Published in Endocrinology on January 24, 2008
Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry (2010) 6.15
Inactivation of the Fto gene protects from obesity. Nature (2009) 5.61
Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet (2010) 4.37
A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest (2013) 2.23
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A (2010) 2.12
The genetics of obesity: FTO leads the way. Trends Genet (2010) 1.90
Hypothalamic FTO is associated with the regulation of energy intake not feeding reward. BMC Neurosci (2009) 1.48
FTO genotype and weight loss in diet and lifestyle interventions: a systematic review and meta-analysis. Am J Clin Nutr (2016) 1.41
Recent progress in the genetics of common obesity. Br J Clin Pharmacol (2009) 1.40
FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth. BMC Med Genet (2010) 1.38
Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. Hum Genet (2009) 1.36
FTO gene polymorphisms and obesity risk: a meta-analysis. BMC Med (2011) 1.34
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet (2013) 1.31
Expression of multiple horizontally acquired genes is a hallmark of both vertebrate and invertebrate genomes. Genome Biol (2015) 1.30
Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004. Am J Epidemiol (2011) 1.29
Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program. Diabetologia (2008) 1.27
Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. Eur J Hum Genet (2010) 1.26
Pediatric obesity: etiology and treatment. Endocrinol Metab Clin North Am (2009) 1.22
Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction. Mol Med (2011) 1.20
Fat: an evolving issue. Dis Model Mech (2012) 1.15
Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men. PLoS One (2009) 1.14
FTO genotype is associated with exercise training-induced changes in body composition. Obesity (Silver Spring) (2009) 1.11
The genetics of obesity. Curr Diab Rep (2010) 1.11
The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children. BMC Med Genet (2010) 1.09
The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study. Circ Cardiovasc Genet (2009) 1.07
Dietary energy density affects fat mass in early adolescence and is not modified by FTO variants. PLoS One (2009) 1.07
Adiposity as a cause of cardiovascular disease: a Mendelian randomization study. Int J Epidemiol (2015) 1.04
The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women. PLoS One (2011) 1.03
Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling. Am J Epidemiol (2010) 1.02
FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting. PLoS One (2011) 1.02
Recent advances in obesity: genetics and beyond. ISRN Endocrinol (2012) 0.98
Beyond the fourth wave of genome-wide obesity association studies. Nutr Diabetes (2012) 0.98
The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species. Mol Biol Evol (2010) 0.97
Interaction of FTO and physical activity level on adiposity in African-American and European-American adults: the ARIC study. Obesity (Silver Spring) (2011) 0.97
The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation. PLoS One (2015) 0.95
Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study. Am J Epidemiol (2013) 0.94
Association of genetic polymorphism of PPARγ-2, ACE, MTHFR, FABP-2 and FTO genes in risk prediction of type 2 diabetes mellitus. J Biomed Sci (2013) 0.92
Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-Trøndelag Health Study. Diabetes (2009) 0.92
Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2010) 0.90
Rs9939609 variant of the fat mass and obesity-associated gene and trunk obesity in adolescents. J Obes (2011) 0.90
Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children. Int J Obes (Lond) (2012) 0.90
FTO at rs9939609, food responsiveness, emotional control and symptoms of ADHD in preschool children. PLoS One (2012) 0.89
Obesity genetics in mouse and human: back and forth, and back again. PeerJ (2015) 0.89
Nutritional regulation of genome-wide association obesity genes in a tissue-dependent manner. Nutr Metab (Lond) (2012) 0.87
Genome wide analysis reveals single nucleotide polymorphisms associated with fatness and putative novel copy number variants in three pig breeds. BMC Genomics (2013) 0.87
Obesity-related known and candidate SNP markers can significantly change affinity of TATA-binding protein for human gene promoters. BMC Genomics (2015) 0.86
Association of FTO polymorphisms with early age of obesity in obese Italian subjects. Exp Diabetes Res (2012) 0.86
Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents. Diabetes (2015) 0.85
Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases. J Transl Med (2015) 0.85
FTO Gene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women. Diabetes Metab J (2014) 0.84
Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children. BMC Med Genet (2013) 0.83
The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a Mendelian randomisation study. Ann Rheum Dis (2013) 0.83
LPS-induced inflammation in the chicken is associated with CCAAT/enhancer binding protein beta-mediated fat mass and obesity associated gene down-regulation in the liver but not hypothalamus. BMC Vet Res (2013) 0.83
Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice. Am J Hum Genet (2013) 0.82
The FTO A/T polymorphism and elite athletic performance: a study involving three groups of European athletes. PLoS One (2013) 0.82
Fat mass and obesity-associated (FTO) protein interacts with CaMKII and modulates the activity of CREB signaling pathway. Hum Mol Genet (2014) 0.82
FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver. Cell Commun Signal (2014) 0.82
Interaction between common variants of FTO and MC4R is associated with risk of PCOS. Reprod Biol Endocrinol (2015) 0.82
Early hypothalamic FTO overexpression in response to maternal obesity--potential contribution to postweaning hyperphagia. PLoS One (2011) 0.81
Pediatric obesity. An introduction. Appetite (2015) 0.81
Highly adaptable triple-negative breast cancer cells as a functional model for testing anticancer agents. PLoS One (2014) 0.80
Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats. Eur J Hum Genet (2011) 0.80
Fasting induced cytoplasmic Fto expression in some neurons of rat hypothalamus. PLoS One (2013) 0.80
Fat mass and obesity associated gene (FTO) expression is regulated negatively by the transcription factor Foxa2. PLoS One (2012) 0.80
Impact of metabolic regulators on the expression of the obesity associated genes FTO and NAMPT in human preadipocytes and adipocytes. PLoS One (2011) 0.80
Impact of variation at the FTO locus on milk fat yield in Holstein dairy cattle. PLoS One (2013) 0.79
Fat mass and obesity-associated gene rs11642015 polymorphism is significantly associated with prediabetes and type 2 diabetes subsequent to adjustment for body mass index. Biomed Rep (2014) 0.79
Expression of miR-33 from an SREBF2 intron targets the FTO gene in the chicken. PLoS One (2014) 0.79
Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis. BMC Infect Dis (2014) 0.79
Impaired hypothalamic Fto expression in response to fasting and glucose in obese mice. Nutr Diabetes (2011) 0.79
Dietary Fat Modifies the Effects of FTO Genotype on Changes in Insulin Sensitivity. J Nutr (2015) 0.78
Does the FTO gene interact with the socioeconomic status on the obesity development among young European children? Results from the IDEFICS study. Int J Obes (Lond) (2014) 0.78
Pediatric obesity: etiology and treatment. Pediatr Clin North Am (2011) 0.78
Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway. BMC Neurosci (2011) 0.78
Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies. Transl Psychiatry (2013) 0.78
A randomized trial of the clinical utility of genetic testing for obesity: design and implementation considerations. Clin Trials (2013) 0.77
FTO Is Associated with Aortic Valve Stenosis in a Gender Specific Manner of Heterozygote Advantage: A Population-Based Case-Control Study. PLoS One (2015) 0.77
Resting-State Brain and the FTO Obesity Risk Allele: Default Mode, Sensorimotor, and Salience Network Connectivity Underlying Different Somatosensory Integration and Reward Processing between Genotypes. Front Hum Neurosci (2016) 0.77
Effect of the Common Fat Mass and Obesity Associated Gene Variants on Obesity in Pakistani Population: A Case-Control Study. Biomed Res Int (2015) 0.77
Differences in the heritability of growth and growth velocity during infancy and associations with FTO variants. Obesity (Silver Spring) (2011) 0.77
FTO Biology and Obesity: Why Do a Billion of Us Weigh 3 kg More? Front Endocrinol (Lausanne) (2011) 0.77
Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects. Clin Psychopharmacol Neurosci (2012) 0.77
The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults. Indian J Endocrinol Metab (2012) 0.77
Association of Glutathione-S-Transferase (GSTM1 and GSTT1) and FTO Gene Polymorphisms with Type 2 Diabetes Mellitus Cases in Northern India. Balkan J Med Genet (2014) 0.77
A 680 kb duplication at the FTO locus in a kindred with obesity and a distinct body fat distribution. Eur J Hum Genet (2013) 0.77
Knockdown of the fat mass and obesity gene disrupts cellular energy balance in a cell-type specific manner. PLoS One (2012) 0.77
The genetics of obesity in transition. Coll Antropol (2012) 0.77
Scrutinizing the FTO locus: compelling evidence for a complex, long-range regulatory context. Hum Genet (2015) 0.76
FTO polymorphisms moderate the association of food reinforcement with energy intake. Physiol Behav (2014) 0.76
Uncovering the biology of FTO. Mol Metab (2012) 0.76
Role of a common variant of Fat Mass and Obesity associated (FTO) gene in obesity and coronary artery disease in subjects from Punjab, Pakistan: a case control study. Lipids Health Dis (2016) 0.76
The Association of FTO SNP rs9939609 with Weight Gain at University. Obes Facts (2015) 0.75
Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans. PLoS One (2016) 0.75
Physical activity and FTO genotype by physical activity interactive influences on obesity. BMC Genet (2016) 0.75
Novel SNP in the coding region of the FTO gene is associated with marbling score in Hanwoo (Korean cattle). J Anim Sci Technol (2014) 0.75
Association of FTO Mutations with Risk and Survival of Breast Cancer in a Chinese Population. Dis Markers (2015) 0.75
Important Role of FTO in the Survival of Rare Panresistant Triple-Negative Inflammatory Breast Cancer Cells Facing a Severe Metabolic Challenge. PLoS One (2016) 0.75
The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol (2003) 9.99
Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov (2008) 6.18
The repertoire of G-protein-coupled receptors in fully sequenced genomes. Mol Pharmacol (2005) 4.07
Trends in the exploitation of novel drug targets. Nat Rev Drug Discov (2011) 3.60
Preventing sexual abusers of children from reoffending: systematic review of medical and psychological interventions. BMJ (2013) 2.13
Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin. BMC Biol (2009) 2.07
Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens. Peptides (2005) 1.91
The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics (2004) 1.90
The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication. Annu Rev Pharmacol Toxicol (2013) 1.85
Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. Genomics (2006) 1.80
Cannabinoids, opioids and eating behavior: the molecular face of hedonism? Brain Res Rev (2005) 1.75
Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia. Endocrinology (2005) 1.63
Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett (2003) 1.59
Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. Genomics (2006) 1.55
Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. Biochem Biophys Res Commun (2008) 1.55
Ghrelin increases anxiety-like behavior and memory retention in rats. Biochem Biophys Res Commun (2002) 1.54
Acute sleep deprivation enhances the brain's response to hedonic food stimuli: an fMRI study. J Clin Endocrinol Metab (2012) 1.51
Hypothalamic FTO is associated with the regulation of energy intake not feeding reward. BMC Neurosci (2009) 1.48
The G protein-coupled receptor subset of the rat genome. BMC Genomics (2007) 1.45
Organics: evidence of nutritional superiority is weak [corrected]. Science (2009) 1.38
Genome wide analysis reveals association of a FTO gene variant with epigenetic changes. Genomics (2012) 1.36
Health informatics and the delivery of care to older people. Maturitas (2009) 1.36
The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families. FEBS Lett (2008) 1.34
Increased prefrontal and parahippocampal activation with reduced dorsolateral prefrontal and insular cortex activation to food images in obesity: a meta-analysis of fMRI studies. PLoS One (2013) 1.33
Differential neural responses to food images in women with bulimia versus anorexia nervosa. PLoS One (2011) 1.33
G protein-coupled receptor deorphanizations. Annu Rev Pharmacol Toxicol (2012) 1.33
The contribution of brain reward circuits to the obesity epidemic. Neurosci Biobehav Rev (2012) 1.30
There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem Biophys Res Commun (2003) 1.30
Comparison of the current RefSeq, Ensembl and EST databases for counting genes and gene discovery. FEBS Lett (2005) 1.30
Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin. Biochem Biophys Res Commun (2004) 1.29
The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi. PLoS One (2012) 1.23
SPRIT: Identifying horizontal gene transfer in rooted phylogenetic trees. BMC Evol Biol (2010) 1.23
A survey of binge eating and obesity treatment practices among primary care providers. Int J Eat Disord (2004) 1.22
Eating motives and the controversy over dieting: eating less than needed versus less than wanted. Obes Res (2005) 1.22
The G protein-coupled receptor subset of the chicken genome. PLoS Comput Biol (2006) 1.20
The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors. Gene (2005) 1.18
The repertoire of trace amine G-protein-coupled receptors: large expansion in zebrafish. Mol Phylogenet Evol (2005) 1.18
Independent HHsearch, Needleman--Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families. Mol Biol Evol (2011) 1.17
Impaired insulin sensitivity as indexed by the HOMA score is associated with deficits in verbal fluency and temporal lobe gray matter volume in the elderly. Diabetes Care (2012) 1.16
The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38. J Mol Neurosci (2008) 1.16
The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924. BMC Med Genet (2009) 1.16
The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs. Mol Biol Evol (2003) 1.16
Central opioids and consumption of sweet tastants: when reward outweighs homeostasis. Physiol Behav (2007) 1.15
Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity. Peptides (2003) 1.15
Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair. J Invest Dermatol (2004) 1.13
Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim Biophys Acta (2005) 1.11
The dispanins: a novel gene family of ancient origin that contains 14 human members. PLoS One (2012) 1.11
Effects of portion size on chronic energy intake. Int J Behav Nutr Phys Act (2007) 1.11
Paraventricular opioids alter intake of high-fat but not high-sucrose diet depending on diet preference in a binge model of feeding. Am J Physiol Regul Integr Comp Physiol (2007) 1.10
The repertoire of solute carriers of family 6: identification of new human and rodent genes. Biochem Biophys Res Commun (2005) 1.09
Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus. Peptides (2003) 1.09
Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Genomics (2007) 1.09
The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors. BMC Evol Biol (2008) 1.09
The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children. BMC Med Genet (2010) 1.09
The Secretin GPCRs descended from the family of Adhesion GPCRs. Mol Biol Evol (2008) 1.07
Intranasal treatment of central nervous system dysfunction in humans. Pharm Res (2012) 1.07
Molecular mechanisms underlying anorexia nervosa: focus on human gene association studies and systems controlling food intake. Brain Res Rev (2009) 1.07
Acute sleep deprivation increases portion size and affects food choice in young men. Psychoneuroendocrinology (2013) 1.07
A bi-directional mu-opioid-opioid connection between the nucleus of the accumbens shell and the central nucleus of the amygdala in the rat. Brain Res (2004) 1.06
Growth hormone-releasing hormone improves cognitive function in older adults: sleep on it. JAMA Neurol (2013) 1.06
Oxytocin as feeding inhibitor: maintaining homeostasis in consummatory behavior. Pharmacol Biochem Behav (2010) 1.05
Increased mRNA levels of tyrosine hydroxylase and dopamine transporter in the VTA of male rats after chronic food restriction. Eur J Neurosci (2006) 1.04
Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function. J Neurosci (2009) 1.04
Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study. BMC Psychiatry (2011) 1.04
Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men. Diabetes (2010) 1.02
Analysis of the network of feeding neuroregulators using the Allen Brain Atlas. Neurosci Biobehav Rev (2008) 1.02
Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone. J Biol Chem (2003) 1.02
Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies. BMC Psychiatry (2013) 1.02
Intranasal insulin as a therapeutic option in the treatment of cognitive impairments. Exp Gerontol (2010) 1.01
Association of feather colour with constitutively active melanocortin 1 receptors in chicken. Eur J Biochem (2003) 1.01
Effects of the opioid antagonist naltrexone on feeding induced by DAMGO in the ventral tegmental area and in the nucleus accumbens shell region in the rat. Am J Physiol Regul Integr Comp Physiol (2003) 1.00
Agouti-related proteins (AGRPs) and agouti-signaling peptide (ASIP) in fish and chicken. Ann N Y Acad Sci (2005) 1.00
The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents. BMC Genomics (2009) 1.00
Association between physical activity and brain health in older adults. Neurobiol Aging (2012) 0.99
Obestatin improves memory performance and causes anxiolytic effects in rats. Biochem Biophys Res Commun (2006) 0.99
Molecular, immunohistochemical, and pharmacological evidence of oxytocin's role as inhibitor of carbohydrate but not fat intake. Endocrinology (2010) 0.99
Thinking about eating food activates visual cortex with reduced bilateral cerebellar activation in females with anorexia nervosa: an fMRI study. PLoS One (2012) 0.99
Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure. Brain Res (2010) 0.99
Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters. Gene (2010) 0.98
Withdrawal from free-choice high-fat high-sugar diet induces craving only in obesity-prone animals. Psychopharmacology (Berl) (2009) 0.98
Effects of melanocortin receptor ligands on ethanol intake and opioid peptide levels in alcohol-preferring AA rats. Brain Res Bull (2002) 0.98
Alterations in food intake by opioid and dopamine signaling pathways between the ventral tegmental area and the shell of the nucleus accumbens. Brain Res (2004) 0.98
The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species. Mol Biol Evol (2010) 0.97