Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin.

PubWeight™: 1.16‹?› | Rank: Top 10%

🔗 View Article (PMC 2268908)

Published in Bioorg Med Chem Lett on January 01, 2008

Authors

Guang Liang1, Xiaokun Li, Li Chen, Shulin Yang, Xudong Wu, Elaine Studer, Emily Gurley, Phillip B Hylemon, Faqing Ye, Yueru Li, Huiping Zhou

Author Affiliations

1: College of Pharmacy, Wenzhou Medical College, Wenzhou, Zhejiang 325035, PR China.

Articles citing this

Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers. Br J Pharmacol (2013) 1.21

Inhibition of LPS-induced production of inflammatory factors in the macrophages by mono-carbonyl analogues of curcumin. J Cell Mol Med (2009) 1.10

Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats. Br J Pharmacol (2012) 1.02

Curcumin-loaded poly(epsilon-caprolactone) nanofibres: diabetic wound dressing with anti-oxidant and anti-inflammatory properties. Clin Exp Pharmacol Physiol (2009) 0.99

Evaluation of a curcumin analog as an anti-cancer agent inducing ER stress-mediated apoptosis in non-small cell lung cancer cells. BMC Cancer (2013) 0.90

Discovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents. Drug Des Devel Ther (2014) 0.90

BDMC33, A curcumin derivative suppresses inflammatory responses in macrophage-like cellular system: role of inhibition in NF-κB and MAPK signaling pathways. Int J Mol Sci (2012) 0.86

A novel compound C12 inhibits inflammatory cytokine production and protects from inflammatory injury in vivo. PLoS One (2011) 0.86

Eliminating the heart from the curcumin molecule: monocarbonyl curcumin mimics (MACs). Molecules (2014) 0.85

Curcumin as a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase 1: improving lipid profiles in high-fat-diet-treated rats. PLoS One (2013) 0.82

Biocomposite nanofibrous strategies for the controlled release of biomolecules for skin tissue regeneration. Int J Nanomedicine (2014) 0.80

Discovery and evaluation of novel anti-inflammatory derivatives of natural bioactive curcumin. Drug Des Devel Ther (2014) 0.80

Antioxidant properties and PC12 cell protective effects of a novel curcumin analogue (2E,6E)-2,6-bis(3,5- dimethoxybenzylidene)cyclohexanone (MCH). Int J Mol Sci (2014) 0.78

EF24 induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in gastric cancer cells. Oncotarget (2016) 0.78

A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis. Sci Rep (2016) 0.78

A novel synthetic mono-carbonyl analogue of curcumin, A13, exhibits anti-inflammatory effects in vivo by inhibition of inflammatory mediators. Inflammation (2012) 0.77

Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-α-induced NF-κB activation. Biomed Res Int (2014) 0.75

(1E,4E)-1,5-Bis(2,4-dimethyl-phen-yl)penta-1,4-dien-3-one. Acta Crystallogr Sect E Struct Rep Online (2009) 0.75

Articles cited by this

Obesity, inflammation, and insulin resistance. Gastroenterology (2007) 7.54

Curcumin: the Indian solid gold. Adv Exp Med Biol (2007) 4.12

Multiple biological activities of curcumin: a short review. Life Sci (2006) 3.96

The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J Lipid Res (2007) 2.15

Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol (2007) 2.05

Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. Br J Cancer (2004) 1.97

Curcumin is an in vivo inhibitor of angiogenesis. Mol Med (1998) 1.81

Anti-inflammatory drugs in the 21st century. Subcell Biochem (2007) 1.78

Pharmacokinetics and pharmacodynamics of curcumin. Adv Exp Med Biol (2007) 1.68

Multiple molecular targets in cancer chemoprevention by curcumin. AAPS J (2006) 1.55

Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer. Mol Cancer Ther (2006) 1.37

Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutr Metab (Lond) (2007) 1.36

Enhancement of wound healing by curcumin in animals. Wound Repair Regen (1999) 1.34

Inflammatory mechanisms of diabetic complications. Curr Diab Rep (2007) 1.32

The role of chemokines and chemokine receptors in mucosal inflammation. Inflamm Bowel Dis (2000) 1.27

HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuR. Atherosclerosis (2007) 1.24

Inhibition of tumor necrosis factor by curcumin, a phytochemical. Biochem Pharmacol (1995) 1.23

Metabolic syndrome, inflammation and atherosclerosis. Vasc Health Risk Manag (2006) 1.23

Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets. Int J Mol Med (2007) 1.22

Regulation of COX and LOX by curcumin. Adv Exp Med Biol (2007) 1.17

Therapeutic potential and strategies for inhibiting tumor necrosis factor-alpha. J Med Chem (1999) 1.12

Turmeric--chemistry, technology, and quality. Crit Rev Food Sci Nutr (1980) 1.08

Activation of NFkappaB is inhibited by curcumin and related enones. Bioorg Med Chem (2005) 1.05

Immunomodulation by curcumin. Adv Exp Med Biol (2007) 1.00

Inflammation and disease progression. Cancer Metastasis Rev (2006) 1.00

Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (COX-1) inhibitors. Chem Pharm Bull (Tokyo) (2007) 0.98

Articles by these authors

Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02

Prevalence of diabetes among men and women in China. N Engl J Med (2010) 19.98

Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature (2012) 15.91

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

The Protein Data Bank and structural genomics. Nucleic Acids Res (2003) 8.34

The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema. Nucleic Acids Res (2005) 7.81

The distribution and query systems of the RCSB Protein Data Bank. Nucleic Acids Res (2004) 7.03

Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer. Nat Med (2009) 6.61

The RCSB PDB information portal for structural genomics. Nucleic Acids Res (2006) 6.36

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31

Bile salt biotransformations by human intestinal bacteria. J Lipid Res (2005) 6.00

Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature (2002) 5.54

The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30

Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci U S A (2006) 5.16

An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China. J Clin Virol (2009) 4.62

Tools for the automatic identification and classification of RNA base pairs. Nucleic Acids Res (2003) 4.12

Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08

The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology (2009) 3.48

Deep RNA sequencing at single base-pair resolution reveals high complexity of the rice transcriptome. Genome Res (2010) 3.34

Bile acids as regulatory molecules. J Lipid Res (2009) 3.23

Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature (2011) 3.19

Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet (2010) 3.15

A comparison of three highly active antiretroviral treatment strategies consisting of non-nucleoside reverse transcriptase inhibitors, protease inhibitors, or both in the presence of nucleoside reverse transcriptase inhibitors as initial therapy (CPCRA 058 FIRST Study): a long-term randomised trial. Lancet (2006) 3.10

Gene dosage of the common variant 9p21 predicts severity of coronary artery disease. J Am Coll Cardiol (2010) 3.07

Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification. Neuron (2008) 2.98

Foodborne transmission of Nipah virus, Bangladesh. Emerg Infect Dis (2006) 2.85

Potential clinical and economic consequences of noncardiac incidental findings on cardiac computed tomography. J Am Coll Cardiol (2009) 2.76

Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. Cancer Discov (2014) 2.64

Ambient air pollution, birth weight and preterm birth: a systematic review and meta-analysis. Environ Res (2012) 2.63

Darbepoetin alpha for the treatment of anemia in patients with active cancer not receiving chemotherapy or radiotherapy: results of a phase III, multicenter, randomized, double-blind, placebo-controlled study. J Clin Oncol (2008) 2.60

Prevalence of cardiovascular disease risk factor in the Chinese population: the 2007-2008 China National Diabetes and Metabolic Disorders Study. Eur Heart J (2011) 2.57

Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation (2006) 2.50

Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab (2013) 2.49

Horizontal transfer of an adaptive chimeric photoreceptor from bryophytes to ferns. Proc Natl Acad Sci U S A (2014) 2.42

Prostaglandin catabolizing enzymes. Prostaglandins Other Lipid Mediat (2002) 2.36

Linkage of gut microbiome with cognition in hepatic encephalopathy. Am J Physiol Gastrointest Liver Physiol (2011) 2.23

Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy. J Am Coll Cardiol (2006) 2.21

Prognostic value of 64-slice cardiac computed tomography severity of coronary artery disease, coronary atherosclerosis, and left ventricular ejection fraction. J Am Coll Cardiol (2010) 2.21

Ligand Depot: a data warehouse for ligands bound to macromolecules. Bioinformatics (2004) 2.21

Evaluation and discovery of novel synthetic chalcone derivatives as anti-inflammatory agents. J Med Chem (2011) 2.18

Diagnostic accuracy and impact of computed tomographic coronary angiography on utilization of invasive coronary angiography. Circ Cardiovasc Imaging (2009) 2.16

Molecular evidence of persistent epidemic and evolution of subgenotype B1 coxsackievirus A16-associated hand, foot, and mouth disease in China. J Clin Microbiol (2009) 2.11

Prognostic value of CT angiography in coronary bypass patients. JACC Cardiovasc Imaging (2011) 2.10

Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation (2008) 2.09

The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Exp Diabetes Res (2009) 2.08

Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature. J Clin Gastroenterol (2005) 2.08

Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents. Bioorg Med Chem (2008) 2.03

Crop diversity for yield increase. PLoS One (2009) 2.02

Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis. Gastroenterology (2008) 1.99

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med (2012) 1.99

Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation. Am J Physiol Gastrointest Liver Physiol (2012) 1.98

Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell Metab (2012) 1.97

The locus of fixation and the foveal cone mosaic. J Vis (2005) 1.96

Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart. J Am Coll Cardiol (2008) 1.95

Prevalence of ideal cardiovascular health and its relationship with the 4-year cardiovascular events in a northern Chinese industrial city. Circ Cardiovasc Qual Outcomes (2012) 1.93

Incremental prognostic value of cardiac computed tomography in coronary artery disease using CONFIRM: COroNary computed tomography angiography evaluation for clinical outcomes: an InteRnational Multicenter registry. Circ Cardiovasc Imaging (2011) 1.89

Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Hepatology (2002) 1.85

Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo. Diabetes (2011) 1.84

Acute effects of air pollution on pulmonary function, airway inflammation, and oxidative stress in asthmatic children. Environ Health Perspect (2008) 1.83

Bipolar resistance switching characteristics with opposite polarity of Au/SrTiO3/Ti memory cells. Nanoscale Res Lett (2011) 1.82

Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: a double-blind, randomized, placebo-controlled study in healthy male volunteers. Clin Ther (2006) 1.82

Plant-symbiotic fungi as chemical engineers: multi-genome analysis of the clavicipitaceae reveals dynamics of alkaloid loci. PLoS Genet (2013) 1.81

Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression. Hepatology (2015) 1.81

Questionable value of planting thirsty trees in dry regions. Nature (2010) 1.81

Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2. Hepatology (2014) 1.76

Proteasome-mediated degradation of cotranslationally damaged proteins involves translation elongation factor 1A. Mol Cell Biol (2005) 1.74

Synthesis of mono-carbonyl analogues of curcumin and their effects on inhibition of cytokine release in LPS-stimulated RAW 264.7 macrophages. Bioorg Med Chem (2010) 1.73

An integrated transcriptomic and computational analysis for biomarker identification in gastric cancer. Nucleic Acids Res (2010) 1.73

Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. Cancer Res (2012) 1.71

Can differences in corrected coronary opacification measured with computed tomography predict resting coronary artery flow? J Am Coll Cardiol (2011) 1.70

mirTools: microRNA profiling and discovery based on high-throughput sequencing. Nucleic Acids Res (2010) 1.70

Heart valve prosthesis selection in patients with end-stage renal disease requiring dialysis: a systematic review and meta-analysis. Heart (2011) 1.70

Disharmony between society and environmental carrying capacity: a historical review, with an emphasis on China. Ambio (2007) 1.68

A novel superhydrophilic and underwater superoleophobic hydrogel-coated mesh for oil/water separation. Adv Mater (2011) 1.67

Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell Res (2010) 1.67

Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. J Hepatol (2013) 1.66

Type 2 vaccine-derived poliovirus from patients with acute flaccid paralysis in china: current immunization strategy effectively prevented its sustained transmission. J Infect Dis (2010) 1.65

Kinesin family member 6 variant Trp719Arg does not associate with angiographically defined coronary artery disease in the Ottawa Heart Genomics Study. J Am Coll Cardiol (2009) 1.64

Resveratrol attenuates ventricular arrhythmias and improves the long-term survival in rats with myocardial infarction. Cardiovasc Drugs Ther (2008) 1.63

Smartphone versus pen-and-paper data collection of infant feeding practices in rural China. J Med Internet Res (2012) 1.62

Midregional pro-adrenomedullin as a predictor for therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome. J Am Coll Cardiol (2012) 1.61

Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer. Nature (2014) 1.60

The PP2A inhibitor SET regulates granzyme B expression in human natural killer cells. Blood (2010) 1.60

Outdoor air pollution and emergency department visits for asthma among children and adults: a case-crossover study in northern Alberta, Canada. Environ Health (2007) 1.55

Network meta-analysis of prasugrel, ticagrelor, high- and standard-dose clopidogrel in patients scheduled for percutaneous coronary interventions. Thromb Haemost (2012) 1.54

Neural compensation for the eye's optical aberrations. J Vis (2004) 1.53

The effects of continuous positive airway pressure on myocardial energetics in patients with heart failure and obstructive sleep apnea. J Am Coll Cardiol (2007) 1.53

What is the prognostic value of myocardial perfusion imaging using rubidium-82 positron emission tomography? J Am Coll Cardiol (2006) 1.52

Cardiac complications in patients with community-acquired pneumonia: incidence, timing, risk factors, and association with short-term mortality. Circulation (2012) 1.52

Global functional analyses of cellular responses to pore-forming toxins. PLoS Pathog (2011) 1.52

Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy. PLoS One (2013) 1.51

Associations between outdoor air pollution and emergency department visits for stroke in Edmonton, Canada. Eur J Epidemiol (2006) 1.51

Attenuation of diabetes-induced renal dysfunction by multiple exposures to low-dose radiation is associated with the suppression of systemic and renal inflammation. Am J Physiol Endocrinol Metab (2009) 1.51