Published in PLoS One on December 19, 2007
Notch exhibits ligand bias and maneuvers stage-specific steering of neural differentiation in embryonic stem cells. Mol Cell Biol (2010) 0.89
Derivation of high purity neuronal progenitors from human embryonic stem cells. PLoS One (2011) 0.85
Engraftment of mouse embryonic stem cells differentiated by default leads to neuroprotection, behaviour revival and astrogliosis in parkinsonian rats. PLoS One (2013) 0.78
The class I-specific HDAC inhibitor MS-275 modulates the differentiation potential of mouse embryonic stem cells. Biol Open (2013) 0.78
Temporal and contextual orchestration of cardiac fate by WNT-BMP synergy and threshold. J Cell Mol Med (2010) 0.77
Developmental cues and persistent neurogenic potential within an in vitro neural niche. BMC Dev Biol (2010) 0.77
Induction of alternative fate other than default neuronal fate of embryonic stem cells in a membrane-based two-chambered microbioreactor by cell-secreted BMP4. Biomicrofluidics (2012) 0.75
Embryonic stem cell lines derived from human blastocysts. Science (1998) 65.53
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell (2003) 20.16
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell (2003) 17.72
Hedgehog signaling in animal development: paradigms and principles. Genes Dev (2001) 14.75
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell (2003) 13.47
CNS stem cells express a new class of intermediate filament protein. Cell (1990) 11.96
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol (2003) 9.41
Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. PLoS Biol (2005) 9.12
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev (1998) 8.51
Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron (2000) 6.33
Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol (2000) 6.21
Notch signaling: control of cell communication and cell fate. Development (2004) 5.95
Embryonic stem cells express neuronal properties in vitro. Dev Biol (1995) 5.03
Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol (2002) 5.00
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J (1999) 4.55
Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells. Cell (2000) 3.87
Neural induction, the default model and embryonic stem cells. Nat Rev Neurosci (2002) 3.53
Neural induction by the secreted polypeptide noggin. Science (1993) 3.45
Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech Dev (1996) 3.45
Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron (2001) 3.42
Generalized potential of adult neural stem cells. Science (2000) 3.15
Induction of epidermis and inhibition of neural fate by Bmp-4. Nature (1995) 3.01
Initiation of neural induction by FGF signalling before gastrulation. Nature (2000) 2.49
LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells. Stem Cells (2004) 2.37
BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc Natl Acad Sci U S A (2004) 2.25
Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A (2006) 2.10
Beta-catenin signaling is required for neural differentiation of embryonic stem cells. Development (2004) 1.92
Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern. Development (1995) 1.63
Vertebrate embryonic cells will become nerve cells unless told otherwise. Cell (1997) 1.61
Hedgehog and patched in neural development and disease. Neuron (1998) 1.61
The mechanisms of dorsoventral patterning in the vertebrate neural tube. Dev Biol (2005) 1.58
An evolutionarily conserved region in the second intron of the human nestin gene directs gene expression to CNS progenitor cells and to early neural crest cells. Eur J Neurosci (1997) 1.55
Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences. J Cell Biol (2006) 1.54
Neural induction requires BMP inhibition only as a late step, and involves signals other than FGF and Wnt antagonists. Development (2004) 1.50
The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity. Development (2006) 1.35
Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells. Stem Cells (2005) 1.22
Vertebrate neural induction: inducers, inhibitors, and a new synthesis. Neuron (1997) 1.12
Distinct effects of caudalizing factors on regional specification of embryonic stem cell-derived neural precursors. Brain Res Dev Brain Res (2005) 1.06
Neural induction. A bird's eye view. Trends Genet (1999) 1.03
Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling. Development (2006) 1.01
Nestin-specific green fluorescent protein expression in embryonic stem cell-derived neural precursor cells used for transplantation. Stem Cells (2001) 1.00
Identification of both general and region-specific embryonic CNS enhancer elements in the nestin promoter. Exp Cell Res (1999) 0.95
Quantitation and functional characterization of neural cells derived from ES cells using nestin enhancer-mediated targeting in vitro. J Cell Sci (2002) 0.89
Neural induction takes a transcriptional twist. Dev Dyn (2001) 0.86
The choice between epidermal and neural fate: a matter of calcium. Int J Dev Biol (2004) 0.85
One-step induction of neurons from mouse embryonic stem cells in serum-free media containing vitamin B12 and heparin. Cell Transplant (2006) 0.80
Derivation and characterization of neural cells from embryonic stem cells using nestin enhancer. Methods Mol Biol (2006) 0.80