Published in Science on April 30, 1999
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila. Genes Dev (2006) 6.30
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev (2006) 6.19
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res (2004) 5.60
Muscle satellite cells adopt divergent fates: a mechanism for self-renewal? J Cell Biol (2004) 5.35
Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev (2008) 5.34
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev (2003) 4.89
Direct inhibition of the NOTCH transcription factor complex. Nature (2009) 4.82
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med (2007) 4.59
The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci U S A (2007) 4.52
The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol (2008) 4.43
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol (2003) 4.43
Heart valve development: endothelial cell signaling and differentiation. Circ Res (2004) 4.41
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev (2009) 4.29
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A (2007) 4.27
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med (2011) 4.25
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol (2010) 4.22
Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta. Proc Natl Acad Sci U S A (2001) 4.20
Epithelial stem cells: turning over new leaves. Cell (2007) 4.10
A microRNA imparts robustness against environmental fluctuation during development. Cell (2009) 4.08
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med (2007) 4.04
Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol (2004) 3.87
Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev (2000) 3.86
MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci U S A (2005) 3.78
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev (2006) 3.72
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med (2008) 3.64
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev (2002) 3.55
Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev (2006) 3.51
Satellite cells and the muscle stem cell niche. Physiol Rev (2013) 3.40
Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell (2009) 3.37
Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell (2011) 3.32
Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev (2002) 3.22
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
Calcium depletion dissociates and activates heterodimeric notch receptors. Mol Cell Biol (2000) 3.15
Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell (2008) 3.09
Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell (2008) 3.08
Activating Notch1 mutations in mouse models of T-ALL. Blood (2005) 3.08
Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol (2013) 3.07
Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Nature (2010) 3.06
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep (2008) 3.03
The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients. J Clin Invest (2000) 3.02
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev (2004) 3.00
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol Cell Biol (2006) 2.94
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest (2015) 2.93
Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc Natl Acad Sci U S A (2006) 2.92
Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood (2005) 2.91
Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev (1999) 2.90
The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. Mol Cell Biol (2001) 2.87
Dimorphic effects of Notch signaling in bone homeostasis. Nat Med (2008) 2.82
Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. Mol Cell Biol (2000) 2.80
The Notch signalling system: recent insights into the complexity of a conserved pathway. Nat Rev Genet (2012) 2.77
Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell (2012) 2.75
Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature (2009) 2.68
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A (2004) 2.66
p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol Cell Biol (2001) 2.64
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev (2002) 2.64
Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. Genes Dev (2007) 2.61
A FoxO-Smad synexpression group in human keratinocytes. Proc Natl Acad Sci U S A (2006) 2.60
Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity (2000) 2.58
The many facets of Notch ligands. Oncogene (2008) 2.57
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res (2010) 2.54
Notch signaling is essential for ventricular chamber development. Dev Cell (2007) 2.53
SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Site clustering over random expectation. Proc Natl Acad Sci U S A (2002) 2.51
Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci U S A (2006) 2.49
Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol (2003) 2.47
Defining single molecular forces required to activate integrin and notch signaling. Science (2013) 2.44
MicroRNA regulation of cardiovascular development. Circ Res (2009) 2.42
Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J (2000) 2.41
Direct regulation of intestinal fate by Notch. Proc Natl Acad Sci U S A (2005) 2.41
Numb is an endocytic protein. J Cell Biol (2000) 2.39
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest (2005) 2.38
The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota. Clin Microbiol Rev (2006) 2.36
Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis. Genes Dev (2001) 2.32
Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. J Cell Biol (2008) 2.32
Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus. Proc Natl Acad Sci U S A (2007) 2.31
p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol Cell Biol (2002) 2.29
Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia. Blood (2007) 2.29
Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol (2000) 2.27
Notch tumor suppressor function. Oncogene (2008) 2.26
Hypoxia, notch signalling, and prostate cancer. Nat Rev Urol (2013) 2.24
Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood (2008) 2.24
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition. Nat Struct Mol Biol (2008) 2.22
Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1). J Clin Invest (2003) 2.21
Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins. EMBO Rep (2002) 2.21
Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins. J Cell Biol (2001) 2.20
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers. Genes Dev (2007) 2.19
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev (2005) 2.17
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2009) 2.17
Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J (2005) 2.16
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A (2002) 2.16
Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation. J Exp Med (2005) 2.15
PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L. Mol Cell Biol (2006) 2.13
Ex vivo expansion of human hematopoietic stem and progenitor cells. Blood (2011) 2.12
Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell (2009) 2.11
A microwell array system for stem cell culture. Biomaterials (2007) 2.10
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A (2010) 2.10
An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest (2007) 2.09
Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science (1999) 2.71
The mechanism of inactivation of human factor V and human factor Va by activated protein C. J Biol Chem (1994) 1.65
Characterization of the molecular defect in factor VR506Q. J Biol Chem (1995) 1.05
Kuz and TACE can activate Notch independent of ligand. Cell Mol Life Sci (2008) 1.03
Economic cost to New Zealand of foodborne infectious disease. N Z Med J (2000) 1.00
Membrane-dependent reactions in blood coagulation: role of the vitamin K-dependent enzyme complexes. Biochim Biophys Acta (1994) 0.89
Rapid detection of Listeria monocytogenes in ham samples using immunomagnetic separation followed by polymerase chain reaction. J Appl Microbiol (2001) 0.89
Acute gastrointestinal illness in New Zealand: a community study. Epidemiol Infect (2010) 0.87
Factor Va-membrane interaction is mediated by two regions located on the light chain of the cofactor. Biochemistry (1994) 0.87
The effects of methylmercury on Notch signaling during embryonic neural development in Drosophila melanogaster. Toxicol In Vitro (2011) 0.86
Survey of domestic food handling practices in New Zealand. Int J Food Microbiol (2007) 0.85
Factor V. Methods Enzymol (1993) 0.84
NOESY on neurotoxins: NMR and conformational assignments of picrotoxins. Phytochem Anal (2001) 0.84
Phosphorylation of factor Va and factor VIIIa by activated platelets. Blood (1993) 0.82
Incubation period for campylobacteriosis and its importance in the estimation of incidence related to travel. Euro Surveill (2013) 0.78
Factor VNew Brunswick: Ala221-to-Val substitution results in reduced cofactor activity. Blood (1995) 0.78
Comparison of mouse bioassay and sodium channel cytotoxicity assay for detecting paralytic shellfish poisoning toxins in shellfish extracts. J AOAC Int (1996) 0.76