Published in Apoptosis on February 01, 2008
Triggering of Toll-like receptor 4 expressed on human head and neck squamous cell carcinoma promotes tumor development and protects the tumor from immune attack. Cancer Res (2009) 1.85
Cellular responses to Cisplatin-induced DNA damage. J Nucleic Acids (2010) 1.82
Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. J Clin Oncol (2009) 1.61
Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Res (2010) 1.55
Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation. J Biol Chem (2013) 1.22
Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family. Cancer Res (2012) 1.11
Crizotinib (PF-02341066) reverses multidrug resistance in cancer cells by inhibiting the function of P-glycoprotein. Br J Pharmacol (2012) 1.08
The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer. J Transl Med (2012) 1.08
Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer. PLoS One (2013) 1.03
Endometrial carcinoma: a review of chemotherapy, drug resistance, and the search for new agents. Oncologist (2010) 1.03
PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy. Lung Cancer (2010) 1.02
Neratinib reverses ATP-binding cassette B1-mediated chemotherapeutic drug resistance in vitro, in vivo, and ex vivo. Mol Pharmacol (2012) 0.92
XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling. Mol Cancer (2010) 0.91
The role of the dysfunctional akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug development. Scientifica (Cairo) (2013) 0.89
Saracatinib (AZD0530) is a potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo. Int J Cancer (2012) 0.88
Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition. Cell Cycle (2011) 0.87
Axitinib targeted cancer stemlike cells to enhance efficacy of chemotherapeutic drugs via inhibiting the drug transport function of ABCG2. Mol Med (2012) 0.87
The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells. J Gynecol Oncol (2010) 0.87
Progesterone receptor-B induction of BIRC3 protects endometrial cancer cells from AP1-59-mediated apoptosis. Horm Cancer (2011) 0.86
Afatinib reverses multidrug resistance in ovarian cancer via dually inhibiting ATP binding cassette subfamily B member 1. Oncotarget (2015) 0.86
MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer. Cell Death Dis (2015) 0.83
Artemisinin triggers a G1 cell cycle arrest of human Ishikawa endometrial cancer cells and inhibits cyclin-dependent kinase-4 promoter activity and expression by disrupting nuclear factor-κB transcriptional signaling. Anticancer Drugs (2014) 0.83
Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells. Mol Cancer (2009) 0.82
Lapatinib antagonizes multidrug resistance-associated protein 1-mediated multidrug resistance by inhibiting its transport function. Mol Med (2014) 0.82
Effect of ceritinib (LDK378) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo. Oncotarget (2015) 0.81
Targeting X-linked inhibitor of apoptosis protein inhibits pancreatic cancer cell growth through p-Akt depletion. World J Gastroenterol (2012) 0.81
Prognostic and predictive value of Phospho-p44/42 and pAKT in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy. World J Surg Oncol (2013) 0.81
Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance. BMC Cancer (2013) 0.81
Expression of HER-2 affects patient survival and paclitaxel sensitivity in endometrial cancer. Br J Cancer (2010) 0.80
Genistein enhances the effect of cisplatin on the inhibition of non-small cell lung cancer A549 cell growth in vitro and in vivo. Oncol Lett (2014) 0.79
Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis. Cell Death Dis (2015) 0.78
Parasporin-2 from a New Bacillus thuringiensis 4R2 Strain Induces Caspases Activation and Apoptosis in Human Cancer Cells. PLoS One (2015) 0.76
Chemoresistance and targeted therapies in ovarian and endometrial cancers. Oncotarget (2017) 0.75
Cetuximab enhanced the efficacy of chemotherapeutic agent in ABCB1/P-glycoprotein-overexpressing cancer cells. Oncotarget (2015) 0.75
Therapeutically blocking Interleukin-11 Receptor-α enhances doxorubicin cytotoxicity in high grade type I endometrioid tumours. Oncotarget (2017) 0.75
Identification of LEFTY as a molecular marker for ovarian clear cell carcinoma. Oncotarget (2017) 0.75
Chemical Entities of Biological Interest: an update. Nucleic Acids Res (2009) 8.92
The ChEBI reference database and ontology for biologically relevant chemistry: enhancements for 2013. Nucleic Acids Res (2012) 6.90
A window into third-generation sequencing. Hum Mol Genet (2010) 4.07
Difficulties in selecting an appropriate neonatal thyroid stimulating hormone (TSH) screening threshold. Arch Dis Child (2009) 2.98
Rhea--a manually curated resource of biochemical reactions. Nucleic Acids Res (2011) 2.87
Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. Immunity (2004) 1.77
The prevalence of metabolic syndrome in children: a systematic review of the literature. Metab Syndr Relat Disord (2012) 1.45
X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization. J Biol Chem (2009) 1.44
Impact of a bronchiolitis clinical care pathway on treatment and hospital stay. Eur J Pediatr (2011) 1.43
Serum 25-hydroxyvitamin D measurement in a large population survey with statistical harmonization of assay variation to an international standard. J Clin Endocrinol Metab (2007) 1.37
Dovetailing biology and chemistry: integrating the Gene Ontology with the ChEBI chemical ontology. BMC Genomics (2013) 1.27
AKT involvement in cisplatin chemoresistance of human uterine cancer cells. Gynecol Oncol (2004) 1.22
Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation. J Biol Chem (2013) 1.22
Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors. J Endocrinol (2011) 1.18
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells. Mol Cancer (2006) 1.18
Invisible displacement understanding in domestic dogs (Canis familiaris): the role of visual cues in search behavior. Anim Cogn (2006) 1.18
Resistance to chemotherapy and hormone therapy in endometrial cancer. Endocr Relat Cancer (2009) 1.14
Applying multiple models to predict clinicians' behavioural intention and objective behaviour when managing children's teeth. Psychol Health (2009) 1.12
Regulation of MMP-9 gene expression for the development of novel molecular targets against cancer and inflammatory diseases. Expert Opin Ther Targets (2004) 1.10
Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-kappaB/IkappaB pathway. Mol Cancer (2004) 1.07
Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer. Exp Cell Res (2012) 1.06
Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells. Int J Oncol (2004) 1.05
Prostate apoptosis response 4 (Par-4), a novel substrate of caspase-3 during apoptosis activation. Mol Cell Biol (2011) 1.03
Target fortification of breast milk with fat, protein, and carbohydrates for preterm infants. J Pediatr (2013) 1.01
Career choices for paediatrics: national surveys of graduates of 1974-2002 from UK medical schools. Child Care Health Dev (2007) 1.00
Evidence for the role of promoter methylation in the regulation of MMP-9 gene expression. Biochem Biophys Res Commun (2002) 0.99
Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1. Int J Oncol (2003) 0.98
An FDA bioinformatics tool for microbial genomics research on molecular characterization of bacterial foodborne pathogens using microarrays. BMC Bioinformatics (2010) 0.97
Regulation of prohibitin expression during follicular development and atresia in the mammalian ovary. Biol Reprod (2004) 0.94
Emerging features in the regulation of MMP-9 gene expression for the development of novel molecular targets and therapeutic strategies. Curr Drug Targets Inflamm Allergy (2003) 0.93
OntoQuery: easy-to-use web-based OWL querying. Bioinformatics (2013) 0.92
XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling. Mol Cancer (2010) 0.91
TGF-beta expression during rat pregnancy and activity on decidual cell survival. Reprod Biol Endocrinol (2005) 0.90
Associations between environmental exposures and asthma control and exacerbations in young children: a systematic review. BMJ Open (2014) 0.90
Regulation of Akt expression and phosphorylation by 17beta-estradiol in the rat uterus during estrous cycle. Reprod Biol Endocrinol (2003) 0.89
Vitamin D status in paediatric patients with cancer. Pediatr Blood Cancer (2011) 0.89
Probing the binding sites of antibiotic drugs doxorubicin and N-(trifluoroacetyl) doxorubicin with human and bovine serum albumins. PLoS One (2012) 0.89
Longitudinal measurements of exhaled nitric oxide in children-what is a significant change in FE(NO) ? Pediatr Allergy Immunol (2013) 0.87
Involvement of Akt isoforms in chemoresistance of endometrial carcinoma cells. Gynecol Oncol (2012) 0.87
Opposite regulation of XIAP and Smac/DIABLO in the rat endometrium in response to 17beta-estradiol at estrus. Reprod Biol Endocrinol (2003) 0.86
PAX2 is activated by estradiol in breast cancer cells of the luminal subgroup selectively, to confer a low invasive phenotype. Mol Cancer (2011) 0.86
Nuclear factor kappaB-mediated induction of Flice-like inhibitory protein prevents tumor necrosis factor alpha-induced apoptosis in rat granulosa cells. Biol Reprod (2002) 0.86
Effects of 4-hydroxytamoxifen, raloxifene and ICI 182 780 on survival of uterine cancer cell lines in the presence and absence of exogenous estrogens. Int J Oncol (2007) 0.86
Ubiquitin-proteasomal degradation of COX-2 in TGF-β stimulated human endometrial cells is mediated through endoplasmic reticulum mannosidase I. Endocrinology (2011) 0.85
Permanent and transient congenital hypothyroidism in preterm infants. Acta Paediatr (2011) 0.84
Increasing Incidence, but Lack of Seasonality, of Elevated TSH Levels, on Newborn Screening, in the North of England. J Thyroid Res (2010) 0.83
Transforming growth factor Beta regulates proliferation and invasion of rat placental cell lines. Biol Reprod (2010) 0.83
Inhaled fluticasone dipropionate decreases levels of nitric oxide in recurrenty wheezy infants. Pediatr Pulmonol (2004) 0.83
Akt isoforms regulate intermediate filament protein levels in epithelial carcinoma cells. FEBS Lett (2010) 0.82
Leukemia inhibitory factor regulates differentiation of trophoblastlike BeWo cells through the activation of JAK/STAT and MAPK3/1 MAP kinase-signaling pathways. Biol Reprod (2012) 0.82
Expression of COX-1 and COX-2 in the endometrium of cyclic, pregnant and in a model of pseudopregnant rats and their regulation by sex steroids. Reprod Biol Endocrinol (2010) 0.82
Cisplatin increases B-cell-lymphoma-2 expression via activation of protein kinase C and Akt2 in endometrial cancer cells. Int J Cancer (2011) 0.82
Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance. BMC Cancer (2013) 0.81
Characterization of EN-1078D, a poorly differentiated human endometrial carcinoma cell line: a novel tool to study endometrial invasion in vitro. Reprod Biol Endocrinol (2007) 0.81
VP-128, a novel oestradiol-platinum(II) hybrid with selective anti-tumour activity towards hormone-dependent breast cancer cells in vivo. Endocr Relat Cancer (2009) 0.81
Pro-inflammatory type-1 and anti-inflammatory type-2 macrophages differentially modulate cell survival and invasion of human bladder carcinoma T24 cells. Mol Immunol (2011) 0.81
Maternal serum placental growth factor and α-fetoprotein testing in first trimester screening for Down syndrome. Prenat Diagn (2013) 0.81
Oxytocin increases invasive properties of endometrial cancer cells through phosphatidylinositol 3-kinase/AKT-dependent up-regulation of cyclooxygenase-1, -2, and X-linked inhibitor of apoptosis protein. Biol Reprod (2011) 0.81
Transforming growth factor beta isoforms regulation of Akt activity and XIAP levels in rat endometrium during estrous cycle, in a model of pseudopregnancy and in cultured decidual cells. Reprod Biol Endocrinol (2009) 0.81
Synthesis of unique 17beta-estradiol homo-dimers, estrogen receptors binding affinity evaluation and cytocidal activity on breast, intestinal and skin cancer cell lines. Steroids (2006) 0.81
Resveratrol modulates the expression of PTGS2 and cellular proliferation in the normal rat endometrium in an AKT-dependent manner. Biol Reprod (2011) 0.80
Biological evaluation of novel estrogen-platinum(II) hybrid molecules on uterine and ovarian cancers-molecular modeling studies. Bioorg Med Chem Lett (2004) 0.80
Regulation of prostaglandin D synthase and prostacyclin synthase in the endometrium of cyclic, pregnant, and pseudopregnant rats and their regulation by sex steroids. J Endocrinol (2007) 0.79
Transfer RNA bindings to antitumor estradiol-platinum(II) hybrid and cisplatin. DNA Cell Biol (2008) 0.79
Synthesis of 17beta-estradiol platinum(II) complexes: biological evaluation on breast cancer cell lines. Bioorg Med Chem Lett (2003) 0.79
First synthesis of separable isomeric testosterone dimers showing differential activities on prostate cancer cells. Bioorg Med Chem Lett (2010) 0.79
TSH levels in relation to gestation, birth weight and sex. Horm Res (2009) 0.79
Synthesis, antiproliferative activity and estrogen receptor α affinity of novel estradiol-linked platinum(II) complex analogs to carboplatin and oxaliplatin. Potential vector complexes to target estrogen-dependent tissues. Eur J Med Chem (2011) 0.79
Neutrophil gelatinase-associated lipocalin: its response to hypoxia and association with acute mountain sickness. Dis Markers (2013) 0.79
Space-time clustering of elevated thyroid stimulating hormone levels. Eur J Epidemiol (2011) 0.78
High-dose inhaled corticosteroid use in childhood asthma: an observational study of GP prescribing. Br J Gen Pract (2006) 0.78
Classroom carbon dioxide concentration, school attendance, and educational attainment. J Sch Health (2014) 0.78
Regulation of the PI3-K/Akt survival pathway in the rat endometrium. Biol Reprod (2013) 0.78
X-linked inhibitor of apoptosis protein levels and protein kinase C activity regulate the sensitivity of human endometrial carcinoma cells to tumor necrosis factor alpha-induced apoptosis. Endocrinology (2008) 0.78
Involvement of transforming growth factor alpha in the regulation of rat ovarian X-linked inhibitor of apoptosis protein expression and follicular growth by follicle-stimulating hormone. Biol Reprod (2002) 0.78
Synthesis of 17beta-estradiol-platinum(II) hybrid molecules showing cytotoxic activity on breast cancer cell lines. Bioorg Med Chem Lett (2008) 0.77
Second trimester maternal serum ADAM12 levels in Down's syndrome pregnancies. Prenat Diagn (2008) 0.77
Design, synthesis and biological evaluation of estradiol-PEG-linked platinum(II) hybrid molecules: comparative molecular modeling study of three distinct families of hybrids. Steroids (2010) 0.77
Functional specificity of Akt isoforms in cancer progression. Biomol Concepts (2011) 0.77
DNA interaction with novel antitumor estradiol-platinum(II) hybrid molecule: a comparative study with cisplatin drug. DNA Cell Biol (2008) 0.77
A novel series of potent cytotoxic agents targeting G2/M phase of the cell cycle and demonstrating cell killing by apoptosis in human breast cancer cells. Bioorg Med Chem Lett (2007) 0.77
An exploratory survey into primary care nurses and dementia care. Br J Nurs (2003) 0.77