Published in Cardiovasc Res on December 18, 2007
Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. Br J Pharmacol (2011) 1.51
Endothelium-dependent contractions and endothelial dysfunction in human hypertension. Br J Pharmacol (2009) 1.27
Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets. Curr Hypertens Rep (2010) 1.25
Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rats. Clin Sci (Lond) (2012) 1.23
A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study. Am J Med Genet B Neuropsychiatr Genet (2008) 1.14
Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch (2010) 1.14
Endothelium-dependent contractions: when a good guy turns bad! J Physiol (2008) 1.08
Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptors. Br J Pharmacol (2009) 1.07
Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat. Br J Pharmacol (2008) 0.93
Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli. J Lipid Res (2011) 0.85
Astrocyte inositol triphosphate receptor type 2 and cytosolic phospholipase A2 alpha regulate arteriole responses in mouse neocortical brain slices. PLoS One (2012) 0.84
Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes. Br J Pharmacol (2015) 0.82
Acyl chain-dependent effect of lysophosphatidylcholine on endothelium-dependent vasorelaxation. PLoS One (2013) 0.82
Endothelium modulates vasoconstrictor response to prostaglandin I2 in rat mesenteric resistance arteries: interaction between EP1 and TP receptors. Br J Pharmacol (2009) 0.82
Protein kinase C delta contributes to increase in EP3 agonist-induced contraction in mesenteric arteries from type 2 diabetic Goto-Kakizaki rats. Pflugers Arch (2012) 0.81
Towards developing new strategies to reduce the adverse side-effects of nonsteroidal anti-inflammatory drugs. Clin Exp Nephrol (2011) 0.80
Prostaglandin receptors EP and FP are regulated by estradiol and progesterone in the uterus of ovariectomized rats. Reprod Biol Endocrinol (2012) 0.79
Developmental changes in the effects of prostaglandin E2 in the chicken ductus arteriosus. J Comp Physiol B (2008) 0.79
Prostaglandin E2 does not attenuate adrenergic-induced cardiac contractile response. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.77
α1 -Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats. Br J Pharmacol (2015) 0.77
Diminished neurogenic femoral artery vasoconstrictor response in a Zucker obese rat model: differential regulation of NOS and COX derivatives. PLoS One (2014) 0.75
EDHF: bringing the concepts together. Trends Pharmacol Sci (2002) 3.69
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am J Physiol Heart Circ Physiol (2006) 2.97
Endothelium-derived hyperpolarizing factor: where are we now? Arterioscler Thromb Vasc Biol (2006) 2.69
Plasmin in nephrotic urine activates the epithelial sodium channel. J Am Soc Nephrol (2008) 2.57
SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells. Circ Res (2010) 2.20
Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension. Circ Res (2004) 2.13
Acetaminophen increases blood pressure in patients with coronary artery disease. Circulation (2010) 1.85
Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res (2008) 1.78
Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention. Clin Sci (Lond) (2008) 1.77
Role of potassium in regulating blood flow and blood pressure. Am J Physiol Regul Integr Comp Physiol (2006) 1.74
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes (2010) 1.71
EDHF: an update. Clin Sci (Lond) (2009) 1.67
Activation of A(2) adenosine receptors dilates cortical efferent arterioles in mouse. Kidney Int (2009) 1.60
Endothelium-dependent contractions in hypertension. Br J Pharmacol (2005) 1.59
Contribution of the basolateral isoform of the Na-K-2Cl- cotransporter (NKCC1/BSC2) to renin secretion. Am J Physiol Renal Physiol (2005) 1.57
Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction. Circulation (2013) 1.54
Decreased arteriolar density in endothelial nitric oxide synthase knockout mice is due to hypertension, not to the constitutive defect in endothelial nitric oxide synthase enzyme. J Hypertens (2002) 1.54
Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. Br J Pharmacol (2011) 1.51
Endothelium-dependent hyperpolarizations: past beliefs and present facts. Ann Med (2007) 1.47
Remission of nephrotic syndrome diminishes urinary plasmin content and abolishes activation of ENaC. Pediatr Nephrol (2013) 1.46
Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Hypertension (2011) 1.45
Adiponectin and cardiovascular health: an update. Br J Pharmacol (2012) 1.42
Neuronal nitric oxide synthase supports Renin release during sodium restriction through inhibition of phosphodiesterase 3. Am J Hypertens (2010) 1.41
Prostasin and matriptase (ST14) in placenta from preeclamptic and healthy pregnant women. J Hypertens (2016) 1.39
Cellular signaling and NO production. Pflugers Arch (2010) 1.38
Multiple ryanodine receptor subtypes and heterogeneous ryanodine receptor-gated Ca2+ stores in pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2005) 1.38
APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice. Cell Metab (2009) 1.36
Characterization of a charybdotoxin-sensitive intermediate conductance Ca2+-activated K+ channel in porcine coronary endothelium: relevance to EDHF. Br J Pharmacol (2002) 1.34
Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension. Circ Res (2010) 1.33
Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins. Proteomics (2009) 1.31
Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1. J Biol Chem (2010) 1.28
Oxygen-derived free radicals mediate endothelium-dependent contractions to acetylcholine in aortas from spontaneously hypertensive rats. Br J Pharmacol (2002) 1.28
Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids. Br J Pharmacol (2005) 1.28
Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. Physiol Genomics (2007) 1.27
Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets. Curr Hypertens Rep (2010) 1.25
Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol (2008) 1.23
Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin. Br J Pharmacol (2005) 1.21
EDHF: new therapeutic targets? Pharmacol Res (2004) 1.21
Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells. Cancer Res (2008) 1.20
Endothelium-dependent contractions occur in the aorta of wild-type and COX2-/- knockout but not COX1-/- knockout mice. J Cardiovasc Pharmacol (2005) 1.19
Renin release. Physiology (Bethesda) (2007) 1.18
Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardiovasc Res (2009) 1.17
Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3. Am J Physiol Gastrointest Liver Physiol (2009) 1.15
SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model. FEBS Lett (2010) 1.15
Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. Eur Heart J (2012) 1.15
Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch (2010) 1.14
Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease. Am J Physiol Heart Circ Physiol (2011) 1.13
Nitric oxide: orchestrator of endothelium-dependent responses. Ann Med (2011) 1.13
Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthase. Hypertension (2007) 1.13
A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR. Hypertension (2003) 1.12
Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations. Am J Physiol Regul Integr Comp Physiol (2009) 1.09
Vasoconstrictor prostanoids. Pflugers Arch (2010) 1.09
Prostanoids and reactive oxygen species: team players in endothelium-dependent contractions. Pharmacol Ther (2009) 1.09
Control of renin secretion from rat juxtaglomerular cells by cAMP-specific phosphodiesterases. Circ Res (2002) 1.08
Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. Circulation (2008) 1.07
Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptors. Br J Pharmacol (2009) 1.07
N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes. Free Radic Biol Med (2013) 1.07
Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells. Br J Pharmacol (2011) 1.07
Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice. Cell Metab (2011) 1.07
Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion. J Gen Physiol (2010) 1.06
MMP-7 and cardiovascular disease: not so surprising! Basic Clin Pharmacol Toxicol (2012) 1.06
Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs. Br J Pharmacol (2012) 1.05
COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction. Am J Physiol Renal Physiol (2005) 1.04
Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells. Arterioscler Thromb Vasc Biol (2011) 1.04
Augmented endothelium-derived hyperpolarizing factor-mediated relaxations attenuate endothelial dysfunction in femoral and mesenteric, but not in carotid arteries from type I diabetic rats. J Pharmacol Exp Ther (2006) 1.03
Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway. Diabetes (2010) 1.01
Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats. Antioxid Redox Signal (2011) 1.01
Genomic changes in regenerated porcine coronary arterial endothelial cells. Arterioscler Thromb Vasc Biol (2007) 1.01
Angiotensin II promotes development of the renal microcirculation through AT1 receptors. J Am Soc Nephrol (2010) 1.00
Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis. Proc Natl Acad Sci U S A (2009) 1.00
N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic rats. PLoS One (2013) 1.00
Inhibition of cGMP-specific phosphodiesterase type 5 reduces sodium excretion and arterial blood pressure in patients with NaCl retention and ascites. Am J Physiol Renal Physiol (2004) 1.00
Acetylcholine and sodium nitroprusside cause long-term inhibition of EDCF-mediated contractions. Am J Physiol Heart Circ Physiol (2005) 0.99
Cell-cell interaction underlies formation of fluid in the male reproductive tract of the rat. J Gen Physiol (2005) 0.99
Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4. Arterioscler Thromb Vasc Biol (2013) 0.98
Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. Circulation (2012) 0.98
PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Clin Sci (Lond) (2012) 0.98
Role of SK(Ca) and IK(Ca) in endothelium-dependent hyperpolarizations of the guinea-pig isolated carotid artery. Br J Pharmacol (2005) 0.98
Tissue injury after lithium treatment in human and rat postnatal kidney involves glycogen synthase kinase-3β-positive epithelium. Am J Physiol Renal Physiol (2011) 0.98
The role of pharmacology in drug discovery. Nat Rev Drug Discov (2002) 0.97
Anti-inflammation therapy by activation of prostaglandin EP4 receptor in cardiovascular and other inflammatory diseases. J Cardiovasc Pharmacol (2012) 0.96
Chronic treatment with vitamin D lowers arterial blood pressure and reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol (2010) 0.96
APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. Diabetes (2011) 0.96
Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice. Endocrinology (2008) 0.95
Anti-Parkinsonian drug discovery from herbal medicines: what have we got from neurotoxic models? J Ethnopharmacol (2011) 0.95
Endothelium-dependent contractions to acetylcholine, ATP and the calcium ionophore A 23187 in aortas from spontaneously hypertensive and normotensive rats. Fundam Clin Pharmacol (2004) 0.95
Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery. Eur J Pharmacol (2006) 0.94
Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat. J Pharmacol Exp Ther (2010) 0.93
Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature. Hypertension (2011) 0.93