Published in Chem Biol on April 01, 2002
Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell (2010) 1.89
Reversine increases the plasticity of lineage-committed mammalian cells. Proc Natl Acad Sci U S A (2007) 1.39
Ca2+ sparks and T tubule reorganization in dedifferentiating adult mouse skeletal muscle fibers. Am J Physiol Cell Physiol (2006) 1.20
Microtubule binding distinguishes dystrophin from utrophin. Proc Natl Acad Sci U S A (2014) 0.98
Down-regulation of myogenin can reverse terminal muscle cell differentiation. PLoS One (2012) 0.90
Identification of 12Cysbeta on tubulin as the binding site of tubulyzine. Bioorg Med Chem (2005) 0.76
Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature (2007) 7.12
Adding new chemistries to the genetic code. Annu Rev Biochem (2010) 6.32
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A (2009) 5.86
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science (2010) 5.50
Genomic analysis of the host response to hepatitis C virus infection. Proc Natl Acad Sci U S A (2002) 5.28
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A (2008) 4.80
An expanded eukaryotic genetic code. Science (2003) 4.66
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A (2006) 3.83
Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli. Proc Natl Acad Sci U S A (2002) 3.77
Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling. Cell (2012) 3.50
Genetic incorporation of unnatural amino acids into proteins in mammalian cells. Nat Methods (2007) 3.45
Expanding the genetic code. Annu Rev Biophys Biomol Struct (2006) 3.36
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol (2008) 3.23
A stem cell-based approach to cartilage repair. Science (2012) 3.22
An enhanced system for unnatural amino acid mutagenesis in E. coli. J Mol Biol (2009) 3.20
The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. Proc Natl Acad Sci U S A (2008) 3.13
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (2011) 3.07
Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. J Am Chem Soc (2002) 2.88
Addition of the keto functional group to the genetic code of Escherichia coli. Proc Natl Acad Sci U S A (2002) 2.84
Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides. Proc Natl Acad Sci U S A (2005) 2.83
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A (2009) 2.80
Expanding the genetic code. Angew Chem Int Ed Engl (2004) 2.78
Genomically recoded organisms expand biological functions. Science (2013) 2.73
Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A (2006) 2.65
An efficient rapid system for profiling the cellular activities of molecular libraries. Proc Natl Acad Sci U S A (2006) 2.51
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A (2013) 2.49
Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc Natl Acad Sci U S A (2003) 2.45
Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. Cancer Res (2010) 2.45
A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. Proc Natl Acad Sci U S A (2008) 2.39
A chemical toolkit for proteins--an expanded genetic code. Nat Rev Mol Cell Biol (2006) 2.39
Recombinant expression of selectively sulfated proteins in Escherichia coli. Nat Biotechnol (2006) 2.31
Genome-wide functional analysis of human cell-cycle regulators. Proc Natl Acad Sci U S A (2006) 2.31
Efficient incorporation of unnatural amino acids into proteins in Escherichia coli. Nat Methods (2006) 2.24
Substrate recognition by the AAA+ chaperone ClpB. Nat Struct Mol Biol (2004) 2.19
Oxysterols direct immune cell migration via EBI2. Nature (2011) 2.19
A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide. ACS Chem Biol (2006) 2.09
An expanded genetic code with a functional quadruplet codon. Proc Natl Acad Sci U S A (2004) 2.09
Synthetic small molecules that control stem cell fate. Proc Natl Acad Sci U S A (2003) 2.06
A facile system for encoding unnatural amino acids in mammalian cells. Angew Chem Int Ed Engl (2009) 2.02
Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation. Immunity (2009) 2.00
Control of protein phosphorylation with a genetically encoded photocaged amino acid. Nat Chem Biol (2007) 1.99
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids. Proc Natl Acad Sci U S A (2012) 1.99
Identification of small molecule activators of cryptochrome. Science (2012) 1.95
A role for chemistry in stem cell biology. Nat Biotechnol (2004) 1.95
A genetically encoded fluorescent amino acid. J Am Chem Soc (2006) 1.93
The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination. Nat Biotechnol (2004) 1.93
Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae. J Am Chem Soc (2003) 1.93
Exploring the limits of codon and anticodon size. Chem Biol (2002) 1.89
A combinatorial scaffold approach toward kinase-directed heterocycle libraries. J Am Chem Soc (2002) 1.79
Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. Science (2008) 1.79
A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. Proc Natl Acad Sci U S A (2006) 1.78
A small molecule primes embryonic stem cells for differentiation. Cell Stem Cell (2009) 1.78
A general approach to site-specific antibody drug conjugates. Proc Natl Acad Sci U S A (2014) 1.77
Directed evolution of the site specificity of Cre recombinase. Proc Natl Acad Sci U S A (2002) 1.77
Profiling protein function with small molecule microarrays. Proc Natl Acad Sci U S A (2002) 1.77
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol (2009) 1.73
An efficient system for the evolution of aminoacyl-tRNA synthetase specificity. Nat Biotechnol (2002) 1.73
A genetically encoded metabolically stable analogue of phosphotyrosine in Escherichia coli. ACS Chem Biol (2007) 1.72
A genetically encoded infrared probe. J Am Chem Soc (2006) 1.71
An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proc Natl Acad Sci U S A (2003) 1.71
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proc Natl Acad Sci U S A (2003) 1.68
Progress toward an expanded eukaryotic genetic code. Chem Biol (2003) 1.66
A genetically encoded fluorescent amino acid. Proc Natl Acad Sci U S A (2006) 1.66
Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening. J Biol Chem (2007) 1.65
Site-directed spin labeling of a genetically encoded unnatural amino acid. Proc Natl Acad Sci U S A (2009) 1.65
A genetically encoded photocaged amino acid. J Am Chem Soc (2004) 1.65
A small-molecule inducer of the antioxidant response element. Chem Biol (2010) 1.65
Identification of a novel protein regulating microtubule stability through a chemical approach. Chem Biol (2004) 1.64
Small molecules that induce cardiomyogenesis in embryonic stem cells. J Am Chem Soc (2004) 1.63
RNA-selective, live cell imaging probes for studying nuclear structure and function. Chem Biol (2006) 1.63
A single-cell analysis of myogenic dedifferentiation induced by small molecules. Chem Biol (2005) 1.63
Tom40 protein import channel binds to non-native proteins and prevents their aggregation. Nat Struct Biol (2003) 1.62
Generation of a bacterium with a 21 amino acid genetic code. J Am Chem Soc (2003) 1.62
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol (2004) 1.60
A genetically encoded bidentate, metal-binding amino acid. Angew Chem Int Ed Engl (2007) 1.57
In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy. J Am Chem Soc (2008) 1.57
Dedifferentiation of lineage-committed cells by a small molecule. J Am Chem Soc (2004) 1.56
A genetically encoded photocaged tyrosine. Angew Chem Int Ed Engl (2006) 1.56
A general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer. J Am Chem Soc (2008) 1.56
A genetically encoded boronate-containing amino acid. Angew Chem Int Ed Engl (2008) 1.54
Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation. J Am Chem Soc (2007) 1.54
Beyond the canonical 20 amino acids: expanding the genetic lexicon. J Biol Chem (2010) 1.53
A new strategy for the site-specific modification of proteins in vivo. Biochemistry (2003) 1.52
Bispecific small molecule-antibody conjugate targeting prostate cancer. Proc Natl Acad Sci U S A (2013) 1.52
Enthalpy arrays. Proc Natl Acad Sci U S A (2004) 1.52
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc Natl Acad Sci U S A (2013) 1.51
Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice. Proc Natl Acad Sci U S A (2002) 1.51
Dissection of melanogenesis with small molecules identifies prohibitin as a regulator. Chem Biol (2005) 1.48
Identification of p53 regulators by genome-wide functional analysis. Proc Natl Acad Sci U S A (2004) 1.48
Structural plasticity and the evolution of antibody affinity and specificity. J Mol Biol (2003) 1.47
Novel orthogonal strategy toward solid-phase synthesis of 1,3,5-substituted triazines. Org Lett (2003) 1.46
A genomic screen for activators of the antioxidant response element. Proc Natl Acad Sci U S A (2007) 1.44
A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl (2005) 1.44
Retracted A new strategy for the synthesis of glycoproteins. Science (2004) 1.44
Ribosomal route to small-molecule diversity. J Am Chem Soc (2011) 1.43
Expanding the genetic code. Chem Commun (Camb) (2002) 1.43