Published in Methods Mol Med on January 01, 2007
Scaffold-free culture of mesenchymal stem cell spheroids in suspension preserves multilineage potential. Cell Tissue Res (2011) 1.26
Advances in the formation, use and understanding of multi-cellular spheroids. Expert Opin Biol Ther (2012) 1.25
Stiffening of human mesenchymal stem cell spheroid microenvironments induced by incorporation of gelatin microparticles. J Mech Behav Biomed Mater (2012) 1.02
Continuously perfused microbubble array for 3D tumor spheroid model. Biomicrofluidics (2011) 1.01
LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues. J Cell Biol (2014) 0.97
Microfluidic device for recreating a tumor microenvironment in vitro. J Vis Exp (2011) 0.88
Bronchial smooth muscle cells of asthmatics promote angiogenesis through elevated secretion of CXC-chemokines (ENA-78, GRO-α, and IL-8). PLoS One (2013) 0.87
A hierarchy of endothelial colony-forming cell activity displayed by bovine corneal endothelial cells. Invest Ophthalmol Vis Sci (2010) 0.86
High Throughput, Polymeric Aqueous Two-Phase Printing of Tumor Spheroids. Adv Funct Mater (2014) 0.83
A Cancer Cell Spheroid Assay to Assess Invasion in a 3D Setting. J Vis Exp (2015) 0.83
Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids. PLoS One (2012) 0.82
Isolation of mammary epithelial cells from three-dimensional mixed-cell spheroid co-culture. J Vis Exp (2012) 0.82
Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity. Oncotarget (2015) 0.82
Generation and functional assessment of 3D multicellular spheroids in droplet based microfluidics platform. Lab Chip (2016) 0.81
Tumor bioengineering using a transglutaminase crosslinked hydrogel. PLoS One (2014) 0.80
Low-dose 6-bromoindirubin-3'-oxime induces partial dedifferentiation of endothelial cells to promote increased neovascularization. Stem Cells (2014) 0.80
Longitudinal measurement of extracellular matrix rigidity in 3D tumor models using particle-tracking microrheology. J Vis Exp (2014) 0.79
3D tissue-engineered model of Ewing's sarcoma. Adv Drug Deliv Rev (2014) 0.79
Generation of three-dimensional multiple spheroid model of olfactory ensheathing cells using floating liquid marbles. Sci Rep (2015) 0.78
Hypoxia exerts dualistic effects on inflammatory and proliferative responses of healthy and asthmatic primary human bronchial smooth muscle cells. PLoS One (2014) 0.78
Innate predisposition to immune escape in follicular lymphoma cells. Oncoimmunology (2012) 0.77
The Heat Shock Transcription Factor HSF1 Induces Ovarian Cancer Epithelial-Mesenchymal Transition in a 3D Spheroid Growth Model. PLoS One (2016) 0.75
Engineered Breast Cancer Cell Spheroids Reproduce Biologic Properties of Solid Tumors. Adv Healthc Mater (2016) 0.75
Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids. J Exp Clin Cancer Res (2017) 0.75
Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types. Biotechnol Bioeng (2003) 3.04
Fermentative butanol production by Clostridia. Biotechnol Bioeng (2008) 2.49
Towards quantitative metabolomics of mammalian cells: development of a metabolite extraction protocol. Anal Biochem (2010) 2.17
Molecular composition of IMP1 ribonucleoprotein granules. Mol Cell Proteomics (2007) 1.80
The genome sequence of E. coli W (ATCC 9637): comparative genome analysis and an improved genome-scale reconstruction of E. coli. BMC Genomics (2011) 1.63
OpenFLUX: efficient modelling software for 13C-based metabolic flux analysis. Microb Cell Fact (2009) 1.61
Modeling hybridoma cell metabolism using a generic genome-scale metabolic model of Mus musculus. Biotechnol Prog (2005) 1.60
Microbial hyaluronic acid production. Appl Microbiol Biotechnol (2004) 1.42
DNase I-hypersensitive exons colocalize with promoters and distal regulatory elements. Nat Genet (2013) 1.40
Metabolic flux analysis in mammalian cell culture. Metab Eng (2009) 1.24
Deep sequencing-based transcriptome analysis of Plutella xylostella larvae parasitized by Diadegma semiclausum. BMC Genomics (2011) 1.18
AlgaGEM--a genome-scale metabolic reconstruction of algae based on the Chlamydomonas reinhardtii genome. BMC Genomics (2011) 1.15
On the reconstruction of the Mus musculus genome-scale metabolic network model. Genome Inform (2008) 1.13
Design of artificial myocardial microtissues. Tissue Eng (2004) 1.12
Ultra-high-yield manufacture of red blood cells from hematopoietic stem cells. Tissue Eng Part C Methods (2011) 1.09
IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS. Immunol Cell Biol (2006) 1.05
Blood cell manufacture: current methods and future challenges. Trends Biotechnol (2009) 1.03
Metabolic and practical considerations on microbial electrosynthesis. Curr Opin Biotechnol (2011) 1.03
Evolution of the hyaluronic acid synthesis (has) operon in Streptococcus zooepidemicus and other pathogenic streptococci. J Mol Evol (2008) 1.02
Knock-in/Knock-out (KIKO) vectors for rapid integration of large DNA sequences, including whole metabolic pathways, onto the Escherichia coli chromosome at well-characterised loci. Microb Cell Fact (2013) 0.98
Hanging-drop multicellular spheroids as a model of tumour angiogenesis. Angiogenesis (2004) 0.98
Stable production of hyaluronic acid in Streptococcus zooepidemicus chemostats operated at high dilution rate. Biotechnol Bioeng (2005) 0.97
Alleviating monoterpene toxicity using a two-phase extractive fermentation for the bioproduction of jet fuel mixtures in Saccharomyces cerevisiae. Biotechnol Bioeng (2012) 0.96
Development of chemically defined medium for Mannheimia succiniciproducens based on its genome sequence. Appl Microbiol Biotechnol (2008) 0.91
Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production. Antonie Van Leeuwenhoek (2012) 0.91
Amplifying the cellular reduction potential of Streptococcus zooepidemicus. J Biotechnol (2003) 0.90
Saccharopolyspora erythraea's genome is organised in high-order transcriptional regions mediated by targeted degradation at the metabolic switch. BMC Genomics (2013) 0.90
Re-annotation of the Saccharopolyspora erythraea genome using a systems biology approach. BMC Genomics (2013) 0.88
Quantitative analysis of intracellular sugar phosphates and sugar nucleotides in encapsulated streptococci using HPAEC-PAD. Biotechnol J (2009) 0.88
Metabolite profiling of CHO cells with different growth characteristics. Biotechnol Bioeng (2012) 0.87
A transferable sucrose utilization approach for non-sucrose-utilizing Escherichia coli strains. Biotechnol Adv (2011) 0.87
Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption. Biotechnol Bioeng (2012) 0.87
Mammalian cells as biopharmaceutical production hosts in the age of omics. Biotechnol J (2011) 0.87
Enhanced polyhydroxybutyrate production in transgenic sugarcane. Plant Biotechnol J (2012) 0.86
Production of polyhydroxybutyrate in sugarcane. Plant Biotechnol J (2007) 0.86
A multi-omics analysis of recombinant protein production in Hek293 cells. PLoS One (2012) 0.86
Functional proteomic analysis of GS-NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate. Biotechnol Bioeng (2006) 0.85
Physiological and transcriptional responses of Saccharomyces cerevisiae to d-limonene show changes to the cell wall but not to the plasma membrane. Appl Environ Microbiol (2013) 0.85
Engineered quorum sensing using pheromone-mediated cell-to-cell communication in Saccharomyces cerevisiae. ACS Synth Biol (2013) 0.85
2,2-Diphenyl-1-picrylhydrazyl as a screening tool for recombinant monoterpene biosynthesis. Microb Cell Fact (2013) 0.85
Genome scale transcriptomics of baculovirus-insect interactions. Viruses (2013) 0.85
Deletion of cscR in Escherichia coli W improves growth and poly-3-hydroxybutyrate (PHB) production from sucrose in fed batch culture. J Biotechnol (2011) 0.85
Monocyte-derived DC primed with TLR agonists secrete IL-12p70 in a CD40-dependent manner under hyperthermic conditions. J Immunother (2006) 0.84
Engineering and adaptive evolution of Escherichia coli for D-lactate fermentation reveals GatC as a xylose transporter. Metab Eng (2012) 0.84
Increased biomass yield of Lactococcus lactis during energetically limited growth and respiratory conditions. Biotechnol Appl Biochem (2008) 0.84
HR index--a simple method for the prediction of oxygen uptake. Med Sci Sports Exerc (2011) 0.83
In vitro production of Helicoverpa baculovirus biopesticides--automated selection of insect cell clones for manufacturing and systems biology studies. J Virol Methods (2011) 0.83
Understanding plasmid effect on hyaluronic acid molecular weight produced by Streptococcus equi subsp. zooepidemicus. Metab Eng (2009) 0.83
Short-term exposure of umbilical cord blood CD34+ cells to granulocyte-macrophage colony-stimulating factor early in culture improves ex vivo expansion of neutrophils. Cytotherapy (2010) 0.83
Molecular control of sucrose utilization in Escherichia coli W, an efficient sucrose-utilizing strain. Appl Environ Microbiol (2012) 0.83
Generation and maturation of dendritic cells for clinical application under serum-free conditions. J Immunother (2005) 0.82
Importance of virus-medium interactions on the biological activity of wild-type Heliothine nucleopolyhedroviruses propagated via suspension insect cell cultures. J Virol Methods (2006) 0.82
Development of sucrose-utilizing Escherichia coli K-12 strain by cloning β-fructofuranosidases and its application for L-threonine production. Appl Microbiol Biotechnol (2010) 0.82
Surface-bound stem cell factor and the promotion of hematopoietic cell expansion. Biomaterials (2009) 0.82
The ascorbic acid paradox. Biochem Biophys Res Commun (2010) 0.81
Kinetic characterization of the group II Helicoverpa armigera nucleopolyhedrovirus propagated in suspension cell cultures: implications for development of a biopesticides production process. Biotechnol Prog (2011) 0.81
Ligand-receptor interactions and membrane structure investigated by AFM and time-resolved fluorescence microscopy. J Mol Recognit (2007) 0.81
Genome scale analysis of differential mRNA expression of Helicoverpa zea insect cells infected with a H. armigera baculovirus. Virology (2013) 0.81
PATHLOGIC-S: a scalable Boolean framework for modelling cellular signalling. PLoS One (2012) 0.81
Chemical inhibition of acetyl coenzyme A carboxylase as a strategy to increase polyhydroxybutyrate yields in transgenic sugarcane. Plant Biotechnol J (2013) 0.81
Dual gene expression cassette vectors with antibiotic selection markers for engineering in Saccharomyces cerevisiae. Microb Cell Fact (2013) 0.81
Synthesis and characterization of alginate/poly-L-ornithine/alginate microcapsules for local immunosuppression. J Microencapsul (2008) 0.80
Spatio-temporal characterization of polyhydroxybutyrate accumulation in sugarcane. Plant Biotechnol J (2007) 0.80
Clinical scale ex vivo manufacture of neutrophils from hematopoietic progenitor cells. Biotechnol Bioeng (2009) 0.80
Insight into hyaluronic acid molecular weight control. Appl Microbiol Biotechnol (2014) 0.80
Absolute counting of neutrophils in whole blood using flow cytometry. Cytometry A (2014) 0.79
Extracting reaction networks from databases-opening Pandora's box. Brief Bioinform (2013) 0.79
Plant genome-scale modeling and implementation. Methods Mol Biol (2014) 0.79
Membrane bioreactors enhance microenvironmental conditioning and tissue development. Tissue Eng Part C Methods (2010) 0.79
Bioreactor for blood product production. Cell Transplant (2012) 0.78
Altered fatty acid metabolism in long duration road transport: An NMR-based metabonomics study in sheep. J Proteome Res (2011) 0.78
Temporal dynamics of the Saccharopolyspora erythraea phosphoproteome. Mol Cell Proteomics (2014) 0.78
Non-invasive monitoring of sucrose mobilization from culm storage parenchyma by magnetic resonance spectroscopy. Biosci Biotechnol Biochem (2013) 0.78
Transcriptome sequencing of and microarray development for a Helicoverpa zea cell line to investigate in vitro insect cell-baculovirus interactions. PLoS One (2012) 0.78
Factors affecting polyhydroxybutyrate accumulation in mesophyll cells of sugarcane and switchgrass. BMC Biotechnol (2014) 0.78
Development of quenching and washing protocols for quantitative intracellular metabolite analysis of uninfected and baculovirus-infected insect cells. Methods (2011) 0.78
Metabolic engineering: from retrofitting to green field. Nat Chem Biol (2011) 0.78
Allantoin catabolism influences the production of antibiotics in Streptomyces coelicolor. Appl Microbiol Biotechnol (2013) 0.77
A depth-first search algorithm to compute elementary flux modes by linear programming. BMC Syst Biol (2014) 0.77
Steady-state ¹³C fluxomics using OpenFLUX. Methods Mol Biol (2014) 0.77
Properties of a unique mutant of Helicoverpa armigera single-nucleocapsid nucleopolyhedrovirus that exhibits a partial many polyhedra and few polyhedra phenotype on extended serial passaging in suspension cell cultures. In Vitro Cell Dev Biol Anim (2006) 0.76
Identification of three gene candidates for multicellular resistance in colon carcinoma. Cytotechnology (2005) 0.76
High-antibody-producing Chinese hamster ovary cells up-regulate intracellular protein transport and glutathione synthesis. J Proteome Res (2015) 0.76
Suspension culture titration: A simple method for measuring baculovirus titers. J Virol Methods (2012) 0.76
The effect of cell line, phylogenetics and medium on baculovirus budded virus yield and quality. Arch Virol (2013) 0.76
Quantification of l-alanyl-l-glutamine in mammalian cell culture broth: Evaluation of different detectors. Anal Biochem (2011) 0.76
NExT: integration of thermodynamic constraints and metabolomics data into a metabolic network. Methods Mol Biol (2014) 0.75
Escherichia coli W shows fast, highly oxidative sucrose metabolism and low acetate formation. Appl Microbiol Biotechnol (2014) 0.75
RNAi-mediated abrogation of trehalase expression does not affect trehalase activity in sugarcane. Springerplus (2012) 0.75
Production of the short peptide surfactant DAMP4 from glucose or sucrose in high cell density cultures of Escherichia coli BL21(DE3). Microb Cell Fact (2014) 0.75
Proteome analysis of the hyaluronic acid-producing bacterium, Streptococcus zooepidemicus. Proteome Sci (2009) 0.75
Concise review: next-generation cell therapies to prevent infections in neutropenic patients. Stem Cells Transl Med (2014) 0.75
Decline in baculovirus-expressed recombinant protein production with increasing cell density is strongly correlated to impairment of virus replication and mRNA expression. Appl Microbiol Biotechnol (2013) 0.75
Towards synthetic biology strategies for adipic acid production - an in-silico tool for combined thermodynamics and stoichiometric analysis of metabolic networks. ACS Synth Biol (2017) 0.75
Customization of ¹³C-MFA strategy according to cell culture system. Methods Mol Biol (2014) 0.75
A physiological product-release model for baculovirus infected insect cells. Biotechnol Bioeng (2005) 0.75
Improving the robustness of a low-cost insect cell medium for baculovirus biopesticides production, via hydrolysate streamlining using a tube bioreactor-based statistical optimization routine. Biotechnol Prog (2012) 0.75
Decline in Helicoverpa armigera nucleopolyhedrovirus occlusion body yields with increasing infection cell density in vitro is strongly correlated with viral DNA levels. Arch Virol (2015) 0.75
Filling the void: allogeneic myeloid cells for transplantation. Curr Opin Hematol (2016) 0.75
Effect of the peak cell density of recombinant AcMNPV-infected Hi5 cells on baculovirus yields. Appl Microbiol Biotechnol (2014) 0.75