Published in Nat Rev Drug Discov on January 01, 2008
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo. Nat Biotechnol (2014) 2.75
A vector-free microfluidic platform for intracellular delivery. Proc Natl Acad Sci U S A (2013) 2.40
The safety and side effects of monoclonal antibodies. Nat Rev Drug Discov (2010) 2.23
Inhibition of α-helix-mediated protein-protein interactions using designed molecules. Nat Chem (2013) 2.02
The role of tumour-stromal interactions in modifying drug response: challenges and opportunities. Nat Rev Drug Discov (2013) 1.93
Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers. Proc Natl Acad Sci U S A (2009) 1.87
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag. Proc Natl Acad Sci U S A (2009) 1.83
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Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization. Nat Mater (2015) 1.65
Macromolecular diffusion and release from self-assembled beta-hairpin peptide hydrogels. Biomaterials (2008) 1.42
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Cell-based therapy in ischemic stroke. Expert Rev Neurother (2008) 1.33
Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag. Angew Chem Int Ed Engl (2012) 1.25
Polymeric nanomedicine for cancer MR imaging and drug delivery. Chem Commun (Camb) (2009) 1.24
The effect of protein structure on their controlled release from an injectable peptide hydrogel. Biomaterials (2010) 1.23
Sortase-catalyzed transformations that improve the properties of cytokines. Proc Natl Acad Sci U S A (2011) 1.21
Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift. Proc Natl Acad Sci U S A (2011) 1.18
Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules. ACS Nano (2013) 1.10
Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics. Adv Drug Deliv Rev (2009) 1.07
Soluble monomeric IgG1 Fc. J Biol Chem (2012) 1.06
Stimuli-responsive nanomaterials for therapeutic protein delivery. J Control Release (2014) 1.04
Conformation and dynamics of biopharmaceuticals: transition of mass spectrometry-based tools from academe to industry. J Am Soc Mass Spectrom (2009) 1.04
Decoding mechanisms by which silent codon changes influence protein biogenesis and function. Int J Biochem Cell Biol (2015) 1.04
Structure-guided deimmunization of therapeutic proteins. J Comput Biol (2013) 1.04
Insertion of the designed helical linker led to increased expression of tf-based fusion proteins. Pharm Res (2008) 1.02
A protein therapeutic modality founded on molecular regulation. Proc Natl Acad Sci U S A (2011) 1.01
New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics. Evid Based Complement Alternat Med (2013) 1.00
Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells. J Med Chem (2012) 1.00
Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'. Sci Rep (2013) 0.99
Delivery of intact transcription factor by using self-assembled supramolecular nanoparticles. Angew Chem Int Ed Engl (2011) 0.98
Targeted delivery of paclitaxel to EphA2-expressing cancer cells. Clin Cancer Res (2012) 0.96
Development of anti-infectives using phage display: biological agents against bacteria, viruses, and parasites. Antimicrob Agents Chemother (2012) 0.95
Cellular uptake mechanisms and endosomal trafficking of supercharged proteins. Chem Biol (2012) 0.95
Magnetically-enabled and MR-monitored selective brain tumor protein delivery in rats via magnetic nanocarriers. Biomaterials (2011) 0.95
Noninvasive and targeted drug delivery to the brain using focused ultrasound. ACS Chem Neurosci (2013) 0.95
Cell-free biology: exploiting the interface between synthetic biology and synthetic chemistry. Curr Opin Biotechnol (2012) 0.93
Dynamic fluctuations of protein-carbohydrate interactions promote protein aggregation. PLoS One (2009) 0.92
Induction of erythropoiesis using human vascular networks genetically engineered for controlled erythropoietin release. Blood (2011) 0.92
Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists. Proc Natl Acad Sci U S A (2015) 0.91
Harnessing gene conversion in chicken B cells to create a human antibody sequence repertoire. PLoS One (2013) 0.91
Trehalose glycopolymers as excipients for protein stabilization. Biomacromolecules (2013) 0.91
Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions. Chem Biol (2015) 0.91
Standardizing terms, definitions and concepts for describing and interpreting unwanted immunogenicity of biopharmaceuticals: recommendations of the Innovative Medicines Initiative ABIRISK consortium. Clin Exp Immunol (2015) 0.91
What we know that could influence future treatment of phenylketonuria. J Inherit Metab Dis (2008) 0.90
Converting an injectable protein therapeutic into an oral form: phenylalanine ammonia lyase for phenylketonuria. Mol Genet Metab (2010) 0.89
Effects of receptor binding on plasma half-life of bifunctional transferrin fusion proteins. Mol Pharm (2011) 0.89
Controlled protein delivery based on enzyme-responsive nanocapsules. Adv Mater (2011) 0.89
Recombinant vaccine displaying the loop-neutralizing determinant from protective antigen completely protects rabbits from experimental inhalation anthrax. Clin Vaccine Immunol (2013) 0.88
SINEUPs are modular antisense long non-coding RNAs that increase synthesis of target proteins in cells. Front Cell Neurosci (2015) 0.88
Therapeutic antibodies against cancer. Hematol Oncol Clin North Am (2012) 0.87
Influence of multivalent nitrilotriacetic acid lipid-ligand affinity on the circulation half-life in mice of a liposome-attached His6-protein. Bioconjug Chem (2010) 0.87
Conformational and aggregation properties of a PEGylated alanine-rich polypeptide. Biomacromolecules (2011) 0.87
Mechanisms of macromolecular protease inhibitors. Chembiochem (2010) 0.87
Superparamagnetic iron oxide nanoparticle-based delivery systems for biotherapeutics. Expert Opin Drug Deliv (2012) 0.86
Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants. J Biol Chem (2010) 0.86
PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases. J Control Release (2013) 0.86
Computational design of protein-ligand interfaces: potential in therapeutic development. Trends Biotechnol (2011) 0.85
Constitutive secretion in Tetrahymena thermophila. Eukaryot Cell (2010) 0.85
Biosimilar insulins: a European perspective. Diabetes Obes Metab (2014) 0.85
PEGylation extends circulation half-life while preserving in vitro and in vivo activity of tissue inhibitor of metalloproteinases-1 (TIMP-1). PLoS One (2012) 0.85
Radiolabeled nanobodies as theranostic tools in targeted radionuclide therapy of cancer. Expert Opin Drug Deliv (2014) 0.85
Poly(2-oxazoline)s as materials for biomedical applications. J Mater Sci Mater Med (2013) 0.85
Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery. Adv Mater (2016) 0.84
Active-learning exercises to teach drug-receptor interactions in a medicinal chemistry course. Am J Pharm Educ (2010) 0.84
Emerging mass spectrometry-based approaches to probe protein-receptor interactions: focus on overcoming physiological barriers. Adv Drug Deliv Rev (2013) 0.84
Long-lasting enfuvirtide carrier pentasaccharide conjugates with potent anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother (2009) 0.84
Post-production protein stability: trouble beyond the cell factory. Microb Cell Fact (2011) 0.84
Do clustering monoclonal antibody solutions really have a concentration dependence of viscosity? Biophys J (2013) 0.84
Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice. J Invest Dermatol (2015) 0.84
Reprogramming the specificity of sortase enzymes. Proc Natl Acad Sci U S A (2014) 0.83
Engineering bispecificity into a single albumin-binding domain. PLoS One (2011) 0.83
Arginine and the Hofmeister Series: the role of ion-ion interactions in protein aggregation suppression. J Phys Chem B (2011) 0.83
Drug delivery: Relieving PEGylation. Nat Chem (2011) 0.83
Intracellular Delivery of Proteins via Fusion Peptides in Intact Plants. PLoS One (2016) 0.83
Conformationally constrained peptides from CD2 to modulate protein-protein interactions between CD2 and CD58. J Med Chem (2011) 0.83
Immunogenicity to Biotherapeutics - The Role of Anti-drug Immune Complexes. Front Immunol (2016) 0.83
Chemical glycosylation of cytochrome c improves physical and chemical protein stability. BMC Biochem (2014) 0.83
Quality assessment and optimization of purified protein samples: why and how? Microb Cell Fact (2014) 0.82
A novel 18F-labeled two-helix scaffold protein for PET imaging of HER2-positive tumor. Eur J Nucl Med Mol Imaging (2011) 0.82
NanoScript: a nanoparticle-based artificial transcription factor for effective gene regulation. ACS Nano (2014) 0.82
pH-Responsive poly(itaconic acid-co-N-vinylpyrrolidone) hydrogels with reduced ionic strength loading solutions offer improved oral delivery potential for high isoelectric point-exhibiting therapeutic proteins. Int J Pharm (2014) 0.82
Biologics: the role of delivery systems in improved therapy. Biologics (2014) 0.82
Characterization of monobody scaffold interactions with ligand via force spectroscopy and steered molecular dynamics. Sci Rep (2015) 0.82
Insulin analogs for the treatment of diabetes mellitus: therapeutic applications of protein engineering. Ann N Y Acad Sci (2012) 0.82
Toward a magic or imaginary bullet? Ligands for drug targeting to cancer cells: principles, hopes, and challenges. Int J Nanomedicine (2015) 0.82
Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control. Adv Mater (2015) 0.82
Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein. Biomacromolecules (2015) 0.82
Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles. Proc Natl Acad Sci U S A (2016) 0.81
A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives. Saudi Pharm J (2014) 0.81
Protein-based tumor molecular imaging probes. Amino Acids (2010) 0.81
Predictive tools for stabilization of therapeutic proteins. MAbs (2009) 0.81
A peptide from the beta-strand region of CD2 protein that inhibits cell adhesion and suppresses arthritis in a mouse model. Chem Biol Drug Des (2010) 0.81
Monomeric IgG1 Fc molecules displaying unique Fc receptor interactions that are exploitable to treat inflammation-mediated diseases. MAbs (2014) 0.81
A synonymous codon change alters the drug sensitivity of ΔF508 cystic fibrosis transmembrane conductance regulator. FASEB J (2015) 0.81
Consequences of periodic α-to-β(3) residue replacement for immunological recognition of peptide epitopes. ACS Chem Biol (2015) 0.80
Molecular logistics using cytocleavable polyrotaxanes for the reactivation of enzymes delivered in living cells. Sci Rep (2013) 0.80
Rational stabilization of complex proteins: a divide and combine approach. Sci Rep (2015) 0.80
Unnatural amino acid incorporation in E. coli: current and future applications in the design of therapeutic proteins. Front Chem (2014) 0.80
Human interferon alpha-2b: a therapeutic protein for cancer treatment. Scientifica (Cairo) (2014) 0.80
Biochemical and structural insights into mesotrypsin: an unusual human trypsin. Int J Biochem Mol Biol (2013) 0.80
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol (2005) 9.25
Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase. Proc Natl Acad Sci U S A (2005) 2.03
Receptor-regulated dynamic S-nitrosylation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem (2005) 1.96
Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases. ACS Chem Biol (2007) 1.94
Site-specific protein labeling by Sfp phosphopantetheinyl transferase. Nat Protoc (2006) 1.82
Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress. PLoS Pathog (2009) 1.82
Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa. Am J Physiol Cell Physiol (2009) 1.72
Cytoskeletal regulation couples LFA-1 conformational changes to receptor lateral mobility and clustering. Immunity (2006) 1.59
Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration. J Immunol (2006) 1.51
p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. Blood (2008) 1.48
CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation. Proc Natl Acad Sci U S A (2002) 1.44
Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. J Biol Chem (2004) 1.43
Host resistance to lung infection mediated by major vault protein in epithelial cells. Science (2007) 1.30
Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1 receptor. Infect Immun (2007) 1.30
Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion molecules. Biophys J (2006) 1.25
Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion. Proc Natl Acad Sci U S A (2008) 1.21
Atrial natriuretic peptide-initiated cGMP pathways regulate vasodilator-stimulated phosphoprotein phosphorylation and angiogenesis in vascular endothelium. J Biol Chem (2007) 1.15
Subcellular targeting and agonist-induced site-specific phosphorylation of endothelial nitric-oxide synthase. J Biol Chem (2002) 1.10
Ligation of complement receptor 1 increases erythrocyte membrane deformability. Blood (2010) 1.09
Critical role of mitochondrial damage in determining outcome of macrophage infection with Mycobacterium tuberculosis. J Immunol (2002) 1.07
C3b deposition on human erythrocytes induces the formation of a membrane skeleton-linked protein complex. J Clin Invest (2009) 1.03
Single-cell FRET imaging of transferrin receptor trafficking dynamics by Sfp-catalyzed, site-specific protein labeling. Chem Biol (2005) 0.99
Adherent leukocytes capture sickle erythrocytes in an in vitro flow model of vaso-occlusion. Am J Hematol (2007) 0.97
Dynamic regulation of CD45 lateral mobility by the spectrin-ankyrin cytoskeleton of T cells. J Biol Chem (2010) 0.97
CD151 restricts the α6 integrin diffusion mode. J Cell Sci (2012) 0.95
Enhanced proteolytic activity of covalently bound enzymes in photopolymerized sol gel. Anal Chem (2005) 0.94
Inactivation of retinoblastoma protein does not overcome the requirement for human cytomegalovirus UL97 in lamina disruption and nuclear egress. J Virol (2013) 0.93
Mechanisms of Cellular Avidity Regulation in CD2-CD58-Mediated T Cell Adhesion. ACS Chem Biol (2006) 0.91
Disruption of CFTR-dependent lipid rafts reduces bacterial levels and corneal disease in a murine model of Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci (2008) 0.91
Receptor-regulated dynamic interaction between endothelial nitric oxide synthase and calmodulin revealed by fluorescence resonance energy transfer in living cells. Biochemistry (2003) 0.87
Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement. J Cell Sci (2012) 0.87
Physiologic electrical stimulation provokes intracellular calcium increase mediated by phospholipase C activation in human osteoblasts. FASEB J (2004) 0.86
MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability. Proc Natl Acad Sci U S A (2012) 0.85
Control of calcium entry in human fibroblasts by frequency-dependent electrical stimulation. Front Biosci (2002) 0.82
Analysis of molecular diffusion by first-passage time variance identifies the size of confinement zones. Biophys J (2011) 0.81
T cell adhesion mechanisms revealed by receptor lateral mobility. Biopolymers (2008) 0.81
Membrane protein dynamics and functional implications in mammalian cells. Curr Top Membr (2013) 0.79
Membrane compartmentalization in Southeast Asian ovalocytosis red blood cells. Br J Haematol (2011) 0.77