Published in Nat Med on June 03, 2002
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T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell (2008) 4.32
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CD81 is required for hepatitis C virus glycoprotein-mediated viral infection. J Virol (2004) 3.53
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc Natl Acad Sci U S A (2003) 3.48
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Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron. Nucleic Acids Res (2008) 1.65
Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs. J Virol (2004) 1.61
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Prolonged transcriptional silencing and CpG methylation induced by siRNAs targeted to the HIV-1 promoter region. J RNAi Gene Silencing (2005) 1.57
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RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. Mol Ther (2009) 1.55
A single siRNA suppresses fatal encephalitis induced by two different flaviviruses. PLoS Med (2006) 1.55
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Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury. Crit Care Med (2010) 1.49
The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. Mol Biol Cell (2004) 1.45
Murine gammaherpesvirus 68 open reading frame 31 is required for viral replication. J Virol (2004) 1.40
Rotavirus gene silencing by small interfering RNAs. EMBO Rep (2002) 1.36
Nucleotide sequence homology requirements of HIV-1-specific short hairpin RNA. Nucleic Acids Res (2003) 1.35
Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein. J Virol (2006) 1.33
Engineering RNA for targeted siRNA delivery and medical application. Adv Drug Deliv Rev (2010) 1.32
Inhibition of coxsackievirus B3 replication by small interfering RNAs requires perfect sequence match in the central region of the viral positive strand. J Virol (2005) 1.30
Development of topical microbicides to prevent the sexual transmission of HIV. Antiviral Res (2009) 1.30
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Functional delivery of siRNA in mice using dendriworms. ACS Nano (2009) 1.27
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Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1). J Virol (2004) 1.26
Small interfering RNA-mediated inhibition of hepatitis C virus replication in the human hepatoma cell line Huh-7. J Virol (2003) 1.25
Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration. J Virol (2006) 1.21
Derivation of normal macrophages from human embryonic stem (hES) cells for applications in HIV gene therapy. Retrovirology (2006) 1.21
The virion-associated incoming HIV-1 RNA genome is not targeted by RNA interference. Retrovirology (2006) 1.20
CHARMM force field parameters for simulation of reactive intermediates in native and thio-substituted ribozymes. J Comput Chem (2007) 1.18
RNA interference targeting VP1 inhibits foot-and-mouth disease virus replication in BHK-21 cells and suckling mice. J Virol (2004) 1.16
Transcriptional regulation of mammalian miRNA genes. Genomics (2010) 1.16
Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice. Mol Ther (2011) 1.16
Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism. Proc Natl Acad Sci U S A (2006) 1.15
Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector. J Virol (2012) 1.12
Sequence homology required by human immunodeficiency virus type 1 to escape from short interfering RNAs. J Virol (2006) 1.12
Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge. Mol Ther (2012) 1.10
CXCR4 and CCR5 shRNA transgenic CD34+ cell derived macrophages are functionally normal and resist HIV-1 infection. Retrovirology (2005) 1.10
Relative gene-silencing efficiencies of small interfering RNAs targeting sense and antisense transcripts from the same genetic locus. Nucleic Acids Res (2004) 1.10
RNA interference with measles virus N, P, and L mRNAs efficiently prevents and with matrix protein mRNA enhances viral transcription. J Virol (2006) 1.09
Inhibition of gammaherpesvirus replication by RNA interference. J Virol (2003) 1.08
DBR1 siRNA inhibition of HIV-1 replication. Retrovirology (2005) 1.08
HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-κB pathway and can be silenced by gp120-specific siRNA. J Neuroinflammation (2010) 1.08
RNA interference directed against Poly(ADP-Ribose) polymerase 1 efficiently suppresses human immunodeficiency virus type 1 replication in human cells. J Virol (2004) 1.07
Design of extended short hairpin RNAs for HIV-1 inhibition. Nucleic Acids Res (2007) 1.06
A novel approach for inhibition of HIV-1 by RNA interference: counteracting viral escape with a second generation of siRNAs. J RNAi Gene Silencing (2005) 1.06
Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5. Genet Vaccines Ther (2009) 1.05
HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector. AIDS Res Ther (2005) 1.05
Molecular strategies to inhibit HIV-1 replication. Retrovirology (2005) 1.05
Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5. Retrovirology (2004) 1.05
Preintegration HIV-1 inhibition by a combination lentiviral vector containing a chimeric TRIM5 alpha protein, a CCR5 shRNA, and a TAR decoy. Mol Ther (2009) 1.03
Inhibition of HIV-1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transduction. J Gene Med (2010) 1.02
LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1. Nucleic Acids Res (2004) 0.97
Targeted delivery of mutant tolerant anti-coxsackievirus artificial microRNAs using folate conjugated bacteriophage Phi29 pRNA. PLoS One (2011) 0.96
RNA interference: antiviral weapon and beyond. World J Gastroenterol (2003) 0.95
Trans-inhibition of HIV-1 by a long hairpin RNA expressed within the viral genome. Retrovirology (2007) 0.95
Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther (2013) 0.95
Inhibition of Epstein-Barr virus (EBV) reactivation by short interfering RNAs targeting p38 mitogen-activated protein kinase or c-myc in EBV-positive epithelial cells. J Virol (2004) 0.94
Drosha as an interferon-independent antiviral factor. Proc Natl Acad Sci U S A (2014) 0.94
Stem cell-based anti-HIV gene therapy. Virology (2011) 0.94
Intracranial administration of P gene siRNA protects mice from lethal Chandipura virus encephalitis. PLoS One (2010) 0.94
Antiviral effects of human immunodeficiency virus type 1-specific small interfering RNAs against targets conserved in select neurotropic viral strains. J Virol (2004) 0.93
Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14
Predictive identification of exonic splicing enhancers in human genes. Science (2002) 16.86
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
siRNAs can function as miRNAs. Genes Dev (2003) 16.08
Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods (2007) 13.94
let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell (2007) 13.69
Embryonic stem cell-specific MicroRNAs. Dev Cell (2003) 13.05
Identification of host proteins required for HIV infection through a functional genomic screen. Science (2008) 12.44
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
c-Myc regulates transcriptional pause release. Cell (2010) 11.64
Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science (2008) 11.33
Divergent transcription from active promoters. Science (2008) 11.03
Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A (2004) 9.33
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Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med (2014) 7.64
Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol (2003) 7.38
RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med (2003) 7.37
Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell (2011) 7.02
Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A (2008) 6.89
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol (2011) 6.73
Short RNAs repress translation after initiation in mammalian cells. Mol Cell (2006) 6.70
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol (2005) 6.40
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Roles for microRNAs in conferring robustness to biological processes. Cell (2012) 6.32
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56
miRNA profiling of naïve, effector and memory CD8 T cells. PLoS One (2007) 5.43
Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science (2004) 5.31
RNA sequence analysis defines Dicer's role in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2007) 5.26
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
Transvascular delivery of small interfering RNA to the central nervous system. Nature (2007) 5.21
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Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet (2007) 4.76
The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol (2010) 4.58
MicroRNA functions in stress responses. Mol Cell (2010) 4.46
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature (2005) 4.33
T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell (2008) 4.32
Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science (2012) 4.20
Exploring concordance and discordance for return of incidental findings from clinical sequencing. Genet Med (2012) 4.04
Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc Natl Acad Sci U S A (2006) 4.02
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MicroRNAs can generate thresholds in target gene expression. Nat Genet (2011) 3.90
Bayesian community-wide culture-independent microbial source tracking. Nat Methods (2011) 3.88
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell (2003) 3.86
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RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc Natl Acad Sci U S A (2003) 3.48
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Disordered microbial communities in the upper respiratory tract of cigarette smokers. PLoS One (2010) 2.60
miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells. Nat Struct Mol Biol (2009) 2.54
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The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Mol Cell (2006) 2.21