Published in Invest Ophthalmol Vis Sci on February 01, 2008
Desiccating stress induces CD4+ T-cell-mediated Sjögren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-γ. Am J Pathol (2011) 1.07
Entrapment of conjunctival goblet cells by desiccation-induced cornification. Invest Ophthalmol Vis Sci (2011) 1.03
Spdef null mice lack conjunctival goblet cells and provide a model of dry eye. Am J Pathol (2013) 0.95
Molecular mechanism of proinflammatory cytokine-mediated squamous metaplasia in human corneal epithelial cells. Invest Ophthalmol Vis Sci (2009) 0.94
Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. Arch Ophthalmol (2009) 0.92
Dynamics and function of the tear film in relation to the blink cycle. Prog Retin Eye Res (2014) 0.91
Hyperosmolar Tears Induce Functional and Structural Alterations of Corneal Nerves: Electrophysiological and Anatomical Evidence Toward Neurotoxicity. Invest Ophthalmol Vis Sci (2015) 0.90
Hyperosmotic stress-induced corneal epithelial cell death through activation of Polo-like kinase 3 and c-Jun. Invest Ophthalmol Vis Sci (2011) 0.89
DUSP5 and DUSP6 modulate corneal epithelial cell proliferation. Mol Vis (2010) 0.88
Influence of sex on gene expression in human corneal epithelial cells. Mol Vis (2009) 0.88
Tissue transglutaminase is a negative regulator of monomeric lacritin bioactivity. Invest Ophthalmol Vis Sci (2013) 0.87
Hyperosmolarity potentiates toxic effects of benzalkonium chloride on conjunctival epithelial cells in vitro. Mol Vis (2012) 0.87
Quantitative analysis of tear film fluorescence and discomfort during tear film instability and thinning. Invest Ophthalmol Vis Sci (2013) 0.87
Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction. Br J Ophthalmol (2016) 0.85
Effects of L-carnitine, erythritol and betaine on pro-inflammatory markers in primary human corneal epithelial cells exposed to hyperosmotic stress. Curr Eye Res (2014) 0.84
Differential effects of hepatocyte growth factor and keratinocyte growth factor on corneal epithelial cell cycle protein expression, cell survival, and growth. Mol Vis (2014) 0.82
Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease. Invest Ophthalmol Vis Sci (2014) 0.80
Heightened expression of MICA enhances the cytotoxicity of NK cells or CD8+T cells to human corneal epithelium in vitro. BMC Ophthalmol (2012) 0.80
17-β-estradiol inhibits hyperosmolarity-induced proinflammatory cytokine elevation via the p38 MAPK pathway in human corneal epithelial cells. Mol Vis (2012) 0.77
Lacritin and other autophagy associated proteins in ocular surface health. Exp Eye Res (2015) 0.77
Differential contribution of hypertonic electrolytes to corneal epithelial dysfunction. Exp Eye Res (2012) 0.77
Effects of osmolarity on human epithelial conjunctival cells using an electrical technique. Graefes Arch Clin Exp Ophthalmol (2011) 0.76
Magainin 2 induces bacterial cell death showing apoptotic properties. Curr Microbiol (2014) 0.76
In Vitro Inhibition of NFAT5-Mediated Induction of CCL2 in Hyperosmotic Conditions by Cyclosporine and Dexamethasone on Human HeLa-Modified Conjunctiva-Derived Cells. PLoS One (2016) 0.75
An Antifungal Mechanism of Protolichesterinic Acid from the Lichen Usnea albopunctata Lies in the Accumulation of Intracellular ROS and Mitochondria-Mediated Cell Death Due to Apoptosis in Candida tropicalis. Front Pharmacol (2017) 0.75
The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research. Ophthalmology (2017) 0.75
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci (2004) 3.22
Dysfunctional tear syndrome: a Delphi approach to treatment recommendations. Cornea (2006) 3.18
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95
Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells (2004) 2.73
The incidence and risk factors for developing dry eye after myopic LASIK. Am J Ophthalmol (2006) 2.58
Tear cytokine profiles in dysfunctional tear syndrome. Am J Ophthalmol (2008) 2.37
Desiccating stress induces T cell-mediated Sjögren's Syndrome-like lacrimal keratoconjunctivitis. J Immunol (2006) 2.33
Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res (2006) 2.27
Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity. Proc Natl Acad Sci U S A (2003) 2.24
Atropine for the treatment of childhood myopia. Ophthalmology (2006) 2.17
Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass. J Biol Chem (2002) 2.12
Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci (2007) 2.09
Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures. Exp Eye Res (2004) 2.02
Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol (2005) 1.96
Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Invest Ophthalmol Vis Sci (2004) 1.95
ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells. Stem Cells (2005) 1.95
Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol Endocrinol (2003) 1.93
Topical ophthalmic cyclosporine: pharmacology and clinical uses. Surv Ophthalmol (2009) 1.91
The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res (2004) 1.88
On Trk--the TrkB signal transduction pathway is an increasingly important target in cancer biology. Clin Cancer Res (2009) 1.88
Incidence and progression of myopia in Singaporean school children. Invest Ophthalmol Vis Sci (2005) 1.88
Dry eye as a mucosal autoimmune disease. Int Rev Immunol (2013) 1.85
Current strategy for the treatment of symptomatic spontaneous isolated dissection of superior mesenteric artery. J Vasc Surg (2011) 1.79
Assessing the severity of keratitis sicca with videokeratoscopic indices. Ophthalmology (2003) 1.78
Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Invest Ophthalmol Vis Sci (2007) 1.78
JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells. Exp Eye Res (2005) 1.76
Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Invest Ophthalmol Vis Sci (2009) 1.75
A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci (2002) 1.73
Apoptosis of ocular surface cells in experimentally induced dry eye. Invest Ophthalmol Vis Sci (2003) 1.72
Myopia-related optic disc and retinal changes in adolescent children from singapore. Ophthalmology (2011) 1.68
Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye Contact Lens (2005) 1.67
Minimal clinically important difference for the ocular surface disease index. Arch Ophthalmol (2010) 1.67
Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. Invest Ophthalmol Vis Sci (2006) 1.63
Distribution and determinants of ocular biometric parameters in an Asian population: the Singapore Malay eye study. Invest Ophthalmol Vis Sci (2009) 1.62
The international workshop on meibomian gland dysfunction: report of the subcommittee on the epidemiology of, and associated risk factors for, MGD. Invest Ophthalmol Vis Sci (2011) 1.49
Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Invest Ophthalmol Vis Sci (2006) 1.46
Recombinant human tumor necrosis factor receptor Fc fusion protein (Etanercept): experience as a therapy for sight-threatening scleritis and sterile corneal ulceration. Eye Contact Lens (2004) 1.46
EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR. Cancer Res (2011) 1.46
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc Natl Acad Sci U S A (2007) 1.38
Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics. J Proteome Res (2009) 1.36
Inflammation in dry eye. Ocul Surf (2004) 1.35
pFind 2.0: a software package for peptide and protein identification via tandem mass spectrometry. Rapid Commun Mass Spectrom (2007) 1.34
Cell size correlates with phenotype and proliferative capacity in human corneal epithelial cells. Stem Cells (2005) 1.34
Doxycycline inhibits TGF-beta1-induced MMP-9 via Smad and MAPK pathways in human corneal epithelial cells. Invest Ophthalmol Vis Sci (2005) 1.33
Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca. Cornea (2005) 1.31
Strain-related cytokine profiles on the murine ocular surface in response to desiccating stress. Cornea (2007) 1.31
Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest Ophthalmol Vis Sci (2010) 1.29
Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways. Cornea (2007) 1.29
In vivo confocal microscopy of the ocular surface: from bench to bedside. Curr Eye Res (2013) 1.27
Epithelial-immune cell interaction in dry eye. Cornea (2008) 1.27
Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford) (2009) 1.26
Cornea biomechanical characteristics and their correlates with refractive error in Singaporean children. Invest Ophthalmol Vis Sci (2008) 1.25
Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells. Stem Cells (2006) 1.23
β-Adrenergic system, a backstage manipulator regulating tumour progression and drug target in cancer therapy. Semin Cancer Biol (2013) 1.22
Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation. Am J Ophthalmol (2004) 1.20
Regulated expression of collagenases MMP-1, -8, and -13 and stromelysins MMP-3, -10, and -11 by human corneal epithelial cells. Invest Ophthalmol Vis Sci (2003) 1.20
Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis. Clin Infect Dis (2005) 1.20
Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci (2003) 1.20
Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. Invest Ophthalmol Vis Sci (2009) 1.20
Overexpression of Insulin-like growth factor-binding protein-2 in pterygium body fibroblasts. Invest Ophthalmol Vis Sci (2003) 1.18
Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo. Oncotarget (2013) 1.17
Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. J Allergy Clin Immunol (2011) 1.17
Meibum lipid composition in Asians with dry eye disease. PLoS One (2011) 1.16
Sequencing by Cyclic Ligation and Cleavage (CycLiC) directly on a microarray captured template. Nucleic Acids Res (2008) 1.16
Phase III safety evaluation of cyclosporine 0.1% ophthalmic emulsion administered twice daily to dry eye disease patients for up to 3 years. Ophthalmology (2005) 1.15
Therapy of progressive rheumatoid arthritis-associated corneal ulceration with infliximab. Cornea (2005) 1.15
Anterior segment optical coherence tomography: a diagnostic instrument for conjunctivochalasis. Am J Ophthalmol (2010) 1.13
TGF-beta1 stimulates production of gelatinase (MMP-9), collagenases (MMP-1, -13) and stromelysins (MMP-3, -10, -11) by human corneal epithelial cells. Exp Eye Res (2004) 1.12