Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits.

The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry (2011) 6.66

A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. Am J Psychiatry (2011) 5.15

Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci (2012) 4.71

Neurobiology of resilience. Nat Neurosci (2012) 2.13

A longitudinal study of epigenetic variation in twins. Epigenetics (2010) 2.06

The role of early life stress as a predictor for alcohol and drug dependence. Psychopharmacology (Berl) (2010) 2.04

Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results. J Affect Disord (2011) 1.84

The serotonin transporter gene alters sensitivity to attention bias modification: evidence for a plasticity gene. Biol Psychiatry (2011) 1.81

The genetics of major depression. Neuron (2014) 1.80

Pharmacogenetic approaches to the treatment of alcohol addiction. Nat Rev Neurosci (2011) 1.74

What have we learnt about the causes of ADHD? J Child Psychol Psychiatry (2012) 1.67

Adolescence: what do transmission, transition, and translation have to do with it? Neuron (2010) 1.61

Combined role of childhood maltreatment, family history, and gender in the risk for alcohol dependence. Psychol Med (2012) 1.61

Is depression an inflammatory disorder? Curr Psychiatry Rep (2011) 1.60

The Emerging Field of Human Social Genomics. Clin Psychol Sci (2013) 1.57

Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype and stressful life events interact to predict preschool-onset depression: a replication and developmental extension. J Child Psychol Psychiatry (2013) 1.53

Addiction science: Uncovering neurobiological complexity. Neuropharmacology (2013) 1.50

Strain differences in stress responsivity are associated with divergent amygdala gene expression and glutamate-mediated neuronal excitability. J Neurosci (2010) 1.49

Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry. Biol Psychiatry (2012) 1.43

Gene-environment interaction in psychological traits and disorders. Annu Rev Clin Psychol (2011) 1.40

Overview of the genetics of major depressive disorder. Curr Psychiatry Rep (2010) 1.39

Influence of Serotonin Transporter Gene Polymorphisms and Adverse Life Events on Depressive Symptoms in the Elderly: A Population-Based Study. PLoS One (2015) 1.38

Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression. Arch Gen Psychiatry (2010) 1.37

The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review. Clin Psychol Rev (2011) 1.36

The wear and tear of daily stressors on mental health. Psychol Sci (2013) 1.35

Gene-environment interplay in common complex diseases: forging an integrative model—recommendations from an NIH workshop. Genet Epidemiol (2011) 1.33

Differential susceptibility in youth: evidence that 5-HTTLPR x positive parenting is associated with positive affect 'for better and worse'. Transl Psychiatry (2011) 1.32

Gene-environment interactions: early life stress and risk for depressive and anxiety disorders. Psychopharmacology (Berl) (2011) 1.30

Efficacy of attention bias modification using threat and appetitive stimuli: a meta-analytic review. Behav Ther (2012) 1.29

50 years of hurdles and hope in anxiolytic drug discovery. Nat Rev Drug Discov (2013) 1.28

Clustering of depression and inflammation in adolescents previously exposed to childhood adversity. Biol Psychiatry (2012) 1.26

Connectomic intermediate phenotypes for psychiatric disorders. Front Psychiatry (2012) 1.26

Life stress, 5-HTTLPR and mental disorder: findings from a 30-year longitudinal study. Br J Psychiatry (2011) 1.22

The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome. Psychoneuroendocrinology (2013) 1.22

Reduced structural connectivity of a major frontolimbic pathway in generalized anxiety disorder. Arch Gen Psychiatry (2012) 1.21

Perceived social support moderates the link between threat-related amygdala reactivity and trait anxiety. Neuropsychologia (2010) 1.19

SLC6 transporters: structure, function, regulation, disease association and therapeutics. Mol Aspects Med (2013) 1.18

Candidate and non-candidate genes in behavior genetics. Curr Opin Neurobiol (2012) 1.17

The developmental psychopathology of irritability. Dev Psychopathol (2013) 1.16

Comorbidities and continuities as ontogenic processes: toward a developmental spectrum model of externalizing psychopathology. Dev Psychopathol (2013) 1.16

Annual Research Review: Resilient functioning in maltreated children--past, present, and future perspectives. J Child Psychol Psychiatry (2012) 1.15

Cumulative socioeconomic status risk, allostatic load, and adjustment: a prospective latent profile analysis with contextual and genetic protective factors. Dev Psychol (2012) 1.14

Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis. BMC Med (2014) 1.14

A new life-span approach to conscientiousness and health: combining the pieces of the causal puzzle. Dev Psychol (2012) 1.13

Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene. PLoS One (2011) 1.13

The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption. Hum Genet (2012) 1.13

Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance. Dev Psychol (2011) 1.12

Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memory. Proc Natl Acad Sci U S A (2012) 1.12

Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression. Front Behav Neurosci (2014) 1.12

Gene expression and methylation signatures of MAN2C1 are associated with PTSD. Dis Markers (2011) 1.12

Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes. Neuropsychopharmacology (2012) 1.11

Beyond genotype: serotonin transporter epigenetic modification predicts human brain function. Nat Neurosci (2014) 1.11

Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world. Dev Psychopathol (2012) 1.10

Individual differences in recovery from traumatic fear. Trends Neurosci (2012) 1.10

Resting amygdala and medial prefrontal metabolism predicts functional activation of the fear extinction circuit. Am J Psychiatry (2012) 1.09

Gene-environment interactions in severe mental illness. Front Psychiatry (2014) 1.09

Research review: gene-environment interaction research in youth depression - a systematic review with recommendations for future research. J Child Psychol Psychiatry (2011) 1.08

Genetic sensitivity to the caregiving context: the influence of 5httlpr and BDNF val66met on indiscriminate social behavior. Physiol Behav (2011) 1.07

Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions. Expert Rev Neurother (2012) 1.05

Role of mother's genes and environment in postpartum depression. Proc Natl Acad Sci U S A (2011) 1.05

Interactive effects of corticotropin releasing hormone receptor 1, serotonin transporter linked polymorphic region, and child maltreatment on diurnal cortisol regulation and internalizing symptomatology. Dev Psychopathol (2011) 1.05

Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy. Pharmgenomics Pers Med (2012) 1.04

Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease. Curr Opin Pharmacol (2011) 1.04

Psychopathology, trauma and delinquency: subtypes of aggression and their relevance for understanding young offenders. Child Adolesc Psychiatry Ment Health (2011) 1.02

Genetic determinants of depression: recent findings and future directions. Harv Rev Psychiatry (2015) 1.02

Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins. Psychol Med (2012) 1.02

Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences. Psychopharmacology (Berl) (2010) 1.02

Therapygenetics: Using genetic markers to predict response to psychological treatment for mood and anxiety disorders. Biol Mood Anxiety Disord (2013) 1.01

5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination. Genes Brain Behav (2011) 1.01

The neurobiological correlates of childhood adversity and implications for treatment. Acta Psychiatr Scand (2013) 1.01

Gene × Environment interaction and resilience: effects of child maltreatment and serotonin, corticotropin releasing hormone, dopamine, and oxytocin genes. Dev Psychopathol (2012) 1.00

Future directions in vulnerability to depression among youth: integrating risk factors and processes across multiple levels of analysis. J Clin Child Adolesc Psychol (2012) 1.00

Neurogenetics of depression: a focus on reward processing and stress sensitivity. Neurobiol Dis (2012) 1.00

Interaction between serotonin transporter polymorphism (5-HTTLPR) and stressful life events in adolescents' trajectories of anxious/depressed symptoms. Dev Psychol (2012) 1.00

Toward an integration of cognitive and genetic models of risk for depression. Cogn Emot (2012) 0.99

Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: a longitudinal, multilevel, mediated moderation analysis. Dev Psychopathol (2012) 0.99

Genetic moderation of early child-care effects on social functioning across childhood: a developmental analysis. Child Dev (2013) 0.99

Interaction of 5-HTTLPR and idiographic stressors predicts prospective depressive symptoms specifically among youth in a multiwave design. J Clin Child Adolesc Psychol (2011) 0.99

Reward-related behavioral paradigms for addiction research in the mouse: performance of common inbred strains. PLoS One (2011) 0.99

Meta-analyses of the 5-HTTLPR polymorphisms and post-traumatic stress disorder. PLoS One (2013) 0.99

Understanding risk for psychopathology through imaging gene-environment interactions. Trends Cogn Sci (2011) 0.99

Translational epidemiology in psychiatry: linking population to clinical and basic sciences. Arch Gen Psychiatry (2011) 0.98

Attention to threats and combat-related posttraumatic stress symptoms: prospective associations and moderation by the serotonin transporter gene. JAMA Psychiatry (2013) 0.98

Stress and Fear Extinction. Neuropsychopharmacology (2015) 0.98

Perceived discrimination, serotonin transporter linked polymorphic region status, and the development of conduct problems. Dev Psychopathol (2011) 0.98

The effects of child maltreatment on early signs of antisocial behavior: genetic moderation by tryptophan hydroxylase, serotonin transporter, and monoamine oxidase A genes. Dev Psychopathol (2012) 0.98

Strain-specific cognitive deficits in adult mice exposed to early life stress. Behav Neurosci (2011) 0.97

The other allele: exploring the long allele of the serotonin transporter gene as a potential risk factor for psychopathy: a review of the parallels in findings. Neurosci Biobehav Rev (2010) 0.97

Genetics of emotion. Trends Cogn Sci (2011) 0.97

Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression. Arch Gen Psychiatry (2012) 0.97

Relational interventions for child maltreatment: past, present, and future perspectives. Dev Psychopathol (2013) 0.97

Therapygenetics: moving towards personalized psychotherapy treatment. Trends Cogn Sci (2011) 0.97

Supportive family environments, genes that confer sensitivity, and allostatic load among rural African American emerging adults: a prospective analysis. J Fam Psychol (2012) 0.96

Differential susceptibility in spillover between interparental conflict and maternal parenting practices: evidence for OXTR and 5-HTT genes. J Fam Psychol (2012) 0.96

Genetically informative research on adolescent substance use: methods, findings, and challenges. J Am Acad Child Adolesc Psychiatry (2010) 0.96

Ontogeny and regulation of the serotonin transporter: providing insights into human disorders. Pharmacol Ther (2011) 0.96

Etiological features of borderline personality related characteristics in a birth cohort of 12-year-old children. Dev Psychopathol (2012) 0.95

The effect of the serotonin transporter polymorphism (5-HTTLPR) on empathic and self-conscious emotional reactivity. Emotion (2012) 0.95

Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder. BMC Psychiatry (2011) 0.95

The urban environment and mental disorders: Epigenetic links. Epigenetics (2011) 0.95

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science (2003) 28.61

Replicating genotype-phenotype associations. Nature (2007) 16.11

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science (1996) 16.04

Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA (2009) 12.35

Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28

5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci (2005) 10.13

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86

Serotonin transporter genetic variation and the response of the human amygdala. Science (2002) 9.31

Statistical difficulties of detecting interactions and moderator effects. Psychol Bull (1993) 7.01

Behavioral observations at age 3 years predict adult psychiatric disorders. Longitudinal evidence from a birth cohort. Arch Gen Psychiatry (1996) 6.92

Negative affectivity: the disposition to experience aversive emotional states. Psychol Bull (1984) 5.93

An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med (2008) 5.88

A framework for interpreting genome-wide association studies of psychiatric disorders. Mol Psychiatry (2008) 5.80

Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat Rev Neurosci (2006) 5.25

Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry (2008) 4.65

Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. Int J Epidemiol (2008) 4.53

A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry (2005) 4.33

Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science (2004) 4.31

Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes (2007) 4.19

Diathesis-stress theories in the context of life stress research: implications for the depressive disorders. Psychol Bull (1991) 4.13

Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proc Natl Acad Sci U S A (2009) 4.11

Genetics of human gene expression: mapping DNA variants that influence gene expression. Nat Rev Genet (2009) 4.05

Observational research, randomised trials, and two views of medical science. PLoS Med (2008) 4.02

Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry (2005) 4.01

Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn Sci (2006) 3.92

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. Nat Genet (2009) 3.83

Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab (2008) 3.80

The ascent of mouse: advances in modelling human depression and anxiety. Nat Rev Drug Discov (2005) 3.80

Gene X environment interactions at the serotonin transporter locus. Biol Psychiatry (2008) 3.80

The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci (2003) 3.79

Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci (2004) 3.56

An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med (2002) 3.39

The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol Psychiatry (2007) 3.34

A contrarian view of the five-factor approach to personality description. Psychol Bull (1995) 3.24

Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch Intern Med (2008) 3.15

Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet B Neuropsychiatr Genet (2004) 3.11

The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology (2008) 2.97

HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biol Psychiatry (2007) 2.87

Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry (2002) 2.85

The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol Psychiatry (2010) 2.82

Sturdy childhood predictors of adult antisocial behaviour: replications from longitudinal studies. Psychol Med (1978) 2.53

Modern approaches to conceptualizing and measuring human life stress. Annu Rev Clin Psychol (2008) 2.50

Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biol Psychiatry (2004) 2.49

Looking on the bright side: biased attention and the human serotonin transporter gene. Proc Biol Sci (2009) 2.49

The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychol Med (2005) 2.45

Inventorying stressful life events as risk factors for psychopathology: Toward resolution of the problem of intracategory variability. Psychol Bull (2006) 2.35

The structural integrity of an amygdala-prefrontal pathway predicts trait anxiety. J Neurosci (2009) 2.35

Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proc Natl Acad Sci U S A (2007) 2.32

A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry (2000) 2.32

Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry (2006) 2.31

Personality traits are differentially linked to mental disorders: a multitrait-multidiagnosis study of an adolescent birth cohort. J Abnorm Psychol (1996) 2.31

Neural correlates of epigenesis. Proc Natl Acad Sci U S A (2006) 2.24

Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proc Natl Acad Sci U S A (2005) 2.24

Targeting the murine serotonin transporter: insights into human neurobiology. Nat Rev Neurosci (2008) 2.21

The serotonin transporter promoter polymorphism is associated with cortisol response to psychosocial stress. Biol Psychiatry (2009) 2.21

Invited commentary: from genome-wide association studies to gene-environment-wide interaction studies--challenges and opportunities. Am J Epidemiol (2008) 2.20

Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene. Am J Clin Nutr (2009) 2.14

Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism. J Neurosci (2009) 2.05

Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. Arch Gen Psychiatry (2004) 1.98

Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations. Arch Gen Psychiatry (2009) 1.97

Measured Gene-Environment Interactions in Psychopathology: Concepts, Research Strategies, and Implications for Research, Intervention, and Public Understanding of Genetics. Perspect Psychol Sci (2006) 1.94

Gene-environment interactions in depression research: genetic polymorphisms and life-stress polyprocedures. Psychol Sci (2008) 1.91

The utility of the non-human primate; model for studying gene by environment interactions in behavioral research. Genes Brain Behav (2003) 1.91

The role of orbitofrontal cortex in drug addiction: a review of preclinical studies. Biol Psychiatry (2007) 1.89

FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. J Clin Endocrinol Metab (2009) 1.87

Required sample size and nonreplicability thresholds for heterogeneous genetic associations. Proc Natl Acad Sci U S A (2008) 1.84

The neurobiology of individual differences in complex behavioral traits. Annu Rev Neurosci (2009) 1.79

Construct validity: advances in theory and methodology. Annu Rev Clin Psychol (2009) 1.77

A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. J Neurosci (2005) 1.77

Genetic gating of human fear learning and extinction: possible implications for gene-environment interaction in anxiety disorder. Psychol Sci (2009) 1.76

Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression. Arch Gen Psychiatry (2006) 1.74

Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli. J Abnorm Psychol (2009) 1.74

Polymorphisms of the serotonin transporter gene and their relation to premature ejaculation in individuals from Iran. J Urol (2009) 1.72

Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders. Neuropsychopharmacology (2007) 1.71

Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proc Natl Acad Sci U S A (2004) 1.71

Researching genetic versus nongenetic determinants of disease: a comparison and proposed unification. Sci Transl Med (2009) 1.67

Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults. Diabetologia (2009) 1.62

Serotonin transporter genetic variation and biased attention for emotional word stimuli among psychiatric inpatients. J Abnorm Psychol (2007) 1.61

Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: gene x environment hypotheses tested via a randomized prevention design. Child Dev (2009) 1.60

Interaction between childhood trauma and serotonin transporter gene variation in suicide. Neuropsychopharmacology (2007) 1.60

A genetically mediated bias in decision making driven by failure of amygdala control. J Neurosci (2009) 1.59

Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. Biol Psychiatry (2006) 1.57

Glutamate and monoamine transporters: new visions of form and function. Curr Opin Neurobiol (2007) 1.57

Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style. Biol Psychiatry (2005) 1.55

Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk. Mol Psychiatry (2008) 1.51

Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction. J Affect Disord (2008) 1.50

Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders. Am J Med Genet B Neuropsychiatr Genet (2005) 1.50

Interplay of genes and early mother-child relationship in the development of self-regulation from toddler to preschool age. J Child Psychol Psychiatry (2009) 1.49

Children's attentional biases and 5-HTTLPR genotype: potential mechanisms linking mother and child depression. J Clin Child Adolesc Psychol (2009) 1.49

Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice. Cereb Cortex (2009) 1.48

Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system. Neuroscience (2007) 1.47

Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia. Neurosci Lett (2004) 1.47

Serotonin transporter gene polymorphism (5-HTTLPR) and anxiety reactivity in daily life: a daily process approach to gene-environment interaction. Psychosom Med (2007) 1.47

The serotonin transporter genotype is associated with intermediate brain phenotypes that depend on the context of eliciting stressor. Mol Psychiatry (2008) 1.46

Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood. Psychol Sci (2005) 1.46

5-HTTLPR biases amygdala activity in response to masked facial expressions in major depression. Neuropsychopharmacology (2007) 1.44

No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by PET. Synapse (2003) 1.44

Gene-environment interactions: biologically valid pathway or artifact? Arch Gen Psychiatry (2009) 1.43

Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission. Mol Psychiatry (2009) 1.42

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 41.47

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science (2003) 28.61

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 26.95

Role of genotype in the cycle of violence in maltreated children. Science (2002) 13.50

The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. JAMA (2013) 10.43

5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci (2005) 10.13

Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort. Arch Gen Psychiatry (2003) 7.28

A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry (2012) 6.34

Developmental trajectories of childhood disruptive behaviors and adolescent delinquency: a six-site, cross-national study. Dev Psychol (2003) 5.87

Persistent cannabis users show neuropsychological decline from childhood to midlife. Proc Natl Acad Sci U S A (2012) 5.67

Association between children's experience of socioeconomic disadvantage and adult health: a life-course study. Lancet (2002) 5.32

Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat Rev Neurosci (2006) 5.25

Gene-environment interplay and psychopathology: multiple varieties but real effects. J Child Psychol Psychiatry (2006) 4.92

Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. Biol Psychiatry (2005) 4.85

Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry (2007) 4.71

Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci U S A (2003) 4.21

Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn Sci (2006) 3.92

Differences in early childhood risk factors for juvenile-onset and adult-onset depression. Arch Gen Psychiatry (2002) 3.84

The ascent of mouse: advances in modelling human depression and anxiety. Nat Rev Drug Discov (2005) 3.80

Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder: results from a longitudinal birth cohort. Arch Gen Psychiatry (2002) 3.59

Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Arch Pediatr Adolesc Med (2009) 3.41

Childhood trauma and children's emerging psychotic symptoms: A genetically sensitive longitudinal cohort study. Am J Psychiatry (2010) 3.36

Life with (or without) father: the benefits of living with two biological parents depend on the father's antisocial behavior. Child Dev (2003) 3.30

Female and male antisocial trajectories: from childhood origins to adult outcomes. Dev Psychopathol (2008) 3.07

Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study. BMJ (2002) 3.06

Static and dynamic cognitive deficits in childhood preceding adult schizophrenia: a 30-year study. Am J Psychiatry (2010) 3.05

Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder. Am J Psychiatry (2008) 3.01

Impaired fear extinction learning and cortico-amygdala circuit abnormalities in a common genetic mouse strain. J Neurosci (2008) 2.87

Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Arch Gen Psychiatry (2008) 2.82

Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. Arch Pediatr Adolesc Med (2012) 2.70

Using sex differences in psychopathology to study causal mechanisms: unifying issues and research strategies. J Child Psychol Psychiatry (2003) 2.69

Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci U S A (2005) 2.68

Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in mice. J Neurosci (2006) 2.68

Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. Am J Psychiatry (2012) 2.67

Why New Zealand must rapidly halve its greenhouse gas emissions. N Z Med J (2009) 2.67

Genetic variation in human NPY expression affects stress response and emotion. Nature (2008) 2.65

Evidence for substantial genetic risk for psychopathy in 7-year-olds. J Child Psychol Psychiatry (2005) 2.64

Longitudinal evidence that psychopathy scores in early adolescence predict adult psychopathy. J Abnorm Psychol (2007) 2.62

Maternal expressed emotion predicts children's antisocial behavior problems: using monozygotic-twin differences to identify environmental effects on behavioral development. Dev Psychol (2004) 2.61

Early childhood factors associated with the development of post-traumatic stress disorder: results from a longitudinal birth cohort. Psychol Med (2006) 2.57

Neuropsychological decline in schizophrenia from the premorbid to the postonset period: evidence from a population-representative longitudinal study. Am J Psychiatry (2014) 2.51

Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings. JAMA Psychiatry (2013) 2.51

Neural correlates of genetically abnormal social cognition in Williams syndrome. Nat Neurosci (2005) 2.50

Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci U S A (2004) 2.36

Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proc Natl Acad Sci U S A (2007) 2.32

Cannabis smoking and periodontal disease among young adults. JAMA (2008) 2.30

Prediction of differential adult health burden by conduct problem subtypes in males. Arch Gen Psychiatry (2007) 2.25

A longitudinal evaluation of adolescent depression and adult obesity. Arch Pediatr Adolesc Med (2003) 2.21

Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesis. Am J Psychiatry (2008) 2.19

Genome-wide association study of major recurrent depression in the U.K. population. Am J Psychiatry (2010) 2.17

Why do children from socioeconomically disadvantaged families suffer from poor health when they reach adulthood? A life-course study. Am J Epidemiol (2007) 2.16

Work experiences and personality development in young adulthood. J Pers Soc Psychol (2003) 2.16

Maternal depression and children's antisocial behavior: nature and nurture effects. Arch Gen Psychiatry (2005) 2.10

Neurophysiological correlates of age-related changes in working memory capacity. Neurosci Lett (2005) 2.06

Physical maltreatment victim to antisocial child: evidence of an environmentally mediated process. J Abnorm Psychol (2004) 2.06

A longitudinal study of epigenetic variation in twins. Epigenetics (2010) 2.06

The role of inositol 1,4,5-trisphosphate receptors in Ca(2+) signalling and the generation of arrhythmias in rat atrial myocytes. J Physiol (2002) 2.05

Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. Arch Gen Psychiatry (2009) 2.01

Is it important to prevent early exposure to drugs and alcohol among adolescents? Psychol Sci (2008) 2.01

Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains. Neurosci Biobehav Rev (2006) 2.00

Low self-esteem is related to aggression, antisocial behavior, and delinquency. Psychol Sci (2005) 2.00

Work stress precipitates depression and anxiety in young, working women and men. Psychol Med (2007) 1.99

Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. J Neurosci (2010) 1.99

Perigenual anterior cingulate morphology covaries with perceived social standing. Soc Cogn Affect Neurosci (2007) 1.98

Prenatal smoking and early childhood conduct problems: testing genetic and environmental explanations of the association. Arch Gen Psychiatry (2004) 1.98

Socially isolated children 20 years later: risk of cardiovascular disease. Arch Pediatr Adolesc Med (2006) 1.97

Nature X nurture: genetic vulnerabilities interact with physical maltreatment to promote conduct problems. Dev Psychopathol (2005) 1.96

Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation. Arch Gen Psychiatry (2006) 1.94

Prospective longitudinal associations between persistent sleep problems in childhood and anxiety and depression disorders in adulthood. J Abnorm Child Psychol (2005) 1.94

Low self-esteem during adolescence predicts poor health, criminal behavior, and limited economic prospects during adulthood. Dev Psychol (2006) 1.91

Sex differences in developmental reading disability: new findings from 4 epidemiological studies. JAMA (2004) 1.89

Revisiting the association between reading achievement and antisocial behavior: new evidence of an environmental explanation from a twin study. Child Dev (2006) 1.89

Neural correlates of facial affect processing in children and adolescents with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry (2004) 1.89

Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: a meta-analysis of family high-risk studies. Schizophr Bull (2013) 1.89

Individual, family, and neighborhood factors distinguish resilient from non-resilient maltreated children: a cumulative stressors model. Child Abuse Negl (2007) 1.89

Interleukin-6 covaries inversely with hippocampal grey matter volume in middle-aged adults. Biol Psychiatry (2008) 1.85

Substance abuse hinders desistance in young adults' antisocial behavior. Dev Psychopathol (2004) 1.85

Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort. Arch Gen Psychiatry (2010) 1.85

Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results. J Affect Disord (2011) 1.84

The evolution of class 1 integrons and the rise of antibiotic resistance. J Bacteriol (2008) 1.83

Individual differences in stressor-evoked blood pressure reactivity vary with activation, volume, and functional connectivity of the amygdala. J Neurosci (2008) 1.83

Mental health context of food insecurity: a representative cohort of families with young children. Pediatrics (2009) 1.82

A discordant monozygotic twin design shows blunted cortisol reactivity among bullied children. J Am Acad Child Adolesc Psychiatry (2011) 1.80

Obsessions and compulsions in the community: prevalence, interference, help-seeking, developmental stability, and co-occurring psychiatric conditions. Am J Psychiatry (2009) 1.77

Individual differences in typical reappraisal use predict amygdala and prefrontal responses. Biol Psychiatry (2008) 1.77

A longitudinal study of the effects of tobacco and cannabis exposure on lung function in young adults. Addiction (2002) 1.75

The protective effects of neighborhood collective efficacy on British children growing up in deprivation: a developmental analysis. Dev Psychol (2009) 1.74

Contribution of common genetic variants to antidepressant response. Biol Psychiatry (2012) 1.73

The limits of child effects: evidence for genetically mediated child effects on corporal punishment but not on physical maltreatment. Dev Psychol (2004) 1.70

Systematic social observation of children's neighborhoods using Google Street View: a reliable and cost-effective method. J Child Psychol Psychiatry (2012) 1.68

Bullying victimization uniquely contributes to adjustment problems in young children: a nationally representative cohort study. Pediatrics (2006) 1.68

It's not just who you're with, it's who you are: personality and relationship experiences across multiple relationships. J Pers (2002) 1.68

School, neighborhood, and family factors are associated with children's bullying involvement: a nationally representative longitudinal study. J Am Acad Child Adolesc Psychiatry (2009) 1.65

Developmental change in amygdala reactivity during adolescence: effects of family history of depression and stressful life events. Am J Psychiatry (2014) 1.63

Children's behavioral styles at age 3 are linked to their adult personality traits at age 26. J Pers (2003) 1.60

A longitudinal behavioral genetic analysis of the etiology of aggressive and nonaggressive antisocial behavior. Dev Psychopathol (2003) 1.59

Strong genetic effects on cross-situational antisocial behaviour among 5-year-old children according to mothers, teachers, examiner-observers, and twins' self-reports. J Child Psychol Psychiatry (2003) 1.58

Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic- and antidepressant-like effects in mice. Neuropsychopharmacology (2006) 1.58

How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology (2008) 1.56