Published in Nat Rev Immunol on June 01, 2005
Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol (2008) 3.98
Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol (2007) 3.57
Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities. Genome Res (2010) 3.46
Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiol Mol Biol Rev (2006) 3.30
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immunol (2008) 3.23
The role of retinoic acid in tolerance and immunity. Immunity (2011) 3.16
Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell (2012) 2.79
NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol (2010) 2.77
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nat Genet (2007) 2.77
Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation. J Clin Invest (2009) 2.75
Role for miR-204 in human pulmonary arterial hypertension. J Exp Med (2011) 2.60
Calcium signaling in lymphocytes. Curr Opin Immunol (2008) 2.38
NFAT proteins: emerging roles in cancer progression. Nat Rev Cancer (2009) 2.18
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol (2009) 2.17
Ion channels in innate and adaptive immunity. Annu Rev Immunol (2015) 1.99
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells. Immunity (2015) 1.94
The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Proc Natl Acad Sci U S A (2007) 1.93
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol (2015) 1.88
Calcineurin regulates innate antifungal immunity in neutrophils. J Exp Med (2010) 1.76
Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin. J Biol Chem (2008) 1.67
The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells. Nat Immunol (2009) 1.66
Calcium signalling and cell-fate choice in B cells. Nat Rev Immunol (2007) 1.64
Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell (2008) 1.63
Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. Cytokine Growth Factor Rev (2010) 1.61
The metabolic life and times of a T-cell. Immunol Rev (2010) 1.57
Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors. Mol Cell Biol (2008) 1.52
Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki. Mol Biol Evol (2010) 1.43
Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells. Blood (2007) 1.43
Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling. Nat Struct Mol Biol (2012) 1.42
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology. Front Oncol (2013) 1.42
Molecular mechanisms of treg-mediated T cell suppression. Front Immunol (2012) 1.41
Promiscuous partnerships in Ewing's sarcoma. Cancer Genet (2011) 1.41
p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation. PLoS One (2016) 1.40
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nat Immunol (2010) 1.39
Immunodeficiency due to mutations in ORAI1 and STIM1. Clin Immunol (2010) 1.39
Molecular mechanisms for adaptive tolerance and other T cell anergy models. Semin Immunol (2007) 1.38
Perforin is a critical physiologic regulator of T-cell activation. Blood (2011) 1.32
Transcriptional control of the TNF gene. Curr Dir Autoimmun (2010) 1.32
Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes. Mol Cell Biol (2007) 1.30
NFAT signaling in neural development and axon growth. Int J Dev Neurosci (2007) 1.30
CCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation. J Immunol (2009) 1.26
Targeting protein serine/threonine phosphatases for drug development. Mol Pharmacol (2009) 1.25
Transcriptional control of invariant NKT cell development. Immunol Rev (2010) 1.24
Resection of non-small cell lung cancers reverses tumor-induced gene expression changes in the peripheral immune system. Clin Cancer Res (2011) 1.24
Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance. J Exp Med (2009) 1.24
T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells. Proc Natl Acad Sci U S A (2011) 1.21
Immunodeficiency due to defects in store-operated calcium entry. Ann N Y Acad Sci (2011) 1.20
Human cytomegalovirus drives epigenetic imprinting of the IFNG locus in NKG2Chi natural killer cells. PLoS Pathog (2014) 1.20
Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation. EMBO J (2011) 1.19
Activation-dependent intrachromosomal interactions formed by the TNF gene promoter and two distal enhancers. Proc Natl Acad Sci U S A (2007) 1.18
Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity. J Physiol (2012) 1.17
The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells. Immunity (2013) 1.17
Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development (2008) 1.16
Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1. J Immunol (2009) 1.16
Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation. J Biol Chem (2010) 1.15
Transcriptome analysis describing new immunity and defense genes in peripheral blood mononuclear cells of rheumatoid arthritis patients. PLoS One (2009) 1.15
p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation. Mol Cell Biol (2007) 1.15
NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network. J Exp Med (2011) 1.15
T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells. Eur J Immunol (2010) 1.14
The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors. PLoS Pathog (2011) 1.14
Proteasome inhibition suppresses essential immune functions of human CD4+ T cells. Immunology (2008) 1.14
Function of the nucleotide exchange activity of vav1 in T cell development and activation. Sci Signal (2009) 1.13
TCR-dependent transformation of mature memory phenotype T cells in mice. J Clin Invest (2011) 1.13
Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase. J Biol Chem (2009) 1.13
NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science (2008) 1.12
Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells. Proc Natl Acad Sci U S A (2007) 1.12
Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling. J Biol Chem (2008) 1.12
Genomic expression profiling of human inflammatory cardiomyopathy (DCMi) suggests novel therapeutic targets. J Mol Med (Berl) (2006) 1.12
The duration of T cell stimulation is a critical determinant of cell fate and plasticity. Sci Signal (2013) 1.12
Activity- and calcineurin-independent nuclear shuttling of NFATc1, but not NFATc3, in adult skeletal muscle fibers. Mol Biol Cell (2006) 1.10
Protein kinase C-induced phosphorylation of Orai1 regulates the intracellular Ca2+ level via the store-operated Ca2+ channel. J Biol Chem (2010) 1.09
Regulation of transcription factor NFAT by ADP-ribosylation. Mol Cell Biol (2008) 1.09
Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development. Proc Natl Acad Sci U S A (2009) 1.09
NFAT promotes carcinoma invasive migration through glypican-6. Biochem J (2011) 1.09
Kawasaki disease: novel insights into etiology and genetic susceptibility. Annu Rev Med (2011) 1.08
RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses. Mol Cell Biol (2007) 1.07
Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis. J Biol Chem (2009) 1.07
Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506? Cell Commun Signal (2009) 1.06
Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter. J Immunol (2007) 1.06
Transcriptional regulation of bone and joint remodeling by NFAT. Immunol Rev (2010) 1.06
USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nat Immunol (2014) 1.06
Orai1-NFAT signalling pathway triggered by T cell receptor stimulation. Mol Cells (2013) 1.05
Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae). Prog Chem Org Nat Prod (2011) 1.05
STAT3 signaling in pulmonary arterial hypertension. JAKSTAT (2012) 1.04
Immune and inflammatory mechanisms in pulmonary arterial hypertension. Prog Cardiovasc Dis (2012) 1.03
Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice. BMC Mol Biol (2008) 1.03
Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet β-cells. Diabetes (2011) 1.03
Rel homology domain-containing transcription factors in the cnidarian Nematostella vectensis. Dev Genes Evol (2006) 1.02
Role of transcription factor NFAT in glucose and insulin homeostasis. Mol Cell Biol (2006) 1.02
CD4⁺ and CD8⁺ T cell-dependent antiviral immunity requires STIM1 and STIM2. J Clin Invest (2014) 1.02
Structure of the calcineurin-NFAT complex: defining a T cell activation switch using solution NMR and crystal coordinates. Structure (2007) 1.02
Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells. J Mol Cell Cardiol (2009) 1.01
Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity. Nat Immunol (2006) 1.01
Concurrent visualization of trafficking, expansion, and activation of T lymphocytes and T-cell precursors in vivo. Blood (2010) 1.01
Prediction of synergistic transcription factors by function conservation. Genome Biol (2007) 1.01
The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma. Mol Cancer (2013) 1.00
Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation. Mol Cell Biol (2009) 1.00