Published in Cell Death Differ on January 25, 2008
Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 7.20
Notch1 is an effector of Akt and hypoxia in melanoma development. J Clin Invest (2008) 1.89
Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis. Cell Res (2009) 1.70
FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death Differ (2011) 1.59
Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer. Cancer Cell (2014) 1.54
Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways. Cancer Metab (2014) 1.45
Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions. J Biol Chem (2009) 1.41
Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta. Mol Cell Biol (2009) 1.37
Diabetes mellitus induces bone marrow microangiopathy. Arterioscler Thromb Vasc Biol (2009) 1.34
AMP-activated protein kinase, stress responses and cardiovascular diseases. Clin Sci (Lond) (2012) 1.29
Oxidative stress, tumor microenvironment, and metabolic reprogramming: a diabolic liaison. Int J Cell Biol (2012) 1.29
Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway. J Biol Chem (2009) 1.19
Mitochondrial regulation of cell cycle and proliferation. Antioxid Redox Signal (2012) 1.19
Role of reactive oxygen and nitrogen species in the vascular responses to inflammation. Free Radic Biol Med (2011) 1.17
Inter-connection between mitochondria and HIFs. J Cell Mol Med (2010) 1.14
Differential contribution of the mitochondrial respiratory chain complexes to reactive oxygen species production by redox cycling agents implicated in parkinsonism. Toxicol Sci (2009) 1.13
Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters. Free Radic Biol Med (2012) 1.12
Antagonism between FOXO and MYC Regulates Cellular Powerhouse. Front Oncol (2013) 1.10
Marine Natural Products as Inhibitors of Hypoxic Signaling in Tumors. Phytochem Rev (2009) 1.08
Membrane potential greatly enhances superoxide generation by the cytochrome bc1 complex reconstituted into phospholipid vesicles. J Biol Chem (2009) 1.07
Protective conditioning of the brain: expressway or roadblock? J Physiol (2011) 1.05
Autophagy: a targetable linchpin of cancer cell metabolism. Trends Endocrinol Metab (2013) 1.04
Roles of reactive oxygen species in the fate of stem cells. Antioxid Redox Signal (2012) 1.02
Neuroprotective roles and mechanisms of neuroglobin. Neurol Res (2009) 0.99
Mammea E/BB, an isoprenylated dihydroxycoumarin protonophore that potently uncouples mitochondrial electron transport, disrupts hypoxic signaling in tumor cells. J Nat Prod (2010) 0.99
Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells. Clin Exp Metastasis (2012) 0.99
Time-dependent stabilization of hypoxia inducible factor-1α by different intracellular sources of reactive oxygen species. PLoS One (2012) 0.98
Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors. Front Aging Neurosci (2010) 0.98
HIF- and non-HIF-regulated hypoxic responses require the estrogen-related receptor in Drosophila melanogaster. PLoS Genet (2013) 0.96
Targeting stem cell niches and trafficking for cardiovascular therapy. Pharmacol Ther (2010) 0.95
Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation. Hepatology (2010) 0.95
Neuroglobin, a novel target for endogenous neuroprotection against stroke and neurodegenerative disorders. Int J Mol Sci (2012) 0.94
Inflammation, Iron, Energy Failure, and Oxidative Stress in the Pathogenesis of Multiple Sclerosis. Oxid Med Cell Longev (2015) 0.92
Oxygen availability and metabolic reprogramming in cancer. J Biol Chem (2017) 0.92
Rheb and mammalian target of rapamycin in mitochondrial homoeostasis. Open Biol (2013) 0.92
Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness. J Signal Transduct (2012) 0.90
Biomarker signatures of mitochondrial NDUFS3 in invasive breast carcinoma. Biochem Biophys Res Commun (2011) 0.90
Hypoxia-induced oxidative base modifications in the VEGF hypoxia-response element are associated with transcriptionally active nucleosomes. Free Radic Biol Med (2008) 0.90
Loss of a conserved tyrosine residue of cytochrome b induces reactive oxygen species production by cytochrome bc1. J Biol Chem (2011) 0.90
The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2011) 0.90
Hypoxia and senescence: the impact of oxygenation on tumor suppression. Mol Cancer Res (2011) 0.89
The determination and analysis of site-specific rates of mitochondrial reactive oxygen species production. Methods Enzymol (2013) 0.89
The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia. PLoS One (2011) 0.89
Biological Activities of Reactive Oxygen and Nitrogen Species: Oxidative Stress versus Signal Transduction. Biomolecules (2015) 0.88
Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors. Clin Cancer Res (2013) 0.86
Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart. Heart Fail Rev (2015) 0.86
Hypoxia and fatty liver. World J Gastroenterol (2014) 0.86
The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α. EMBO Mol Med (2016) 0.85
Mitochondrial regulation of cell survival and death during low-oxygen conditions. Antioxid Redox Signal (2009) 0.85
Mitochondrial DNA mutations in head and neck cancer are infrequent and lack prognostic utility. Br J Cancer (2011) 0.84
Identification of a redox-modulatory interaction between uncoupling protein 3 and thioredoxin 2 in the mitochondrial intermembrane space. Antioxid Redox Signal (2011) 0.84
Curbing cancer's sweet tooth: is there a role for MnSOD in regulation of the Warburg effect? Mitochondrion (2012) 0.84
Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo. Free Radic Biol Med (2013) 0.84
Mitochondrial preconditioning: a potential neuroprotective strategy. Front Aging Neurosci (2010) 0.83
Increased Oxidative Stress as a Selective Anticancer Therapy. Oxid Med Cell Longev (2015) 0.83
The marine sponge metabolite mycothiazole: a novel prototype mitochondrial complex I inhibitor. Bioorg Med Chem (2010) 0.83
α-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion. Cancer Lett (2014) 0.83
Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care. Semin Fetal Neonatal Med (2010) 0.83
Metabolomic analysis of anti-hypoxia and anti-anxiety effects of Fu Fang Jin Jing Oral Liquid. PLoS One (2013) 0.83
Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia. Oncogene (2012) 0.82
Cancer Metabolism: Fueling More than Just Growth. Mol Cells (2016) 0.82
Antioxidant and protective mechanisms against hypoxia and hypoglycaemia in cortical neurons in vitro. Int J Mol Sci (2014) 0.81
Localization of HPV-18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism. PLoS One (2013) 0.81
Hypoperfusion and T1-hypointense lesions in white matter in multiple sclerosis. Mult Scler (2013) 0.80
Transcriptional regulation of yeast oxidative phosphorylation hypoxic genes by oxidative stress. Antioxid Redox Signal (2012) 0.79
The tyrosine phosphatase SHP-1 regulates hypoxia inducible factor-1α (HIF-1α) protein levels in endothelial cells under hypoxia. PLoS One (2015) 0.79
Prognostic significance of ubiquinol-cytochrome c reductase hinge protein expression in patients with clear cell renal cell carcinoma. Am J Cancer Res (2016) 0.78
Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer. Oncotarget (2016) 0.78
Thyrsiferol Inhibits Mitochondrial Respiration and HIF-1 Activation. Phytochem Lett (2011) 0.78
Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Noncoding RNA Hox Transcript Antisense Intergenic RNA (HOTAIR) in HeLa Cells. Mol Cell Proteomics (2015) 0.78
Molecular mechanisms of hypoxia-inducible factor-induced pulmonary arterial smooth muscle cell alterations in pulmonary hypertension. J Physiol (2015) 0.77
Quercetin Impacts Expression of Metabolism- and Obesity-Associated Genes in SGBS Adipocytes. Nutrients (2016) 0.77
RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect. Cell Res (2015) 0.77
Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells. Mar Drugs (2015) 0.77
Oncostatic-Cytoprotective Effect of Melatonin and Other Bioactive Molecules: A Common Target in Mitochondrial Respiration. Int J Mol Sci (2016) 0.77
Glucotoxicity induces glucose-6-phosphatase catalytic unit expression by acting on the interaction of HIF-1α with CREB-binding protein. Diabetes (2012) 0.77
Hypoxia induces a HIF-1α dependent signaling cascade to make a complex metabolic switch in SGBS-adipocytes. Mol Cell Endocrinol (2013) 0.77
The Tumorigenic Roles of the Cellular REDOX Regulatory Systems. Oxid Med Cell Longev (2015) 0.77
H2O2-Activated Mitochondrial Phospholipase iPLA2γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein-Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic β-Cells. Antioxid Redox Signal (2015) 0.76
Partial deficiency of HIF-1α stimulates pathological cardiac changes in streptozotocin-induced diabetic mice. BMC Endocr Disord (2014) 0.76
The twisted survivin connection to angiogenesis. Mol Cancer (2015) 0.76
Mieap-regulated mitochondrial quality control is frequently inactivated in human colorectal cancer. Oncogenesis (2016) 0.76
Mitochondrial ROS control of cancer. Semin Cancer Biol (2017) 0.75
Energizing Genetics and Epi-genetics: Role in the Regulation of Mitochondrial Function. Curr Genomics (2014) 0.75
Pulmonary hypertension and metabolic syndrome: Possible connection, PPARγ and Caveolin-1. World J Cardiol (2014) 0.75
Oxidative stress in oral diseases. Oral Dis (2015) 0.75
Protective effect of allicin on high glucose/hypoxia-induced aortic endothelial cells via reduction of oxidative stress. Exp Ther Med (2015) 0.75
Altered Mitochondrial Signalling and Metabolism in Cancer. Front Oncol (2017) 0.75
Mitochondrial deficiency impairs hypoxic induction of HIF-1 transcriptional activity and retards tumor growth. Oncotarget (2017) 0.75
Mitochondrial composition and function under the control of hypoxia. Redox Biol (2017) 0.75
Leonurine Improves Age-Dependent Impaired Angiogenesis: Possible Involvement of Mitochondrial Function and HIF-1α Dependent VEGF Activation. Front Pharmacol (2017) 0.75
Urinary gas chromatography mass spectrometry metabolomics in asphyxiated newborns undergoing hypothermia: from the birth to the first month of life. Ann Transl Med (2016) 0.75
Mitigation of myocardial ischemia-reperfusion injury via HIF-1α-frataxin signaling. Am J Physiol Heart Circ Physiol (2015) 0.75
Hepatic mitochondrial bioenergetics in aged C57BL/6 mice exhibit delayed recovery from severe burn injury. Biochim Biophys Acta (2017) 0.75
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Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ Res (2001) 3.07
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