in pellet culture. Biomaterials (2006) 1.11

In vitro evaluation of a novel bioreactor based on an integral oxygenator and a spirally wound nonwoven polyester matrix for hepatocyte culture as small aggregates. J Hepatol (1997) 1.11

Results of a randomized trial of end-to-side portacaval shunt and distal splenorenal shunt in alcoholic liver disease and variceal bleeding. Gastroenterology (1986) 1.08

Fetal and adult liver stem cells for liver regeneration and tissue engineering. J Cell Mol Med (2006) 1.07

Phase I clinical trial with the AMC-bioartificial liver. Int J Artif Organs (2002) 1.04

Evaluation of processed bovine cancellous bone matrix seeded with syngenic osteoblasts in a critical size calvarial defect rat model. J Cell Mol Med (2006) 1.04

Liver-specific gene expression in mesenchymal stem cells is induced by liver cells. World J Gastroenterol (2005) 1.03

Stimulation of growth of primary cultured adult rat hepatocytes without growth factors by coculture with nonparenchymal liver cells. Exp Cell Res (1987) 1.01

Gene transfer strategies in tissue engineering. J Cell Mol Med (2007) 1.00

Primary human liver cells as source for modular extracorporeal liver support--a preliminary report. Int J Artif Organs (2002) 0.99

Initial experience with the modified extracorporeal liver-assist device for patients with fulminant hepatic failure: system modifications and clinical impact. Transplantation (2002) 0.97

Autoreactive T cells induce in vitro BM mesenchymal stem cell transdifferentiation to neural stem cells. Cytotherapy (2006) 0.96

Rat hepatocytes prepared without collagenase: prolonged retention of differentiated characteristics in culture. Cell Biol Toxicol (1988) 0.95

Highly porous polymer matrices as a three-dimensional culture system for hepatocytes. Cell Transplant (1997) 0.95

Bilirubin conjugation by an artificial liver composed of cultured cells and synthetic capillaries. Trans Am Soc Artif Intern Organs (1975) 0.95

Anti-Gal antibody-mediated allograft rejection in alpha1,3-galactosyltransferase gene knockout mice: a model of delayed xenograft rejection. Transplantation (1998) 0.93

Enhanced proliferation and differentiation of rat hepatocytes cultured with bone marrow stromal cells. J Cell Physiol (2001) 0.91

Safety observations in phase I clinical evaluation of the Excorp Medical Bioartificial Liver Support System after the first four patients. ASAIO J (2001) 0.91

Bioreactor for a larger scale hepatocyte in vitro perfusion. Transplantation (1994) 0.90

Performance of a new hybrid artificial liver support system using hepatocytes entrapped within a hydrogel. ASAIO Trans (1990) 0.90

Quantitation of transplanted hepatic mass necessary to cure the Gunn rat model of hyperbilirubinemia. J Pediatr Surg (1992) 0.88

A simple perfusion technique applied to glucocorticoid regulation of tryptophan oxygenase turnover and bile production in the isolated rat liver. Hoppe Seylers Z Physiol Chem (1969) 0.86

A new concept of bioartificial liver based on a fluidized bed bioreactor. Ther Apher (1999) 0.86

Selective intraportal hepatocyte transplantation in analbuminemic and Gunn rats. Transplantation (1993) 0.85

Heterotopic hepatocyte transplantation: assessing the impact of hepatotrophic stimulation. Transplant Proc (1994) 0.85

Hepatocyte transplantation and gene therapy. Clin Transplant (1995) 0.84

Cell growth and differentiation of different hepatic cells isolated from fetal rat liver in vitro. Tissue Eng (2006) 0.84

Acute liver failure: liver support therapies. Curr Opin Crit Care (2007) 0.84

Hepatocytic differentiation of mesenchymal stem cells in cocultures with fetal liver cells. World J Gastroenterol (2006) 0.83

Hepatocyte transplantation using biodegradable matrices in ascorbic acid-deficient rats: comparison with heterotopically transplanted liver grafts. Transplantation (2001) 0.83

Isolation of rat hepatocytes with EDTA and their metabolic functions in primary culture. In Vitro Cell Dev Biol (1985) 0.83

The expression of mesenchymal, neural and haematopoietic stem cell markers in adult hepatocytes proliferating in vitro. J Hepatol (2005) 0.83

Long-term hepatocyte transplantation using three-dimensional matrices. Transplant Proc (1999) 0.82

A method to assess biochemical activity of liver cells during clinical application of extracorporeal hybrid liver support. Int J Artif Organs (2002) 0.82

Hepatic tissue engineering on 3-dimensional biodegradable polymers within a pulsatile flow bioreactor. Dig Surg (2001) 0.82

The mesentery as a laminated vascular bed for hepatocyte transplantation. Cell Transplant (1994) 0.81

Is there an optimal concentration of cotransplanted islets of Langerhans for stimulation of hepatocytes in three dimensional matrices? Transplantation (1999) 0.81

Cell transplantation of genetically altered cells on biodegradable polymer scaffolds in syngeneic rats. Transplantation (1993) 0.80

Isolation and primary culture of rat hepatocytes. Hepatobiliary Pancreat Dis Int (2002) 0.80

Intrasplenic hepatocyte allotransplantation in dalmation dogs with and without cyclosporine immunosuppression. Transplantation (1997) 0.79

The UNOS OPTN Waiting List and Donor Registry: 1988-1996. Clin Transpl (1996) 0.79

Flat membrane bioreactor for the replacement of liver functions. Ernst Schering Res Found Workshop (2002) 0.78

Preclinical evaluation of the Excorp Medical, Inc, Bioartificial Liver Support System. J Am Coll Surg (2002) 0.78

Evidence that temporary complete occlusion of splenic vessels prevents massive embolization and sudden death associated with intrasplenic hepatocellular transplantation. Transplantation (1989) 0.76

Biochemical characterization of bioreactors for hybrid liver support: serum-free liver cell coculture of nonparenchymal and parenchymal cells. Transplant Proc (2001) 0.76

The effect of pancreatic islets on transplanted hepatocytes in the treatment of acute liver failure in rats. Res Exp Med (Berl) (1991) 0.76

Interaction of hepatocytes and pancreatic islets cotransplanted in polymeric matrices. Virchows Arch (1999) 0.76

Articles by these authors

Microscale technologies for tissue engineering and biology. Proc Natl Acad Sci U S A (2006) 6.66

Regeneration and orthotopic transplantation of a bioartificial lung. Nat Med (2010) 5.59

Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nat Med (2013) 5.36

Delayed reverse sural flap for staged reconstruction of the foot and lower leg. Plast Reconstr Surg (2005) 2.27

Endothelialized microvasculature based on a biodegradable elastomer. Tissue Eng (2005) 2.23

Progress in tissue engineering. Sci Am (2009) 2.08

Vascularization of the dorsal base of the second metacarpal bone: an anatomical study using C-arm cone beam computed tomography. Plast Reconstr Surg (2014) 2.00

Endothelialized networks with a vascular geometry in microfabricated poly(dimethyl siloxane). Biomed Microdevices (2004) 1.97

Biocompatibility analysis of poly(glycerol sebacate) as a nerve guide material. Biomaterials (2005) 1.93

Immunodominance and functional alterations of tumor-associated antigen-specific CD8+ T-cell responses in hepatocellular carcinoma. Hepatology (2014) 1.76

Enhanced in vivo function of bioartificial lungs in rats. Ann Thorac Surg (2011) 1.75

Tissue-engineered small intestine improves recovery after massive small bowel resection. Ann Surg (2004) 1.64

Correlation between serum creatinine kinase levels and extent of muscle damage in electrical burns. Burns (2004) 1.54

Three-Dimensional Microfluidic Tissue-Engineering Scaffolds Using a Flexible Biodegradable Polymer. Adv Mater (2005) 1.49

Tensiometry as a decision tool for abdominal wall reconstruction with component separation. World J Surg (2009) 1.48

Microfabrication of three-dimensional engineered scaffolds. Tissue Eng (2007) 1.48

Engineered vascularized bone grafts. Proc Natl Acad Sci U S A (2010) 1.47

Tissue-engineered hybrid tooth and bone. Tissue Eng (2005) 1.46

Expression of HIF-1α in ischemia and reperfusion in human microsurgical free muscle tissue transfer. Plast Reconstr Surg (2011) 1.42

Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop. Tissue Eng (2006) 1.40

Hepatic tissue engineering. Transpl Immunol (2004) 1.36

In vivo bone tissue engineering using mesenchymal stem cells on a novel electrospun nanofibrous scaffold. Tissue Eng (2004) 1.34

Liver-specific gene expression in cultured human hematopoietic stem cells. Stem Cells (2003) 1.33

Translating tissue engineering technology platforms into cancer research. J Cell Mol Med (2009) 1.29

Fibrin gel-immobilized VEGF and bFGF efficiently stimulate angiogenesis in the AV loop model. Mol Med (2007) 1.27

50 years experience with Dupuytren's contracture in the Erlangen University Hospital--a retrospective analysis of 2919 operated hands from 1956 to 2006. BMC Musculoskelet Disord (2007) 1.27

Successful human long-term application of in situ bone tissue engineering. J Cell Mol Med (2014) 1.22

Tissue engineering of cultured skin substitutes. J Cell Mol Med (2005) 1.21

Hydrogel-beta-TCP scaffolds and stem cells for tissue engineering bone. Bone (2005) 1.20

The tissue-engineered auricle: past, present, and future. Tissue Eng Part B Rev (2011) 1.20

Local delivery of basic fibroblast growth factor increases both angiogenesis and engraftment of hepatocytes in tissue-engineered polymer devices. Transplantation (2002) 1.17

Tissue engineering auricular reconstruction: in vitro and in vivo studies. Biomaterials (2004) 1.17

Tissue-engineered large intestine resembles native colon with appropriate in vitro physiology and architecture. Ann Surg (2003) 1.17

Percutaneous transvenous cellular cardiomyoplasty. A novel nonsurgical approach for myocardial cell transplantation. J Am Coll Cardiol (2003) 1.15

Future perspectives in tissue engineering. J Cell Mol Med (2006) 1.15

Highly purified müllerian inhibiting substance inhibits human ovarian cancer in vivo. Clin Cancer Res (2002) 1.15

Lung assist device technology with physiologic blood flow developed on a tissue engineered scaffold platform. Lab Chip (2010) 1.13

Reconstruction of mandibular defects with autologous tissue-engineered bone. J Oral Maxillofac Surg (2004) 1.13

Axial prevascularization of porous matrices using an arteriovenous loop promotes survival and differentiation of transplanted autologous osteoblasts. Tissue Eng (2007) 1.09

Tissue-engineered esophagus: experimental substitution by onlay patch or interposition. J Thorac Cardiovasc Surg (2003) 1.08

The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine. Biomaterials (2008) 1.07

In-Flap Anastomosis as Back-Up Option for Anterolateral Thigh Flaps Lacking Suitable Perforators. Plast Reconstr Surg (2016) 1.07

Directly auto-transplanted mesenchymal stem cells induce bone formation in a ceramic bone substitute in an ectopic sheep model. J Cell Mol Med (2010) 1.07

Porous ceramic bone scaffolds for vascularized bone tissue regeneration. J Mater Sci Mater Med (2008) 1.06

Osteoinduction and survival of osteoblasts and bone-marrow stromal cells in 3D biphasic calcium phosphate scaffolds under static and dynamic culture conditions. J Cell Mol Med (2012) 1.05

Cancer stem cell marker expression in hepatocellular carcinoma and liver metastases is not sufficient as single prognostic parameter. Cancer Lett (2008) 1.05

Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma. Ann Surg (2004) 1.05

The quality of aesthetic surgery training in plastic surgery residency. Ann Plast Surg (2014) 1.04

Liver-specific gene expression in mesenchymal stem cells is induced by liver cells. World J Gastroenterol (2005) 1.03

Diaphragmatic repair through fetal tissue engineering: a comparison between mesenchymal amniocyte- and myoblast-based constructs. J Pediatr Surg (2006) 1.03

Engineering skeletal muscle tissue--new perspectives in vitro and in vivo. J Cell Mol Med (2010) 1.02

Insulin attenuates apoptosis and exerts anti-inflammatory effects in endotoxemic human macrophages. J Surg Res (2007) 1.02

Effect of GLP-2 on mucosal morphology and SGLT1 expression in tissue-engineered neointestine. Am J Physiol Gastrointest Liver Physiol (2003) 1.01

Formation of a mandibular condyle in vitro by tissue engineering. J Oral Maxillofac Surg (2003) 1.01

Engineering extracellular matrix through nanotechnology. J R Soc Interface (2010) 1.00

Gene transfer strategies in tissue engineering. J Cell Mol Med (2007) 1.00

Injectable liver: a novel approach using fibrin gel as a matrix for culture and intrahepatic transplantation of hepatocytes. Tissue Eng (2006) 1.00

Melatonin protects kidney grafts from ischemia/reperfusion injury through inhibition of NF-kB and apoptosis after experimental kidney transplantation. J Pineal Res (2009) 1.00

The versatility of the free osteocutaneous fibula flap in the reconstruction of extremities after sarcoma resection. World J Surg Oncol (2004) 1.00

Bone marrow derived pluripotent cells are pericytes which contribute to vascularization. Stem Cell Rev (2009) 1.00

The retention of extracellular matrix proteins and angiogenic and mitogenic cytokines in a decellularized porcine dermis. Biomaterials (2010) 1.00

Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model. J Tissue Eng Regen Med (2010) 0.99

Engineering ear constructs with a composite scaffold to maintain dimensions. Tissue Eng Part A (2011) 0.99

Open Biportal Decompression of the Median Nerve. Dtsch Arztebl Int (2015) 0.98

Prospects for tooth regeneration. Periodontol 2000 (2006) 0.98

Automatic quantitative micro-computed tomography evaluation of angiogenesis in an axially vascularized tissue-engineered bone construct. Tissue Eng Part C Methods (2010) 0.98

Tissue engineering and organ structure: a vascularized approach to liver and lung. Pediatr Res (2008) 0.98

Toward regenerating a human thumb in situ. Tissue Eng Part A (2009) 0.97

Characterization of cell types during rat liver development. Hepatology (2003) 0.97

Tissue engineering and regenerative medicine -where do we stand? J Cell Mol Med (2012) 0.96

Dynamic rotational seeding and cell culture system for vascular tube formation. Tissue Eng (2003) 0.96

Suitability of human mesenchymal stem cells for gene therapy depends on the expansion medium. Exp Cell Res (2008) 0.95

Systemic inhibition of tumor growth and angiogenesis by thrombospondin-2 using cell-based antiangiogenic gene therapy. Cancer Res (2002) 0.95

Dose-finding study of fibrin gel-immobilized vascular endothelial growth factor 165 and basic fibroblast growth factor in the arteriovenous loop rat model. Tissue Eng Part A (2009) 0.95

Bioengineered teeth from tooth bud cells. Dent Clin North Am (2006) 0.95

Engineering axially vascularized bone in the sheep arteriovenous-loop model. J Tissue Eng Regen Med (2012) 0.94

Tissue-engineered small intestine: ontogeny of the immune system. Transplantation (2002) 0.94

The embryology of the diaphragm. Semin Pediatr Surg (2011) 0.94

Liver transection using vascular stapler: a review. HPB (Oxford) (2008) 0.94

Intrapulmonary and cutaneous siliconomas after silent silicone breast implant failure. Breast J (2009) 0.94

Reconstructing mandibular defects using autologous tissue-engineered tooth and bone constructs. J Oral Maxillofac Surg (2009) 0.94