| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs.
|
Pharm Res
|
2002
|
1.37
|
|
2
|
Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.
|
Pharm Res
|
2006
|
1.26
|
|
3
|
Characterization of a stem cell population in lung cancer A549 cells.
|
Biochem Biophys Res Commun
|
2008
|
1.22
|
|
4
|
Amino acid ester prodrugs of the anticancer agent gemcitabine: synthesis, bioconversion, metabolic bioevasion, and hPEPT1-mediated transport.
|
Mol Pharm
|
2005
|
1.21
|
|
5
|
The role of TRPV6 in breast carcinogenesis.
|
Mol Cancer Ther
|
2008
|
1.10
|
|
6
|
Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis.
|
Pharm Res
|
2003
|
1.00
|
|
7
|
Comparative gene expression profiles of intestinal transporters in mice, rats and humans.
|
Pharmacol Res
|
2007
|
0.98
|
|
8
|
Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport.
|
J Bone Miner Res
|
2008
|
0.93
|
|
9
|
Mechanisms and regulation of epithelial Ca2+ absorption in health and disease.
|
Annu Rev Physiol
|
2008
|
0.92
|
|
10
|
A novel high-throughput pepT1 transporter assay differentiates between substrates and antagonists.
|
Mol Pharm
|
2004
|
0.92
|
|
11
|
Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters.
|
Molecules
|
2008
|
0.92
|
|
12
|
Permeability dominates in vivo intestinal absorption of P-gp substrate with high solubility and high permeability.
|
Mol Pharm
|
2005
|
0.91
|
|
13
|
Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells.
|
Mol Cancer Res
|
2009
|
0.89
|
|
14
|
Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo.
|
J Pharmacol Exp Ther
|
2005
|
0.87
|
|
15
|
N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole.
|
Drug Metab Dispos
|
2006
|
0.81
|
|
16
|
Interferon-gamma increases expression of the di/tri-peptide transporter, h-PEPT1, and dipeptide transport in cultured human intestinal monolayers.
|
Pharmacol Res
|
2008
|
0.80
|
|
17
|
Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum.
|
Biochem Biophys Res Commun
|
2003
|
0.78
|
|
18
|
Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs.
|
Mol Pharm
|
2005
|
0.76
|
|
19
|
Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers.
|
Mol Pharm
|
2014
|
0.75
|
|
20
|
Proline prodrug of melphalan, prophalan-L, demonstrates high therapeutic index in a murine melanoma model.
|
Eur J Pharm Biopharm
|
2007
|
0.75
|