Inhibition of telomerase in the endothelial cells disrupts tumor angiogenesis in glioblastoma xenografts.

PubWeight™: 1.55‹?› | Rank: Top 4%

🔗 View Article (PMID 18027853)

Published in Int J Cancer on March 15, 2008

Authors

Maria Laura Falchetti1, Maria Patrizia Mongiardi, Paolo Fiorenzo, Giovanna Petrucci, Francesco Pierconti, Igea D'Agnano, Giorgio D'Alessandris, Giulio Alessandri, Maurizio Gelati, Lucia Ricci-Vitiani, Giulio Maira, Luigi Maria Larocca, Andrea Levi, Roberto Pallini

Author Affiliations

1: Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy. marialaura.falchetti@inmm.cnr.it

Articles citing this

Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol (1985) (2008) 1.87

Prognostic significance of telomerase-associated parameters in glioblastoma: effect of patient age. Neuro Oncol (2013) 1.07

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. Semin Cancer Biol (2015) 0.99

Combination of hTERT knockdown and IFN-gamma treatment inhibited angiogenesis and tumor progression in glioblastoma. Clin Cancer Res (2009) 0.87

Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo. Cell Death Dis (2014) 0.85

Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas. J Neurooncol (2011) 0.85

Therapeutic targeting of replicative immortality. Semin Cancer Biol (2015) 0.83

hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor. Nucleic Acids Res (2016) 0.81

miR-135b suppresses tumorigenesis in glioblastoma stem-like cells impairing proliferation, migration and self-renewal. Oncotarget (2015) 0.80

A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology. PLoS One (2015) 0.78

Spindle cells from acquired immune deficiency syndrome-associated Kaposi's sarcoma lesions express telomerase activity directly relating to the RNA levels of fibroblast growth factor-2. Int J Cancer (2010) 0.76

Evaluation of Energy Balance on Human Telomerase Reverse Transcriptase (hTERT) Alternative Splicing by Semi-quantitative RT-PCR in Human Umbilical Vein Endothelial Cells. Adv Biomed Res (2017) 0.75

Articles by these authors

Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J (2007) 6.26

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature (2010) 6.13

Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential. Eur J Cancer (2007) 3.80

Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling. Circ Res (2009) 3.25

Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme. Clin Cancer Res (2008) 2.52

Safety and efficacy of Gliadel wafers for newly diagnosed and recurrent glioblastoma. Acta Neurochir (Wien) (2012) 2.06

Intrapelvic sciatic notch schwannoma: microsurgical excision using the infragluteal approach. J Neurosurg (2013) 2.03

Targeted therapy with bevacizumab and erlotinib tailored to the molecular profile of patients with recurrent glioblastoma. Preliminary experience. Acta Neurochir (Wien) (2012) 1.99

Glioblastoma-derived tumorospheres identify a population of tumor stem-like cells with angiogenic potential and enhanced multidrug resistance phenotype. Glia (2006) 1.82

Aspirin-insensitive thromboxane biosynthesis in essential thrombocythemia is explained by accelerated renewal of the drug target. Blood (2012) 1.78

Primary empty sella. J Clin Endocrinol Metab (2005) 1.67

Anemia in Hodgkin's lymphoma: the role of interleukin-6 and hepcidin. J Clin Oncol (2010) 1.66

Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study. Blood (2011) 1.62

Mesenchymal stromal cells primed with paclitaxel provide a new approach for cancer therapy. PLoS One (2011) 1.58

Prognostic value of CXCL12 expression in 40 low-grade oligodendrogliomas and oligoastrocytomas. Cancer Biol Ther (2006) 1.54

Molecular analysis of immunoglobulin variable genes in human immunodeficiency virus-related non-Hodgkin's lymphoma reveals implications for disease pathogenesis and histogenesis. Haematologica (2008) 1.54

The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas. Cancer Cell (2012) 1.50

Mutations of the BIK gene in human peripheral B-cell lymphomas. Genes Chromosomes Cancer (2003) 1.50

Anemia in diffuse large B-cell non-Hodgkin lymphoma: the role of interleukin-6, hepcidin and erythropoietin. Leuk Lymphoma (2013) 1.47

The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy. Blood (2009) 1.46

Communicating hydrocephalus following surgery and adjuvant radiochemotherapy for glioblastoma. J Neurosurg (2011) 1.46

Primary plasma cell leukemia followed by testicular plasmacytoma. Int J Hematol (2011) 1.44

Association between polymorphisms rs1333040 and rs7865618 of chromosome 9p21 and sporadic brain arteriovenous malformations. Cerebrovasc Dis (2014) 1.42

Endothelial progenitor cells in HIV-positive patients: what are we talking about? J Acquir Immune Defic Syndr (2013) 1.42

Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice. Gastroenterology (2010) 1.36

Clivus metastases: report of seven patients and literature review. Acta Neurochir (Wien) (2009) 1.34

Neurosphere-derived cells exert a neuroprotective action by changing the ischemic microenvironment. PLoS One (2007) 1.33

Human fetal aorta contains vascular progenitor cells capable of inducing vasculogenesis, angiogenesis, and myogenesis in vitro and in a murine model of peripheral ischemia. Am J Pathol (2007) 1.31

Intracavitary VEGF, bFGF, IL-8, IL-12 levels in primary and recurrent malignant glioma. J Neurooncol (2003) 1.30

Stem cell marker nestin and c-Jun NH2-terminal kinases in tumor and peritumor areas of glioblastoma multiforme: possible prognostic implications. Clin Cancer Res (2007) 1.25

Chordoma of the skull base: predictors of tumor recurrence. J Neurosurg (2003) 1.24

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway. EMBO J (2009) 1.23

Homologous transplantation of neural stem cells to the injured spinal cord of mice. Neurosurgery (2005) 1.22

Role of L-type Ca2+ channels in neural stem/progenitor cell differentiation. Eur J Neurosci (2006) 1.20

Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes. Blood (2009) 1.20

Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation. Blood (2007) 1.19

Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt. Oncogene (2004) 1.17

Role of the life span determinant P66(shcA) in ethanol-induced liver damage. Lab Invest (2008) 1.15

Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction. Cancer Res (2005) 1.15

Hereditary thrombocytosis caused by MPLSer505Asn is associated with a high thrombotic risk, splenomegaly and progression to bone marrow fibrosis. Haematologica (2009) 1.15

CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells. Eur J Immunol (2004) 1.15

HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2. Proc Natl Acad Sci U S A (2012) 1.15

Autocrine production of interleukin-4 and interleukin-10 is required for survival and growth of thyroid cancer cells. Cancer Res (2006) 1.13

Mesenchymal stem/stromal cells: a new ''cells as drugs'' paradigm. Efficacy and critical aspects in cell therapy. Curr Pharm Des (2013) 1.13

PED mediates AKT-dependent chemoresistance in human breast cancer cells. Cancer Res (2005) 1.12

Molecular histogenesis of plasmablastic lymphoma of the oral cavity. Br J Haematol (2002) 1.10

Letter: malignant craniopharyngioma and radiotherapy: the missing link. Neurosurgery (2015) 1.08

Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor. J Neurosurg (2002) 1.08

Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis. Cancer (2010) 1.07

Possible involvement of hMLH1, p16(INK4a) and PTEN in the malignant transformation of endometriosis. Int J Cancer (2002) 1.07

Characterization of a novel peripheral pro-lipolytic mechanism in mice: role of VGF-derived peptide TLQP-21. Biochem J (2012) 1.06

Is morphology alone able to predict BRAF-mutated malignancies on thyroid FNAC? Virchows Arch (2014) 1.06

Can a gene-expression classifier with high negative predictive value solve the indeterminate thyroid fine-needle aspiration dilemma? Cancer Cytopathol (2013) 1.06

Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior. Prostate (2010) 1.06

Human neural stem cells: a model system for the study of Lesch-Nyhan disease neurological aspects. Hum Mol Genet (2010) 1.05

Endothelial progenitor cells are clonal and exhibit the JAK2(V617F) mutation in a subset of thrombotic patients with Ph-negative myeloproliferative neoplasms. Blood (2011) 1.05

Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis. J Interferon Cytokine Res (2002) 1.04

A novel heterozygous HIF2AM535I mutation reinforces the role of oxygen sensing pathway disturbances in the pathogenesis of familial erythrocytosis. Haematologica (2008) 1.04

Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer? Clin Colorectal Cancer (2011) 1.02

Targeting apoptosis pathways in cancer stem cells. Cancer Lett (2011) 1.01

The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. Int J Oncol (2004) 1.01

CCL16 activates an angiogenic program in vascular endothelial cells. Blood (2003) 1.00

Isolation and expansion of human and mouse brain microvascular endothelial cells. Nat Protoc (2013) 1.00

Telomerase inhibition impairs tumor growth in glioblastoma xenografts. Neurol Res (2006) 0.99

MyoD induces apoptosis in the absence of RB function through a p21(WAF1)-dependent re-localization of cyclin/cdk complexes to the nucleus. Oncogene (2002) 0.99

MUC1 oncoprotein promotes refractoriness to chemotherapy in thyroid cancer cells. Cancer Res (2007) 0.99

New models for cancer research: human cancer stem cell xenografts. Curr Opin Pharmacol (2010) 0.99

Thrombocythemia and polycythemia in patients younger than 20 years at diagnosis: clinical and biologic features, treatment, and long-term outcome. Blood (2012) 0.98

MYC prevents apoptosis and enhances endoreduplication induced by paclitaxel. PLoS One (2009) 0.98

CXCL12 in malignant glial tumors: a possible role in angiogenesis and cross-talk between endothelial and tumoral cells. J Neurooncol (2004) 0.97

Genome wide DNA-profiling of HIV-related B-cell lymphomas. Br J Haematol (2009) 0.97

Thyroid cancer resistance to chemotherapeutic drugs via autocrine production of interleukin-4 and interleukin-10. Cancer Res (2003) 0.97

Expression of EGFRvIII in glioblastoma: prognostic significance revisited. Neoplasia (2011) 0.97

Establishing tumor cell lines from aggressive telomerase-positive chordomas of the skull base. Technical note. J Neurosurg (2006) 0.97