Published in J Bacteriol on December 14, 2007
Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development. PLoS Pathog (2011) 1.89
A novel pheromone quorum-sensing system controls the development of natural competence in Streptococcus thermophilus and Streptococcus salivarius. J Bacteriol (2009) 1.81
Horizontal gene transfer and the genomics of enterococcal antibiotic resistance. Curr Opin Microbiol (2010) 1.38
Peptide pheromone signaling in Streptococcus and Enterococcus. FEMS Microbiol Rev (2013) 1.25
Contribution of lipoproteins and lipoprotein processing to endocarditis virulence in Streptococcus sanguinis. J Bacteriol (2009) 1.09
Regulatory circuits controlling enterococcal conjugation: lessons for functional genomics. Curr Opin Microbiol (2011) 1.04
Extra cytoplasmic function σ factor activation. Curr Opin Microbiol (2012) 1.04
Antagonistic self-sensing and mate-sensing signaling controls antibiotic-resistance transfer. Proc Natl Acad Sci U S A (2013) 1.03
Use of recombinase-based in vivo expression technology to characterize Enterococcus faecalis gene expression during infection identifies in vivo-expressed antisense RNAs and implicates the protease Eep in pathogenesis. Infect Immun (2011) 1.03
Extracellular life cycle of ComS, the competence-stimulating peptide of Streptococcus thermophilus. J Bacteriol (2013) 1.02
Secretion of bacterial lipoproteins: through the cytoplasmic membrane, the periplasm and beyond. Biochim Biophys Acta (2014) 0.98
Post-liberation cleavage of signal peptides is catalyzed by the site-2 protease (S2P) in bacteria. Proc Natl Acad Sci U S A (2011) 0.97
New insights into S2P signaling cascades: regulation, variation, and conservation. Protein Sci (2010) 0.95
Rgg-associated SHP signaling peptides mediate cross-talk in Streptococci. PLoS One (2013) 0.90
Eep confers lysozyme resistance to enterococcus faecalis via the activation of the extracytoplasmic function sigma factor SigV. J Bacteriol (2013) 0.90
A genetic determinant in Streptococcus gordonii Challis encodes a peptide with activity similar to that of enterococcal sex pheromone cAM373, which facilitates intergeneric DNA transfer. J Bacteriol (2010) 0.87
Redundant group a streptococcus signaling peptides exhibit unique activation potentials. J Bacteriol (2013) 0.85
The TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa? Dev Cell (2013) 0.84
PepO, a CovRS-controlled endopeptidase, disrupts Streptococcus pyogenes quorum sensing. Mol Microbiol (2015) 0.82
An ABC transporter is required for secretion of peptide sex pheromones in Enterococcus faecalis. MBio (2014) 0.81
Structural Mechanisms of Peptide Recognition and Allosteric Modulation of Gene Regulation by the RRNPP Family of Quorum-Sensing Regulators. J Mol Biol (2016) 0.81
Enterococcal Sex Pheromones: Evolutionary Pathways to Complex, Two-Signal Systems. J Bacteriol (2016) 0.81
MODELING OF GENE REGULATORY PROCESSES BY POPULATION MEDIATED SIGNALING. NEW APPLICATIONS OF POPULATION BALANCES. Chem Eng Sci (2011) 0.78
Function of site-2 proteases in bacteria and bacterial pathogens. Biochim Biophys Acta (2013) 0.77
Identification of a peptide-pheromone that enhances Listeria monocytogenes escape from host cell vacuoles. PLoS Pathog (2015) 0.76
Characterization of Tiki, a New Family of Wnt-specific Metalloproteases. J Biol Chem (2015) 0.75
Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen. Proc Natl Acad Sci U S A (2017) 0.75
Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene (1989) 23.74
Induced cell aggregation and mating in Streptococcus faecalis: evidence for a bacterial sex pheromone. Proc Natl Acad Sci U S A (1978) 9.67
Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science (2003) 8.79
Transmissible toxin (hemolysin) plasmid in Streptococcus faecalis and its mobilization of a noninfectious drug resistance plasmid. J Bacteriol (1975) 8.65
Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell (2000) 8.29
Modification of Streptococcus faecalis sex pheromones after acquisition of plasmid DNA. Proc Natl Acad Sci U S A (1983) 5.27
Improved electroporation and cloning vector system for gram-positive bacteria. Appl Environ Microbiol (1991) 3.80
Plasmid content of Streptococcus faecalis strain 39-5 and identification of a pheromone (cPD1)-induced surface antigen. J Gen Microbiol (1983) 3.80
Improved vectors for nisin-controlled expression in gram-positive bacteria. Plasmid (2000) 3.32
Generation and testing of mutants of Enterococcus faecalis in a mouse peritonitis model. J Infect Dis (1998) 3.28
Direct stimulation of the transfer of antibiotic resistance by sex pheromones in Streptococcus faecalis. Plasmid (1981) 3.07
Bacterial sex pheromone-induced plasmid transfer. Cell (1993) 2.93
Enterococcus faecalis pheromone binding protein, PrgZ, recruits a chromosomal oligopeptide permease system to import sex pheromone cCF10 for induction of conjugation. Proc Natl Acad Sci U S A (1996) 2.27
Development of a host-genotype-independent counterselectable marker and a high-frequency conjugative delivery system and their use in genetic analysis of Enterococcus faecalis. Plasmid (2006) 2.26
A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors. Proc Natl Acad Sci U S A (1999) 2.22
Identification of regions of the Streptococcus faecalis plasmid pCF-10 that encode antibiotic resistance and pheromone response functions. Plasmid (1986) 2.19
Molecular and genetic analysis of a region of plasmid pCF10 containing positive control genes and structural genes encoding surface proteins involved in pheromone-inducible conjugation in Enterococcus faecalis. J Bacteriol (1991) 1.97
Role of the Enterococcus faecalis GelE protease in determination of cellular chain length, supernatant pheromone levels, and degradation of fibrin and misfolded surface proteins. J Bacteriol (2003) 1.85
Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis. Proc Natl Acad Sci U S A (2005) 1.85
Cloning and characterization of a region of the Enterococcus faecalis conjugative plasmid, pCF10, encoding a sex pheromone-binding function. J Bacteriol (1993) 1.84
A microdomain for protein secretion in Gram-positive bacteria. Science (2004) 1.84
Intramembrane proteolysis controls diverse signalling pathways throughout evolution. Curr Opin Genet Dev (2002) 1.83
Identification and characterization of a determinant (eep) on the Enterococcus faecalis chromosome that is involved in production of the peptide sex pheromone cAD1. J Bacteriol (1999) 1.75
Two targets in pCF10 DNA for PrgX binding: their role in production of Qa and prgX mRNA and in regulation of pheromone-inducible conjugation. J Mol Biol (2002) 1.62
Amino acid substrate specificity of Escherichia coli phenylalanyl-tRNA synthetase altered by distinct mutations. J Mol Biol (1991) 1.56
Identification and characterization of the genes of Enterococcus faecalis plasmid pCF10 involved in replication and in negative control of pheromone-inducible conjugation. Plasmid (1996) 1.52
Enterococcal peptide sex pheromones: synthesis and control of biological activity. Peptides (2004) 1.47
Cis-acting, orientation-dependent, positive control system activates pheromone-inducible conjugation functions at distances greater than 10 kilobases upstream from its target in Enterococcus faecalis. Proc Natl Acad Sci U S A (1992) 1.40
Cell-associated pheromone peptide (cCF10) production and pheromone inhibition in Enterococcus faecalis. J Bacteriol (2000) 1.38
Enterococcal sex pheromone precursors are part of signal sequences for surface lipoproteins. Mol Microbiol (2000) 1.37
In vivo induction of virulence and antibiotic resistance transfer in Enterococcus faecalis mediated by the sex pheromone-sensing system of pCF10. Infect Immun (2002) 1.35
Molecular basis for control of conjugation by bacterial pheromone and inhibitor peptides. Mol Microbiol (2006) 1.33
Characterization of cis-acting prgQ mutants: evidence for two distinct repression mechanisms by Qa RNA and PrgX protein in pheromone-inducible enterococcal plasmid pCF10. Mol Microbiol (2004) 1.30
Enterococcus faecalis pheromone-responsive protein PrgX: genetic separation of positive autoregulatory functions from those involved in negative regulation of conjugative plasmid transfer. Mol Microbiol (2004) 1.28
ccfA, the genetic determinant for the cCF10 peptide pheromone in Enterococcus faecalis OG1RF. J Bacteriol (2002) 1.28
A paracrine peptide sex pheromone also acts as an autocrine signal to induce plasmid transfer and virulence factor expression in vivo. Proc Natl Acad Sci U S A (2005) 1.23
Identification of the cAD1 sex pheromone precursor in Enterococcus faecalis. J Bacteriol (2002) 1.22
Specific control of endogenous cCF10 pheromone by a conserved domain of the pCF10-encoded regulatory protein PrgY in Enterococcus faecalis. J Bacteriol (2005) 1.20
Bacillus subtilis Pro-sigmaE fusion protein localizes to the forespore septum and fails to be processed when synthesized in the forespore. J Bacteriol (1997) 1.19
Identification and characterization of genes encoding sex pheromone cAM373 activity in Enterococcus faecalis and Staphylococcus aureus. Mol Microbiol (2002) 1.10
Signal peptidases and signal peptide hydrolases. J Bioenerg Biomembr (1990) 1.07
Dominant-negative mutants of prgX: evidence for a role for PrgX dimerization in negative regulation of pheromone-inducible conjugation. Mol Microbiol (2001) 1.06
Peptide pheromone-induced transfer of plasmid pCF10 in Enterococcus faecalis: probing the genetic and molecular basis for specificity of the pheromone response. Peptides (2001) 1.05
Analysis of the amino acid sequence specificity determinants of the enterococcal cCF10 sex pheromone in interactions with the pheromone-sensing machinery. J Bacteriol (2006) 1.02
Pathogenic Mechanisms of Enterococcal Endocarditis. Curr Infect Dis Rep (2000) 1.00
On the mechanism of SPP-catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane. FEBS Lett (2004) 0.98
Genetic characterization of the conjugative DNA processing system of enterococcal plasmid pCF10. Plasmid (2006) 0.96
Exchange of precursor-specific elements between Pro-sigma E and Pro-sigma K of Bacillus subtilis. J Bacteriol (1996) 0.92
Substrate requirements for regulated intramembrane proteolysis of Bacillus subtilis pro-sigmaK. J Bacteriol (2005) 0.89
Development of a host-genotype-independent counterselectable marker and a high-frequency conjugative delivery system and their use in genetic analysis of Enterococcus faecalis. Plasmid (2006) 2.26
Esp-independent biofilm formation by Enterococcus faecalis. J Bacteriol (2004) 2.20
Role of the Enterococcus faecalis GelE protease in determination of cellular chain length, supernatant pheromone levels, and degradation of fibrin and misfolded surface proteins. J Bacteriol (2003) 1.85
Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis. Proc Natl Acad Sci U S A (2005) 1.85
Comparison of OG1RF and an isogenic fsrB deletion mutant by transcriptional analysis: the Fsr system of Enterococcus faecalis is more than the activator of gelatinase and serine protease. J Bacteriol (2006) 1.71
High-resolution visualization of the microbial glycocalyx with low-voltage scanning electron microscopy: dependence on cationic dyes. J Histochem Cytochem (2004) 1.71
Two targets in pCF10 DNA for PrgX binding: their role in production of Qa and prgX mRNA and in regulation of pheromone-inducible conjugation. J Mol Biol (2002) 1.62
A eukaryotic-type Ser/Thr kinase in Enterococcus faecalis mediates antimicrobial resistance and intestinal persistence. Proc Natl Acad Sci U S A (2007) 1.55
Enterococcal peptide sex pheromones: synthesis and control of biological activity. Peptides (2004) 1.47
In vivo induction of virulence and antibiotic resistance transfer in Enterococcus faecalis mediated by the sex pheromone-sensing system of pCF10. Infect Immun (2002) 1.35
Development of a method for markerless genetic exchange in Enterococcus faecalis and its use in construction of a srtA mutant. Appl Environ Microbiol (2005) 1.34
Molecular basis for control of conjugation by bacterial pheromone and inhibitor peptides. Mol Microbiol (2006) 1.33
Characterization of cis-acting prgQ mutants: evidence for two distinct repression mechanisms by Qa RNA and PrgX protein in pheromone-inducible enterococcal plasmid pCF10. Mol Microbiol (2004) 1.30
Convergent transcription confers a bistable switch in Enterococcus faecalis conjugation. Proc Natl Acad Sci U S A (2011) 1.30
Enterococcus faecalis pheromone-responsive protein PrgX: genetic separation of positive autoregulatory functions from those involved in negative regulation of conjugative plasmid transfer. Mol Microbiol (2004) 1.28
ccfA, the genetic determinant for the cCF10 peptide pheromone in Enterococcus faecalis OG1RF. J Bacteriol (2002) 1.28
A paracrine peptide sex pheromone also acts as an autocrine signal to induce plasmid transfer and virulence factor expression in vivo. Proc Natl Acad Sci U S A (2005) 1.23
Specific control of endogenous cCF10 pheromone by a conserved domain of the pCF10-encoded regulatory protein PrgY in Enterococcus faecalis. J Bacteriol (2005) 1.20
Development and use of an efficient system for random mariner transposon mutagenesis to identify novel genetic determinants of biofilm formation in the core Enterococcus faecalis genome. Appl Environ Microbiol (2008) 1.20
Functional genomics of Enterococcus faecalis: multiple novel genetic determinants for biofilm formation in the core genome. J Bacteriol (2009) 1.15
Bacterial contamination of surgical suture resembles a biofilm. Surg Infect (Larchmt) (2010) 1.15
Multiple functional domains of Enterococcus faecalis aggregation substance Asc10 contribute to endocarditis virulence. Infect Immun (2008) 1.12
Enterococcus faecalis produces abundant extracellular structures containing DNA in the absence of cell lysis during early biofilm formation. MBio (2012) 1.11
Direct evidence for control of the pheromone-inducible prgQ operon of Enterococcus faecalis plasmid pCF10 by a countertranscript-driven attenuation mechanism. J Bacteriol (2010) 1.08
Specificity determinants of conjugative DNA processing in the Enterococcus faecalis plasmid pCF10 and the Lactococcus lactis plasmid pRS01. Mol Microbiol (2007) 1.06
Acceleration of Enterococcus faecalis biofilm formation by aggregation substance expression in an ex vivo model of cardiac valve colonization. PLoS One (2010) 1.03
Enterococcus faecalis PcfC, a spatially localized substrate receptor for type IV secretion of the pCF10 transfer intermediate. J Bacteriol (2008) 1.03
Antagonistic self-sensing and mate-sensing signaling controls antibiotic-resistance transfer. Proc Natl Acad Sci U S A (2013) 1.03
Use of recombinase-based in vivo expression technology to characterize Enterococcus faecalis gene expression during infection identifies in vivo-expressed antisense RNAs and implicates the protease Eep in pathogenesis. Infect Immun (2011) 1.03
Analysis of the amino acid sequence specificity determinants of the enterococcal cCF10 sex pheromone in interactions with the pheromone-sensing machinery. J Bacteriol (2006) 1.02
A conjugation-based system for genetic analysis of group II intron splicing in Lactococcus lactis. J Bacteriol (2004) 1.01
Structural analysis of the Anti-Q-Qs interaction: RNA-mediated regulation of E. faecalis plasmid pCF10 conjugation. Plasmid (2010) 1.01
Conserved target for group II intron insertion in relaxase genes of conjugative elements of gram-positive bacteria. J Bacteriol (2004) 0.99
The aggregation domain of aggregation substance, not the RGD motifs, is critical for efficient internalization by HT-29 enterocytes. Infect Immun (2003) 0.98
Enterococcus faecalis endocarditis severity in rabbits is reduced by IgG Fabs interfering with aggregation substance. PLoS One (2010) 0.98
Genetic characterization of the conjugative DNA processing system of enterococcal plasmid pCF10. Plasmid (2006) 0.96
Bacterial group II introns and their association with mobile genetic elements. Front Biosci (2002) 0.95
RNA-mediated reciprocal regulation between two bacterial operons is RNase III dependent. MBio (2011) 0.95
Relation between antibiotic susceptibility and ultrastructure of Staphylococcus aureus biofilms on surgical suture. Surg Infect (Larchmt) (2011) 0.94
Pheromone-inducible conjugation in Enterococcus faecalis: a model for the evolution of biological complexity? Int J Med Microbiol (2006) 0.91
Characterization of a Staphylococcus aureus surface virulence factor that promotes resistance to oxidative killing and infectious endocarditis. Infect Immun (2010) 0.90
Formation of vegetations during infective endocarditis excludes binding of bacterial-specific host antibodies to Enterococcus faecalis. J Infect Dis (2002) 0.86
In vivo and in vitro analyses of regulation of the pheromone-responsive prgQ promoter by the PrgX pheromone receptor protein. J Bacteriol (2012) 0.85
AhrC and Eep are biofilm infection-associated virulence factors in Enterococcus faecalis. Infect Immun (2013) 0.85
Quantitative analysis of group II intron expression and splicing in Lactococcus lactis. Appl Environ Microbiol (2005) 0.83
Ultrastructure of a novel bacterial form located in Staphylococcus aureus in vitro and in vivo catheter-associated biofilms. J Histochem Cytochem (2012) 0.83
Enterococcus faecalis pCF10-encoded surface proteins PrgA, PrgB (aggregation substance) and PrgC contribute to plasmid transfer, biofilm formation and virulence. Mol Microbiol (2014) 0.80
Analogous telesensing pathways regulate mating and virulence in two opportunistic human pathogens. MBio (2010) 0.79
Occurrence, genetic diversity, and persistence of enterococci in a Lake Superior watershed. Appl Environ Microbiol (2013) 0.78
Identification of a conserved branched RNA structure that functions as a factor-independent terminator. Proc Natl Acad Sci U S A (2014) 0.77
Group effort in toxin synthesis. Nature (2002) 0.75
The Influence of Biofilms in the Biology of Plasmids. Microbiol Spectr (2014) 0.75