PubRank

Akihiko Nunomura

Author PubWeight™ 57.25‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. Am J Pathol 2003 1.66
2 Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. J Biol Chem 2005 1.61
3 Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. J Alzheimers Dis 2010 1.54
4 Oxidative stress in Alzheimer disease: a possibility for prevention. Neuropharmacology 2010 1.46
5 Nucleic acid oxidation in Alzheimer disease. Free Radic Biol Med 2008 1.45
6 Role of mitochondrial dysfunction in Alzheimer's disease. J Neurosci Res 2002 1.37
7 Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radic Biol Med 2002 1.34
8 Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy. Neurobiol Dis 2002 1.34
9 Neuropathology of Alzheimer disease: pathognomonic but not pathogenic. Acta Neuropathol 2006 1.33
10 The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease. Brain Pathol 2002 1.29
11 Mitochondria: a therapeutic target in neurodegeneration. Biochim Biophys Acta 2009 1.25
12 Vascular oxidative stress in Alzheimer disease. J Neurol Sci 2007 1.25
13 Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses. J Pharmacol Exp Ther 2007 1.23
14 Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. Neurosci Lett 2002 1.20
15 Tau phosphorylation in Alzheimer's disease: pathogen or protector? Trends Mol Med 2005 1.20
16 Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol 2007 1.18
17 Alzheimer disease and the role of free radicals in the pathogenesis of the disease. CNS Neurol Disord Drug Targets 2008 1.15
18 Oxidative stress and neurodegeneration. Ann N Y Acad Sci 2005 1.15
19 Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy 2007 1.14
20 Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta. J Alzheimers Dis 2009 1.13
21 Amyloid beta: the alternate hypothesis. Curr Alzheimer Res 2006 1.11
22 The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. Am J Pathol 2009 1.08
23 High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. J Biol Chem 2001 1.07
24 Phosphorylated tau: toxic, protective, or none of the above. J Alzheimers Dis 2008 1.05
25 Chronological primacy of oxidative stress in Alzheimer disease. Neurobiol Aging 2005 1.02
26 Signal transduction cascades associated with oxidative stress in Alzheimer's disease. J Alzheimers Dis 2007 1.01
27 Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron. Biochemistry 2007 1.01
28 Antioxidant therapy in Alzheimer's disease: theory and practice. Mini Rev Med Chem 2008 1.00
29 Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radic Biol Med 2005 0.98
30 Redox metals and oxidative abnormalities in human prion diseases. Acta Neuropathol 2005 0.98
31 Antioxidant approaches for the treatment of Alzheimer's disease. Expert Rev Neurother 2010 0.97
32 Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease. Antioxid Redox Signal 2012 0.94
33 Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease. Int J Biomed Sci 2010 0.94
34 A metabolic basis for Alzheimer disease. Neurochem Res 2003 0.94
35 Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-beta peptide. Free Radic Biol Med 2007 0.94
36 Oxidative stress: the old enemy in Alzheimer's disease pathophysiology. Curr Alzheimer Res 2005 0.93
37 Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs? Neurochem Int 2002 0.91
38 Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways. Antioxid Redox Signal 2003 0.89
39 Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease. Ageing Res Rev 2004 0.89
40 The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease. Peptides 2002 0.89
41 Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease. Methods Mol Biol 2010 0.86
42 Prevention and treatment of Alzheimer disease and aging: antioxidants. Mini Rev Med Chem 2007 0.86
43 Therapeutic options in Alzheimer's disease. Expert Rev Neurother 2006 0.83
44 Sublethal RNA oxidation as a mechanism for neurodegenerative disease. Int J Mol Sci 2008 0.83
45 Indices of metabolic dysfunction and oxidative stress. Neurochem Res 2007 0.82
46 Nuclear and mitochondrial DNA oxidation in Alzheimer's disease. Free Radic Res 2012 0.79
47 Seizure threshold and the half-age method in bilateral electroconvulsive therapy in Japanese patients. Psychiatry Clin Neurosci 2014 0.79
48 Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose! Am J Pathol 2006 0.78
49 Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. Comp Biochem Physiol C Toxicol Pharmacol 2002 0.77
50 Amyloid-beta, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression". Free Radic Biol Med 2006 0.76
51 Tau modifiers as therapeutic targets for Alzheimer's disease. Biochim Biophys Acta 2005 0.76
52 Accumulation of intraneuronal amyloid-β is common in normal brain. Curr Alzheimer Res 2014 0.76
53 Treatment advances in Alzheimer's disease based on the oxidative stress model. F1000 Med Rep 2009 0.75
54 Natural oxidant balance in Parkinson disease. Arch Neurol 2009 0.75
55 Untangling the vascular web from Alzheimer disease and oxidative stress. Can J Neurol Sci 2012 0.75
56 [Role of oxidative stress in the pathophysiology of neuropsychiatric disorders]. Seishin Shinkeigaku Zasshi 2014 0.75
57 Specific reaction of Met 35 in amyloid beta peptide with hypochlorous acid. Free Radic Res 2010 0.75
58 A second look into the oxidant mechanisms in Alzheimer's disease. Curr Neurovasc Res 2005 0.75
59 Plasma Amyloid-β and Alzheimer's Disease-Related Changes in Late-Life Depression. J Alzheimers Dis 2017 0.75
60 [DIAN/DIAN-J/DIAN-TU]. Brain Nerve 2017 0.75
61 Current studies on neuronal death and neurodegenerative diseases. Nihon Yakurigaku Zasshi 2007 0.75