Published in Neoplasia on January 01, 2008
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J (2008) 2.25
Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation. FASEB J (2009) 1.10
Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. Neoplasia (2011) 1.07
Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest. J Biol Chem (2009) 1.05
Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. Neoplasia (2010) 1.03
Insm1 promotes the transition of olfactory progenitors from apical and proliferative to basal, terminally dividing and neuronogenic. Neural Dev (2011) 0.98
Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma. J Hematol Oncol (2009) 0.95
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors. EMBO J (2014) 0.94
INSM1 promoter-driven adenoviral herpes simplex virus thymidine kinase cancer gene therapy for the treatment of primitive neuroectodermal tumors. Hum Gene Ther (2009) 0.85
Derivation of high purity neuronal progenitors from human embryonic stem cells. PLoS One (2011) 0.85
Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Gene Expr Patterns (2011) 0.81
In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. Oncotarget (2016) 0.80
Neoplasia: the second decade. Neoplasia (2008) 0.75
Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1-DNA-complex formation. Beilstein J Org Chem (2014) 0.75
The War on Cancer rages on. Neoplasia (2009) 0.75
INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastoma. Oncotarget (2015) 0.75
Dinosaurs and ancient civilizations: reflections on the treatment of cancer. Neoplasia (2010) 0.75
Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature (2002) 15.36
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Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature (2003) 6.07
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Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci U S A (2003) 2.72
Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem (2001) 2.56
Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development. Nat Rev Neurosci (2006) 2.42
Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev (2004) 2.16
Hedgehog-Gli signalling and the growth of the brain. Nat Rev Neurosci (2002) 2.10
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J (2006) 2.02
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The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev (2006) 1.81
REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. Proc Natl Acad Sci U S A (2004) 1.63
NeuroD: the predicted and the surprising. Mol Cells (2004) 1.53
NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system. J Biol Chem (2003) 1.49
A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs. J Biol Chem (1992) 1.44
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Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence. Nucleic Acids Res (2002) 1.33
High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice. Oncogene (2002) 1.23
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Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets. Oncogene (2006) 1.18
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Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm. Trends Mol Med (2005) 1.16
The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. Biochem Biophys Res Commun (2003) 1.09
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Transcriptional profiling of medulloblastoma in children. J Neurosurg (2003) 0.90
Expression of the bHLH gene NSCL-1 suggests a role in regulating cerebellar granule cell growth and differentiation. J Neurosci Res (1999) 0.89
Expression of the helix-loop-helix genes Id-1 and NSCL-1 during cerebellar development. Dev Dyn (1997) 0.89
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A (2005) 6.26
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell (2004) 4.91
TORCs: transducers of regulated CREB activity. Mol Cell (2003) 4.42
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature (2012) 4.13
Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. J Clin Invest (2002) 3.36
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev (2003) 3.32
Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells. Blood (2008) 2.94
Thyroxine in goiter, Helicobacter pylori infection, and chronic gastritis. N Engl J Med (2006) 2.75
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. Nat Cell Biol (2006) 2.40
The role of limited posterior fossa craniectomy in the surgical treatment of Chiari malformation Type I: experience with a pediatric series. J Neurosurg (2007) 2.40
Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. Nat Cell Biol (2010) 2.25
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J (2008) 2.25
Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Nat Cell Biol (2003) 2.24
MicroRNA profiling in human medulloblastoma. Int J Cancer (2009) 2.12
Second-look surgery for ependymoma: the Italian experience. J Neurosurg Pediatr (2011) 2.12
Intracranial midline dermoid and epidermoid cysts in children. J Neurosurg (2004) 1.94
The natural history of the Chiari Type I anomaly. J Neurosurg Pediatr (2008) 1.86
NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL. Br J Haematol (2010) 1.80
Human MRE11 is inactivated in mismatch repair-deficient cancers. EMBO Rep (2002) 1.80
The multiple functions of Numb. Exp Cell Res (2009) 1.79
Choroid plexus coagulation for hydrocephalus not due to CSF overproduction: a review. Childs Nerv Syst (2012) 1.78
NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. Nat Cell Biol (2011) 1.77
Hedgehog controls neural stem cells through p53-independent regulation of Nanog. EMBO J (2010) 1.73
Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell (2009) 1.73
Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation. J Biol Chem (2008) 1.71
The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. Proc Natl Acad Sci U S A (2007) 1.68
REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. Proc Natl Acad Sci U S A (2004) 1.63
Pre-operative irreducible C1-C2 dislocations: intra-operative reduction and posterior fixation. The "always posterior strategy". Acta Neurochir (Wien) (2009) 1.62
Sylvian fissure arachnoid cysts: a survey on their diagnostic workout and practical management. Childs Nerv Syst (2008) 1.58
Cytogenetic prognostication within medulloblastoma subgroups. J Clin Oncol (2014) 1.56
Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development (2006) 1.56
A late complication of CSF shunting: acquired Chiari I malformation. Childs Nerv Syst (2008) 1.55
Giant anterior sacral meningocele and posterior sagittal approach. Childs Nerv Syst (2003) 1.54
Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc Natl Acad Sci U S A (2002) 1.54
TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. Cancer Cell (2004) 1.54
Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype. Am J Hum Genet (2010) 1.53
Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting. J Biol Chem (2005) 1.52
Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers. Hum Mol Genet (2011) 1.51
The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation. Trends Cell Biol (2012) 1.51
MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. FASEB J (2009) 1.51
Prognostic factors and outcome of children with severe head injury: an 8-year experience. Childs Nerv Syst (2002) 1.47
Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. Oncogene (2004) 1.46
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med (2005) 1.46
High response rate to cisplatin/etoposide regimen in childhood low-grade glioma. J Clin Oncol (2002) 1.45
Towards Microsurgical Correction of Cleft Lip Ex Utero via Restoration of Craniofacial Developmental Programs. Plast Reconstr Surg (2017) 1.39
Specific role for p300/CREB-binding protein-associated factor activity in E2F1 stabilization in response to DNA damage. J Biol Chem (2004) 1.38
Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Development (2011) 1.37
Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia. EMBO J (2006) 1.37
Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level. Exp Cell Res (2004) 1.35
Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy. Cancer Res (2009) 1.34
Proposal of "evolution theory in cerebrospinal fluid dynamics" and minor pathway hydrocephalus in developing immature brain. Childs Nerv Syst (2006) 1.31
A new genetic lesion in B-CLL: a NOTCH1 PEST domain mutation. Br J Haematol (2009) 1.26
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Development (2005) 1.25
MicroRNAs as biomarkers for CNS cancer and other disorders. Brain Res (2010) 1.25
BRCA1/BRCA2 mutation status and clinical-pathologic features of 108 male breast cancer cases from Tuscany: a population-based study in central Italy. Breast Cancer Res Treat (2008) 1.25
The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain. Proc Natl Acad Sci U S A (2009) 1.24