Published in Ann N Y Acad Sci on November 01, 2007
Fluorescence lifetime measurements and biological imaging. Chem Rev (2010) 3.99
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36
Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging. Am J Pathol (2010) 2.20
A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. PLoS One (2010) 1.69
Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities. Circ Res (2012) 1.53
LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice. Hum Mol Genet (2011) 1.52
Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration. J Biol Chem (2012) 1.43
Chemical screening identifies ATM as a target for alleviating senescence. Nat Chem Biol (2017) 1.39
Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy (2013) 1.34
The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet (2008) 1.30
A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology (2012) 1.29
Urban air pollution: influences on olfactory function and pathology in exposed children and young adults. Exp Toxicol Pathol (2009) 1.23
Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proc Natl Acad Sci U S A (2015) 1.21
Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans. PLoS Biol (2013) 1.18
Food inequality negatively impacts cardiac health in rabbits. PLoS One (2008) 1.14
Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. Am J Physiol Heart Circ Physiol (2013) 1.12
Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues. Aging (Albany NY) (2013) 1.09
Label-free separation of human embryonic stem cells and their differentiating progenies by phasor fluorescence lifetime microscopy. J Biomed Opt (2012) 1.08
BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. J Biol Chem (2009) 1.07
Autofluorescence spectroscopy and imaging: a tool for biomedical research and diagnosis. Eur J Histochem (2014) 1.07
A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet (2011) 1.05
Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy. Biol Chem (2013) 1.04
The aging lacrimal gland: changes in structure and function. Ocul Surf (2008) 1.04
Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Rejuvenation Res (2010) 1.02
Gravity receptor aging in the CBA/CaJ strain: a comparison to auditory aging. J Assoc Res Otolaryngol (2010) 1.00
SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons. J Neurosci (2011) 0.98
New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart. Oxid Med Cell Longev (2014) 0.98
Life spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs. Aging Cell (2013) 0.96
Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates--a mini-review. Gerontology (2009) 0.96
Myricetin-mediated lifespan extension in Caenorhabditis elegans is modulated by DAF-16. Int J Mol Sci (2013) 0.94
Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging. PLoS One (2013) 0.92
Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production. Age (Dordr) (2010) 0.91
The malondialdehyde-derived fluorophore DHP-lysine is a potent sensitizer of UVA-induced photooxidative stress in human skin cells. J Photochem Photobiol B (2010) 0.91
Accumulation and autofluorescence of phagocytized rod outer segment material in macrophages and microglial cells. Mol Vis (2012) 0.89
The proteasome and the degradation of oxidized proteins: Part II - protein oxidation and proteasomal degradation. Redox Biol (2013) 0.88
Retrogradely transported fluorogold accumulates in lysosomes of neurons and is detectable ultrastructurally using post-embedding immuno-gold methods. J Neurosci Methods (2009) 0.88
Proteomic identification of cathepsin B and nucleophosmin as novel UVA-targets in human skin fibroblasts. Photochem Photobiol (2010) 0.88
Serum chitotriosidase, a putative marker of chronically activated macrophages, increases with normal aging. J Gerontol A Biol Sci Med Sci (2013) 0.87
The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression. J Biol Chem (2009) 0.87
Depletion of the C. elegans NAC engages the unfolded protein response, resulting in increased chaperone expression and apoptosis. PLoS One (2012) 0.86
Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence. Redox Biol (2016) 0.86
Enhanced expression of the ubiquitin-proteasome system in the myocardium from patients with dilated cardiomyopathy referred for left ventriculoplasty: an immunohistochemical study with special reference to oxidative stress. Heart Vessels (2010) 0.85
Liver physiology and liver diseases in the elderly. World J Gastroenterol (2013) 0.84
Robust, universal biomarker assay to detect senescent cells in biological specimens. Aging Cell (2016) 0.82
Comprehensive transcriptional landscape of aging mouse liver. BMC Genomics (2015) 0.82
The mysterious case of the C. elegans gut granule: death fluorescence, anthranilic acid and the kynurenine pathway. Front Genet (2013) 0.82
Antioxidant and free radical scavenging potential of yakuchinone B derivatives in reduction of lipofuscin formation using H2O2-treated neuroblastoma cells. Iran Biomed J (2011) 0.82
Liver disease in menopause. World J Gastroenterol (2015) 0.81
Energy excess is the main cause of accelerated aging of mammals. Oncotarget (2015) 0.81
Using old liver grafts for liver transplantation: where are the limits? World J Gastroenterol (2014) 0.81
Hepatitis C Infection in the Elderly. Dig Dis Sci (2015) 0.80
IL-33 is required for disposal of unnecessary cells during ovarian atresia through regulation of autophagy and macrophage migration. J Immunol (2015) 0.79
Formation of lipofuscin-like material in the RPE Cell by different components of rod outer segments. Exp Eye Res (2013) 0.78
Molecular and chemical genetic approaches to developmental origins of aging and disease in zebrafish. Biochim Biophys Acta (2013) 0.78
The fuss over lipo"fuss"cin: not all autofluorescence is the same. Eur J Histochem (2015) 0.78
The age related markers lipofuscin and apoptosis show different genetic architecture by QTL mapping in short-lived Nothobranchius fish. Aging (Albany NY) (2014) 0.77
Aging on a different scale--chronological versus pathology-related aging. Aging (Albany NY) (2013) 0.77
Autofluorescence as a measure of senescence in C. elegans: look to red, not blue or green. Aging (Albany NY) (2016) 0.76
Exercise in an electrotactic flow chamber ameliorates age-related degeneration in Caenorhabditis elegans. Sci Rep (2016) 0.76
Identification of Atypical Peri-Nuclear Multivesicular Bodies in Oxidative and Glycolytic Skeletal Muscle of Aged and Pompe's Disease Mouse Models. Front Physiol (2015) 0.75
The crucial impact of lysosomes in aging and longevity. Ageing Res Rev (2016) 0.75
Specific RNA Interference in Caenorhabditis elegans by Ingested dsRNA Expressed in Bacillus subtilis. PLoS One (2015) 0.75
Using zebrafish models to explore genetic and epigenetic impacts on evolutionary developmental origins of aging. Transl Res (2013) 0.75
Estrogen deficiency is associated with hippocampal morphological remodeling of early postmenopausal mice. Oncotarget (2017) 0.75
Shining the Light on Senescence Associated LncRNAs. Aging Dis (2017) 0.75
The Kupffer Cell Number Affects the Outcome of Living Donor Liver Transplantation from Elderly Donors. Transplant Direct (2016) 0.75
Lipofuscins prepared by modification of photoreceptor cells via glycation or lipid peroxidation show the similar phototoxicity. World J Exp Med (2016) 0.75
New insights into cardiac aging. Circulation (2009) 0.75
Growing Old is Mandatory But Growing Up is Optional: An Explanation to Geriatrics. J Clin Diagn Res (2014) 0.75
Gut contents, digestive half-lives and feeding state prediction in the soil predatory mite Pergamasus longicornis (Mesostigmata: Parasitidae). Exp Appl Acarol (2017) 0.75
Effects of Korean ginseng berry on skin antipigmentation and antiaging via FoxO3a activation. J Ginseng Res (2016) 0.75
Progressive accumulation of autofluorescent granules in macrophages in rat striatum after systemic 3-nitropropionic acid: a correlative light- and electron-microscopic study. Histochem Cell Biol (2017) 0.75
Transient postnatal overfeeding causes liver stress-induced premature senescence in adult mice. Sci Rep (2017) 0.75
The proteasomal system. Mol Aspects Med (2009) 2.19
Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome. J Biol Chem (2002) 2.16
Regulation of proteasome-mediated protein degradation during oxidative stress and aging. Biol Chem (2008) 1.80
The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes. Biochem J (2010) 1.65
Pathological aspects of lipid peroxidation. Free Radic Res (2010) 1.56
Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease. J Neurochem (2003) 1.48
Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains. Neurobiol Aging (2006) 1.42
The proteasome and its role in the degradation of oxidized proteins. IUBMB Life (2008) 1.32
Intracellular metabolism of 4-hydroxynonenal. Mol Aspects Med (2003) 1.28
Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. Biochem J (2006) 1.22
Lipofuscin: formation, effects and role of macroautophagy. Redox Biol (2013) 1.21
Oxygen causes cell death in the developing brain. Neurobiol Dis (2004) 1.18
Proteasomal defense of oxidative protein modifications. Antioxid Redox Signal (2006) 1.18
Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes. Free Radic Res (2006) 1.14
Reversible inhibition of mammalian glutamine synthetase by tyrosine nitration. FEBS Lett (2006) 1.12
Protein oxidation in aging and the removal of oxidized proteins. J Proteomics (2013) 1.11
Lipofuscin: detection and quantification by microscopic techniques. Methods Mol Biol (2010) 1.07
Oxidized proteins: intracellular distribution and recognition by the proteasome. Arch Biochem Biophys (2007) 1.06
Protein oxidation and proteolysis. Biol Chem (2006) 1.05
Iron oxide particles for molecular magnetic resonance imaging cause transient oxidative stress in rat macrophages. Free Radic Biol Med (2004) 1.04
Lipofuscin-bound iron is a major intracellular source of oxidants: role in senescent cells. Free Radic Biol Med (2010) 0.99
Protein modification elicited by oxidized low-density lipoprotein (LDL) in endothelial cells: protection by (-)-epicatechin. Free Radic Biol Med (2006) 0.98
Neuronal apoptotic bodies: phagocytosis and degradation by primary microglial cells. FASEB J (2004) 0.98
Protein oxidative modification in the aging organism and the role of the ubiquitin proteasomal system. Curr Pharm Des (2011) 0.95
The proteasome and its role in nuclear protein maintenance. Exp Gerontol (2007) 0.94
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice. FASEB J (2006) 0.94
Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease. Free Radic Res (2010) 0.93
Oxidation-induced ferritin turnover in microglial cells: role of proteasome. Free Radic Biol Med (2005) 0.93
Intracellular distribution of oxidized proteins and proteasome in HT22 cells during oxidative stress. Free Radic Biol Med (2005) 0.93
Anti-fibrosclerotic effects of shock wave therapy in lipedema and cellulite. Biofactors (2005) 0.92
The proteasome and the degradation of oxidized proteins: Part I-structure of proteasomes. Redox Biol (2013) 0.92
Chromatin repair after oxidative stress: role of PARP-mediated proteasome activation. Free Radic Biol Med (2009) 0.92
Lipofuscin inhibits the proteasome by binding to surface motifs. Free Radic Biol Med (2010) 0.92
Hyperammonemia causes protein oxidation and enhanced proteasomal activity in response to mitochondria-mediated oxidative stress in rat primary astrocytes. Arch Biochem Biophys (2007) 0.92
Modifications of glyceraldehyde-3-phosphate dehydrogenase induced by increasing concentrations of peroxynitrite: early recognition by 20S proteasome. Biol Chem (2003) 0.91
Age-related differences in oxidative protein-damage in young and senescent fibroblasts. Arch Biochem Biophys (2008) 0.91
Irradiation of GAPDH: a model for environmentally induced protein damage. Biol Chem (2007) 0.91
Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts. Free Radic Biol Med (2012) 0.91
Short-term CR decreases cardiac mitochondrial oxidant production but increases carbonyl content. Am J Physiol Regul Integr Comp Physiol (2003) 0.91
A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression. Rejuvenation Res (2012) 0.91
The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, microtus agrestis. Free Radic Biol Med (2002) 0.91
Inverse correlation of protein oxidation and proteasome activity in liver and lung. Mech Ageing Dev (2009) 0.90
Cold-induced apoptosis of rat liver endothelial cells: involvement of the proteasome. Transplantation (2003) 0.89
Combination of PDT and inhibitor treatment affects melanoma cells and spares keratinocytes. Free Radic Biol Med (2010) 0.88
Protein oxidation and degradation during aging: role in skin aging and neurodegeneration. Free Radic Res (2006) 0.88
Vimentin is the specific target in skin glycation. Structural prerequisites, functional consequences, and role in skin aging. J Biol Chem (2007) 0.88
Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins. Free Radic Res (2010) 0.88
The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression. J Biol Chem (2009) 0.87
Degradation of glycated bovine serum albumin in microglial cells. Free Radic Biol Med (2005) 0.87
Oxidative stress related changes in the brain of hypercholesterolemic rabbits. Biofactors (2008) 0.87
Interactions of the proteasomal system with chaperones: protein triage and protein quality control. Prog Mol Biol Transl Sci (2012) 0.87
Age-related loss of stress-induced nuclear proteasome activation is due to low PARP-1 activity. Free Radic Biol Med (2010) 0.87
Epigenetic effects of selenium and their implications for health. Epigenetics (2015) 0.87
The relationships between exogenous and endogenous antioxidants with the lipid profile and oxidative damage in hemodialysis patients. BMC Nephrol (2011) 0.86
The plasma retinol levels as pro-oxidant/oxidant agents in haemodialysis patients. Nephrol Dial Transplant (2009) 0.86
Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1. Biochem J (2012) 0.86
The outcome of 5-ALA-mediated photodynamic treatment in melanoma cells is influenced by vitamin C and heme oxygenase-1. Biofactors (2010) 0.86
Rapid and sensitive determination of protein-nitrotyrosine by ELISA: Application to human plasma. Free Radic Res (2012) 0.86
Measurement of HNE-protein adducts in human plasma and serum by ELISA-Comparison of two primary antibodies. Redox Biol (2013) 0.86
Proteolytic response to oxidative stress in mammalian cells. Biol Chem (2002) 0.86
An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples. Free Radic Res (2010) 0.86
Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products. Free Radic Res (2013) 0.85
Biomarkers of protein oxidation from a chemical, biological and medical point of view. Exp Gerontol (2010) 0.85
Impact of magnetic labeling on human and mouse stem cells and their long-term magnetic resonance tracking in a rat model of Parkinson disease. Mol Imaging (2009) 0.85
Ferritin oxidation and proteasomal degradation: protection by antioxidants. Free Radic Res (2006) 0.85
Effects of water-filtered infrared A irradiation on human fibroblasts. Free Radic Biol Med (2009) 0.84
Reexamination of a meta-analysis of the effect of antioxidant supplementation on mortality and health in randomized trials. Nutrients (2010) 0.84
Method for the simultaneous determination of free/protein malondialdehyde and lipid/protein hydroperoxides. Free Radic Biol Med (2012) 0.84
Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK-dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition. Free Radic Biol Med (2012) 0.84
Structure of the proteasome. Prog Mol Biol Transl Sci (2012) 0.82
Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake. Curr Pharm Biotechnol (2010) 0.82
Degradation of HNE-modified proteins--possible role of ubiquitin. Redox Rep (2007) 0.82
Cathepsins D and L reduce the toxicity of advanced glycation end products. Free Radic Biol Med (2012) 0.82
Effects of selenium deficiency on fatty acid metabolism in rats fed fish oil-enriched diets. J Trace Elem Med Biol (2004) 0.81
Oxidative stress in renal anemia of hemodialysis patients is mitigated by epoetin treatment. Kidney Blood Press Res (2006) 0.81
Carbonylation of the cytoskeletal protein actin leads to aggregate formation. Free Radic Biol Med (2012) 0.81
Osmotic regulation of STAT3 stability in H4IIE rat hepatoma cells. FEBS Lett (2005) 0.81
PARP-mediated proteasome activation: a co-ordination of DNA repair and protein degradation? Bioessays (2002) 0.81
Osmotic regulation of MG-132-induced MAP-kinase phosphatase MKP-1 expression in H4IIE rat hepatoma cells. Cell Physiol Biochem (2005) 0.81
Nitrotyrosine and protein carbonyls are equally distributed in HT22 cells after nitrosative stress. Free Radic Biol Med (2006) 0.81
Actin carbonylation: from cell dysfunction to organism disorder. J Proteomics (2013) 0.81
Experimental basis for discriminating between thermal and athermal effects of water-filtered infrared A irradiation. Ann N Y Acad Sci (2012) 0.80
Chaperones, but not oxidized proteins, are ubiquitinated after oxidative stress. Free Radic Biol Med (2012) 0.80
HNE and Further Lipid Peroxidation Products. Biofactors (2005) 0.80
Metabolism-induced oxidative stress is a mediator of glucose toxicity in HT22 neuronal cells. Free Radic Res (2009) 0.80
Copper related toxic effects on cellular protein metabolism in human astrocytes. Biofactors (2005) 0.80
A comparative study into alterations of coenzyme Q redox status in ageing pigs, mice, and worms. Biofactors (2014) 0.79
Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster. Free Radic Biol Med (2013) 0.79
Protective effect of antioxidants against sarcoplasmic reticulum (SR) oxidation by Fenton reaction, however without prevention of Ca-pump activity. Toxicol In Vitro (2008) 0.79
Adenosine triphosphate concentrations are higher in the brain of APOE3- compared to APOE4-targeted replacement mice and can be modulated by curcumin. Genes Nutr (2014) 0.79
Does mitochondrial dysfunction during antiretroviral therapy in human immunodeficiency virus infection suggest antioxidant supplementation as a beneficial option? Redox Rep (2005) 0.79
Ferritin levels in microglia depend upon activation: modulation by reactive oxygen species. Biochim Biophys Acta (2006) 0.79
Proteins bearing oxidation-induced carbonyl groups are not preferentially ubiquitinated. Biochimie (2011) 0.79
The influence of the serum vitamin C levels on oxidative stress biomarkers in elderly women. Clin Biochem (2007) 0.79
Tocopherol-mediated modulation of age-related changes in microglial cells: turnover of extracellular oxidized protein material. Free Radic Biol Med (2006) 0.79
Proteasomal degradation of beta-carotene metabolite--modified proteins. Biofactors (2009) 0.78
Antioxidants effectively prevent oxidation-induced protein damage in OLN 93 cells. Arch Biochem Biophys (2004) 0.78
Metabolism of 4-hydroxy-2-nonenal in human polymorphonuclear leukocytes. Arch Biochem Biophys (2010) 0.78
Protein oxidation and the degradation of oxidized proteins in the rat oligodendrocyte cell line OLN 93-antioxidative effect of the intracellular spin trapping agent PBN. Brain Res Mol Brain Res (2004) 0.78