1
|
Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria.
|
FEMS Microbiol Rev
|
2011
|
2.46
|
2
|
The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes.
|
Antimicrob Agents Chemother
|
2002
|
1.92
|
3
|
Antibiotic stress, genetic response and altered permeability of E. coli.
|
PLoS One
|
2007
|
1.50
|
4
|
Antibiotic efflux pumps in Gram-negative bacteria: the inhibitor response strategy.
|
J Antimicrob Chemother
|
2007
|
1.43
|
5
|
Detection and prevalence of active drug efflux mechanism in various multidrug-resistant Klebsiella pneumoniae strains from Turkey.
|
J Clin Microbiol
|
2004
|
1.30
|
6
|
Chloramphenicol and expression of multidrug efflux pump in Enterobacter aerogenes.
|
Biochem Biophys Res Commun
|
2005
|
1.29
|
7
|
Alkylaminoquinolines inhibit the bacterial antibiotic efflux pump in multidrug-resistant clinical isolates.
|
Biochem J
|
2003
|
1.28
|
8
|
Membrane permeability and regulation of drug "influx and efflux" in enterobacterial pathogens.
|
Curr Drug Targets
|
2008
|
1.26
|
9
|
Modification of outer membrane protein profile and evidence suggesting an active drug pump in Enterobacter aerogenes clinical strains.
|
Antimicrob Agents Chemother
|
2003
|
1.26
|
10
|
Geraniol restores antibiotic activities against multidrug-resistant isolates from gram-negative species.
|
Antimicrob Agents Chemother
|
2009
|
1.26
|
11
|
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
|
Antimicrob Agents Chemother
|
2010
|
1.25
|
12
|
mar Operon involved in multidrug resistance of Enterobacter aerogenes.
|
Antimicrob Agents Chemother
|
2002
|
1.23
|
13
|
The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli.
|
Antimicrob Agents Chemother
|
2004
|
1.20
|
14
|
Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of RamA and other global regulators.
|
Antimicrob Agents Chemother
|
2008
|
1.20
|
15
|
Alteration of pore properties of Escherichia coli OmpF induced by mutation of key residues in anti-loop 3 region.
|
Biochem J
|
2002
|
1.18
|
16
|
Successive emergence of Enterobacter aerogenes strains resistant to imipenem and colistin in a patient.
|
Antimicrob Agents Chemother
|
2005
|
1.14
|
17
|
Implication of porins in beta-lactam resistance of Providencia stuartii.
|
J Biol Chem
|
2010
|
1.14
|
18
|
Identification of an OprD homologue in Acinetobacter baumannii.
|
J Proteome Res
|
2005
|
1.12
|
19
|
Inhibitors of antibiotic efflux pump in resistant Enterobacter aerogenes strains.
|
Biochem Biophys Res Commun
|
2002
|
1.11
|
20
|
Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux.
|
Recent Pat Antiinfect Drug Discov
|
2006
|
1.09
|
21
|
Molecular basis of macrolide resistance in Campylobacter: role of efflux pumps and target mutations.
|
J Antimicrob Chemother
|
2005
|
1.08
|
22
|
Structural and functional study of the phenicol-specific efflux pump FloR belonging to the major facilitator superfamily.
|
Antimicrob Agents Chemother
|
2005
|
1.08
|
23
|
Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative bacteria.
|
FEBS Lett
|
2011
|
1.06
|
24
|
Identification and evolution of drug efflux pump in clinical Enterobacter aerogenes strains isolated in 1995 and 2003.
|
PLoS One
|
2008
|
1.06
|
25
|
Resistance to imipenem, cefepime, and cefpirome associated with mutation in Omp36 osmoporin of Enterobacter aerogenes.
|
Biochem Biophys Res Commun
|
2004
|
1.05
|
26
|
Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities.
|
Int J Antimicrob Agents
|
2008
|
1.04
|
27
|
Imipenem and expression of multidrug efflux pump in Enterobacter aerogenes.
|
Biochem Biophys Res Commun
|
2003
|
1.04
|
28
|
Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation.
|
J Antimicrob Chemother
|
2006
|
1.04
|
29
|
How beta-lactam antibiotics enter bacteria: a dialogue with the porins.
|
PLoS One
|
2009
|
1.04
|
30
|
Antibacterial activity of Thymus maroccanus and Thymus broussonetii essential oils against nosocomial infection - bacteria and their synergistic potential with antibiotics.
|
Phytomedicine
|
2012
|
1.03
|
31
|
Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model.
|
Antimicrob Agents Chemother
|
2010
|
0.99
|
32
|
Beta-lactam screening by specific residues of the OmpF eyelet.
|
J Med Chem
|
2005
|
0.99
|
33
|
Quinoline derivatives as promising inhibitors of antibiotic efflux pump in multidrug resistant Enterobacter aerogenes isolates.
|
Curr Drug Targets
|
2006
|
0.98
|
34
|
A phenylalanine-arginine beta-naphthylamide sensitive multidrug efflux pump involved in intrinsic and acquired resistance of Campylobacter to macrolides.
|
Int J Antimicrob Agents
|
2003
|
0.97
|
35
|
Inhibitors of antibiotic efflux in resistant Enterobacter aerogenes and Klebsiella pneumoniae strains.
|
Antimicrob Agents Chemother
|
2004
|
0.96
|
36
|
Squalamine: an appropriate strategy against the emergence of multidrug resistant gram-negative bacteria?
|
PLoS One
|
2008
|
0.95
|
37
|
An instrument-free method for the demonstration of efflux pump activity of bacteria.
|
In Vivo
|
2006
|
0.94
|
38
|
Enterobacter aerogenes OmpX, a cation-selective channel mar- and osmo-regulated.
|
FEBS Lett
|
2004
|
0.94
|
39
|
Toward screening for antibiotics with enhanced permeation properties through bacterial porins.
|
Biochemistry
|
2010
|
0.94
|
40
|
Functional refolding of the Campylobacter jejuni MOMP (major outer membrane protein) porin by GroEL from the same species.
|
Biochem J
|
2004
|
0.93
|
41
|
Omp35, a new Enterobacter aerogenes porin involved in selective susceptibility to cephalosporins.
|
Antimicrob Agents Chemother
|
2004
|
0.93
|
42
|
An adaptive response of Enterobacter aerogenes to imipenem: regulation of porin balance in clinical isolates.
|
Int J Antimicrob Agents
|
2012
|
0.92
|
43
|
Dihydroethanoanthracene derivatives reverse in vitro quinoline resistance in Plasmodium falciparum malaria.
|
Med Chem
|
2008
|
0.92
|
44
|
An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins.
|
Antimicrob Agents Chemother
|
2007
|
0.92
|
45
|
The eefABC multidrug efflux pump operon is repressed by H-NS in Enterobacter aerogenes.
|
J Bacteriol
|
2005
|
0.92
|
46
|
Identification of efflux pump-mediated multidrug-resistant bacteria by the ethidium bromide-agar cartwheel method.
|
In Vivo
|
2011
|
0.91
|
47
|
Environmental regulation of Campylobacter jejuni major outer membrane protein porin expression in Escherichia coli monitored by using green fluorescent protein.
|
Appl Environ Microbiol
|
2002
|
0.91
|
48
|
Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strains.
|
Int J Antimicrob Agents
|
2010
|
0.88
|
49
|
Fitness costs and stability of a high-level ciprofloxacin resistance phenotype in Salmonella enterica serotype enteritidis: reduced infectivity associated with decreased expression of Salmonella pathogenicity island 1 genes.
|
Antimicrob Agents Chemother
|
2009
|
0.87
|
50
|
Efflux pumps of gram-negative bacteria: genetic responses to stress and the modulation of their activity by pH, inhibitors, and phenothiazines.
|
Adv Enzymol Relat Areas Mol Biol
|
2011
|
0.87
|
51
|
Antibiotic transport in resistant bacteria: synchrotron UV fluorescence microscopy to determine antibiotic accumulation with single cell resolution.
|
PLoS One
|
2012
|
0.87
|
52
|
Colicins, spermine and cephalosporins: a competitive interaction with the OmpF eyelet.
|
Biochem J
|
2003
|
0.87
|
53
|
New antibiotic molecules: bypassing the membrane barrier of gram negative bacteria increases the activity of peptide deformylase inhibitors.
|
PLoS One
|
2009
|
0.86
|
54
|
Efflux mechanism, an attractive target to combat multidrug resistant Plasmodium falciparum and Pseudomonas aeruginosa.
|
Curr Med Chem
|
2009
|
0.86
|
55
|
Involvement of the efflux pumps in chloramphenicol selected strains of Burkholderia thailandensis: proteomic and mechanistic evidence.
|
PLoS One
|
2011
|
0.86
|
56
|
Antibiotic uptake through membrane channels: role of Providencia stuartii OmpPst1 porin in carbapenem resistance.
|
Biochemistry
|
2012
|
0.84
|
57
|
Propyl paraben induces potassium efflux in Escherichia coli.
|
J Antimicrob Chemother
|
2005
|
0.83
|
58
|
4-alkoxy and 4-thioalkoxyquinoline derivatives as chemosensitizers for the chloramphenicol-resistant clinical Enterobacter aerogenes 27 strain.
|
Int J Antimicrob Agents
|
2003
|
0.83
|
59
|
Ethidium bromide efflux by Salmonella: modulation by metabolic energy, pH, ions and phenothiazines.
|
Int J Antimicrob Agents
|
2011
|
0.83
|
60
|
New peptide deformylase inhibitors and cooperative interaction: a combination to improve antibacterial activity.
|
J Antimicrob Chemother
|
2012
|
0.83
|
61
|
pH Modulation of efflux pump activity of multi-drug resistant Escherichia coli: protection during its passage and eventual colonization of the colon.
|
PLoS One
|
2009
|
0.83
|
62
|
Structure, Function and Regulation of Outer Membrane Proteins Involved in Drug Transport in Enterobactericeae: the OmpF/C - TolC Case.
|
Open Microbiol J
|
2013
|
0.83
|
63
|
Use of the omp50 gene for identification of Campylobacter species by PCR.
|
J Clin Microbiol
|
2004
|
0.83
|
64
|
Expression and purification of native and truncated forms of CadF, an outer membrane protein of Campylobacter.
|
Int J Biol Macromol
|
2006
|
0.83
|
65
|
Squalamine, an original chemosensitizer to combat antibiotic-resistant gram-negative bacteria.
|
J Antimicrob Chemother
|
2010
|
0.82
|
66
|
Production of the cryptic EefABC efflux pump in Enterobacter aerogenes chloramphenicol-resistant mutants.
|
J Antimicrob Chemother
|
2006
|
0.81
|
67
|
Antibiotic-resistant Campylobacter: could efflux pump inhibitors control infection?
|
J Antimicrob Chemother
|
2006
|
0.81
|
68
|
Overexpression and purification of the three components of the Enterobacter aerogenes AcrA-AcrB-TolC multidrug efflux pump.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2003
|
0.81
|
69
|
Chemosensitizers in drug transport mechanisms involved in protozoan resistance.
|
Curr Drug Targets Infect Disord
|
2005
|
0.81
|
70
|
Chloroquinolines block antibiotic efflux pumps in antibiotic-resistant Enterobacter aerogenes isolates.
|
Int J Antimicrob Agents
|
2006
|
0.80
|
71
|
New peptides with metal binding abilities and their use as drug carriers.
|
Bioconjug Chem
|
2014
|
0.80
|
72
|
Polyamino geranic derivatives as new chemosensitizers to combat antibiotic resistant gram-negative bacteria.
|
Bioorg Med Chem
|
2013
|
0.80
|
73
|
A Simple Method for Assessment of MDR Bacteria for Over-Expressed Efflux Pumps.
|
Open Microbiol J
|
2013
|
0.79
|
74
|
The Enterobacter aerogenes outer membrane efflux proteins TolC and EefC have different channel properties.
|
Biochim Biophys Acta
|
2007
|
0.78
|
75
|
Search for new tools to combat Gram-negative resistant bacteria among amine derivatives of 5-arylidenehydantoin.
|
Bioorg Med Chem
|
2012
|
0.78
|
76
|
An alkylaminoquinazoline restores antibiotic activity in Gram-negative resistant isolates.
|
Microbiology
|
2010
|
0.78
|
77
|
Conjugation of a new series of dithiocarbazate Schiff base Copper(II) complexes with vectors selected to enhance antibacterial activity.
|
Bioconjug Chem
|
2014
|
0.78
|
78
|
Amine-alkyl derivatives of hydantoin: new tool to combat resistant bacteria.
|
Eur J Med Chem
|
2011
|
0.78
|
79
|
The omp50 gene is transcriptionally controlled by a temperature-dependent mechanism conserved among thermophilic Campylobacter species.
|
Res Microbiol
|
2008
|
0.77
|
80
|
Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases.
|
Antimicrob Agents Chemother
|
2009
|
0.77
|
81
|
Computer simulation of spermine-porin channel interactions.
|
In Vivo
|
2002
|
0.77
|
82
|
Chromosomal His-tagging: an alternative approach to membrane protein purification.
|
Proteomics
|
2007
|
0.77
|
83
|
Prevalence of efflux activity in low-level macrolide-resistant Campylobacter species.
|
J Antimicrob Chemother
|
2006
|
0.75
|
84
|
Expression of the adeB gene and responsiveness to 1-(1-naphthylmethyl)-piperazine and phenylalanyl-arginyl-β-naphthylamide in clinical isolates of Acinetobacter baumannii.
|
J Antimicrob Chemother
|
2013
|
0.75
|
85
|
Corrigendum: A unique peptide deformylase platform to rationally design and challenge novel active compounds.
|
Sci Rep
|
2017
|
0.75
|
86
|
Enterobacter gergoviae membrane modifications are involved in the adaptive response to preservatives used in cosmetic industry.
|
J Appl Microbiol
|
2014
|
0.75
|