Published in Mol Cell on April 09, 2010
Molecular architecture and assembly of the eukaryotic proteasome. Annu Rev Biochem (2013) 2.04
Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97. Curr Biol (2014) 2.01
RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition. PLoS Genet (2010) 1.66
NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies. Mol Biol Cell (2013) 1.59
Regulation of proteasome activity in health and disease. Biochim Biophys Acta (2013) 1.52
Coordinated regulation of protein synthesis and degradation by mTORC1. Nature (2014) 1.51
p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition. Elife (2014) 1.37
Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLoS Genet (2011) 1.35
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy. BMC Biol (2014) 1.29
Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf. PLoS Genet (2013) 1.21
Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration. Proc Natl Acad Sci U S A (2011) 1.20
Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. Elife (2015) 1.12
Proteasome functional insufficiency in cardiac pathogenesis. Am J Physiol Heart Circ Physiol (2011) 1.11
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution. Front Mol Neurosci (2014) 1.10
Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms. Mol Cell Biol (2011) 1.09
Gates, Channels, and Switches: Elements of the Proteasome Machine. Trends Biochem Sci (2015) 1.09
Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia. Blood (2012) 1.05
Ubiquitin receptors and protein quality control. J Mol Cell Cardiol (2012) 1.04
Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress response. J Biol Chem (2011) 1.04
Regulating the 20S proteasome ubiquitin-independent degradation pathway. Biomolecules (2014) 1.02
C termini of proteasomal ATPases play nonequivalent roles in cellular assembly of mammalian 26 S proteasome. J Biol Chem (2011) 1.01
Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome. Mol Cell Biol (2010) 0.99
SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. Free Radic Biol Med (2015) 0.98
Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles. J Biol Chem (2015) 0.98
Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells. Stem Cells (2014) 0.96
The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis. J Biol Chem (2011) 0.95
A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level. J Biol Chem (2012) 0.94
Nrf1 CNC-bZIP protein promotes cell survival and nucleotide excision repair through maintaining glutathione homeostasis. J Biol Chem (2012) 0.93
Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis. Nat Cell Biol (2015) 0.92
NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes. Mol Cell Biol (2012) 0.90
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1. Elife (2016) 0.89
Inflammatory macrophages induce Nrf2 transcription factor-dependent proteasome activity in colonic NCM460 cells and thereby confer anti-apoptotic protection. J Biol Chem (2011) 0.89
mTORC1 signaling activates NRF1 to increase cellular proteasome levels. Cell Cycle (2015) 0.89
The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia. PLoS One (2011) 0.89
Assembly of the 20S proteasome. Biochim Biophys Acta (2013) 0.88
The defective proteasome but not substrate recognition function is responsible for the null phenotypes of the Arabidopsis proteasome subunit RPN10. Plant Cell (2011) 0.88
The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity. Sci Rep (2013) 0.88
Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome. Elife (2015) 0.86
PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy (2014) 0.86
The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression. Mol Cell Biol (2013) 0.86
Preventive and therapeutic effects of MG132 by activating Nrf2-ARE signaling pathway on oxidative stress-induced cardiovascular and renal injury. Oxid Med Cell Longev (2013) 0.86
Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Elife (2015) 0.85
The Nuclear Factor (Erythroid-derived 2)-like 2 and Proteasome Maturation Protein Axis Mediate Bortezomib Resistance in Multiple Myeloma. J Biol Chem (2015) 0.85
Proteome complexity and the forces that drive proteome imbalance. Nature (2016) 0.84
The nrf1 and nrf2 balance in oxidative stress regulation and androgen signaling in prostate cancer cells. Cancers (Basel) (2010) 0.83
Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity. J Biol Chem (2013) 0.83
Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability. FEBS J (2012) 0.82
Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis. PLoS Genet (2015) 0.82
PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol Cell Biol (2010) 0.82
Fenretinide targets chronic myeloid leukemia stem/progenitor cells by regulation of redox signaling. Antioxid Redox Signal (2013) 0.82
TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells. Sci Rep (2016) 0.81
Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio). Free Radic Biol Med (2015) 0.81
Inherent asymmetry in the 26S proteasome is defined by the ubiquitin receptor RPN13. J Biol Chem (2014) 0.81
Transcription factor Nrf1 is topologically repartitioned across membranes to enable target gene transactivation through its acidic glucose-responsive domains. PLoS One (2014) 0.80
Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice. Front Mol Neurosci (2014) 0.80
VWA domain of S5a restricts the ability to bind ubiquitin and Ubl to the 26S proteasome. Mol Biol Cell (2014) 0.80
The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death. Cell Res (2016) 0.80
XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells. Leuk Res (2013) 0.80
Potential usage of proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of metastatic melanoma: basic and clinical aspects. Am J Cancer Res (2011) 0.79
Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy. J Biol Chem (2014) 0.79
A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy. Hum Mol Genet (2016) 0.79
The 26S proteasome and initiation of gene transcription. Biomolecules (2014) 0.79
The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction. Elife (2016) 0.79
mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress. Mol Cell (2016) 0.79
The Proteasome Stress Regulon Is Controlled by a Pair of NAC Transcription Factors in Arabidopsis. Plant Cell (2016) 0.78
Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy. J Mol Cell Cardiol (2016) 0.78
CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion. Antioxid Redox Signal (2015) 0.78
Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis. Cell Res (2014) 0.78
Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway. PLoS Genet (2016) 0.78
Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes. PLoS One (2012) 0.77
Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response. J Biol Chem (2016) 0.77
The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression. Sci Rep (2015) 0.77
Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation. Curr Biol (2016) 0.76
An Inducible System for Rapid Degradation of Specific Cellular Proteins Using Proteasome Adaptors. PLoS One (2016) 0.76
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases. Redox Biol (2017) 0.76
Tuning the proteasome to brighten the end of the journey. Am J Physiol Cell Physiol (2016) 0.76
Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes. Front Biosci (Landmark Ed) (2016) 0.76
The Logic of the 26S Proteasome. Cell (2017) 0.76
Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol (2017) 0.76
Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis. Cell Rep (2017) 0.75
Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1. Exp Cell Res (2013) 0.75
Inhibition of Proteasome Activity Induces Formation of Alternative Proteasome Complexes. J Biol Chem (2016) 0.75
Nano-liquid chromatography-orbitrap MS -based quantitative proteomics reveals differences between the mechanisms of action of carnosic acid and carnosol in colon cancer cells. Mol Cell Proteomics (2016) 0.75
A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways. Mol Cell Biol (2016) 0.75
Zhang & Manning reply. Nature (2016) 0.75
Shaping proteostasis at the cellular, tissue, and organismal level. J Cell Biol (2017) 0.75
Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation. Cell Chem Biol (2017) 0.75
Repulsive parallel MCMC algorithm for discovering diverse motifs from large sequence sets. Bioinformatics (2015) 0.75
Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers. Proc Natl Acad Sci U S A (2016) 0.75
Phospholipase Lpl1 Links Lipid Droplet Function with Quality Control Protein Degradation. Mol Biol Cell (2017) 0.75
Induction of Proteotoxic Stress by the Mycotoxin Patulin. Toxicol Lett (2017) 0.75
Proteostasis, oxidative stress and aging. Redox Biol (2017) 0.75
Immunohistochemical analysis reveals variations in proteasome tissue expression in C. elegans. PLoS One (2017) 0.75
Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma. J Ovarian Res (2017) 0.75
Proteasome Structure and Assembly. J Mol Biol (2017) 0.75
A hypermorphic antioxidant response element is associated with increased MS4A6A expression and Alzheimer's disease. Redox Biol (2017) 0.75
Redox regulation of proteasome function. Redox Biol (2017) 0.75
Structure of 20S proteasome from yeast at 2.4 A resolution. Nature (1997) 12.73
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol (2007) 12.48
Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu Rev Biochem (2009) 8.83
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature (2009) 8.44
Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science (2007) 7.69
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci U S A (1994) 6.72
A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell (1998) 5.78
Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. Proc Natl Acad Sci U S A (1996) 5.15
Proteasomes and their kin: proteases in the machine age. Nat Rev Mol Cell Biol (2004) 5.14
Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol (2005) 4.84
Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature (1993) 4.68
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci U S A (1996) 4.41
Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci U S A (2002) 4.33
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res (2007) 3.85
Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol (1996) 3.72
Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein. Blood (2008) 3.65
Proteasome inhibitors in cancer therapy: lessons from the first decade. Clin Cancer Res (2008) 3.58
The structure of the mammalian 20S proteasome at 2.75 A resolution. Structure (2002) 3.44
Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data. Neoplasia (2005) 3.16
Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer. J Clin Oncol (2004) 3.02
RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit. Proc Natl Acad Sci U S A (2001) 2.85
Molecular mechanisms of proteasome assembly. Nat Rev Mol Cell Biol (2009) 2.82
Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast. FEBS Lett (1999) 2.54
Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates. Methods Enzymol (2005) 2.49
Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol Cell Biol (2003) 2.19
Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J Biol Chem (1999) 2.09
Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature (2009) 2.07
Hexameric assembly of the proteasomal ATPases is templated through their C termini. Nature (2009) 1.97
Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. EMBO J (1998) 1.97
Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomes. J Biol Chem (2003) 1.87
Identification of polymorphic antioxidant response elements in the human genome. Hum Mol Genet (2007) 1.79
Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. J Biol Chem (2006) 1.69
Abnormally high expression of proteasomes in human leukemic cells. Proc Natl Acad Sci U S A (1990) 1.62
Role of Nrf1 in antioxidant response element-mediated gene expression and beyond. Toxicol Appl Pharmacol (2009) 1.49
Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription. Nucleic Acids Res (1998) 1.45
Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis. Cancer Res (2006) 1.41
Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. Biochem J (2006) 1.37
Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2). Oncogene (2009) 1.32
The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. Genes Dev (1997) 1.25
Nrf3 negatively regulates antioxidant-response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. J Biol Chem (2004) 1.23
Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase. J Biol Chem (2004) 1.19
Identification and characterization of a Drosophila proteasome regulatory network. Mol Cell Biol (2005) 1.18
Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesis. Biol Chem (2008) 1.16
Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue. Cancer Res (2005) 1.13
Biting the hand that feeds: Rpn4-dependent feedback regulation of proteasome function. Biochim Biophys Acta (2007) 1.05
Pharmacology, pharmacokinetics, and practical applications of bortezomib. Oncology (Williston Park) (2004) 1.03
Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathway. Biochem Biophys Res Commun (2006) 1.01
Preincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts. Ann N Y Acad Sci (2006) 0.94
Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol (2005) 14.42
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science (2002) 7.49
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science (2002) 4.95
COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases. Cell (2003) 4.25
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol Cell (2008) 4.09
Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome system. Cell (2004) 3.84
Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34. Cell (2005) 3.44
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell (2008) 3.41
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science (2004) 3.28
Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc Natl Acad Sci U S A (2011) 3.20
Structural organization of the 19S proteasome lid: insights from MS of intact complexes. PLoS Biol (2006) 2.56
JAMM: a metalloprotease-like zinc site in the proteasome and signalosome. PLoS Biol (2003) 2.56
Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer. Cancer Prev Res (Phila) (2008) 2.50
Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science (2004) 2.50
Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Res (2006) 2.49
Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates. Cell (2009) 2.40
A putative stimulatory role for activator turnover in gene expression. Nature (2005) 2.28
Risk factors for progression of low-grade dysplasia in patients with Barrett's esophagus. Gastroenterology (2011) 2.27
Detection of sequential polyubiquitylation on a millisecond timescale. Nature (2009) 2.25
Patients with nondysplastic Barrett's esophagus have low risks for developing dysplasia or esophageal adenocarcinoma. Clin Gastroenterol Hepatol (2010) 2.24
Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition. J Mol Biol (2005) 2.22
Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. J Biol Chem (2003) 2.20
Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. Cell (2013) 2.14
Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science (2004) 2.14
Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol Cell Biol (2007) 2.12
Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc Natl Acad Sci U S A (2005) 2.12
Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology (2007) 2.11
Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate. Mol Cell (2011) 1.92
Cdc48/p97 mediates UV-dependent turnover of RNA Pol II. Mol Cell (2011) 1.91
Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast. Mol Cell Proteomics (2003) 1.82
Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation. Nat Cell Biol (2003) 1.79
Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. BMC Biochem (2005) 1.74
Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol (2010) 1.71
Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. J Biol Chem (2006) 1.70
Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. J Biol Chem (2006) 1.69
Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J Biol Chem (2010) 1.68
Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets. Mol Cell Proteomics (2005) 1.65
Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels. BMC Biochem (2006) 1.62
Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. Mol Cell Biol (2005) 1.61
Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2. Toxicol Appl Pharmacol (2007) 1.60
Context of multiubiquitin chain attachment influences the rate of Sic1 degradation. Mol Cell (2003) 1.57
Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Cancer Lett (2006) 1.57
A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. J Mol Biol (2009) 1.54
Quantitative profiling of ubiquitylated proteins reveals proteasome substrates and the substrate repertoire influenced by the Rpn10 receptor pathway. Mol Cell Proteomics (2007) 1.53
Role of Nrf1 in antioxidant response element-mediated gene expression and beyond. Toxicol Appl Pharmacol (2009) 1.49
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome. Elife (2013) 1.44
Nrf1 is critical for redox balance and survival of liver cells during development. Mol Cell Biol (2003) 1.42
p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition. Elife (2014) 1.37
Mapping phosphorylation sites in proteins by mass spectrometry. Methods Enzymol (2002) 1.32
Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis. J Cell Biol (2009) 1.29
Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation. Mol Cell Proteomics (2003) 1.27
Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Pharm Res (2005) 1.27
Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem (2013) 1.25
The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation. Mol Cell Proteomics (2010) 1.24
Cdc5 influences phosphorylation of Net1 and disassembly of the RENT complex. BMC Mol Biol (2002) 1.24
Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis. Cell Stress Chaperones (2006) 1.23
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. Nat Struct Mol Biol (2012) 1.23
Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones. J Biol Chem (2002) 1.23
Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism. J Biol Chem (2012) 1.22
Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray. Life Sci (2006) 1.22
Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration. Proc Natl Acad Sci U S A (2011) 1.20
Identification and characterization of a Drosophila proteasome regulatory network. Mol Cell Biol (2005) 1.18
In vitro reconstitution of SCF substrate ubiquitination with purified proteins. Methods Enzymol (2005) 1.17
The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription. J Biol Chem (2007) 1.17
Evaluation of a diffusion-driven mechanism for substrate ubiquitination by the SCF-Cdc34 ubiquitin ligase complex. Mol Cell (2006) 1.16
Nrf2 protects against As(III)-induced damage in mouse liver and bladder. Toxicol Appl Pharmacol (2009) 1.14
A conditional yeast E1 mutant blocks the ubiquitin-proteasome pathway and reveals a role for ubiquitin conjugates in targeting Rad23 to the proteasome. Mol Biol Cell (2007) 1.14
Chfr is linked to tumour metastasis through the downregulation of HDAC1. Nat Cell Biol (2009) 1.12
Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1. BMC Biol (2011) 1.12
Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin. Mol Cancer Ther (2006) 1.10
Loss of CDC5 function in Saccharomyces cerevisiae leads to defects in Swe1p regulation and Bfa1p/Bub2p-independent cytokinesis. Genetics (2003) 1.10
Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13. Mol Cell Biol (2003) 1.08
Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner. Free Radic Biol Med (2010) 1.08
Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes. Environ Health Perspect (2010) 1.07
Mutations in the hydrophobic core of ubiquitin differentially affect its recognition by receptor proteins. J Mol Biol (2007) 1.07
Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. Free Radic Biol Med (2011) 1.07
Combined chemical and genetic approach to inhibit proteolysis by the proteasome. Yeast (2010) 1.06
The acidic tail of the Cdc34 ubiquitin-conjugating enzyme functions in both binding to and catalysis with ubiquitin ligase SCFCdc4. J Biol Chem (2009) 1.05
Mass spectrometry-based methods for phosphorylation site mapping of hyperphosphorylated proteins applied to Net1, a regulator of exit from mitosis in yeast. Mol Cell Proteomics (2002) 1.04
Development of p97 AAA ATPase inhibitors. Autophagy (2011) 1.03
Gal4 turnover and transcription activation. Nature (2009) 1.00
Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome. Mol Cell Biol (2010) 0.99
Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice. Toxicol Lett (2006) 0.99
Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice. Pharm Res (2006) 0.99
Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system. J Biol Chem (2011) 0.98
Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice. Physiol Genomics (2009) 0.98
Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells. Acta Pharmacol Sin (2010) 0.96
Drosophila proteasome regulator REGgamma: transcriptional activation by DNA replication-related factor DREF and evidence for a role in cell cycle progression. J Mol Biol (2003) 0.95
Multiple telophase arrest bypassed (tab) mutants alleviate the essential requirement for Cdc15 in exit from mitosis in S. cerevisiae. BMC Genet (2002) 0.95
The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis. J Biol Chem (2011) 0.95
Pharmacogenomic profile of soy isoflavone concentrate in the prostate of Nrf2 deficient and wild-type mice. J Pharm Sci (2008) 0.90
Distinct Nrf1/2-independent mechanisms mediate As 3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes. Free Radic Biol Med (2009) 0.88
Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. BMC Biochem (2008) 0.88
Studies on the role of NonA in mRNA biogenesis. Exp Cell Res (2006) 0.88
Designer reagents for mass spectrometry-based proteomics: clickable cross-linkers for elucidation of protein structures and interactions. Anal Chem (2012) 0.87
The TFIIH subunit Tfb3 regulates cullin neddylation. Mol Cell (2011) 0.87
Emerging role of Nrf2 in adipocytes and adipose biology. Adv Nutr (2013) 0.85