Published in Cancer Res on March 15, 2007
Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma. Blood (2012) 1.58
Modulation of insulin-like growth factor-1 receptor and its signaling network for the treatment of cancer: current status and future perspectives. Oncol Rev (2013) 0.79
Potent inhibitory effect of the cyclolignan picropodophyllin (PPP) on human adrenocortical carcinoma cells proliferation. Am J Cancer Res (2011) 0.76
IGF-IR and its inhibitors in gastrointestinal carcinomas (Review). Oncol Lett (2010) 0.75
Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells. Eur J Med Chem (2015) 0.75
Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med (2011) 4.09
Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem (2002) 2.20
Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18. Cancer Res (2004) 2.03
Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA. Int J Cancer (2007) 1.67
The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity. PLoS Genet (2009) 1.64
Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir. Int J Cancer (2008) 1.55
Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis. Mol Cell Biol (2002) 1.54
A novel high-through-put assay for screening of pro-apoptotic drugs. Invest New Drugs (2002) 1.49
Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy. Clin Cancer Res (2007) 1.45
Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. Proc Natl Acad Sci U S A (2004) 1.42
Genomics as a means to understand bacterial phylogeny and ecological adaptation: the case of bifidobacteria. Antonie Van Leeuwenhoek (2006) 1.41
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood (2013) 1.38
The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. J Neurochem (2009) 1.38
Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin. J Biol Chem (2002) 1.38
Molecular classification of borderline ovarian tumors using hierarchical cluster analysis of protein expression profiles. Int J Cancer (2002) 1.30
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. Mol Biol Cell (2005) 1.29
Processing of pulmonary surfactant protein B by napsin and cathepsin H. J Biol Chem (2004) 1.29
Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker. Cancer Lett (2004) 1.25
Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria. Microbiol Mol Biol Rev (2012) 1.19
Autophagy is a protective mechanism for human melanoma cells under acidic stress. J Biol Chem (2012) 1.17
Interferon-alpha-induced apoptosis in U266 cells is associated with activation of the proapoptotic Bcl-2 family members Bak and Bax. Oncogene (2003) 1.14
Large-scale proteomics analysis of human ovarian cancer for biomarkers. J Proteome Res (2007) 1.12
The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival. Lung Cancer (2007) 1.11
Loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin. J Virol (2006) 1.09
Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect? Mini Rev Med Chem (2007) 1.09
3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs. Mol Oncol (2008) 1.08
Phylogenomics and protein signatures elucidating the evolutionary relationships among the Gammaproteobacteria. Int J Syst Evol Microbiol (2009) 1.07
Clinical cancer proteomics: promises and pitfalls. J Proteome Res (2005) 1.07
Proteasome deubiquitinases as novel targets for cancer therapy. Int J Biochem Cell Biol (2012) 1.07
Lysosomes and endoplasmic reticulum: targets for improved, selective anticancer therapy. Drug Resist Updat (2005) 1.06
Phylogenomic analysis of proteins that are distinctive of Archaea and its main subgroups and the origin of methanogenesis. BMC Genomics (2007) 1.06
The T cells specific for the carboxyl-terminal determinants of self (rat) heat-shock protein 65 escape tolerance induction and are involved in regulation of autoimmune arthritis. J Immunol (2004) 1.06
Signature proteins that are distinctive characteristics of Actinobacteria and their subgroups. Antonie Van Leeuwenhoek (2006) 1.05
Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. J Diabetes (2012) 1.04
Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus. Biochem Biophys Res Commun (2009) 1.01
Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells. Biochem Biophys Res Commun (2013) 1.01
Signature sequences in diverse proteins provide evidence for the late divergence of the Order Aquificales. Int Microbiol (2004) 1.01
Conserved indels in protein sequences that are characteristic of the phylum Actinobacteria. Int J Syst Evol Microbiol (2005) 1.01
Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts. Liver Int (2013) 1.00
BLAST screening of chlamydial genomes to identify signature proteins that are unique for the Chlamydiales, Chlamydiaceae, Chlamydophila and Chlamydia groups of species. BMC Genomics (2006) 0.98
Phylogeny and shared conserved inserts in proteins provide evidence that Verrucomicrobia are the closest known free-living relatives of chlamydiae. Microbiology (2007) 0.98
Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system. Int J Cancer (2009) 0.98
Effects of embelin on lipid peroxidation and free radical scavenging activity against liver damage in rats. Basic Clin Pharmacol Toxicol (2009) 0.98
Pentavalent ions dependency is a conserved property of adenosine kinase from diverse sources: identification of a novel motif implicated in phosphate and magnesium ion binding and substrate inhibition. Biochemistry (2002) 0.96
Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells. Mol Cancer Ther (2009) 0.94
Novel mitochondrial extensions provide evidence for a link between microtubule-directed movement and mitochondrial fission. Biochem Biophys Res Commun (2008) 0.94
Alterations in the cellular immune compartment of patients treated with third-party mesenchymal stromal cells following allogeneic hematopoietic stem cell transplantation. Stem Cells (2013) 0.93
Mitochondrial import of human and yeast fumarase in live mammalian cells: retrograde translocation of the yeast enzyme is mainly caused by its poor targeting sequence. Biochem Biophys Res Commun (2006) 0.93
Identification and characterization of human ribokinase and comparison of its properties with E. coli ribokinase and human adenosine kinase. FEBS Lett (2007) 0.93
Signature proteins that are distinctive of alpha proteobacteria. BMC Genomics (2005) 0.92
Distinctive protein signatures provide molecular markers and evidence for the monophyletic nature of the deinococcus-thermus phylum. J Bacteriol (2004) 0.92
Screening for compounds that induce apoptosis of cancer cells grown as multicellular spheroids. J Biomol Screen (2007) 0.92
Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells. Virology (2013) 0.92
Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model. Int J Cancer (2009) 0.91
Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation. Free Radic Biol Med (2009) 0.91
The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death. Mol Pharmacol (2014) 0.90
Structure and protein-protein interaction studies on Chlamydia trachomatis protein CT670 (YscO Homolog). J Bacteriol (2010) 0.90
Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress. Antioxid Redox Signal (2013) 0.90
Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response. Biochem J (2012) 0.89
Approaches to the study of the systematics of anaerobic, gram-negative, non-sporeforming rods: current status and perspectives. Anaerobe (2009) 0.89
Identification of agents that induce apoptosis of multicellular tumour spheroids: enrichment for mitotic inhibitors with hydrophobic properties. Chem Biol Drug Des (2011) 0.88
Phylogenomics and molecular signatures for the order Neisseriales: proposal for division of the order Neisseriales into the emended family Neisseriaceae and Chromobacteriaceae fam. nov. Antonie Van Leeuwenhoek (2013) 0.88
Novel activity of acriflavine against colorectal cancer tumor cells. Cancer Sci (2011) 0.87
Identification of signature proteins that are distinctive of the Deinococcus-Thermus phylum. Int Microbiol (2007) 0.87
Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation. Carcinogenesis (2009) 0.87
Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer. Eur J Cancer (2010) 0.86
Screening of natural products for therapeutic activity against solid tumors. Indian J Exp Biol (2010) 0.85
Induction of endoplasmic reticulum stress by ellipticine plant alkaloids. Mol Cancer Ther (2004) 0.85
Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. PLoS One (2009) 0.85
Conserved inserts in the Hsp60 (GroEL) and Hsp70 (DnaK) proteins are essential for cellular growth. Mol Genet Genomics (2009) 0.85
Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells. Br J Haematol (2015) 0.85
Molecular signatures for Bacillus species: demarcation of the Bacillus subtilis and Bacillus cereus clades in molecular terms and proposal to limit the placement of new species into the genus Bacillus. Int J Syst Evol Microbiol (2013) 0.84
Protein signatures distinctive of chlamydial species: horizontal transfers of cell wall biosynthesis genes glmU from archaea to chlamydiae and murA between chlamydiae and Streptomyces. Microbiology (2002) 0.84
Subcellular localization of fumarase in mammalian cells and tissues. Histochem Cell Biol (2006) 0.84
Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line. Exp Cell Res (2003) 0.84
A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells. Cancer Immunol Immunother (2013) 0.84
Antioxidant activity and protection of pancreatic β-cells by embelin in streptozotocin-induced diabetes. J Diabetes (2012) 0.83
Microbial systematics in the post-genomics era. Antonie Van Leeuwenhoek (2011) 0.83
Phylogenetic analysis and molecular signatures defining a monophyletic clade of heterocystous cyanobacteria and identifying its closest relatives. Photosynth Res (2014) 0.83
Conserved signature indels and signature proteins as novel tools for understanding microbial phylogeny and systematics: identification of molecular signatures that are specific for the phytopathogenic genera Dickeya, Pectobacterium and Brenneria. Int J Syst Evol Microbiol (2014) 0.82
Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts. PLoS One (2012) 0.82
The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity. Lab Invest (2008) 0.82
Molecular signatures (conserved indels) in protein sequences that are specific for the order Pasteurellales and distinguish two of its main clades. Antonie Van Leeuwenhoek (2011) 0.82
Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis. FEBS Lett (2005) 0.82
Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment. Biochem Pharmacol (2011) 0.82
Induction of mitochondrial fusion by cysteine-alkylators ethacrynic acid and N-ethylmaleimide. J Cell Physiol (2005) 0.82
Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines. Scand J Urol Nephrol (2009) 0.82