Published in Neoplasia on November 01, 2007
Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis. Proc Natl Acad Sci U S A (2009) 1.02
Pre-clinical and clinical significance of heparanase in Ewing's sarcoma. J Cell Mol Med (2011) 1.02
Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levels. PLoS One (2011) 1.01
Clinical significance of urine heparanase in bladder cancer progression. Neoplasia (2008) 1.01
Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression. Arterioscler Thromb Vasc Biol (2012) 0.98
Involvement of heparanase in atherosclerosis and other vessel wall pathologies. Matrix Biol (2013) 0.93
Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for tumor invasion. BMC Cancer (2009) 0.92
HLA-A2-restricted cytotoxic T lymphocyte epitopes from human heparanase as novel targets for broad-spectrum tumor immunotherapy. Neoplasia (2008) 0.87
Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function. PLoS One (2012) 0.86
Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII. Haematologica (2010) 0.86
Heparanase regulates thrombosis in vascular injury and stent-induced flow disturbance. J Am Coll Cardiol (2012) 0.86
Impact of heparanase on renal fibrosis. J Transl Med (2015) 0.83
Prognostic value of heparanase expression and cellular localization in oral cancer. Head Neck (2010) 0.81
The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis. PLoS One (2015) 0.79
Crosslinking decreases the hemocompatibility of decellularized, porcine small intestinal submucosa. Acta Biomater (2014) 0.76
Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3. Cell Rep (2016) 0.76
The War on Cancer rages on. Neoplasia (2009) 0.75
Pediatric Hodgkin lymphoma: biomarkers, drugs, and clinical trials for translational science and medicine. Oncotarget (2016) 0.75
Neoplasia: the second decade. Neoplasia (2008) 0.75
Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Int J Biochem Cell Biol (2006) 3.24
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J Clin Invest (2001) 2.98
Heparanase: a key enzyme involved in cell invasion. Biochim Biophys Acta (2001) 2.74
Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis. J Natl Cancer Inst (2004) 2.52
Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate. Curr Pharm Des (2007) 2.14
Lymphoma cell-mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: relationship to tumor cell metastasis. Cancer Res (1983) 2.04
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. Cancer Res (2006) 2.02
Mammalian heparanase: what is the message? J Cell Mol Med (2007) 1.91
Heparanase: a target for drug discovery in cancer and inflammation. Br J Pharmacol (2007) 1.90
Processing and activation of latent heparanase occurs in lysosomes. J Cell Sci (2004) 1.82
Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation. Invasion Metastasis (1992) 1.79
Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem (2004) 1.78
Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis. Matrix Biol (2004) 1.75
Extracellular matrix moieties, cytokines, and enzymes: dynamic effects on immune cell behavior and inflammation. J Leukoc Biol (2000) 1.64
Heparan sulfate degradation: relation to tumor invasive and metastatic properties of mouse B16 melanoma sublines. Science (1983) 1.63
Heparanase activity expressed by platelets, neutrophils, and lymphoma cells releases active fibroblast growth factor from extracellular matrix. Cell Regul (1990) 1.55
Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies. Leukemia (2007) 1.54
Heparanase affects adhesive and tumorigenic potential of human glioma cells. Cancer Res (2003) 1.54
Heparanase, a potential regulator of cell-matrix interactions. Trends Biochem Sci (2000) 1.45
Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase. Nature (1984) 1.42
Development of heparanase inhibitors for anti-cancer therapy. Curr Med Chem (2006) 1.41
Role of endothelial heparanase in delayed-type hypersensitivity. Blood (2005) 1.35
The impact of heparanese and heparin on cancer metastasis and angiogenesis. Pathophysiol Haemost Thromb (2006) 1.29
Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival. Neoplasia (2006) 1.28
Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes. J Clin Invest (1985) 1.27
The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation. Mini Rev Med Chem (2004) 1.24
PI-88 and novel heparan sulfate mimetics inhibit angiogenesis. Semin Thromb Hemost (2007) 1.24
Mechanism of activation of human heparanase investigated by protein engineering. Biochemistry (2004) 1.21
Heparanase induces tissue factor expression in vascular endothelial and cancer cells. J Thromb Haemost (2006) 1.21
Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts. J Immunol (2004) 1.16
Sequential degradation of heparan sulfate in the subendothelial extracellular matrix by highly metastatic lymphoma cells. Int J Cancer (1985) 1.08
Heparanase is involved in the pathogenesis of proteinuria as a result of glomerulonephritis. J Am Soc Nephrol (2004) 1.07
An ELISA method for the detection and quantification of human heparanase. Biochem Biophys Res Commun (2006) 1.03
Heparanase expression in malignant salivary gland tumors inversely correlates with long-term survival. Neoplasia (2006) 0.98
Involvement of human heparanase in the pathogenesis of diabetic nephropathy. Isr Med Assoc J (2002) 0.96
Heparanase inhibition reduces proteinuria in a model of accelerated anti-glomerular basement membrane antibody disease. Nephrology (Carlton) (2005) 0.96
Role of heparanase in platelet and tumor cell interactions with the subendothelial extracellular matrix. Semin Thromb Hemost (1987) 0.94
A synthetic heparanase inhibitor reduces proteinuria in passive Heymann nephritis. J Am Soc Nephrol (2004) 0.93
Antisense-mediated suppression of Heparanase gene inhibits melanoma cell invasion. Neoplasia (2005) 0.93
Heparanase expression during normal liver development and following partial hepatectomy. J Pathol (2004) 0.91
Increased expression of heparanase in puromycin aminonucleoside nephrosis. Kidney Int (2001) 0.88
Heparanase expression in human leukemias is restricted to acute myeloid leukemias. Exp Hematol (2002) 0.88
Heparanase expression in hepatocellular carcinoma and the cirrhotic liver. Hepatol Res (2003) 0.83
Murine macrophage heparanase: inhibition and comparison with metastatic tumor cells. J Cell Physiol (1987) 0.80
Serum VEGF as a significant marker of treatment response in hodgkin lymphoma. Pediatr Hematol Oncol (2007) 0.77
Serum vascular endothelial growth factor as a significant marker of treatment response in pediatric malignancies. Pediatr Hematol Oncol (2005) 0.77
Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Int J Biochem Cell Biol (2006) 3.24
Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis. J Natl Cancer Inst (2004) 2.52
Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis. J Biol Chem (2007) 2.25
Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate. Curr Pharm Des (2007) 2.14
Heparanase: busy at the cell surface. Trends Biochem Sci (2009) 2.07
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. Cancer Res (2006) 2.02
Processing and activation of latent heparanase occurs in lysosomes. J Cell Sci (2004) 1.82
The incremental value of 18F-FDG PET/CT in paediatric malignancies. Eur J Nucl Med Mol Imaging (2006) 1.79
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis. FEBS J (2010) 1.78
Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem (2004) 1.78
Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma. J Clin Invest (2009) 1.73
Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice. Circ Res (2008) 1.64
Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior. FASEB J (2004) 1.64
Heparanase affects adhesive and tumorigenic potential of human glioma cells. Cancer Res (2003) 1.54
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils. Blood (2010) 1.53
Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting. J Biol Chem (2005) 1.52
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy. Blood (2007) 1.49
Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes. J Biol Chem (2013) 1.49
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases. PLoS One (2009) 1.46
Significance of heparanase in cancer and inflammation. Cancer Microenviron (2011) 1.46
Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis. Proc Natl Acad Sci U S A (2002) 1.45
Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46. J Immunol (2004) 1.43
Adults requiring cord blood transplants but have insufficient cell doses from a single cord blood unit can receive two units with successful engraftment kinetics similar to those of children receiving a single unit. Leuk Lymphoma (2011) 1.43
Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. J Biol Chem (2004) 1.43
Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment. J Biol Chem (2008) 1.43
Heparanase promotes growth, angiogenesis and survival of primary breast tumors. Int J Cancer (2006) 1.42
Interleukin-7 receptor alpha (IL-7Ralpha) deficiency: cellular and molecular bases. Analysis of clinical, immunological, and molecular features in 16 novel patients. Immunol Rev (2005) 1.42
Myeloid dysplasia in familial 3-methylglutaconic aciduria. J Pediatr Hematol Oncol (2006) 1.42
Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice. Neurosci Lett (2011) 1.41
Non-anticoagulant heparins and inhibition of cancer. Pathophysiol Haemost Thromb (2009) 1.41
Heparanase mediates cell adhesion independent of its enzymatic activity. FASEB J (2003) 1.41
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development (2007) 1.40
SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis. Clin Cancer Res (2011) 1.40
In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis. Proc Natl Acad Sci U S A (2005) 1.37
Frequency and natural history of inherited bone marrow failure syndromes: the Israeli Inherited Bone Marrow Failure Registry. Haematologica (2010) 1.36
Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. Cancer Res (2008) 1.35
Role of endothelial heparanase in delayed-type hypersensitivity. Blood (2005) 1.35
Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling. Cancer Res (2009) 1.34
Cellular heparan sulfate participates in the metabolism of prions. J Biol Chem (2003) 1.34
Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models. FASEB J (2005) 1.32
Heparan sulfate is a cellular receptor for purified infectious prions. J Biol Chem (2005) 1.32
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice. J Clin Invest (2011) 1.32
Heparanase induces VEGF C and facilitates tumor lymphangiogenesis. Int J Cancer (2008) 1.31
Heparanase: one molecule with multiple functions in cancer progression. Connect Tissue Res (2008) 1.29
Heparanase is essential for the development of diabetic nephropathy in mice. Diabetes (2011) 1.29
The impact of heparanese and heparin on cancer metastasis and angiogenesis. Pathophysiol Haemost Thromb (2006) 1.29
The heparanase system and tumor metastasis: is heparanase the seed and soil? Cancer Metastasis Rev (2011) 1.28
Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival. Neoplasia (2006) 1.28
Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase. J Biol Chem (2005) 1.27
Heparin, heparan sulfate and heparanase in inflammatory reactions. Thromb Haemost (2009) 1.27
Function of heparanase in prostate tumorigenesis: potential for therapy. Clin Cancer Res (2008) 1.25
Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate. Nat Chem Biol (2007) 1.25
The heparanase/syndecan-1 axis in cancer: mechanisms and therapies. FEBS J (2013) 1.24
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity. J Biol Chem (2010) 1.19
Heterodimer formation is essential for heparanase enzymatic activity. Biochem Biophys Res Commun (2003) 1.17
Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts. J Immunol (2004) 1.16
P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins. FASEB J (2007) 1.14
Heparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycans. PLoS One (2008) 1.14
Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase. J Biol Chem (2005) 1.13
A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics. FASEB J (2009) 1.13
Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts. J Cell Sci (2002) 1.12
Role of promoter methylation in regulation of the mammalian heparanase gene. Oncogene (2003) 1.12
Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass. J Cell Physiol (2006) 1.11
Tumorigenic and adhesive properties of heparanase. Semin Cancer Biol (2010) 1.10
Regulation of heparanase gene expression by estrogen in breast cancer. Cancer Res (2003) 1.09
Heparanase upregulation by colonic epithelium in inflammatory bowel disease. Mod Pathol (2006) 1.09
Characterization of mechanisms involved in secretion of active heparanase. J Biol Chem (2006) 1.08
Human heparanase is localized within lysosomes in a stable form. Exp Cell Res (2002) 1.07
Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis. Cancer Res (2009) 1.07
Airway reactivity in children before and after stem cell transplantation. Pediatr Pulmonol (2009) 1.06
Local retention versus systemic release of soluble VEGF receptor-1 are mediated by heparin-binding and regulated by heparanase. Circ Res (2011) 1.04
Heparanase induces Akt phosphorylation via a lipid raft receptor. Biochem Biophys Res Commun (2007) 1.04
An ELISA method for the detection and quantification of human heparanase. Biochem Biophys Res Commun (2006) 1.03
Assessing the use of FDG-PET in the detection of regional and metastatic nodes in alveolar rhabdomyosarcoma of extremities. J Pediatr Hematol Oncol (2006) 1.03