Published in Biochemistry on December 20, 2007
Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both? Expert Opin Drug Metab Toxicol (2008) 1.31
Single-molecule fluorescence spectroscopy using phospholipid bilayer nanodiscs. Methods Enzymol (2010) 1.17
Substrate binding to cytochromes P450. Anal Bioanal Chem (2008) 1.09
Allosteric effects on substrate dissociation from cytochrome P450 3A4 in nanodiscs observed by ensemble and single-molecule fluorescence spectroscopy. J Am Chem Soc (2008) 1.00
Allosteric activation of cytochrome P450 3A4 by α-naphthoflavone: branch point regulation revealed by isotope dilution analysis. Biochemistry (2011) 0.97
Allosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA. Biochemistry (2008) 0.89
Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions. Adv Exp Med Biol (2015) 0.87
Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene. Arch Biochem Biophys (2008) 0.81
Applications of phospholipid bilayer nanodiscs in the study of membranes and membrane proteins. Biochemistry (2007) 3.21
Maternal obesity and the risk of infant death in the United States. Epidemiology (2009) 2.50
Platelet aggregation according to body mass index in patients undergoing coronary stenting: should clopidogrel loading-dose be weight adjusted? J Invasive Cardiol (2004) 1.75
Relation between corneal innervation with confocal microscopy and corneal sensitivity with noncontact esthesiometry in patients with dry eye. Invest Ophthalmol Vis Sci (2007) 1.55
An in vivo confocal masked study on corneal epithelium and subbasal nerves in patients with dry eye. Invest Ophthalmol Vis Sci (2004) 1.51
Sirolimus-eluting stents versus bare-metal stents in patients with in-stent restenosis: results of a pooled analysis of two randomized studies. Catheter Cardiovasc Interv (2008) 1.46
Ligand binding to cytochrome P450 3A4 in phospholipid bilayer nanodiscs: the effect of model membranes. J Biol Chem (2007) 1.42
Protein-induced photophysical changes to the amyloid indicator dye thioflavin T. Proc Natl Acad Sci U S A (2010) 1.35
The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: ligand binding and spin state equilibria. Biochemistry (2005) 1.30
Surface plasmon resonance analysis of antifungal azoles binding to CYP3A4 with kinetic resolution of multiple binding orientations. Biochemistry (2006) 1.17
Single-molecule fluorescence spectroscopy using phospholipid bilayer nanodiscs. Methods Enzymol (2010) 1.17
Energetics of heterotropic cooperativity between alpha-naphthoflavone and testosterone binding to CYP3A4. Arch Biochem Biophys (2007) 1.12
Is psycho-physical stress a risk factor for stroke? A case-control study. J Neurol Neurosurg Psychiatry (2012) 1.12
A quantitative index of substrate promiscuity. Biochemistry (2007) 1.09
Quantitative characterization of the interactions among c-myc transcriptional regulators FUSE, FBP, and FIR. Biochemistry (2010) 1.07
Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2. J Biol Chem (2011) 1.02
Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site. J Am Chem Soc (2002) 1.01
Allosteric effects on substrate dissociation from cytochrome P450 3A4 in nanodiscs observed by ensemble and single-molecule fluorescence spectroscopy. J Am Chem Soc (2008) 1.00
Functional promiscuity correlates with conformational heterogeneity in A-class glutathione S-transferases. J Biol Chem (2007) 0.99
Time-resolved fluorescence studies of heterotropic ligand binding to cytochrome P450 3A4. Biochemistry (2006) 0.98
1.3-A resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site. Proteins (2002) 0.98
Allosteric activation of cytochrome P450 3A4 by α-naphthoflavone: branch point regulation revealed by isotope dilution analysis. Biochemistry (2011) 0.97
Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorg Med Chem Lett (2012) 0.97
Interactions of glutathione transferases with 4-hydroxynonenal. Drug Metab Rev (2011) 0.96
Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b(5). Biochemistry (2012) 0.95
The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4. Biochemistry (2011) 0.95
The stereochemical course of 4-hydroxy-2-nonenal metabolism by glutathione S-transferases. J Biol Chem (2008) 0.95
Association between BRCA1 and BRCA2 mutations and cancer phenotype in Spanish breast/ovarian cancer families: implications for genetic testing. Int J Cancer (2002) 0.95
"Allosterism" in the elementary steps of the cytochrome P450 reaction cycle. Drug Metab Rev (2004) 0.95
Lead, mercury, and cadmium exposure and attention deficit hyperactivity disorder in children. Environ Res (2013) 0.95
Adenylylation and catalytic properties of Mycobacterium tuberculosis glutamine synthetase expressed in Escherichia coli versus mycobacteria. J Biol Chem (2004) 0.94
Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site. Chem Res Toxicol (2007) 0.94
Impact of linker and conjugation chemistry on antigen binding, Fc receptor binding and thermal stability of model antibody-drug conjugates. MAbs (2012) 0.93
Relationship of 25-hydroxyvitamin D and asthma control in children. Ann Allergy Asthma Immunol (2012) 0.93
Erythropoietin requirements: a comparative multicenter study between peritoneal dialysis and hemodialysis. J Nephrol (2004) 0.93
Multiple-ligand binding in CYP2A6: probing mechanisms of cytochrome P450 cooperativity by assessing substrate dynamics. Biochemistry (2008) 0.93
NMR studies of ligand binding to P450(eryF) provides insight into the mechanism of cooperativity. Biochemistry (2006) 0.92
Fluorescent photoaffinity labeling of cytochrome P450 3A4 by lapachenole: identification of modification sites by mass spectrometry. Biochemistry (2005) 0.91
Kinetic characterization of native and cysteine 112-modified glutathione S-transferase A1-1: reassessment of nonsubstrate ligand binding. Biochemistry (2002) 0.88
Interactions of cytochrome P450s with their ligands. Arch Biochem Biophys (2010) 0.87
A theoretical validation of the substrate depletion approach to determining kinetic parameters. Drug Metab Dispos (2006) 0.87
Novel class of bivalent glutathione S-transferase inhibitors. Biochemistry (2003) 0.87
The anomalous pKa of Tyr-9 in glutathione S-transferase A1-1 catalyzes product release. J Biol Chem (2003) 0.86
Ensemble perspective for catalytic promiscuity: calorimetric analysis of the active site conformational landscape of a detoxification enzyme. J Biol Chem (2011) 0.86
Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4. Arch Biochem Biophys (2008) 0.86
A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles. J Virol (2014) 0.86
Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing. Stem Cell Res Ther (2013) 0.86
A novel antioxidant role for ligandin behavior of glutathione S-transferases: attenuation of the photodynamic effects of hypericin. Biochemistry (2004) 0.85
CD38 expression as a prognostic indicator in chronic lymphocytic leukaemia. Hematol J (2004) 0.85
Clinical impact of in-stent late loss after drug-eluting coronary stent implantation. Eur Heart J (2007) 0.84
Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. Biochemistry (2010) 0.84
Intramolecular heme ligation of the cytochrome P450 2C9 R108H mutant demonstrates pronounced conformational flexibility of the B-C loop region: implications for substrate binding. Biochemistry (2010) 0.84
Different prognostic value of silent peripheral artery disease in type 2 diabetic and non-diabetic subjects with stable cardiovascular disease. Atherosclerosis (2010) 0.84
Bivalent inhibitors of glutathione S-transferase: the effect of spacer length on isozyme selectivity. Bioorg Med Chem Lett (2006) 0.83
Cognitive and neuropsychiatric effects of subthalamotomy for Parkinson's disease. Parkinsonism Relat Disord (2010) 0.83
Quantifying and predicting the promiscuity and isoform specificity of small-molecule cytochrome P450 inhibitors. Drug Metab Dispos (2010) 0.83
Addressing prediabetes in childhood obesity treatment programs: support from research and current practice. Child Obes (2014) 0.82
Enzymatic detoxication, conformational selection, and the role of molten globule active sites. J Biol Chem (2013) 0.81
Exploration of in vitro pro-drug activation and futile cycling by glutathione S-transferases: thiol ester hydrolysis and inhibitor maturation. Arch Biochem Biophys (2003) 0.81
Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals. Biochemistry (2009) 0.81
Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase. Arch Biochem Biophys (2006) 0.81
Diaphragm muscle shortening modulates kinematics of lower rib cage in dogs. Am J Physiol Regul Integr Comp Physiol (2010) 0.80
1,2,3-Triazole-heme interactions in cytochrome P450: functionally competent triazole-water-heme complexes. Biochemistry (2012) 0.80
Catalytic versus inhibitory promiscuity in cytochrome P450s: implications for evolution of new function. Biochemistry (2011) 0.79
Glutathione S-transferase P1-1 expression modulates sensitivity of human kidney 293 cells to photodynamic therapy with hypericin. Arch Biochem Biophys (2006) 0.79
A glutathione-based hydrogel and its site-selective interactions with water. Bioconjug Chem (2005) 0.79
Reaction dynamics of ATP hydrolysis catalyzed by P-glycoprotein. Biochemistry (2014) 0.79
Optimization of bivalent glutathione S-transferase inhibitors by combinatorial linker design. J Am Chem Soc (2006) 0.78
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. Bioorg Med Chem Lett (2013) 0.78
Strength of axial water ligation in substrate-free cytochrome P450s is isoform dependent. Biochemistry (2014) 0.78
Relationship of immunohistochemical biomarker expression and lymph node involvement in patients undergoing surgical treatment of NSCLC with long-term follow-up. Tumour Biol (2014) 0.78
Glutathione transferase A4-4 resists adduction by 4-hydroxynonenal. Arch Biochem Biophys (2010) 0.78
The central loop of Escherichia coli glutamine synthetase is flexible and functionally passive. Arch Biochem Biophys (2005) 0.78
Drug modulation of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1. Biochemistry (2015) 0.78
Second-generation drug-eluting stents. Moving the field forward. J Am Coll Cardiol (2011) 0.77
Immunohistochemistry expression of P53, Ki67, CD30, and CD117 and presence of clinical metastasis at diagnosis of testicular seminoma. Appl Immunohistochem Mol Morphol (2011) 0.76
Molecular simulations of the fluctuating conformational dynamics of intrinsically disordered proteins. Phys Rev E Stat Nonlin Soft Matter Phys (2012) 0.76
Yeast-hybrid based high-throughput assay for identification of anthrax lethal factor inhibitors. Biochem Biophys Res Commun (2010) 0.76
Kinetic mechanism of fuculose-1-phosphate aldolase from the hyperthermophilic archaeon Methanococcus jannaschii. Enzyme Microb Technol (2012) 0.76
Stereoselective effects of 4-hydroxynonenal in cultured mouse hepatocytes. Chem Res Toxicol (2010) 0.75
Head-to-head randomized comparisons of limus-eluting coronary stents: pursuing excellence or flying too high? J Am Coll Cardiol (2011) 0.75
Coronary stenting in small vessels. Eur Heart J (2005) 0.75
Diverse presentation of breath holding spells: two case reports with literature review. Case Rep Neurol Med (2013) 0.75
Risk of stent thrombosis after sirolimus or paclitaxel eluting coronary stent implantation. Br J Clin Pharmacol (2007) 0.75
Yeast ornithine decarboxylase and antizyme form a 1:1 complex in vitro: purification and characterization of the inhibitory complex. Biochem Biophys Res Commun (2011) 0.75
Abnormal DAT SCAN in a patient with parkinsonism after a midbrain ischemic lesion. Mov Disord (2012) 0.75
Index of suspicion. Case 1: intermittent groin pain in a 5-year-old boy. Case 2: itchy rash, fever, hypotension in a 15-year-old girl. Case 3: oliguria, fever, irritability after diarrhea in a 2-year-old boy. Pediatr Rev (2013) 0.75
Index of suspicion. Pediatr Rev (2008) 0.75
Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chem Biol (2017) 0.75
On the use of hydrogen/deuterium exchange mass spectrometry data to improve de novo protein structure prediction. Rapid Commun Mass Spectrom (2009) 0.75
[Evolution of children one year post liver transplant]. Medicina (B Aires) (2005) 0.75
Probing the CYP3A4 active site by cysteine scanning mutagenesis and photoaffinity labeling. Arch Biochem Biophys (2005) 0.75