PubRank

Raymond J Deshaies

Author PubWeight™ 127.72‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol 2005 14.42
2 Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science 2002 7.49
3 Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 2002 4.95
4 COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases. Cell 2003 4.25
5 Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol Cell 2008 4.09
6 Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome system. Cell 2004 3.84
7 Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34. Cell 2005 3.44
8 UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell 2008 3.41
9 Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science 2004 3.28
10 Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc Natl Acad Sci U S A 2011 3.20
11 Structural organization of the 19S proteasome lid: insights from MS of intact complexes. PLoS Biol 2006 2.56
12 JAMM: a metalloprotease-like zinc site in the proteasome and signalosome. PLoS Biol 2003 2.56
13 Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science 2004 2.50
14 Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates. Cell 2009 2.40
15 A putative stimulatory role for activator turnover in gene expression. Nature 2005 2.28
16 Detection of sequential polyubiquitylation on a millisecond timescale. Nature 2009 2.25
17 Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. Mol Cell 2010 2.24
18 Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. Cell 2013 2.14
19 Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science 2004 2.14
20 Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate. Mol Cell 2011 1.92
21 Cdc48/p97 mediates UV-dependent turnover of RNA Pol II. Mol Cell 2011 1.91
22 Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast. Mol Cell Proteomics 2003 1.82
23 Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation. Nat Cell Biol 2003 1.79
24 Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. BMC Biochem 2005 1.74
25 Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol 2010 1.71
26 Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets. Mol Cell Proteomics 2005 1.65
27 Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels. BMC Biochem 2006 1.62
28 Context of multiubiquitin chain attachment influences the rate of Sic1 degradation. Mol Cell 2003 1.57
29 Quantitative profiling of ubiquitylated proteins reveals proteasome substrates and the substrate repertoire influenced by the Rpn10 receptor pathway. Mol Cell Proteomics 2007 1.53
30 Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome. Elife 2013 1.44
31 p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition. Elife 2014 1.37
32 Mapping phosphorylation sites in proteins by mass spectrometry. Methods Enzymol 2002 1.32
33 Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis. J Cell Biol 2009 1.29
34 Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation. Mol Cell Proteomics 2003 1.27
35 Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem 2013 1.25
36 The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation. Mol Cell Proteomics 2010 1.24
37 Cdc5 influences phosphorylation of Net1 and disassembly of the RENT complex. BMC Mol Biol 2002 1.24
38 NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. Nat Struct Mol Biol 2012 1.23
39 Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism. J Biol Chem 2012 1.22
40 In vitro reconstitution of SCF substrate ubiquitination with purified proteins. Methods Enzymol 2005 1.17
41 Evaluation of a diffusion-driven mechanism for substrate ubiquitination by the SCF-Cdc34 ubiquitin ligase complex. Mol Cell 2006 1.16
42 A conditional yeast E1 mutant blocks the ubiquitin-proteasome pathway and reveals a role for ubiquitin conjugates in targeting Rad23 to the proteasome. Mol Biol Cell 2007 1.14
43 Chfr is linked to tumour metastasis through the downregulation of HDAC1. Nat Cell Biol 2009 1.12
44 Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1. BMC Biol 2011 1.12
45 Loss of CDC5 function in Saccharomyces cerevisiae leads to defects in Swe1p regulation and Bfa1p/Bub2p-independent cytokinesis. Genetics 2003 1.10
46 Mutations in the hydrophobic core of ubiquitin differentially affect its recognition by receptor proteins. J Mol Biol 2007 1.07
47 Combined chemical and genetic approach to inhibit proteolysis by the proteasome. Yeast 2010 1.06
48 The acidic tail of the Cdc34 ubiquitin-conjugating enzyme functions in both binding to and catalysis with ubiquitin ligase SCFCdc4. J Biol Chem 2009 1.05
49 Mass spectrometry-based methods for phosphorylation site mapping of hyperphosphorylated proteins applied to Net1, a regulator of exit from mitosis in yeast. Mol Cell Proteomics 2002 1.04
50 Development of p97 AAA ATPase inhibitors. Autophagy 2011 1.03
51 Gal4 turnover and transcription activation. Nature 2009 1.00
52 Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system. J Biol Chem 2011 0.98
53 Multiple telophase arrest bypassed (tab) mutants alleviate the essential requirement for Cdc15 in exit from mitosis in S. cerevisiae. BMC Genet 2002 0.95
54 Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. BMC Biochem 2008 0.88
55 The TFIIH subunit Tfb3 regulates cullin neddylation. Mol Cell 2011 0.87
56 Designer reagents for mass spectrometry-based proteomics: clickable cross-linkers for elucidation of protein structures and interactions. Anal Chem 2012 0.87
57 Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. Mol Cell Proteomics 2012 0.85
58 Two-step affinity purification of multiubiquitylated proteins from Saccharomyces cerevisiae. Methods Enzymol 2005 0.83
59 Click chemistry facilitates formation of reporter ions and simplified synthesis of amine-reactive multiplexed isobaric tags for protein quantification. J Am Chem Soc 2012 0.83
60 Physiologically relevant and portable tandem ubiquitin-binding domain stabilizes polyubiquitylated proteins. Proc Natl Acad Sci U S A 2010 0.82
61 Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme. Mol Cell Biol 2013 0.82
62 Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition. Mol Cell Proteomics 2013 0.81
63 Redundant degrons ensure the rapid destruction of Sic1 at the G1/S transition of the budding yeast cell cycle. Cell Cycle 2003 0.81
64 Drug discovery: Fresh target for cancer therapy. Nature 2009 0.79
65 Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J Med Chem 2017 0.76
66 F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage. Mol Cell Proteomics 2014 0.76
67 Corrigendum: Protein degradation: Prime time for PROTACs. Nat Chem Biol 2015 0.75
68 Correction to Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J Med Chem 2017 0.75