Published in Br J Pharmacol on January 19, 2009
Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol (2011) 4.67
Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. Br J Pharmacol (2011) 1.51
Role of reactive oxygen and nitrogen species in the vascular responses to inflammation. Free Radic Biol Med (2011) 1.17
Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans. Hypertension (2011) 1.15
Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch (2010) 1.14
Oxidative stress in hypertension: role of the kidney. Antioxid Redox Signal (2013) 1.13
Ketorolac alters blood flow during normothermia but not during hyperthermia in middle-aged human skin. J Appl Physiol (1985) (2009) 1.09
Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide. PLoS One (2011) 1.07
Peripheral mechanisms of thermoregulatory control of skin blood flow in aged humans. J Appl Physiol (1985) (2010) 1.03
COX-mediated endothelium-dependent contractions: from the past to recent discoveries. Acta Pharmacol Sin (2010) 0.99
Endothelium in pharmacology: 30 years on. Br J Pharmacol (2009) 0.96
Contribution of oxidative stress to endothelial dysfunction in hypertension. Front Physiol (2012) 0.91
Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes. Br J Pharmacol (2015) 0.82
Treatment with the arginase inhibitor Nw-hydroxy-nor-L-arginine restores endothelial function in rat adjuvant-induced arthritis. Arthritis Res Ther (2012) 0.82
Acyl chain-dependent effect of lysophosphatidylcholine on endothelium-dependent vasorelaxation. PLoS One (2013) 0.82
Endothelial dysfunction in experimental models of arterial hypertension: cause or consequence? Biomed Res Int (2014) 0.82
Rho-Kinase activity and cutaneous vasoconstriction is upregulated in essential hypertensive humans. Microvasc Res (2013) 0.81
Mechanisms of endothelial dysfunction in rheumatoid arthritis: lessons from animal studies. Arthritis Res Ther (2014) 0.80
Aging-shifted prostaglandin profile in endothelium as a factor in cardiovascular disorders. J Aging Res (2012) 0.79
Dietary fish oil improves endothelial function and lowers blood pressure via suppression of sphingolipid-mediated contractions in spontaneously hypertensive rats. J Hypertens (2014) 0.79
KCa 3.1 channels maintain endothelium-dependent vasodilatation in isolated perfused kidneys of spontaneously hypertensive rats after chronic inhibition of NOS. Br J Pharmacol (2012) 0.78
Age-related alterations in endothelial function of femoral artery in young SHR and WKY rats. Biomed Res Int (2014) 0.77
Vasomotor Reaction to Cyclooxygenase-1-Mediated Prostacyclin Synthesis in Carotid Arteries from Two-Kidney-One-Clip Hypertensive Mice. PLoS One (2015) 0.77
Pioglitazone treatment increases COX-2-derived prostacyclin production and reduces oxidative stress in hypertensive rats: role in vascular function. Br J Pharmacol (2012) 0.76
Robert F. Furchgott, Nobel laureate (1916-2009)--a personal reflection. Br J Pharmacol (2009) 0.76
Reduced Activity of the Aortic Gamma-Glutamyltransferase Does Not Decrease S-Nitrosoglutathione Induced Vasorelaxation of Rat Aortic Rings. Front Physiol (2016) 0.75
Effects of Aspirin on Endothelial Function and Hypertension. Curr Hypertens Rep (2016) 0.75
Role of E-type prostaglandin receptor EP3 in the vasoconstrictor activity evoked by prostacyclin in thromboxane-prostanoid receptor deficient mice. Sci Rep (2017) 0.75
Dual NEP/ECE inhibition improves endothelial function in mesenteric resistance arteries of 32-week-old SHR. Hypertens Res (2017) 0.75
Guide to Receptors and Channels (GRAC), 3rd edition. Br J Pharmacol (2008) 13.18
Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol (1998) 7.22
A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci U S A (1990) 5.31
Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci U S A (1992) 5.21
Role of prostacyclin in the cardiovascular response to thromboxane A2. Science (2002) 4.59
EDHF: bringing the concepts together. Trends Pharmacol Sci (2002) 3.69
cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci U S A (1992) 3.65
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am J Physiol Heart Circ Physiol (2006) 2.97
Endothelium-derived hyperpolarizing factor: where are we now? Arterioscler Thromb Vasc Biol (2006) 2.69
Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension (1986) 2.30
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc Natl Acad Sci U S A (1988) 2.16
The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis. Arterioscler Thromb Vasc Biol (2000) 2.11
Endothelium-dependent relaxation of the pig aorta: relationship to stimulation of 86Rb efflux from isolated endothelial cells. Br J Pharmacol (1983) 1.94
Participation of prostacyclin in endothelial dysfunction induced by aldosterone in normotensive and hypertensive rats. Hypertension (2005) 1.83
Decreased endothelium-dependent hyperpolarization to acetylcholine in smooth muscle of the mesenteric artery of spontaneously hypertensive rats. Circ Res (1992) 1.66
Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase). J Biol Chem (1988) 1.61
Endothelium-dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis? Br J Pharmacol (2004) 1.61
Endothelium-dependent contractions in hypertension. Br J Pharmacol (2005) 1.59
K+ currents underlying the action of endothelium-derived hyperpolarizing factor in guinea-pig, rat and human blood vessels. J Physiol (2001) 1.52
Roles of prostaglandin I(2) and thromboxane A(2) in cardiac ischemia-reperfusion injury: a study using mice lacking their respective receptors. Circulation (2001) 1.51
Superoxide anion is an endothelium-derived contracting factor. Am J Physiol (1989) 1.49
Regulation of P2y-purinoceptor-mediated prostacyclin release from human endothelial cells by cytoplasmic calcium concentration. Br J Pharmacol (1988) 1.48
Endothelium-derived factors and hyperpolarization of the carotid artery of the guinea-pig. Br J Pharmacol (1996) 1.46
Oxygen-derived free radicals mediate endothelium-dependent contractions to acetylcholine in aortas from spontaneously hypertensive rats. Br J Pharmacol (2002) 1.28
Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. Physiol Genomics (2007) 1.27
Prostaglandin H2 may be the endothelium-derived contracting factor released by acetylcholine in the aorta of the rat. Hypertension (1990) 1.26
The loss of endothelium-dependent vascular relaxation in hypertension. Hypertension (1986) 1.24
Prostaglandin H synthase and vascular function. Circ Res (2001) 1.23
Rate of vasoconstrictor prostanoids released by endothelial cells depends on cyclooxygenase-2 expression and prostaglandin I synthase activity. Circ Res (1998) 1.22
Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin. Br J Pharmacol (2005) 1.21
EDHF: new therapeutic targets? Pharmacol Res (2004) 1.21
Endothelium-dependent contractions are associated with both augmented expression of prostaglandin H synthase-1 and hypersensitivity to prostaglandin H2 in the SHR aorta. Circ Res (1995) 1.20
Effects of aging and hypertension on endothelium-dependent vascular relaxation in rat carotid artery. Stroke (1988) 1.20
Endothelium-dependent responses in carotid and renal arteries of normotensive and hypertensive rats. Hypertension (1988) 1.19
Endothelium-dependent contractions occur in the aorta of wild-type and COX2-/- knockout but not COX1-/- knockout mice. J Cardiovasc Pharmacol (2005) 1.19
Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition. Circ Res (2008) 1.17
Age and hypertension promote endothelium-dependent contractions to acetylcholine in the aorta of the rat. Hypertension (1989) 1.17
Direct in situ measurement of nitric oxide in mesenteric resistance arteries. Increased decomposition by superoxide in hypertension. Hypertension (1996) 1.16
AKT participates in endothelial dysfunction in hypertension. Circulation (2004) 1.15
Role of hydrogen peroxide in the neutrophil-mediated release of prostacyclin from cultured endothelial cells. J Clin Invest (1984) 1.14
Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes. Am J Physiol Heart Circ Physiol (2008) 1.14
Gender difference in endothelial dysfunction in the aorta of spontaneously hypertensive rats. Hypertension (1995) 1.13
A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR. Hypertension (2003) 1.12
Vascular gap junctions and implications for hypertension. Clin Exp Pharmacol Physiol (2004) 1.11
Prostanoid receptor subtypes. Prostaglandins Other Lipid Mediat (2002) 1.11
Angiotensin II receptor blockade corrects altered expression of gap junctions in vascular endothelial cells from hypertensive rats. Am J Physiol Heart Circ Physiol (2004) 1.10
Mediation by M3-muscarinic receptors of both endothelium-dependent contraction and relaxation to acetylcholine in the aorta of the spontaneously hypertensive rat. Br J Pharmacol (1994) 1.09
Thromboxane A2 receptor antagonists inhibit endothelium-dependent contractions. Hypertension (1990) 1.09
Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease-activated receptor-2 activation. Stroke (1999) 1.07
Age-related changes in endothelium-dependent hyperpolarization in the rat mesenteric artery. Am J Physiol (1993) 1.07
Improved endothelial function by the thromboxane A2 receptor antagonist S 18886 in patients with coronary artery disease treated with aspirin. J Am Coll Cardiol (2003) 1.06
Contractions to oxygen-derived free radicals are augmented in aorta of the spontaneously hypertensive rat. Hypertension (1989) 1.06
The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice. Diabetes (2006) 1.05
Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium-derived contracting factor. Br J Pharmacol (2007) 1.04
Aged spontaneously hypertensive rats exhibit a selective loss of EDHF-mediated relaxation in the renal artery. Hypertension (2003) 1.04
Hypertension increases the participation of vasoconstrictor prostanoids from cyclooxygenase-2 in phenylephrine responses. J Hypertens (2005) 1.03
Aldosterone induces endothelial dysfunction in resistance arteries from normotensive and hypertensive rats by increasing thromboxane A2 and prostacyclin. Br J Pharmacol (2008) 1.03
Prostacyclin-deficient mice develop ischemic renal disorders, including nephrosclerosis and renal infarction. Circulation (2002) 1.02
Imbalance between endothelium-derived relaxing and contracting factors in mesenteric arteries from aged OLETF rats, a model of Type 2 diabetes. Am J Physiol Heart Circ Physiol (2007) 1.02
Endothelial dysfunction augments myogenic arteriolar constriction in hypertension. Hypertension (1993) 1.00
Nitric oxide inactivates endothelium-derived contracting factor in the rat aorta. Hypertension (1992) 0.98
The role of prostaglandin E and thromboxane-prostanoid receptors in the response to prostaglandin E2 in the aorta of Wistar Kyoto rats and spontaneously hypertensive rats. Cardiovasc Res (2007) 0.98
Prostaglandin H2 and thromboxane A2 are contractile factors in intrarenal arteries of spontaneously hypertensive rats. Hypertension (1992) 0.98
Role of prostaglandins in acetylcholine-induced contraction of aorta from spontaneously hypertensive and Wistar-Kyoto rats. Hypertension (1996) 0.97
Endothelium-dependent contractions to acetylcholine, ATP and the calcium ionophore A 23187 in aortas from spontaneously hypertensive and normotensive rats. Fundam Clin Pharmacol (2004) 0.95
Endothelial dysfunction in hypertension. J Cardiovasc Pharmacol (2001) 0.95
Mass spectrometric analysis of leukotriene A4 and other chemically reactive metabolites of arachidonic acid. J Am Soc Mass Spectrom (2002) 0.94
Oxidative stress induced by tert-butyl hydroperoxide causes vasoconstriction in the aorta from hypertensive and aged rats: role of cyclooxygenase-2 isoform. J Pharmacol Exp Ther (2000) 0.94
Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat. Br J Pharmacol (2008) 0.93
Increased activity of constitutive nitric oxide synthase in cardiac endothelium in spontaneous hypertension. Circulation (1995) 0.93
Effect of aging and hypertension on contractility of resistance arteries: modulation by endothelial factors. Am J Physiol (1995) 0.93
Microvascular display of xanthine oxidase and NADPH oxidase in the spontaneously hypertensive rat. Microcirculation (2006) 0.93
Purinergic endothelium-dependent and -independent contractions in rat aorta. Hypertension (1993) 0.93
Role of endothelium in endothelin-evoked contractions in the rat aorta. Hypertension (1993) 0.93
Influence of female sex hormones on endothelium-derived vasoconstrictor prostanoid generation in microvessels of spontaneously hypertensive rats. Hypertension (1999) 0.93
Indomethacin improves the impaired endothelium-dependent relaxations in small mesenteric arteries of the spontaneously hypertensive rat. Am J Hypertens (1990) 0.92
Altered gene expression of prostacyclin synthase and prostacyclin receptor in the thoracic aorta of spontaneously hypertensive rats. Cardiovasc Res (1999) 0.92
Impairment of endothelium-dependent dilatation of basilar artery during chronic hypertension. Am J Physiol (1990) 0.92
In SHR aorta, calcium ionophore A-23187 releases prostacyclin and thromboxane A2 as endothelium-derived contracting factors. Am J Physiol Heart Circ Physiol (2006) 0.91
Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta. J Clin Invest (1983) 0.90
Specific potentiation of endothelium-dependent contractions in SHR by tetrahydrobiopterin. Hypertension (2003) 0.90
Age and hypertension differently affect coronary contractions to endothelin-1, serotonin, and angiotensins. Circulation (1995) 0.88
Increased response to prostaglandin H2 precedes changes in PGH synthase-1 expression in the SHR aorta. Zhongguo Yao Li Xue Bao (1999) 0.88
Superoxide stimulates IP3-induced Ca2+ release from vascular smooth muscle sarcoplasmic reticulum. Am J Physiol (1992) 0.88
Ageing suppresses endothelium-dependent relaxation and generates contraction mediated by the muscarinic receptors in vascular smooth muscle of normotensive Wistar-Kyoto and spontaneously hypertensive rats. J Hypertens Suppl (1988) 0.87
Vascular dysfunction in type 2 diabetic TallyHo mice: role for an increase in the contribution of PGH2/TxA2 receptor activation and cytochrome p450 products. Can J Physiol Pharmacol (2007) 0.87
Correlation with blood pressure of the acetylcholine-induced endothelium-derived contracting factor in the rat aorta. Hypertension (1992) 0.87
The calcium ionophore A23187 induces endothelium-dependent contractions in femoral arteries from rats with streptozotocin-induced diabetes. Br J Pharmacol (2007) 0.87
Roles of nitric oxide and endothelium-derived hyperpolarizing factor in vasorelaxant effect of acetylcholine as influenced by aging and hypertension. J Cardiovasc Pharmacol (1995) 0.86
Antihypertensive therapy augments endothelium-dependent relaxations in coronary arteries of spontaneously hypertensive rats. Circulation (1994) 0.86
Endothelium-dependent contractions to endothelin in the rat aorta are mediated by thromboxane A2. J Cardiovasc Pharmacol (1993) 0.86
Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX isoforms in normal aortic endothelium. Biochim Biophys Acta (2006) 0.86
Aging and prostacyclin responses in aorta and platelets from WKY and SHR rats. Am J Physiol Heart Circ Physiol (2008) 0.86
Synthesis of 8-epi-prostaglandin F2alpha by human endothelial cells: role of prostaglandin H2 synthase. Biochem J (1999) 0.85
Oxidative stress attenuates NO-induced modulation of sympathetic neurotransmission in the mesenteric arterial bed of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol (2007) 0.84
Changes in the endothelial cyclooxygenase pathway in resistance arteries of spontaneously hypertensive rats. J Cardiovasc Pharmacol (1994) 0.84
Are endothelium-derived hyperpolarizing and contracting factors isoprostanes? Trends Pharmacol Sci (2002) 0.83
Excessive salt or cholesterol intake alters the balance among endothelium-derived factors released from renal arteries in spontaneously hypertensive rats. J Cardiovasc Pharmacol (1999) 0.83
Mechanisms for altered endothelium-dependent vasorelaxation in isolated kidneys from experimental hypertensive rats. Am J Physiol (1993) 0.83
Impaired response to acetylcholine despite intact endothelium-derived relaxing factor/nitric oxide in isolated microperfused afferent arterioles of the spontaneously hypertensive rat. J Cardiovasc Pharmacol (1992) 0.83
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem (2008) 4.16
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab (2011) 3.98
Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes (2006) 3.85
EDHF: bringing the concepts together. Trends Pharmacol Sci (2002) 3.69
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am J Physiol Heart Circ Physiol (2006) 2.97
Endothelium-derived hyperpolarizing factor: where are we now? Arterioscler Thromb Vasc Biol (2006) 2.69
SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells. Circ Res (2010) 2.20
Acetaminophen increases blood pressure in patients with coronary artery disease. Circulation (2010) 1.85
Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res (2008) 1.78
Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention. Clin Sci (Lond) (2008) 1.77
Role of potassium in regulating blood flow and blood pressure. Am J Physiol Regul Integr Comp Physiol (2006) 1.74
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes (2010) 1.71
EDHF: an update. Clin Sci (Lond) (2009) 1.67
Activation of A(2) adenosine receptors dilates cortical efferent arterioles in mouse. Kidney Int (2009) 1.60
Calcium-activated potassium channels and endothelial dysfunction: therapeutic options? Br J Pharmacol (2009) 1.60
Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. Br J Pharmacol (2011) 1.51
Endothelium-dependent hyperpolarizations: past beliefs and present facts. Ann Med (2007) 1.47
Carbon monoxide induces relaxation of human internal thoracic and radial arterial grafts. Interact Cardiovasc Thorac Surg (2008) 1.45
Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Hypertension (2011) 1.45
Adiponectin and cardiovascular health: an update. Br J Pharmacol (2012) 1.42
Cellular signaling and NO production. Pflugers Arch (2010) 1.38
APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice. Cell Metab (2009) 1.36
Characterization of a charybdotoxin-sensitive intermediate conductance Ca2+-activated K+ channel in porcine coronary endothelium: relevance to EDHF. Br J Pharmacol (2002) 1.34
Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension. Circ Res (2010) 1.33
The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Circulation (2012) 1.32
Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins. Proteomics (2009) 1.31
Oxygen-derived free radicals mediate endothelium-dependent contractions to acetylcholine in aortas from spontaneously hypertensive rats. Br J Pharmacol (2002) 1.28
Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1. J Biol Chem (2010) 1.28
Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids. Br J Pharmacol (2005) 1.28
Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. Physiol Genomics (2007) 1.27
Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets. Curr Hypertens Rep (2010) 1.25
Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol (2008) 1.23
Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin. Br J Pharmacol (2005) 1.21
EDHF: new therapeutic targets? Pharmacol Res (2004) 1.21
Endothelium-dependent contractions occur in the aorta of wild-type and COX2-/- knockout but not COX1-/- knockout mice. J Cardiovasc Pharmacol (2005) 1.19
Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardiovasc Res (2009) 1.17
SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model. FEBS Lett (2010) 1.15
Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. Eur Heart J (2012) 1.15
Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch (2010) 1.14
Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease. Am J Physiol Heart Circ Physiol (2011) 1.13
Nitric oxide: orchestrator of endothelium-dependent responses. Ann Med (2011) 1.13
The thromboxane A2 receptor antagonist S18886 prevents enhanced atherogenesis caused by diabetes mellitus. Circulation (2005) 1.13
A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR. Hypertension (2003) 1.12
Prostanoids and reactive oxygen species: team players in endothelium-dependent contractions. Pharmacol Ther (2009) 1.09
Vasoconstrictor prostanoids. Pflugers Arch (2010) 1.09
Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. Circulation (2008) 1.07
N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes. Free Radic Biol Med (2013) 1.07
Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice. Cell Metab (2011) 1.07
Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells. Br J Pharmacol (2011) 1.07
MMP-7 and cardiovascular disease: not so surprising! Basic Clin Pharmacol Toxicol (2012) 1.06
The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice. Diabetes (2006) 1.05
Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa. Blood (2008) 1.05
Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells. Arterioscler Thromb Vasc Biol (2011) 1.04
Augmented endothelium-derived hyperpolarizing factor-mediated relaxations attenuate endothelial dysfunction in femoral and mesenteric, but not in carotid arteries from type I diabetic rats. J Pharmacol Exp Ther (2006) 1.03
Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis. Proc Natl Acad Sci U S A (2004) 1.03
Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats. Antioxid Redox Signal (2011) 1.01
Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway. Diabetes (2010) 1.01
(Pro)renin promotes fibrosis gene expression in HEK cells through a Nox4-dependent mechanism. Am J Physiol Renal Physiol (2011) 1.01
Genomic changes in regenerated porcine coronary arterial endothelial cells. Arterioscler Thromb Vasc Biol (2007) 1.01
N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic rats. PLoS One (2013) 1.00
Acetylcholine and sodium nitroprusside cause long-term inhibition of EDCF-mediated contractions. Am J Physiol Heart Circ Physiol (2005) 0.99
Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4. Arterioscler Thromb Vasc Biol (2013) 0.98
Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. Circulation (2012) 0.98
PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Clin Sci (Lond) (2012) 0.98
Role of SK(Ca) and IK(Ca) in endothelium-dependent hyperpolarizations of the guinea-pig isolated carotid artery. Br J Pharmacol (2005) 0.98
The role of prostaglandin E and thromboxane-prostanoid receptors in the response to prostaglandin E2 in the aorta of Wistar Kyoto rats and spontaneously hypertensive rats. Cardiovasc Res (2007) 0.98
The role of pharmacology in drug discovery. Nat Rev Drug Discov (2002) 0.97
Chronic treatment with vitamin D lowers arterial blood pressure and reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol (2010) 0.96
Anti-inflammation therapy by activation of prostaglandin EP4 receptor in cardiovascular and other inflammatory diseases. J Cardiovasc Pharmacol (2012) 0.96
APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. Diabetes (2011) 0.96
Endothelium-dependent contractions to acetylcholine, ATP and the calcium ionophore A 23187 in aortas from spontaneously hypertensive and normotensive rats. Fundam Clin Pharmacol (2004) 0.95
Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice. Endocrinology (2008) 0.95
Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery. Eur J Pharmacol (2006) 0.94
Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat. J Pharmacol Exp Ther (2010) 0.93
Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells. Thromb Res (2009) 0.92
Blockade of beta 1- and desensitization of beta 2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis. Eur J Pharmacol (2004) 0.91
Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome. FASEB J (2013) 0.91
The thromboxane/endoperoxide receptor (TP): the common villain. J Cardiovasc Pharmacol (2010) 0.91
In SHR aorta, calcium ionophore A-23187 releases prostacyclin and thromboxane A2 as endothelium-derived contracting factors. Am J Physiol Heart Circ Physiol (2006) 0.91
Endothelial mediators of the acetylcholine-induced relaxation of the rat femoral artery. Vascul Pharmacol (2006) 0.91
Oxidative stress and pathological changes after coronary artery interventions. J Am Coll Cardiol (2013) 0.91
Non-genomic activation of adenylyl cyclase and protein kinase G by 17β-estradiol in vascular smooth muscle of the rat superior mesenteric artery. Pharmacol Res (2011) 0.90
Acute impairment of contractile responses by 17beta-estradiol is cAMP and protein kinase G dependent in vascular smooth muscle cells of the porcine coronary arteries. Br J Pharmacol (2005) 0.90
Vascular actions of adipokines molecular mechanisms and therapeutic implications. Adv Pharmacol (2010) 0.90
Decreased production of collagen Type III in cultured smooth muscle cells from varicose vein patients is due to a degradation by MMPs: possible implication of MMP-3. J Vasc Res (2005) 0.90
Specific potentiation of endothelium-dependent contractions in SHR by tetrahydrobiopterin. Hypertension (2003) 0.90
Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries. Am J Physiol Heart Circ Physiol (2011) 0.89
High binding capacity of cyclophilin B to chondrocyte heparan sulfate proteoglycans and its release from the cell surface by matrix metalloproteinases: possible role as a proinflammatory mediator in arthritis. Arthritis Rheum (2003) 0.89
Tissues cIMPly do not lie. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.88
Calcium-independent phospholipase A(2) plays a key role in the endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol (2010) 0.88
Two isoforms of cyclooxygenase contribute to augmented endothelium-dependent contractions in femoral arteries of 1-year-old rats. Acta Pharmacol Sin (2008) 0.88
Comparison of extracellular matrix in skin and saphenous veins from patients with varicose veins: does the skin reflect venous matrix changes? Clin Sci (Lond) (2007) 0.88
Acidosis prevents and alkalosis augments endothelium-dependent contractions in mouse arteries. Pflugers Arch (2013) 0.88
Serum retinol-binding protein 4 as a marker for cardiovascular disease in women. PLoS One (2012) 0.88
Gap junction inhibitors reduce endothelium-dependent contractions in the aorta of spontaneously hypertensive rats. J Pharmacol Exp Ther (2008) 0.87
Senescence of cultured porcine coronary arterial endothelial cells is associated with accelerated oxidative stress and activation of NFkB. J Vasc Res (2009) 0.87
MicroRNA 299-3p modulates replicative senescence in endothelial cells. Physiol Genomics (2013) 0.87
Synthesis of collagen is dysregulated in cultured fibroblasts derived from skin of subjects with varicose veins as it is in venous smooth muscle cells. Circulation (2002) 0.87