Published in Bioorg Med Chem on December 15, 2007
Modification of nociception and morphine tolerance by the selective opiate receptor-like orphan receptor antagonist (-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111). J Pharmacol Exp Ther (2003) 1.36
Menthol: a natural analgesic compound. Neurosci Lett (2002) 1.32
Implication of an outer surface lipoprotein in adhesion of Bifidobacterium bifidum to Caco-2 cells. Appl Environ Microbiol (2008) 1.21
Spleen tyrosine kinases: biology, therapeutic targets and drugs. Drug Discov Today (2010) 1.19
Bacterial cinnamoyl esterase activity screening for the production of a novel functional food product. Appl Environ Microbiol (2007) 1.14
Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. J Med Chem (2005) 1.07
Morphologic features and glial activation in rat oxaliplatin-dependent neuropathic pain. J Pain (2013) 1.05
Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin. J Pain (2012) 1.02
Signaling pathway of morphine induced acute thermal hyperalgesia in mice. Pain (2006) 1.01
Medicinal chemistry and therapeutic potential of muscarinic M3 antagonists. Med Res Rev (2009) 1.00
[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents. J Med Chem (2003) 0.97
A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain. Sci Rep (2013) 0.95
Inhibition of Plasmodium falciparum pH regulation by small molecule indole derivatives results in rapid parasite death. Biochem Pharmacol (2010) 0.95
Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing rats. Br J Nutr (2010) 0.93
Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes. Learn Mem (2008) 0.93
Protective effect of alpha7 nAChR: behavioural and morphological features on neuropathy. Pain (2010) 0.92
Novel potent 5-HT(3) receptor ligands based on the pyrrolidone structure: synthesis, biological evaluation, and computational rationalization of the ligand-receptor interaction modalities. Bioorg Med Chem (2002) 0.91
Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: a role for the nicotinic receptor. J Neurosci Res (2009) 0.91
Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action. J Med Chem (2006) 0.91
Development, characterization and in vivo evaluation of benzocaine-loaded liposomes. Eur J Pharm Biopharm (2007) 0.91
Effect of preparation technique on the properties and in vivo efficacy of benzocaine-loaded ethosomes. J Liposome Res (2009) 0.90
Study of the adhesion of Bifidobacterium bifidum MIMBb75 to human intestinal cell lines. Curr Microbiol (2009) 0.90
Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype. Behav Brain Res (2004) 0.89
4-amino-5-substituted-3(2H)-pyridazinones as orally active antinociceptive agents: synthesis and studies on the mechanism of action. J Med Chem (2007) 0.89
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent. J Med Chem (2008) 0.89
Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo. J Med Chem (2014) 0.89
A smart platform for hyperthermia application in cancer treatment: cobalt-doped ferrite nanoparticles mineralized in human ferritin cages. ACS Nano (2014) 0.88
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists. Bioorg Med Chem Lett (2007) 0.88
Low dose native type II collagen prevents pain in a rat osteoarthritis model. BMC Musculoskelet Disord (2013) 0.88
Pleiotropic effect of histamine H4 receptor modulation in the central nervous system. Neuropharmacology (2013) 0.88
Alpha2-agonists as analgesic agents. Med Res Rev (2009) 0.87
Molecular interaction in the mouse PAG between NMDA and opioid receptors in morphine-induced acute thermal nociception. J Neurochem (2007) 0.87
Identification of small molecule agonists of the motilin receptor. Bioorg Med Chem Lett (2008) 0.87
Salvianolic acid B and its liposomal formulations: anti-hyperalgesic activity in the treatment of neuropathic pain. Eur J Pharm Sci (2011) 0.86
Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation. Pain (2015) 0.86
Regionally selective activation and differential regulation of ERK, JNK and p38 MAP kinase signalling pathway by protein kinase C in mood modulation. Int J Neuropsychopharmacol (2011) 0.86
Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia. J Neurochem (2009) 0.86
Synthesis of (+)-dumetorine and congeners by using flow chemistry technologies. Chemistry (2011) 0.86
Conditions affecting cell surface properties of human intestinal bifidobacteria. Antonie Van Leeuwenhoek (2005) 0.86
Blockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test. Neuropharmacology (2005) 0.85
Construction, characterization and exemplificative application of bioluminescent Bifidobacterium longum biovar longum. Int J Food Microbiol (2008) 0.85
Acetyl-L-carnitine requires phospholipase C-IP3 pathway activation to induce antinociception. Neuropharmacology (2004) 0.85
Analgesic and antineuropathic drugs acting through central cholinergic mechanisms. Recent Pat CNS Drug Discov (2011) 0.85
Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies. J Med Chem (2006) 0.84
H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway. Neuropharmacology (2004) 0.83
Dopamine is necessary to endogenous morphine formation in mammalian brain in vivo. J Neurochem (2008) 0.83
Therapeutic effects of the superoxide dismutase mimetic compound MnIIMe2DO2A on experimental articular pain in rats. Mediators Inflamm (2013) 0.82
Aspartate biosynthesis is essential for the growth of Streptococcus thermophilus in milk, and aspartate availability modulates the level of urease activity. Appl Environ Microbiol (2007) 0.82
A novel manganese complex effective as superoxide anion scavenger and therapeutic agent against cell and tissue oxidative injury. J Med Chem (2009) 0.82
Urease biogenesis in Streptococcus thermophilus. Res Microbiol (2005) 0.82
Molecular characterization of Bifidobacterium longum biovar longum NAL8 plasmids and construction of a novel replicon screening system. Appl Microbiol Biotechnol (2006) 0.82
Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage. Bioorg Med Chem (2007) 0.82
Methylamine, but not ammonia, is hypophagic in mouse by interaction with brain Kv1.6 channel subtype. Br J Pharmacol (2004) 0.81
Synthesis of photoactivable inhibitors of osteoclast vacuolar ATPase. Bioorg Med Chem (2003) 0.81
Inhibition of the PKCγ-ε pathway relieves from meningeal nociception in an animal model: an innovative perspective for migraine therapy? Neurotherapeutics (2013) 0.81
Activation of JNK pathway in spinal astrocytes contributes to acute ultra-low-dose morphine thermal hyperalgesia. Pain (2015) 0.81
Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs. Curr Pharm Des (2002) 0.81
Methylamine: a new endogenous modulator of neuron firing? Med Sci Monit (2005) 0.80
Role of intracellular calcium in acute thermal pain perception. Neuropharmacology (2004) 0.80
Selective modulation of the PKCɛ/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline. Neuropharmacology (2011) 0.80
Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine. Pharmacol Res (2002) 0.80
Liposomal formulations of prilocaine: effect of complexation with hydroxypropyl-ß-cyclodextrin on drug anesthetic efficacy. J Liposome Res (2010) 0.80
The phospholipase C-IP3 pathway is involved in muscarinic antinociception. Neuropsychopharmacology (2002) 0.79
Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies. Bioorg Med Chem (2008) 0.79
Reversal of NO-induced nociceptive hypersensitivity by St. John's wort and hypericin: NF-κB, CREB and STAT1 as molecular targets. Psychopharmacology (Berl) (2012) 0.79
Role of Gi proteins in the antidepressant-like effect of amitriptyline and clomipramine. Neuropsychopharmacology (2002) 0.79
Antidepressant-like effect of artemin in mice: a mechanism for acetyl-L-carnitine activity on depression. Psychopharmacology (Berl) (2011) 0.79
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity. Bioorg Med Chem (2013) 0.79
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties. J Med Chem (2011) 0.79
Aminopyrrolic synthetic receptors for monosaccharides: a class of carbohydrate-binding agents endowed with antibiotic activity versus pathogenic yeasts. Chemistry (2012) 0.79
Activity and expression of semicarbazide-sensitive benzylamine oxidase in a rodent model of diabetes: interactive effects with methylamine and alpha-aminoguanidine. Eur J Pharmacol (2005) 0.79
Generation and comparison of bioluminescent and fluorescent Bacillus licheniformis. Curr Microbiol (2008) 0.79
Effects of endogenous morphine deprivation on memory retention of passive avoidance learning in mice. Int J Neuropsychopharmacol (2004) 0.79
New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems. Bioorg Med Chem Lett (2008) 0.79
A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice. J Neurochem (2008) 0.78
Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. J Med Chem (2007) 0.78
St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity. Biochem Pharmacol (2010) 0.78
Synthesis and biological evaluation of chiral alpha-aminoanilides with central antinociceptive activity. J Med Chem (2007) 0.78
Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors. J Med Chem (2010) 0.78
Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity. J Med Chem (2003) 0.78
Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors. J Med Chem (2013) 0.78
Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels. J Med Chem (2012) 0.78
Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation. J Med Chem (2010) 0.78
AMPAkines Target the Nucleus Accumbens to Relieve Postoperative Pain. Anesthesiology (2016) 0.78
Chiral aryloxyalkylamines: Selective 5-HT(1B/1D) activation and analgesic activity. ChemMedChem (2010) 0.77
Efficient continuous flow synthesis of hydroxamic acids and suberoylanilide hydroxamic acid preparation. J Org Chem (2009) 0.77
Antagonists at the neurokinin receptors--recent patent literature. IDrugs (2003) 0.77
Antidepressant phenotype by inhibiting the phospholipase Cβ(1)--protein kinase Cγ pathway in the forced swim test. Neuropharmacology (2011) 0.77