Prediction of synergistic transcription factors by function conservation.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMC 2246259)

Published in Genome Biol on January 01, 2007

Authors

Zihua Hu1, Boyu Hu, James F Collins

Author Affiliations

1: New York State Center of Excellence in Bioinformatics and Life Sciences, Department of Biostatistics, Department of Medicine, University at Buffalo, State University of New York (SUNY), Buffalo, NY 14260, USA. zihuahu@ccr.buffalo.edu

Articles citing this

Associating transcription factor-binding site motifs with target GO terms and target genes. Nucleic Acids Res (2008) 2.69

Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers. Genome Res (2010) 2.12

Variable locus length in the human genome leads to ascertainment bias in functional inference for non-coding elements. Bioinformatics (2009) 1.49

Genome-wide identification of conserved regulatory function in diverged sequences. Genome Res (2011) 1.07

Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis. Br J Cancer (2008) 1.04

Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells. Am J Physiol Cell Physiol (2011) 1.02

Simplified method to predict mutual interactions of human transcription factors based on their primary structure. PLoS One (2011) 0.86

Identification of interacting transcription factors regulating tissue gene expression in human. BMC Genomics (2010) 0.85

Functional annotation of novel lineage-specific genes using co-expression and promoter analysis. BMC Genomics (2010) 0.80

Combinatorial Cis-regulation in Saccharomyces Species. G3 (Bethesda) (2016) 0.79

Identification of HMX1 target genes: a predictive promoter model approach. Mol Vis (2013) 0.78

PC-TraFF: identification of potentially collaborating transcription factors using pointwise mutual information. BMC Bioinformatics (2015) 0.76

Searching for synergies: matrix algebraic approaches for efficient pair screening. PLoS One (2013) 0.75

Articles cited by this

Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52

DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol (2003) 84.79

Transcriptional regulatory networks in Saccharomyces cerevisiae. Science (2002) 43.52

TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Res (2003) 29.26

TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic Acids Res (2006) 22.20

MATCH: A tool for searching transcription factor binding sites in DNA sequences. Nucleic Acids Res (2003) 11.82

Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol (1997) 11.57

Applied bioinformatics for the identification of regulatory elements. Nat Rev Genet (2004) 9.96

Identifying regulatory networks by combinatorial analysis of promoter elements. Nat Genet (2001) 7.74

rVista for comparative sequence-based discovery of functional transcription factor binding sites. Genome Res (2002) 7.33

Tissue-specific transcriptional regulation has diverged significantly between human and mouse. Nat Genet (2007) 6.92

Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genome. Genome Res (2006) 6.54

Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell (2006) 6.49

NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol (2005) 6.25

Sp1- and Krüppel-like transcription factors. Genome Biol (2003) 5.42

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev (1994) 4.93

A compilation of composite regulatory elements affecting gene transcription in vertebrates. Nucleic Acids Res (1995) 4.93

Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu Rev Biochem (1994) 4.00

Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis. Curr Mol Med (2006) 3.86

Nuclear activators and coactivators in mammalian mitochondrial biogenesis. Biochim Biophys Acta (2002) 3.34

Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev (1994) 3.27

Roles of the NFI/CTF gene family in transcription and development. Gene (2000) 3.00

Interferon regulatory factors: the next generation. Gene (1999) 2.98

Identification of common transcriptional regulatory elements in interleukin-17 target genes. J Biol Chem (2006) 2.65

Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors. Cell (2000) 2.60

DBTSS: DataBase of Human Transcription Start Sites, progress report 2006. Nucleic Acids Res (2006) 2.52

Identifying cooperativity among transcription factors controlling the cell cycle in yeast. Nucleic Acids Res (2003) 2.50

Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol Cell Biol (1996) 2.46

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes. Immunol Today (1994) 2.43

MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination. Proc Natl Acad Sci U S A (1992) 2.40

Computational analysis of tissue-specific combinatorial gene regulation: predicting interaction between transcription factors in human tissues. Nucleic Acids Res (2006) 2.26

Identifying combinatorial regulation of transcription factors and binding motifs. Genome Biol (2004) 2.12

Interacting models of cooperative gene regulation. Proc Natl Acad Sci U S A (2004) 2.09

Statistical methods for identifying yeast cell cycle transcription factors. Proc Natl Acad Sci U S A (2005) 1.81

Mining ChIP-chip data for transcription factor and cofactor binding sites. Bioinformatics (2005) 1.81

Identification of regulatory elements using a feature selection method. Bioinformatics (2002) 1.80

Co-regulation of B-Myb expression by E2F1 and EGF receptor. Mol Carcinog (2006) 1.78

The ZIC gene family in development and disease. Clin Genet (2005) 1.66

Predicting transcription factor synergism. Nucleic Acids Res (2002) 1.66

Genome-wide prediction and characterization of interactions between transcription factors in Saccharomyces cerevisiae. Nucleic Acids Res (2006) 1.65

Early transcriptional events in cell growth: the Egr family. J Am Soc Nephrol (1990) 1.61

Signalling into the T-cell nucleus: NFAT regulation. Cell Signal (1998) 1.58

Egr transcription factors in the nervous system. Neurochem Int (1997) 1.56

Discovering functional transcription-factor combinations in the human cell cycle. Genome Res (2005) 1.53

Mzf1 controls cell proliferation and tumorigenesis. Genes Dev (2001) 1.43

Phylogenetically and spatially conserved word pairs associated with gene-expression changes in yeasts. Genome Biol (2003) 1.40

Inhibition of the mammalian transcription factor LSF induces S-phase-dependent apoptosis by downregulating thymidylate synthase expression. EMBO J (2000) 1.36

Sp1-like transcription factors are regulators of embryonic development in vertebrates. Dev Growth Differ (2005) 1.31

Extraction of transcription regulatory signals from genome-wide DNA-protein interaction data. Nucleic Acids Res (2005) 1.27

Transcription factor TFIIIB and transcription by RNA polymerase III. Biochem Soc Trans (2006) 1.13

Identifying cooperative transcriptional regulations using protein-protein interactions. Nucleic Acids Res (2005) 1.09

Correlation between E2F-1 requirement in the S phase and E2F-1 transactivation of cell cycle-related genes in human cells. Cancer Res (1994) 1.09

Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylation. Mol Pharmacol (2006) 1.04

The ZiN/POZ domain of ZF5 is required for both transcriptional activation and repression. Nucleic Acids Res (1997) 1.04

Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts. Exp Cell Res (2005) 1.03

SP1 transcription factors in male germ cell development and differentiation. Mol Cell Endocrinol (2007) 1.01

Transcription factor activator protein-2 is required for continued luteinizing hormone-releasing hormone expression in the forebrain of developing mice. Endocrinology (2000) 1.01

Activation of the adenovirus major late promoter by transcription factors MAZ and Sp1. J Virol (1997) 1.00

Visualization and analysis of protein interactions. Bioinformatics (2003) 1.00

Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo. Dev Biol (2007) 0.97

Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor. Endocrinology (2001) 0.96

Molecular characterization of cDNA encoding a novel protein related to transcriptional enhancer factor-1 from neural precursor cells. J Biol Chem (1995) 0.95

Functional roles of E2F in cell cycle regulation. Oncogene (1997) 0.92

Maintaining HNF6 expression prevents AdHNF3beta-mediated decrease in hepatic levels of Glut-2 and glycogen. Hepatology (2002) 0.92

Progesterone synthesis and myelin formation in peripheral nerves. Brain Res Brain Res Rev (2001) 0.92

Identification of domains mediating transcription activation, repression, and inhibition in the paired-related homeobox protein, Prx2 (S8). DNA Cell Biol (2001) 0.91

Sp1 is a co-activator with Ets-1, and Net is an important repressor of the transcription of CTP:phosphocholine cytidylyltransferase alpha. J Biol Chem (2005) 0.87

Cell cycle-mediated regulation of smooth muscle alpha-actin gene transcription in fibroblasts and vascular smooth muscle cells involves multiple adenovirus E1A-interacting cofactors. J Biol Chem (2004) 0.85

Promoter analysis of intestinal genes induced during iron-deprivation reveals enrichment of conserved SP1-like binding sites. BMC Genomics (2007) 0.83

ZF5, which is a Kruppel-type transcriptional repressor, requires the zinc finger domain for self-association. Biochem Biophys Res Commun (1999) 0.83

PU.1 negatively regulates the CD11c integrin gene promoter through recognition of the major transcriptional start site. Eur J Immunol (1997) 0.81

Molecular principles of Oct2-mediated gene activation in B cells. Immunobiology (1995) 0.80

Molecular cloning and characterization of human acid sensing ion channel (ASIC)2 gene promoter. Gene (2003) 0.78

c-Krox down-regulates the expression of UDP-glucose dehydrogenase in chondrocytes. Biochem Biophys Res Commun (2005) 0.78

Identification of human autoantibodies to the transcriptional repressor ZF5. J Autoimmun (2000) 0.78

Sp1 interacts with the consensus sequence for Egr-1 gene product with a cellular factor(s) and activates the transcription through this element. Biochem Biophys Res Commun (1993) 0.76

Articles by these authors

1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport. Am J Physiol Gastrointest Liver Physiol (2005) 2.08

Silencing the Menkes copper-transporting ATPase (Atp7a) gene in rat intestinal epithelial (IEC-6) cells increases iron flux via transcriptional induction of ferroportin 1 (Fpn1). J Nutr (2013) 1.51

Menkes Copper ATPase (Atp7a) is a novel metal-responsive gene in rat duodenum, and immunoreactive protein is present on brush-border and basolateral membrane domains. J Biol Chem (2005) 1.28

Age-dependent regulation of rat intestinal type IIb sodium-phosphate cotransporter by 1,25-(OH)(2) vitamin D(3). Am J Physiol Cell Physiol (2002) 1.09

Serum ceruloplasmin protein expression and activity increases in iron-deficient rats and is further enhanced by higher dietary copper intake. Blood (2011) 1.09

Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen. Am J Physiol Gastrointest Liver Physiol (2003) 1.06

Transcriptional regulation of the rat NHE3 gene. Functional interactions between GATA-5 and Sp family transcription factors. J Biol Chem (2002) 1.05

Glucocorticoid regulation and glycosylation of mouse intestinal type IIb Na-P(i) cotransporter during ontogeny. Am J Physiol Gastrointest Liver Physiol (2002) 1.03

Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells. Am J Physiol Cell Physiol (2011) 1.02

Exploration of the copper-related compensatory response in the Belgrade rat model of genetic iron deficiency. Am J Physiol Gastrointest Liver Physiol (2011) 0.99

Discovery of a cytosolic/soluble ferroxidase in rodent enterocytes. Proc Natl Acad Sci U S A (2012) 0.96

Cross-species comparison of genomewide gene expression profiles reveals induction of hypoxia-inducible factor-responsive genes in iron-deprived intestinal epithelial cells. Am J Physiol Cell Physiol (2010) 0.95

Transcriptional regulation of the human NaPi-IIb cotransporter by EGF in Caco-2 cells involves c-myb. Am J Physiol Cell Physiol (2003) 0.94

Immunoreactive hephaestin and ferroxidase activity are present in the cytosolic fraction of rat enterocytes. Biometals (2012) 0.92

NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene. Am J Physiol Gastrointest Liver Physiol (2004) 0.86

Investigation of iron metabolism in mice expressing a mutant Menke's copper transporting ATPase (Atp7a) protein with diminished activity (Brindled; Mo (Br) (/y) ). PLoS One (2013) 0.86

Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia. J Biol Chem (2013) 0.85

Effects of angiotensin II on NaPi-IIa co-transporter expression and activity in rat renal cortex. Biochim Biophys Acta (2004) 0.84

Molecular mediators governing iron-copper interactions. Annu Rev Nutr (2014) 0.84

Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells. J Nutr (2013) 0.84

Effect of angiotensin-II on renal Na+/H+ exchanger-NHE3 and NHE2. Biochim Biophys Acta (2004) 0.83

Copper stabilizes the Menkes copper-transporting ATPase (Atp7a) protein expressed in rat intestinal epithelial cells. Am J Physiol Cell Physiol (2012) 0.82

1,25-dihydroxyvitamin D3 down-regulation of PHEX gene expression is mediated by apparent repression of a 110 kDa transfactor that binds to a polyadenine element in the promoter. J Biol Chem (2004) 0.82

Glucocorticoid regulation of the murine PHEX gene. Am J Physiol Renal Physiol (2002) 0.81

Functional characterization of the human intestinal NaPi-IIb cotransporter in hamster fibroblasts and Xenopus oocytes. Biochim Biophys Acta (2002) 0.79

Multiple Menkes copper ATPase (Atp7a) transcript and protein variants are induced by iron deficiency in rat duodenal enterocytes. J Trace Elem Med Biol (2012) 0.76

Catholic charities. Soc Work (2004) 0.75

Genetic responses to dietary phosphorus deprivation: lessons learned from the rainbow trout. Am J Physiol Regul Integr Comp Physiol (2004) 0.75