PubRank

Judy Lieberman

Author PubWeight™ 206.80‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007 13.69
2 Identification of host proteins required for HIV infection through a functional genomic screen. Science 2008 12.44
3 RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 2003 7.37
4 Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 2011 7.02
5 Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol 2005 6.40
6 Interfering with disease: a progress report on siRNA-based therapeutics. Nat Rev Drug Discov 2007 6.37
7 siRNA-directed inhibition of HIV-1 infection. Nat Med 2002 6.36
8 Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science 2004 5.31
9 miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell 2009 5.22
10 Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet 2007 4.76
11 The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol 2010 4.58
12 A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature 2005 4.33
13 Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 2003 3.86
14 Desperately seeking microRNA targets. Nat Struct Mol Biol 2010 3.85
15 gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell 2005 3.24
16 p16(INK4a) translation suppressed by miR-24. PLoS One 2008 3.08
17 Death by a thousand cuts: granzyme pathways of programmed cell death. Annu Rev Immunol 2008 2.97
18 miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One 2009 2.97
19 An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 2005 2.87
20 miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells. Nat Struct Mol Biol 2009 2.54
21 Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat Immunol 2003 2.48
22 A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol Cell 2008 2.28
23 Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proc Natl Acad Sci U S A 2007 2.27
24 Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. J Virol 2003 2.26
25 The silent revolution: RNA interference as basic biology, research tool, and therapeutic. Annu Rev Med 2005 2.24
26 The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Mol Cell 2006 2.21
27 Whither or wither microbicides? Science 2008 2.17
28 Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity 2005 2.11
29 Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. Cell 2008 2.04
30 Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet 2011 2.00
31 Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic. Blood 2002 1.94
32 Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest 2011 1.92
33 Delivering the kiss of death: progress on understanding how perforin works. Curr Opin Immunol 2007 1.91
34 Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. Cell Host Microbe 2009 1.90
35 A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus. J Mol Med (Berl) 2007 1.88
36 Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J 2009 1.87
37 Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Sci Transl Med 2012 1.86
38 Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc Natl Acad Sci U S A 2004 1.82
39 The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1. Blood 2009 1.65
40 Knocking down disease with siRNAs. Cell 2006 1.60
41 Harvard's women four years later. Nat Immunol 2009 1.60
42 Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat Immunol 2011 1.57
43 Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet 2011 1.55
44 Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis. Immunity 2005 1.55
45 Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV. Blood 2005 1.54
46 miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53. Blood 2009 1.54
47 miR-200-containing extracellular vesicles promote breast cancer cell metastasis. J Clin Invest 2014 1.36
48 Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs. Annu Rev Biomed Eng 2006 1.31
49 Promise and challenge of RNA interference-based therapy for cancer. J Clin Oncol 2010 1.29
50 A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells. Cancer Cell 2013 1.29
51 The SET complex acts as a barrier to autointegration of HIV-1. PLoS Pathog 2009 1.28
52 Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity. J Virol 2008 1.27
53 HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol Cell Biol 2002 1.25
54 The prospect of silencing disease using RNA interference. JAMA 2005 1.24
55 Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Blood 2009 1.24
56 Small RNAs guide hematopoietic cell differentiation and function. J Immunol 2010 1.24
57 Gaining a foothold: how HIV avoids innate immune recognition. Curr Opin Immunol 2010 1.24
58 Listeria-infected myeloid dendritic cells produce IFN-beta, priming T cell activation. J Immunol 2005 1.16
59 Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism. Proc Natl Acad Sci U S A 2006 1.15
60 Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem 2011 1.10
61 HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family. J Biol Chem 2002 1.09
62 The functional CD8 T cell response to HIV becomes type-specific in progressive disease. J Clin Invest 2002 1.09
63 Mapping cross-clade HIV-1 vaccine epitopes using a bioinformatics approach. Vaccine 2003 1.07
64 Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion. J Virol 2005 1.06
65 Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70. EMBO Rep 2006 1.03
66 Micromanipulating cancer: microRNA-based therapeutics? RNA Biol 2009 1.02
67 Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol 2012 1.02
68 Adenovirus protein VII functions throughout early phase and interacts with cellular proteins SET and pp32. J Virol 2005 1.01
69 Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. Vaccine 2011 1.01
70 HIV DNA is heavily uracilated, which protects it from autointegration. Proc Natl Acad Sci U S A 2011 1.00
71 Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis. J Immunol 2005 1.00
72 Efficient and specific gene knockdown by small interfering RNAs produced in bacteria. Nat Biotechnol 2013 1.00
73 Isolation of cytotoxic T cell and NK granules and purification of their effector proteins. Curr Protoc Cell Biol 2010 0.99
74 NFAT5 regulates HIV-1 in primary monocytes via a highly conserved long terminal repeat site. PLoS Pathog 2006 0.99
75 Live attenuated Listeria monocytogenes expressing HIV Gag: immunogenicity in rhesus monkeys. Vaccine 2007 0.97
76 Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen-specific effector CD8 T cells and its impact on CD8 T-cell function. Immunology 2004 0.95
77 Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther 2013 0.95
78 Numbers matter: quantitative and dynamic analysis of the formation of an immunological synapse using imaging flow cytometry. J Immunol Methods 2009 0.94
79 A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen. Proc Natl Acad Sci U S A 2003 0.93
80 The gp49B1 inhibitory receptor regulates the IFN-gamma responses of T cells and NK cells. J Immunol 2003 0.92
81 Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Mol Biol Cell 2013 0.92
82 Silencing viral infection. PLoS Med 2006 0.91
83 Live or let die: posttranscriptional gene regulation in cell stress and cell death. Immunol Rev 2013 0.89
84 Distribution of immune cells in the human cervix and implications for HIV transmission. Am J Reprod Immunol 2014 0.86
85 RNA interference and cancer: endogenous pathways and therapeutic approaches. Adv Exp Med Biol 2008 0.86
86 Micromanagers of immune cell fate and function. Adv Immunol 2009 0.85
87 Alterations in RNA processing during immune-mediated programmed cell death. Proc Natl Acad Sci U S A 2012 0.84
88 Micromanaging hepatitis C virus. N Engl J Med 2013 0.82
89 Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. J Immunol 2010 0.82
90 SAMHD1 does it again, now in resting T cells. Nat Med 2012 0.81
91 Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV. J Immune Based Ther Vaccines 2011 0.81
92 Production of highly potent recombinant siRNAs in Escherichia coli. Nat Protoc 2013 0.81
93 Perforin: a key pore-forming protein for immune control of viruses and cancer. Subcell Biochem 2014 0.80
94 Cross-clade CD8 T-cell responses to HIV(IIIB) and Chinese B' and C/B' viruses in North American and Chinese HIV-seropositive donors. J Acquir Immune Defic Syndr 2004 0.80
95 Proliferation responses to HIVp24 during antiretroviral therapy do not reflect improved immune phenotype or function. AIDS 2004 0.78
96 Micromanaging cancer. N Engl J Med 2009 0.77
97 RIG-ing an antitumor response. Nat Med 2008 0.77
98 Your health in the 21st century. Silencing bad genes. Newsweek 2005 0.75
99 Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes. Cell 2015 0.75