Published in J Biomol Screen on November 26, 2007
Nectin 4 overexpression in ovarian cancer tissues and serum: potential role as a serum biomarker. Am J Clin Pathol (2010) 1.42
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nat Commun (2014) 1.19
Development of multicellular tumor spheroid (MCTS) culture from breast cancer cell and a high throughput screening method using the MTT assay. PLoS One (2012) 1.02
Advanced cell culture techniques for cancer drug discovery. Biology (Basel) (2014) 1.01
Prediction of individual response to anticancer therapy: historical and future perspectives. Cell Mol Life Sci (2014) 0.86
Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. PLoS One (2009) 0.85
High-content assays for characterizing the viability and morphology of 3D cancer spheroid cultures. Assay Drug Dev Technol (2015) 0.85
Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors. Int J Mol Sci (2015) 0.82
Large-scale pharmacological profiling of 3D tumor models of cancer cells. Cell Death Dis (2016) 0.75
An armed, YB-1-dependent oncolytic adenovirus as a candidate for a combinatorial anti-glioma approach of virotherapy, suicide gene therapy and chemotherapeutic treatment. Cancer Gene Ther (2014) 0.75
Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med (2011) 4.09
Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem (2002) 2.20
Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18. Cancer Res (2004) 2.03
Gastric marginal zone B-cell lymphomas of MALT type develop along 2 distinct pathogenetic pathways. Blood (2002) 2.00
Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA. Int J Cancer (2007) 1.67
Simultaneous detection of HER2/neu gene amplification and protein overexpression in paraffin-embedded breast cancer. J Pathol (2005) 1.60
Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir. Int J Cancer (2008) 1.55
Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis. Mol Cell Biol (2002) 1.54
A novel high-through-put assay for screening of pro-apoptotic drugs. Invest New Drugs (2002) 1.49
Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy. Clin Cancer Res (2007) 1.45
Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. Proc Natl Acad Sci U S A (2004) 1.42
Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients. Breast Cancer Res (2008) 1.40
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood (2013) 1.38
Molecular classification of borderline ovarian tumors using hierarchical cluster analysis of protein expression profiles. Int J Cancer (2002) 1.30
Processing of pulmonary surfactant protein B by napsin and cathepsin H. J Biol Chem (2004) 1.29
Autophagy is a protective mechanism for human melanoma cells under acidic stress. J Biol Chem (2012) 1.17
Correlating genetic aberrations with World Health Organization-defined histology and stage across the spectrum of thymomas. Cancer Res (2003) 1.12
Large-scale proteomics analysis of human ovarian cancer for biomarkers. J Proteome Res (2007) 1.12
The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival. Lung Cancer (2007) 1.11
Loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin. J Virol (2006) 1.09
Infraorbital cutaneous angiosarcoma: a diagnostic and therapeutic dilemma. Head Face Med (2008) 1.09
Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect? Mini Rev Med Chem (2007) 1.09
Osteotomy and primary wound closure in bisphosphonate-associated osteonecrosis of the jaw: a prospective clinical study with 12 months follow-up. Support Care Cancer (2009) 1.08
Clinical cancer proteomics: promises and pitfalls. J Proteome Res (2005) 1.07
Proteasome deubiquitinases as novel targets for cancer therapy. Int J Biochem Cell Biol (2012) 1.07
Cisplatin and oxaliplatin toxicity: importance of cochlear kinetics as a determinant for ototoxicity. J Natl Cancer Inst (2008) 1.02
Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells. Biochem Biophys Res Commun (2013) 1.01
Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts. Liver Int (2013) 1.00
Imaging of objects through active electrolocation in Gnathonemus petersii. J Physiol Paris (2003) 0.98
Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system. Int J Cancer (2009) 0.98
Alterations in the cellular immune compartment of patients treated with third-party mesenchymal stromal cells following allogeneic hematopoietic stem cell transplantation. Stem Cells (2013) 0.93
EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis. Hum Pathol (2011) 0.93
Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells. Virology (2013) 0.92
Carcinoma ex pleomorphic adenoma with special reference to the prognostic significance of histological progression: a clinicopathological investigation of 41 cases. Histopathology (2011) 0.92
Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation. Free Radic Biol Med (2009) 0.91
Fatal pulmonary failure attributable to viral pneumonia with human herpes virus 6 (HHV6) in a young immunocompetent woman. J Intensive Care Med (2005) 0.91
Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model. Int J Cancer (2009) 0.91
High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma. Cancer Res (2004) 0.91
The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death. Mol Pharmacol (2014) 0.90
Morphological differentiation of severe aplastic anaemia from hypocellular refractory cytopenia of childhood: reproducibility of histopathological diagnostic criteria. Histopathology (2012) 0.90
Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress. Antioxid Redox Signal (2013) 0.90
Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response. Biochem J (2012) 0.89
KRAS status and epidermal growth factor receptor expression as determinants for anti-EGFR therapies in salivary gland carcinomas. Oral Oncol (2009) 0.88
Fluorescein-aided confocal laser endomicroscopy of the lung. Respiration (2010) 0.88
Identification of agents that induce apoptosis of multicellular tumour spheroids: enrichment for mitotic inhibitors with hydrophobic properties. Chem Biol Drug Des (2011) 0.88
Novel activity of acriflavine against colorectal cancer tumor cells. Cancer Sci (2011) 0.87
Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood. Haematologica (2013) 0.87
Presence of HER4 associates with increased sensitivity to Herceptin in patients with metastatic breast cancer. Breast Cancer Res (2009) 0.86
Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer. Eur J Cancer (2010) 0.86
Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor. Cancer Res (2007) 0.86
Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. PLoS One (2009) 0.85
Induction of endoplasmic reticulum stress by ellipticine plant alkaloids. Mol Cancer Ther (2004) 0.85
Screening of natural products for therapeutic activity against solid tumors. Indian J Exp Biol (2010) 0.85
[Comparison of clinical immunohistochemical findings in keratocystic odontogenic tumours and ameloblastomas considering their risk of recurrence]. Mund Kiefer Gesichtschir (2007) 0.85
Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells. Br J Haematol (2015) 0.85
Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line. Exp Cell Res (2003) 0.84
A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells. Cancer Immunol Immunother (2013) 0.84
The buccal minor salivary glands as starting point for a metastasizing adenocarcinoma--report of a case. Head Face Med (2008) 0.84
Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment. Biochem Pharmacol (2011) 0.82
The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity. Lab Invest (2008) 0.82
Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts. PLoS One (2012) 0.82
Multicolor FISH (UroVysion) facilitates follow-up of patients with high-grade urothelial carcinoma of the bladder. Am J Clin Pathol (2010) 0.82
Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis. FEBS Lett (2005) 0.82
Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines. Scand J Urol Nephrol (2009) 0.82
Foreign body reaction after usage of tissue adhesives for skin closure: a case report and review of the literature. Arch Orthop Trauma Surg (2008) 0.81
Target specificity and off-target effects as determinants of cancer drug efficacy. Expert Opin Drug Metab Toxicol (2008) 0.81
A close association between alteration in growth kinetics by neoadjuvant chemotherapy and survival outcome in primary breast cancer. Int J Oncol (2004) 0.81
Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis. Mol Biosyst (2010) 0.81
The prognostic impact of human leukocyte antigen (HLA) class I antigen abnormalities in salivary gland cancer. A clinicopathological study of 288 cases. Histopathology (2013) 0.79
Nonclassical antifolates, part 4. 5-(2-aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: synthesis, biological evaluation and molecular modeling study. Eur J Med Chem (2013) 0.78
A natural anticancer agent thaspine targets human topoisomerase IB. Anticancer Agents Med Chem (2013) 0.78
Expression of UPA and UPAR is associated with the clinical course of urinary bladder neoplasms. Int J Cancer (2002) 0.78
Low level STK15 amplification in histologically benign urothelium of patients with bladder cancer adversely predicts patient outcome following cystectomy. Int J Oncol (2007) 0.78
Volcano-like intermittent bleeding activity for seven years from an arterio-enteric fistula on a kidney graft site after pancreas-kidney transplantation: a case report. J Med Case Rep (2010) 0.78
Genetic analysis of de novo CD5+ diffuse large B-cell lymphomas suggests an origin from a somatically mutated CD5+ progenitor B cell. Blood (2002) 0.78
Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs. Int J Cancer (2014) 0.78
Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system. Invest New Drugs (2012) 0.78
Oropharyngeal tularemia--a differential diagnosis of tonsillopharyngitis and cervical lymphadenitis. Wien Klin Wochenschr (2010) 0.78
Contribution to in vitro screening of Egyptian plants for schistosomicidal activity. Pharm Biol (2011) 0.77
Prognostic value of O-6-methylguanine-DNA methyltransferase loss in salivary gland carcinomas. Head Neck (2013) 0.77
Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance. BMC Cancer (2013) 0.77
Utilization of a right-handed coiled-coil protein from archaebacterium Staphylothermus marinus as a carrier for cisplatin. Anticancer Res (2009) 0.77
EGFR (HER) family protein expression and cytogenetics in 219 squamous cell carcinomas of the upper respiratory tract: ERBB2 overexpression independent prediction of poor prognosis. Anal Quant Cytol Histol (2010) 0.77
Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1. Exp Cell Res (2006) 0.76
Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death. Biochim Biophys Acta (2013) 0.76
Expression of leptin, leptin receptor, and connective tissue growth factor in degenerative disk lesions in the wrist. Arthroscopy (2011) 0.76
The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy. Eur J Cancer (2011) 0.76
Determination of cell death modes using circulating biomarkers. Liver Int (2011) 0.75
MAGE-A as a novel approach in the diagnostic accuracy of oral squamous cell cancer: a case report. Head Neck Oncol (2009) 0.75
Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis. J Chem Biol (2009) 0.75
Caspase-cleaved keratin 18 as a biomarker for non-alcoholic steatohepatitis (NASH) - the need for correct terminology. J Hepatol (2011) 0.75