Published in Mol Cancer Ther on February 01, 2008
Calcium channels and pumps in cancer: changes and consequences. J Biol Chem (2012) 1.49
The role of the TRPV6 channel in cancer. J Physiol (2012) 1.14
The Discovery of Novel Biomarkers Improves Breast Cancer Intrinsic Subtype Prediction and Reconciles the Labels in the METABRIC Data Set. PLoS One (2015) 1.06
Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy. Cancer Cell Int (2009) 0.97
Calcium influx pathways in breast cancer: opportunities for pharmacological intervention. Br J Pharmacol (2014) 0.96
Estrogen regulation of TRPM8 expression in breast cancer cells. BMC Cancer (2010) 0.92
Suppression of aberrant transient receptor potential cation channel, subfamily V, member 6 expression in hyperproliferative colonic crypts by dietary calcium. Am J Physiol Gastrointest Liver Physiol (2010) 0.90
In vivo detection of human TRPV6-rich tumors with anti-cancer peptides derived from soricidin. PLoS One (2013) 0.87
The progesterone receptor regulates the expression of TRPV4 channel. Pflugers Arch (2009) 0.87
Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. Cell Death Differ (2013) 0.84
Kv3.4 potassium channel-mediated electrosignaling controls cell cycle and survival of irradiated leukemia cells. Pflugers Arch (2013) 0.84
Emerging roles of Orai3 in pathophysiology. Channels (Austin) (2013) 0.84
Cellular calcium dynamics in lactation and breast cancer: from physiology to pathology. Am J Physiol Cell Physiol (2013) 0.84
Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway. Apoptosis (2014) 0.83
Accelerated suicidal erythrocyte death in Klotho-deficient mice. Pflugers Arch (2009) 0.83
Role of TRP ion channels in cancer and tumorigenesis. Semin Immunopathol (2016) 0.79
Lidocaine inhibits the invasion and migration of TRPV6-expressing cancer cells by TRPV6 downregulation. Oncol Lett (2016) 0.77
Identification and characterization of a vitamin D₃ decomposition product bactericidal against Helicobacter pylori. Sci Rep (2015) 0.77
The in vivo TRPV6 protein starts at a non-AUG triplet, decoded as methionine, upstream of canonical initiation at AUG. J Biol Chem (2013) 0.77
TRPV6 plays a new role in predicting survival of patients with esophageal squamous cell carcinoma. Diagn Pathol (2016) 0.76
The calcium-cancer signalling nexus. Nat Rev Cancer (2017) 0.75
First-in-human phase I study of SOR-C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors. Invest New Drugs (2017) 0.75
TRPV6 modulates proliferation of human pancreatic neuroendocrine BON-1 tumour cells. Biosci Rep (2016) 0.75
Transient silencing of DNA repair genes improves targeted gene integration in the filamentous fungus Trichoderma reesei. Appl Environ Microbiol (2017) 0.75
Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. Am J Hum Genet (2006) 2.96
The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects. Pflugers Arch (2003) 1.75
Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res (2007) 1.56
The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. J Clin Invest (2003) 1.53
Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes. Pflugers Arch (2005) 1.46
Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1). Biochem J (2007) 1.38
Calcium transporter 1 and epithelial calcium channel messenger ribonucleic acid are differentially regulated by 1,25 dihydroxyvitamin D3 in the intestine and kidney of mice. Endocrinology (2003) 1.37
Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs. Pharm Res (2002) 1.37
The glutamate and neutral amino acid transporter family: physiological and pharmacological implications. Eur J Pharmacol (2003) 1.33
Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications. Mol Aspects Med (2013) 1.33
Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab Invest (2002) 1.30
Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model. Pharm Res (2006) 1.26
Characterization of a stem cell population in lung cancer A549 cells. Biochem Biophys Res Commun (2008) 1.22
Amino acid ester prodrugs of the anticancer agent gemcitabine: synthesis, bioconversion, metabolic bioevasion, and hPEPT1-mediated transport. Mol Pharm (2005) 1.21
Sodium-dependent ascorbic acid transporter family SLC23. Pflugers Arch (2003) 1.20
Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons. J Biol Chem (2003) 1.17
CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells. J Physiol (2004) 1.14
The SLC14 gene family of urea transporters. Pflugers Arch (2003) 1.12
Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino. J Biol Chem (2005) 1.09
New view at C. Nat Med (2002) 1.09
Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain. Biochem Biophys Res Commun (2005) 1.08
SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1. Pflugers Arch (2003) 1.06
The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med (2013) 1.05
Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond. J Physiol (2003) 1.02
Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis. Pharm Res (2003) 1.00
Comparative gene expression profiles of intestinal transporters in mice, rats and humans. Pharmacol Res (2007) 0.98
Mammalian iron transporters: families SLC11 and SLC40. Mol Aspects Med (2013) 0.96
Distribution of the glutamate transporters GLT-1 (SLC1A2) and GLAST (SLC1A3) in peripheral organs. Anat Embryol (Berl) (2006) 0.96
The urea transporter family (SLC14): physiological, pathological and structural aspects. Mol Aspects Med (2013) 0.94
The sodium-dependent ascorbic acid transporter family SLC23. Mol Aspects Med (2013) 0.94
Effect of middle cerebral artery occlusion on mRNA expression for the sodium-coupled vitamin C transporter SVCT2 in rat brain. J Neurochem (2003) 0.94
Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport. J Bone Miner Res (2008) 0.93
Intestinal expression of genes involved in iron absorption in humans. Am J Physiol Gastrointest Liver Physiol (2002) 0.93
Kidney function: gateway to a long life? Nature (2002) 0.93
Mechanisms and regulation of epithelial Ca2+ absorption in health and disease. Annu Rev Physiol (2008) 0.92
Iron transport: emerging roles in health and disease. Biochem Cell Biol (2002) 0.92
A novel high-throughput pepT1 transporter assay differentiates between substrates and antagonists. Mol Pharm (2004) 0.92
Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters. Molecules (2008) 0.92
Permeability dominates in vivo intestinal absorption of P-gp substrate with high solubility and high permeability. Mol Pharm (2005) 0.91
Gain-of-function haplotype in the epithelial calcium channel TRPV6 is a risk factor for renal calcium stone formation. Hum Mol Genet (2008) 0.91
Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells. Mol Cancer Res (2009) 0.89
Inhibition of the human epithelial calcium channel TRPV6 by 2-aminoethoxydiphenyl borate (2-APB). Cell Calcium (2012) 0.88
Apical entry channels in calcium-transporting epithelia. News Physiol Sci (2003) 0.87
Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo. J Pharmacol Exp Ther (2005) 0.87
Tissue-engineered neomucosa: morphology, enterocyte dynamics, and SGLT1 expression topography. Transplantation (2003) 0.86
Functional and physiological role of vitamin C transporters. Curr Top Membr (2012) 0.85
Nutrient transport in the mammary gland: calcium, trace minerals and water soluble vitamins. J Mammary Gland Biol Neoplasia (2014) 0.84
A family of calcium-permeable channels in the kidney: distinct roles in renal calcium handling. Curr Opin Nephrol Hypertens (2002) 0.83
Frog oocytes to unveil the structure and supramolecular organization of human transport proteins. PLoS One (2011) 0.83
Transport model of the human Na+-coupled L-ascorbic acid (vitamin C) transporter SVCT1. Am J Physiol Cell Physiol (2007) 0.83
Heavy metal cations permeate the TRPV6 epithelial cation channel. Cell Calcium (2010) 0.82
N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole. Drug Metab Dispos (2006) 0.81
Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity. Cell Calcium (2013) 0.81
Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. J Biol Chem (2011) 0.81
Interferon-gamma increases expression of the di/tri-peptide transporter, h-PEPT1, and dipeptide transport in cultured human intestinal monolayers. Pharmacol Res (2008) 0.80
Solute carriers (SLCs) in cancer. Mol Aspects Med (2013) 0.79
Investigation of the inhibitory effects of the benzodiazepine derivative, 5-BDBD on P2X4 purinergic receptors by two complementary methods. Cell Physiol Biochem (2013) 0.79
Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. Biochem Biophys Res Commun (2003) 0.78
Chemical inhibitors of the calcium entry channel TRPV6. Pharm Res (2010) 0.77
Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs. Mol Pharm (2005) 0.76
K+ amino acid transporter KAAT1 mutant Y147F has increased transport activity and altered substrate selectivity. J Exp Biol (2003) 0.76
Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. Bioorg Med Chem (2013) 0.75
Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers. Mol Pharm (2014) 0.75
Channels and transporters. Mini-symposium of the Division of Medicinal Chemistry (DMC) of the Swiss Chemical Society (SCS) at the Department of Chemistry, University of Basel, May 27, 2010. Chimia (Aarau) (2010) 0.75
Proline prodrug of melphalan, prophalan-L, demonstrates high therapeutic index in a murine melanoma model. Eur J Pharm Biopharm (2007) 0.75