Published in Carcinogenesis on January 03, 2008
Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res (2009) 3.66
Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin Cancer Res (2008) 3.59
G protein-coupled receptors: novel targets for drug discovery in cancer. Nat Rev Drug Discov (2011) 3.31
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest (2008) 2.89
Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal (2014) 2.42
Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology (2009) 2.25
TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis. Cancer Res (2011) 1.49
Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival. BMC Cancer (2009) 1.43
TGF-β - an excellent servant but a bad master. J Transl Med (2012) 1.41
Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies. Pharmacol Rev (2010) 1.33
Up-regulation of sonic hedgehog contributes to TGF-β1-induced epithelial to mesenchymal transition in NSCLC cells. PLoS One (2011) 1.30
Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells. Biochem Pharmacol (2010) 1.28
Requirement of TGFbeta signaling for SMO-mediated carcinogenesis. J Biol Chem (2010) 1.14
Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon. World J Gastroenterol (2012) 1.09
Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta (2010) 1.07
Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways. J Biol Chem (2008) 1.03
ZIC1 modulates cell-cycle distributions and cell migration through regulation of sonic hedgehog, PI(3)K and MAPK signaling pathways in gastric cancer. BMC Cancer (2012) 1.00
PTCH1, a receptor of Hedgehog signaling pathway, is correlated with metastatic potential of colorectal cancer. Ups J Med Sci (2010) 0.99
The matricellular protein CCN1/Cyr61 is a critical regulator of Sonic Hedgehog in pancreatic carcinogenesis. J Biol Chem (2012) 0.98
MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells. BMC Cancer (2014) 0.97
Resveratrol, MicroRNAs, Inflammation, and Cancer. J Nucleic Acids (2011) 0.96
Role of Radiation-induced TGF-beta Signaling in Cancer Therapy. Mol Cell Pharmacol (2009) 0.95
Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin β4-mediated FAK signaling. PLoS One (2014) 0.94
Hedgehog signaling: networking to nurture a promalignant tumor microenvironment. Mol Cancer Res (2011) 0.94
Multipotent mesenchymal stromal cells increase tPA expression and concomitantly decrease PAI-1 expression in astrocytes through the sonic hedgehog signaling pathway after stroke (in vitro study). J Cereb Blood Flow Metab (2011) 0.92
Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish. PLoS One (2011) 0.92
Decrease of miR-202-3p expression, a novel tumor suppressor, in gastric cancer. PLoS One (2013) 0.90
Gelatinase expression in retinoblastoma: modulation of LH(BETA)T(AG) retinal tumor development by anecortave acetate. Invest Ophthalmol Vis Sci (2010) 0.89
The Bone Morphogenesis Protein-2 (BMP-2) is associated with progression to metastatic disease in gastric cancer. Cancer Res Treat (2008) 0.88
Expression of glioma-associated oncogene homolog 1 is associated with invasion and postoperative liver metastasis in colon cancer. Int J Med Sci (2012) 0.88
Identification of significant pathways in gastric cancer based on protein-protein interaction networks and cluster analysis. Genet Mol Biol (2012) 0.87
Epigenetic silencing of DACH1 induces the invasion and metastasis of gastric cancer by activating TGF-β signalling. J Cell Mol Med (2014) 0.87
Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis. PLoS One (2013) 0.86
Gastric stem cells and gastric cancer stem cells. Anat Cell Biol (2013) 0.86
Derivation of high purity neuronal progenitors from human embryonic stem cells. PLoS One (2011) 0.85
Hedgehog inhibition reduces angiogenesis by downregulation of tumoral VEGF-A expression in hepatocellular carcinoma. United European Gastroenterol J (2013) 0.83
Hedgehog signaling pathway and ovarian cancer. Chin J Cancer Res (2013) 0.83
Clinicopathological correlation and prognostic significance of sonic hedgehog protein overexpression in human gastric cancer. Int J Clin Exp Pathol (2014) 0.81
Combination of meta-analysis and graph clustering to identify prognostic markers of ESCC. Genet Mol Biol (2012) 0.81
Crosstalk between Shh and TGF-β signaling in cyclosporine-enhanced cell proliferation in human gingival fibroblasts. PLoS One (2013) 0.80
Activation of SHH signaling pathway promotes vasculogenesis in post-myocardial ischemic-reperfusion injury. Int J Clin Exp Pathol (2015) 0.78
Identification of signature genes for detecting hedgehog signaling activation in gastric cancer. Mol Med Rep (2011) 0.78
Characterization of sonic hedgehog inhibition in gastric carcinoma cells. Oncol Lett (2014) 0.78
Sonic hedgehog delivery from self-assembled nanofiber hydrogels reduces the fibrotic response in models of erectile dysfunction. Acta Biomater (2016) 0.78
Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer. J Exp Clin Cancer Res (2009) 0.78
Interaction between gastric cancer stem cells and the tumor microenvironment. J Gastroenterol (2014) 0.78
Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway. Oncol Lett (2016) 0.77
Aberrant expression of laminin-332 promotes cell proliferation and cyst growth in ARPKD. Am J Physiol Renal Physiol (2013) 0.77
The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met. Oncotarget (2016) 0.77
Sonic hedgehog increases the skin wound-healing ability of mouse embryonic stem cells through the microRNA 200 family. Br J Pharmacol (2014) 0.77
The sonic hedgehog signaling pathway induces myopic development by activating matrix metalloproteinase (MMP)-2 in Guinea pigs. PLoS One (2014) 0.77
Methylation of PTCH1a gene in a subset of gastric cancers. World J Gastroenterol (2009) 0.77
A unified model of the hierarchical and stochastic theories of gastric cancer. Br J Cancer (2017) 0.75
Effects and mechanisms of blocking the hedgehog signaling pathway in human gastric cancer cells. Oncol Lett (2015) 0.75
Galectin-1 from cancer-associated fibroblasts induces epithelial-mesenchymal transition through β1 integrin-mediated upregulation of Gli1 in gastric cancer. J Exp Clin Cancer Res (2016) 0.75
TRAIL, Wnt, Sonic Hedgehog, TGFβ, and miRNA Signalings Are Potential Targets for Oral Cancer Therapy. Int J Mol Sci (2017) 0.75
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol (2008) 23.93
Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial. Lancet Oncol (2013) 3.53
Gemcitabine and oxaliplatin with or without erlotinib in advanced biliary-tract cancer: a multicentre, open-label, randomised, phase 3 study. Lancet Oncol (2011) 2.89
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer. Cancer Res (2011) 1.97
The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet (2010) 1.90
Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma. Clin Cancer Res (2011) 1.89
Kyphoplasty for the treatment of vertebral compression fractures in a cancer patient with neurological deficits and anterior vertebral wall destruction. Pain Physician (2011) 1.61
Association of a vascular endothelial growth factor gene 936 C/T polymorphism with breast cancer risk: a meta-analysis. Breast Cancer Res Treat (2010) 1.50
Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: subset analyses of the phase III Sorafenib Asia-Pacific trial. Eur J Cancer (2012) 1.45
BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Exp Cell Res (2009) 1.27
Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1. Mol Cell Biol (2005) 1.21
Metastatic function of BMP-2 in gastric cancer cells: the role of PI3K/AKT, MAPK, the NF-κB pathway, and MMP-9 expression. Exp Cell Res (2011) 1.16
The attitudes of cancer patients and their families toward the disclosure of terminal illness. J Clin Oncol (2004) 1.15
Prevalence and characteristics of anemia in the elderly: cross-sectional study of three urban Korean population samples. Am J Hematol (2004) 1.14
RASSF1A suppresses the c-Jun-NH2-kinase pathway and inhibits cell cycle progression. Cancer Res (2005) 1.08
Drug resistance to 5-FU linked to reactive oxygen species modulator 1. Biochem Biophys Res Commun (2007) 1.08
Tumor-infiltrating lymphocytes, tumor characteristics, and recurrence in patients with early breast cancer. Am J Clin Oncol (2013) 1.07
Phase II trial of gemcitabine combined with cisplatin in patients with inoperable biliary tract carcinomas. Cancer Chemother Pharmacol (2007) 1.04
A novel protein, Romo1, induces ROS production in the mitochondria. Biochem Biophys Res Commun (2006) 1.02
Prognostic significance of the lymphocyte-to-monocyte ratio in patients with small cell lung cancer. Med Oncol (2014) 0.99
Gemcitabine and oxaliplatin in patients with unresectable biliary cancer including gall bladder cancer: a Korean Cancer Study Group phase II trial. Cancer Chemother Pharmacol (2009) 0.98
Case Report of Pulmonary Sarcoidosis Suspected to be Pulmonary Metastasis in a Patient with Breast Cancer. Cancer Res Treat (2014) 0.97
Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1). Biochem Biophys Res Commun (2005) 0.97
A multicenter phase II study of gemcitabine and S-1 combination chemotherapy in patients with unresectable pancreatic cancer. Cancer Chemother Pharmacol (2009) 0.95
Increased expression of ICAM-3 is associated with radiation resistance in cervical cancer. Int J Cancer (2005) 0.94
The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targeting caspase. Acta Haematol (2011) 0.94
Prevalence of BRCA1 and BRCA2 mutations in Korean breast cancer patients. J Korean Med Sci (2004) 0.93
Serum vascular endothelial growth factor per platelet count in hepatocellular carcinoma: correlations with clinical parameters and survival. Jpn J Clin Oncol (2004) 0.93
Treatment outcome of front-line systemic chemotherapy for localized extranodal NK/T cell lymphoma in nasal and upper aerodigestive tract. Leuk Lymphoma (2006) 0.93
Phase II study with a combination of epirubicin, cisplatin, UFT, and leucovorin in advanced hepatocellular carcinoma. Cancer Chemother Pharmacol (2005) 0.93
Economic burdens and quality of life of family caregivers of cancer patients. Oncology (2005) 0.93
A phase II study of S-1 and oxaliplatin (SOx) combination chemotherapy as a first-line therapy for patients with advanced gastric cancer. Invest New Drugs (2010) 0.93
Human placenta-derived feeders support prolonged undifferentiated propagation of a human embryonic stem cell line, SNUhES3: comparison with human bone marrow-derived feeders. Stem Cells Dev (2007) 0.92
Graphene oxide as a multi-functional p-dopant of transparent single-walled carbon nanotube films for optoelectronic devices. Nanoscale (2012) 0.92
Inhibition of PI3 kinase/Akt pathway is required for BMP2-induced EMT and invasion. Oncol Rep (2009) 0.91
Bone morphogenetic protein-2 levels are elevated in the patients with gastric cancer and correlate with disease progression. Med Oncol (2009) 0.91
The cutoff value of serum ferritin for the diagnosis of iron deficiency in community-residing older persons. Ann Hematol (2005) 0.90
Phase II study of a gemcitabine and cisplatin combination regimen in taxane resistant metastatic breast cancer. Cancer Chemother Pharmacol (2006) 0.90
Increased serum 90K and Galectin-3 expression are associated with advanced stage and a worse prognosis in diffuse large B-cell lymphomas. Acta Haematol (2009) 0.90
Comparison of prognostic genomic predictors in colorectal cancer. PLoS One (2013) 0.90
Can serum be used for analyzing the EGFR mutation status in patients with advanced non-small cell lung cancer? Am J Clin Oncol (2013) 0.90
Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia. Hum Genet (2012) 0.90
Successful treatment of syncope with chemotherapy irresponsive to cardiac pacemaker in head and neck cancer. Yonsei Med J (2009) 0.89
Prognostic significance of serum vascular endothelial growth factor per platelet count in unresectable advanced gastric cancer patients. Jpn J Clin Oncol (2010) 0.89
c-Myc exerts a protective function through ornithine decarboxylase against cellular insults. Mol Pharmacol (2002) 0.89
Putative association of the single nucleotide polymorphisms in RASSF1A promoter with Korean lung cancer. Lung Cancer (2008) 0.89
Characteristics of aortic valve dysfunction and ascending aorta dimensions according to bicuspid aortic valve morphology. Eur Radiol (2015) 0.89
BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer. Hum Mutat (2004) 0.88
The Bone Morphogenesis Protein-2 (BMP-2) is associated with progression to metastatic disease in gastric cancer. Cancer Res Treat (2008) 0.88
A Phase II Trial of Gemcitabine plus Capecitabine for Patients with Advanced Pancreatic Cancer. Cancer Res Treat (2012) 0.88
Early lymphopenia as a risk factor for chemotherapy-induced febrile neutropenia. Am J Hematol (2003) 0.88
Corticosteroid rotation to alleviate dexamethasone-induced hiccup: a case series at a single institution. J Pain Symptom Manage (2011) 0.88
Impact of KRAS Mutation Status on Outcomes in Metastatic Colon Cancer Patients without Anti-Epidermal Growth Factor Receptor Therapy. Cancer Res Treat (2013) 0.87
Reduced dose of imatinib for patients with chronic myeloid leukemia and low body surface area. Acta Haematol (2007) 0.87
Phase II study of vinorelbine monotherapy in anthracycline and taxane pre-treated metastatic breast cancer. Invest New Drugs (2009) 0.87
Outcomes of third-line docetaxel-based chemotherapy in advanced gastric cancer who failed previous oxaliplatin-based and irinotecan-based chemotherapies. Cancer Res Treat (2012) 0.87
How does inhibition of the renin-angiotensin system affect the prognosis of advanced gastric cancer patients receiving platinum-based chemotherapy?. Oncology (2012) 0.86
The relationship between preeclampsia, pregnancy-induced hypertension and maternal risk of breast cancer: a meta-analysis. Acta Oncol (2012) 0.86
Association study of TP53 polymorphisms with lung cancer in a Korean population. J Hum Genet (2008) 0.86
Combination of gemcitabine and carboplatin as first line treatment in elderly patients or those unfit for cisplatin-based chemotherapy with advanced transitional cell carcinoma of the urinary tract. Cancer Chemother Pharmacol (2013) 0.86
Meta-analysis of pre-operative aromatase inhibitor versus tamoxifen in postmenopausal woman with hormone receptor-positive breast cancer. Cancer Chemother Pharmacol (2008) 0.86
Telomere length shortening of peripheral blood mononuclear cells in solid-cancer patients undergoing standard-dose chemotherapy might be correlated with good treatment response and neutropenia severity. Acta Haematol (2007) 0.85
Treatment results including more than third-line chemotherapy for patients with advanced non-small cell lung cancer. Oncol Lett (2010) 0.85
The relationship between Helicobacter pylori infection and the effects of chemotherapy in patients with advanced or metastatic gastric cancer. Cancer Chemother Pharmacol (2012) 0.85
Awareness of incurable cancer status and health-related quality of life among advanced cancer patients: a prospective cohort study. Palliat Med (2011) 0.85
The functional implications of Akt activity and TGF-beta signaling in tamoxifen-resistant breast cancer. Biochim Biophys Acta (2007) 0.85
Effects of oral iron chelator deferasirox on human malignant lymphoma cells. Korean J Hematol (2012) 0.85
Prognostic value of carbonic anhydrase IX and Ki-67 expression in squamous cell carcinoma of the tongue. Jpn J Clin Oncol (2007) 0.84
Factors influencing preferences for place of terminal care and of death among cancer patients and their families in Korea. Support Care Cancer (2005) 0.84
The human myotubularin-related protein suppresses the growth of lung carcinoma cells. Oncol Rep (2004) 0.83
High serum YKL-40 is a poor prognostic marker in patients with advanced non-small cell lung cancer. Acta Oncol (2010) 0.83
Incidence of anemia in older Koreans: community-based cohort study. Arch Gerontol Geriatr (2005) 0.83
ESHAP salvage therapy for relapsed or refractory non-Hodgkin's lymphoma. J Korean Med Sci (2002) 0.83
The serum bone morphogenetic protein-2 level in non-small-cell lung cancer patients. Med Oncol (2011) 0.82
A prognostic model to identify patients with advanced pancreas adenocarcinoma who could benefit from second-line chemotherapy. Clin Oncol (R Coll Radiol) (2011) 0.82