Published in J Biomed Sci on February 06, 2008
High dosage of Exendin-4 increased early insulin secretion in differentiated beta cells from mouse embryonic stem cells. Acta Pharmacol Sin (2010) 0.81
Stages based molecular mechanisms for generating cholangiocytes from liver stem/progenitor cells. World J Gastroenterol (2013) 0.75
Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells. PLoS One (2015) 0.75
Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension (2006) 11.68
Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity. J Virol (2002) 5.82
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest (2003) 5.32
Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med (2002) 5.15
Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006. Am J Med (2009) 4.53
Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes (2008) 4.50
Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clin Chem (2006) 3.44
Persistently increased acetaminophen concentrations in a patient with acute liver failure. Clin Chem (2011) 2.76
Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proc Natl Acad Sci U S A (2005) 2.63
Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin Chem (2006) 2.63
Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004. Ann Epidemiol (2008) 2.63
Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab (2013) 2.49
Identification of novel porcine and bovine parvoviruses closely related to human parvovirus 4. J Gen Virol (2008) 2.41
Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy. J Am Coll Cardiol (2006) 2.37
Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation (2007) 2.29
Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J Biol Chem (2005) 2.28
Post-translational modifications of adiponectin: mechanisms and functional implications. Biochem J (2008) 2.27
Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study. Hypertension (2007) 2.23
Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes (2007) 2.08
Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice. Endocrinology (2003) 2.02
Obstructive sleep apnea and the metabolic syndrome in community-based Chinese adults in Hong Kong. Respir Med (2005) 1.92
Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. J Biol Chem (2005) 1.92
Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease. Hepatology (2009) 1.91
Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort. Diabetes Care (2007) 1.88
Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice. Hepatology (2014) 1.80
Contribution of polyol pathway to diabetes-induced oxidative stress. J Am Soc Nephrol (2003) 1.79
Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention. Clin Sci (Lond) (2008) 1.77
Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. Cancer Res (2006) 1.75
The structure and pharmacological functions of coumarins and their derivatives. Curr Med Chem (2009) 1.74
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes (2010) 1.71
Characterization of genome integrity for oversized recombinant AAV vector. Mol Ther (2009) 1.71
Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2). Am J Hypertens (2008) 1.69
Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling. J Immunol (2010) 1.67
Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex. J Biol Chem (2006) 1.64
Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1. Blood (2003) 1.62
Reduction of C-reactive protein with isoflavone supplement reverses endothelial dysfunction in patients with ischaemic stroke. Eur Heart J (2008) 1.55
Generation and characterization of chimeric recombinant AAV vectors. Mol Ther (2003) 1.54
Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity. J Biol Chem (2012) 1.53
Habitual physical activity is associated with endothelial function and endothelial progenitor cells in patients with stable coronary artery disease. Eur J Cardiovasc Prev Rehabil (2009) 1.51
Aryl Hydrocarbon Receptor Activation Down-Regulates IL-7 and Reduces Inflammation in a Mouse Model of DSS-Induced Colitis. Dig Dis Sci (2015) 1.50
Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension. Hypertension (2008) 1.49
Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. Biochem Biophys Res Commun (2006) 1.48
A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proc Natl Acad Sci U S A (2008) 1.48
Potential uses of microRNA in lung cancer diagnosis, prognosis, and therapy. Curr Cancer Drug Targets (2009) 1.46
Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives. Clin Endocrinol (Oxf) (2013) 1.44
Development of diabetes in Chinese with the metabolic syndrome: a 6-year prospective study. Diabetes Care (2007) 1.43
Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans. Clin Chem (2011) 1.42
Adiponectin and cardiovascular health: an update. Br J Pharmacol (2012) 1.42
Thyroid arsenic content and papillary thyroid carcinoma arising 10 years after oral arsenic trioxide therapy for refractory acute promyelocytic leukemia. Leuk Lymphoma (2013) 1.41
Prevalence, awareness, treatment, and control of hypertension: United States National Health and Nutrition Examination Survey 2001-2002. J Clin Hypertens (Greenwich) (2006) 1.41
A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure. J Am Coll Cardiol (2010) 1.40
Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes. Atherosclerosis (2012) 1.39
APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice. Cell Metab (2009) 1.36
Xanthomonas T3S Effector XopN Suppresses PAMP-Triggered Immunity and Interacts with a Tomato Atypical Receptor-Like Kinase and TFT1. Plant Cell (2009) 1.33
HDL dysfunction in obstructive sleep apnea. Atherosclerosis (2005) 1.33
Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins. Proteomics (2009) 1.31
Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population. J Clin Endocrinol Metab (2010) 1.29
Characterization of tissue tropism determinants of adeno-associated virus type 1. J Virol (2003) 1.29
Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1. J Biol Chem (2010) 1.28
Diagnosis and spectrum of melamine-related renal disease: plausible mechanism of stone formation in humans. Clin Chim Acta (2009) 1.27
Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4. Arterioscler Thromb Vasc Biol (2008) 1.27
Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice. Diabetes (2011) 1.26
Impact of obesity and body fat distribution on cardiovascular risk factors in Hong Kong Chinese. Obes Res (2004) 1.26
RAR1, a central player in plant immunity, is targeted by Pseudomonas syringae effector AvrB. Proc Natl Acad Sci U S A (2006) 1.26
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes (2013) 1.25
Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. J Clin Endocrinol Metab (2011) 1.25
Osmotic response element-binding protein (OREBP) is an essential regulator of the urine concentrating mechanism. J Biol Chem (2004) 1.23
Advanced glycation end products and endothelial dysfunction in type 2 diabetes. Diabetes Care (2002) 1.22
Determinants of cerebrospinal fluid arsenic concentration in patients with acute promyelocytic leukemia on oral arsenic trioxide therapy. Blood (2008) 1.20
Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice. J Biol Chem (2010) 1.20
Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice. J Biol Chem (2009) 1.20
Improved hepatic gene transfer by using an adeno-associated virus serotype 5 vector. J Virol (2002) 1.19
Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension (2012) 1.18
Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardiovasc Res (2009) 1.17
Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. Eur J Endocrinol (2010) 1.17
Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients. Diabetes Care (2008) 1.17
Total thyroidectomy replaces subtotal thyroidectomy as the preferred surgical treatment for Graves' disease. ANZ J Surg (2005) 1.17
Intracellular viral processing, not single-stranded DNA accumulation, is crucial for recombinant adeno-associated virus transduction. J Virol (2004) 1.17
Overexpression of soluble TRAIL induces apoptosis in human lung adenocarcinoma and inhibits growth of tumor xenografts in nude mice. Cancer Res (2005) 1.15
Renin angiotensin aldosterone system blockade and renal disease in patients with type 2 diabetes. An Asian perspective from the RENAAL Study. Diabetes Care (2004) 1.15
Diabetes gene therapy: potential and challenges. Curr Gene Ther (2003) 1.15
Complete correction of hemophilia A with adeno-associated viral vectors containing a full-size expression cassette. Hum Gene Ther (2008) 1.13
Loss of enteral nutrition in a mouse model results in intestinal epithelial barrier dysfunction. Ann N Y Acad Sci (2012) 1.13
Existence of transient functional double-stranded DNA intermediates during recombinant AAV transduction. Proc Natl Acad Sci U S A (2007) 1.12
Antiangiogenic therapy enhances the efficacy of transcatheter arterial embolization for hepatocellular carcinomas. Int J Cancer (2007) 1.12
Tracking cell surface GABAB receptors using an alpha-bungarotoxin tag. J Biol Chem (2008) 1.12
A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization. J Biol Chem (2009) 1.12
Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy. Curr Genomics (2009) 1.11
Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption. Mol Cell Biol (2007) 1.11
Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice. Gut (2012) 1.10
Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities. PLoS One (2009) 1.10
High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects. Diabetes Care (2011) 1.10