Published in Bioorg Med Chem Lett on January 09, 2008
Hedgehog-Gli signaling pathway inhibitors as anticancer agents. J Med Chem (2009) 1.14
Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors. Cancers (Basel) (2016) 0.91
Powerful partners: Arabidopsis and chemical genomics. Arabidopsis Book (2009) 0.91
Isolation, purification, and full NMR assignments of cyclopamine from Veratrum californicum. Chem Cent J (2008) 0.83
Enhancement of cyclopamine via conjugation with nonmetabolic sugars. Org Lett (2012) 0.82
Investigations on inhibitors of hedgehog signal pathway: a quantitative structure-activity relationship study. Int J Mol Sci (2011) 0.82
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A piperidine chiron for the Veratrum alkaloids. J Org Chem (2012) 0.75
Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature (2004) 6.82
Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling. Cell (2012) 3.50
Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides. Proc Natl Acad Sci U S A (2005) 2.83
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell (2010) 2.54
Echocardiographic epicardial fat thickness and coronary artery disease. Circ J (2007) 2.40
A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide. ACS Chem Biol (2006) 2.09
Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation. Immunity (2009) 2.00
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci U S A (2010) 2.00
Recommended immunization schedule for children and adolescents: the Korean Pediatric Society, 2013. Korean J Pediatr (2013) 1.73
Identification of a novel protein regulating microtubule stability through a chemical approach. Chem Biol (2004) 1.64
RNA-selective, live cell imaging probes for studying nuclear structure and function. Chem Biol (2006) 1.63
A single-cell analysis of myogenic dedifferentiation induced by small molecules. Chem Biol (2005) 1.63
Dissection of melanogenesis with small molecules identifies prohibitin as a regulator. Chem Biol (2005) 1.48
Novel orthogonal strategy toward solid-phase synthesis of 1,3,5-substituted triazines. Org Lett (2003) 1.46
Triazine-based tyrosinase inhibitors identified by chemical genetic screening. Pigment Cell Res (2005) 1.40
Chemical genetics. Chem Rev (2006) 1.37
Combinatorial strategies in fluorescent probe development. Chem Rev (2012) 1.28
Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss. J Nutr Biochem (2007) 1.25
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression. Cell Metab (2005) 1.23
Small molecule microarrays: recent advances and applications. Curr Opin Chem Biol (2005) 1.22
Forward chemical genetic approach identifies new role for GAPDH in insulin signaling. Nat Chem Biol (2006) 1.19
Ultrasensitive near-infrared Raman reporters for SERS-based in vivo cancer detection. Angew Chem Int Ed Engl (2011) 1.18
Involvement of AtLAC15 in lignin synthesis in seeds and in root elongation of Arabidopsis. Planta (2006) 1.14
Control of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a children's hospital by changing antimicrobial agent usage policy. J Antimicrob Chemother (2007) 1.13
Identification of a new class of prostaglandin transporter inhibitors and characterization of their biological effects on prostaglandin E2 transport. J Pharmacol Exp Ther (2005) 1.10
Surface-enhanced Raman scattering in cancer detection and imaging. Trends Biotechnol (2013) 1.09
Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening. J Am Chem Soc (2003) 1.07
Combinatorial rosamine library and application to in vivo glutathione probe. J Am Chem Soc (2007) 1.06
A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration. J Neurosci (2010) 1.05
Discovery of amyloid-beta aggregation inhibitors using an engineered assay for intracellular protein folding and solubility. Protein Sci (2009) 1.03
Development of photostable near-infrared cyanine dyes. Chem Commun (Camb) (2010) 1.01
A fluorescent rosamine compound selectively stains pluripotent stem cells. Angew Chem Int Ed Engl (2010) 1.01
Colorimetric identification of carbohydrates by a pH indicator/pH change inducer ensemble. Angew Chem Int Ed Engl (2006) 1.00
Multiplex cancer cell detection by SERS nanotags with cyanine and triphenylmethine Raman reporters. Chem Commun (Camb) (2011) 0.99
Asexual endophytes and associated alkaloids alter arthropod community structure and increase herbivore abundances on a native grass. Ecol Lett (2009) 0.99
A novel zebrafish human tumor xenograft model validated for anti-cancer drug screening. Mol Biosyst (2012) 0.99
Tools for target identification and validation. Curr Opin Chem Biol (2004) 0.98
Novel use of fluorescent glucose analogues to identify a new class of triazine-based insulin mimetics possessing useful secondary effects. Mol Biosyst (2010) 0.98
Structural and functional modeling of human lysozyme reveals a unique nonapeptide, HL9, with anti-HIV activity. Biochemistry (2005) 0.97
Relative toxicities and neuromuscular nicotinic receptor agonistic potencies of anabasine enantiomers and anabaseine. Neurotoxicol Teratol (2006) 0.97
Diversity-oriented optical imaging probe development. Curr Opin Chem Biol (2011) 0.96
Embryonic and induced pluripotent stem cell staining and sorting with the live-cell fluorescence imaging probe CDy1. Nat Protoc (2011) 0.96
Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1. Am J Hematol (2013) 0.96
Surprising alteration of antibacterial activity of 5"-modified neomycin against resistant bacteria. J Med Chem (2008) 0.95
Glycodiversification for the optimization of the kanamycin class aminoglycosides. J Med Chem (2005) 0.95
Establishment of a robust dengue virus NS3-NS5 binding assay for identification of protein-protein interaction inhibitors. Antiviral Res (2012) 0.95
Combinatorial approach to organelle-targeted fluorescent library based on the styryl scaffold. J Am Chem Soc (2003) 0.95
Intracellular glutathione detection using MnO(2)-nanosheet-modified upconversion nanoparticles. J Am Chem Soc (2011) 0.95
Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries. J Comb Chem (2007) 0.95
Development of biocompatible SERS nanotag with increased stability by chemisorption of reporter molecule for in vivo cancer detection. Biosens Bioelectron (2010) 0.94
Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment. Biochem Biophys Res Commun (2003) 0.94
The causative organisms of bacterial meningitis in Korean children in 1996-2005. J Korean Med Sci (2010) 0.94
Microarrays of tagged combinatorial triazine libraries in the discovery of small-molecule ligands of human IgG. J Comb Chem (2004) 0.93
Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents. PLoS One (2010) 0.93
A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening. J Am Chem Soc (2002) 0.93
Sonication-assisted library synthesis of oxazolidinone-carbohydrate conjugates. J Comb Chem (2007) 0.93
Diversity-oriented fluorescence library approaches for probe discovery and development. Curr Opin Chem Biol (2010) 0.93
Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2. J Biol Chem (2004) 0.92
Neural stem cell specific fluorescent chemical probe binding to FABP7. Proc Natl Acad Sci U S A (2012) 0.92
Diversity-oriented fluorescence library approach for the discovery of sensors and probes. Mol Biosyst (2009) 0.92
Phytic acid synthesis and vacuolar accumulation in suspension-cultured cells of Catharanthus roseus induced by high concentration of inorganic phosphate and cations. Plant Physiol (2005) 0.90
Diversity-driven chemical probe development for biomolecules: beyond hypothesis-driven approach. Chem Soc Rev (2011) 0.90
Application of the synthetic aminosugars for glycodiversification: synthesis and antimicrobial studies of pyranmycin. J Org Chem (2004) 0.90
Solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor. Chem Commun (Camb) (2011) 0.90
Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening. J Am Chem Soc (2008) 0.90
Pericardial fat is more abundant in patients with coronary atherosclerosis and even in the non-obese patients: evaluation with cardiac CT angiography. Int J Cardiovasc Imaging (2010) 0.90
Tuning the regioselectivity of the Staudinger reaction for the facile synthesis of kanamycin and neomycin class antibiotics with N-1 modification. Org Lett (2005) 0.89
Styryl-based compounds as potential in vivo imaging agents for beta-amyloid plaques. Chembiochem (2007) 0.89
Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors. Chem Biol (2002) 0.89
Investigations of the molecular mechanism of metal-induced Abeta (1-40) amyloidogenesis. Biochemistry (2007) 0.89
Accelerating fluorescent sensor discovery: unbiased screening of a diversity-oriented BODIPY library. Chem Commun (Camb) (2010) 0.88
A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids. J Am Chem Soc (2011) 0.88
Synthesis of trehalose-based compounds and their inhibitory activities against Mycobacterium smegmatis. Bioorg Med Chem (2004) 0.88
Synthesis of a BODIPY library and its application to the development of live cell glucagon imaging probe. J Am Chem Soc (2009) 0.88
Bimolecular fluorescence complementation; lighting-up tau-tau interaction in living cells. PLoS One (2013) 0.87
High-content live cell imaging with RNA probes: advancements in high-throughput antimalarial drug discovery. BMC Cell Biol (2009) 0.87
Solid-phase synthesis of styryl dyes and their application as amyloid sensors. Angew Chem Int Ed Engl (2004) 0.87
Development of a high-affinity inhibitor of the prostaglandin transporter. J Pharmacol Exp Ther (2011) 0.86
A unique small molecule inhibitor of enolase clarifies its role in fundamental biological processes. ACS Chem Biol (2013) 0.86
Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. fusion [corrected] inhibition. Biochem Biophys Res Commun (2007) 0.86
The role of "disaggregation" in optical probe development. Chem Soc Rev (2014) 0.86
Diversity oriented fluorescence library approach (DOFLA) for live cell imaging probe development. Acc Chem Res (2014) 0.86
Clinical significance of aortic knob width and calcification in unstable angina. Circ J (2006) 0.85
Cellular differentiation-induced attenuation of LPS response in HT-29 cells is related to the down-regulation of TLR4 expression. Biochem Biophys Res Commun (2005) 0.84
Development of novel cell-permeable DNA sensitive dyes using combinatorial synthesis and cell-based screening. Chem Commun (Camb) (2003) 0.84
Multivessel versus single vessel spasm, as assessed by the intracoronary acetylcholine provocation test, in Korean patients. Clin Exp Pharmacol Physiol (2011) 0.84
Investigation of the regioselectivity for the staudinger reaction and its application for the synthesis of aminoglycosides with N-1 modification. J Org Chem (2007) 0.84
Sonochemistry: a powerful way of enhancing the efficiency of carbohydrate synthesis. J Org Chem (2006) 0.84
Combinatorial synthesis of benzimidazolium dyes and its diversity directed application toward GTP-selective fluorescent chemosensors. J Am Chem Soc (2006) 0.84
A photostable near-infrared protein labeling dye for in vivo imaging. Chem Asian J (2011) 0.84
Identification of the F1F0 mitochondrial ATPase as a target for modulating skin pigmentation by screening a tagged triazine library in zebrafish. Mol Biosyst (2005) 0.84
A macrophage-specific fluorescent probe for intraoperative lymph node staging. Cancer Res (2013) 0.83
Tagged library approach facilitates forward chemical genetics. Mol Biosyst (2007) 0.83
Tagged small molecule library approach for facilitated chemical genetics. Acc Chem Res (2007) 0.83