Published in J Pharmacol Exp Ther on January 17, 2007
Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity. J Neuropathol Exp Neurol (2007) 2.65
Changing perspectives regarding late-life dementia. Nat Rev Neurol (2009) 2.04
Reassessing the amyloid cascade hypothesis of Alzheimer's disease. Int J Biochem Cell Biol (2008) 1.78
Alzheimer disease pathology as a host response. J Neuropathol Exp Neurol (2008) 1.45
Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci U S A (2009) 1.37
Amyloid-β as a modulator of synaptic plasticity. J Alzheimers Dis (2010) 1.22
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 1.21
Natural products as a source of Alzheimer's drug leads. Nat Prod Rep (2010) 1.13
Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta. J Alzheimers Dis (2009) 1.13
Role of metal dyshomeostasis in Alzheimer's disease. Metallomics (2011) 1.12
Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease? Mol Neurodegener (2011) 0.99
Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. Curr Alzheimer Res (2015) 0.98
Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis. Transl Neurodegener (2012) 0.98
Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice. Nutr Neurosci (2009) 0.98
Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer's disease (AD). Expert Opin Emerg Drugs (2012) 0.97
Soluble aggregates of the amyloid-beta protein selectively stimulate permeability in human brain microvascular endothelial monolayers. J Neurochem (2008) 0.97
Quantitative structural MRI for early detection of Alzheimer's disease. Expert Rev Neurother (2010) 0.96
Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis. Expert Rev Neurother (2010) 0.93
Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits. J Neurochem (2009) 0.92
Amyloid-β positron emission tomography imaging probes: a critical review. J Alzheimers Dis (2013) 0.90
Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice. J Neurochem (2013) 0.89
Chronic neuroinflammation in Alzheimer's disease: new perspectives on animal models and promising candidate drugs. Biomed Res Int (2014) 0.87
Nanoparticle delivery of transition-metal chelators to the brain: Oxidative stress will never see it coming! CNS Neurol Disord Drug Targets (2012) 0.84
Moving beyond anti-amyloid therapy for the prevention and treatment of Alzheimer's disease. BMC Neurol (2014) 0.84
Amyloid Beta and tau proteins as therapeutic targets for Alzheimer's disease treatment: rethinking the current strategy. Int J Alzheimers Dis (2012) 0.84
Biomarkers for early diagnosis of Alzheimer disease: 'ALZheimer ASsociated gene'--a new blood biomarker? J Cell Mol Med (2008) 0.82
Widespread distribution of reticulon-3 in various neurodegenerative diseases. Neuropathology (2010) 0.81
Biomarkers for the clinical evaluation of the cognitively impaired elderly: amyloid is not enough. Imaging Med (2012) 0.79
Neurotoxicity in Alzheimer's disease: is covalently crosslinked A beta responsible? Eur Biophys J (2007) 0.79
Mechanisms of neural and behavioral dysfunction in Alzheimer's disease. Mol Neurobiol (2011) 0.78
Interactions between amyloid-β and Tau fragments promote aberrant aggregates: implications for amyloid toxicity. J Phys Chem B (2014) 0.78
Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents. J Neuroinflammation (2016) 0.77
Few-layer bismuth selenides exfoliated by hemin inhibit amyloid-β1-42 fibril formation. Sci Rep (2015) 0.76
Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease. J Amino Acids (2011) 0.76
Temperature and toxic Tau in Alzheimer's disease: new insights. Temperature (Austin) (2015) 0.76
Opposing Effects of Cucurbit[7]uril and 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranose on Amyloid β25-35 Assembly. ACS Chem Neurosci (2015) 0.75
Characterizing affinity epitopes between prion protein and β-amyloid using an epitope mapping immunoassay. Exp Mol Med (2013) 0.75
A derangement of the brain wound healing process may cause some cases of Alzheimer's disease. Discov Med (2016) 0.75
Extremely low frequency electromagnetic fields stimulation modulates autoimmunity and immune responses: a possible immuno-modulatory therapeutic effect in neurodegenerative diseases. Neural Regen Res (2016) 0.75
Pathology's new role: defining disease process and protective responses. Int J Clin Exp Pathol (2008) 0.75
Genetic epistasis regulates amyloid deposition in resilient aging. Alzheimers Dement (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. Genome Res (2005) 8.38
Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci (2009) 3.77
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci U S A (2008) 3.68
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest (2007) 3.32
The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest (2005) 2.40
Oxidative stress and neurotoxicity. Chem Res Toxicol (2007) 2.12
Vesicular stomatitis virus-based ebola vaccine is well-tolerated and protects immunocompromised nonhuman primates. PLoS Pathog (2008) 2.10
Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients. Am J Pathol (2008) 2.09
Neural circuit involved in idiopathic infantile nystagmus syndrome based on FMRI. J Pediatr Ophthalmol Strabismus (2011) 2.02
Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta. Brain Res Brain Res Rev (2003) 1.97
Involvement of oxidative stress in Alzheimer disease. J Neuropathol Exp Neurol (2006) 1.92
Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence. Biochemistry (2003) 1.89
Oxidative stress increases expression and activity of BACE in NT2 neurons. Neurobiol Dis (2002) 1.85
Alzheimer's disease: the two-hit hypothesis. Lancet Neurol (2004) 1.81
Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion. Prog Neurobiol (2011) 1.80
A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression. Biol Psychiatry (2012) 1.76
Subcellular and metabolic examination of amyloid-beta peptides in Alzheimer disease pathogenesis: evidence for Abeta(25-35). Exp Neurol (2009) 1.75
Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic Biol Med (2012) 1.67
The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J Neurochem (2009) 1.67
Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein. Ann Neurol (2010) 1.66
Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. Biochim Biophys Acta (2009) 1.66
Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. Am J Pathol (2003) 1.66
Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine. J Neurochem (2002) 1.65
Alzheimer disease. Dis Mon (2010) 1.64
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. J Biol Chem (2005) 1.61
Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. J Neurochem (2007) 1.61
Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab (2009) 1.59
Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease. J Neurochem (2011) 1.57
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1. Hum Mol Genet (2012) 1.56
The role of mitogen-activated protein kinase pathways in Alzheimer's disease. Neurosignals (2003) 1.56
Alzheimer disease, the two-hit hypothesis: an update. Biochim Biophys Acta (2006) 1.56
A new model of oxidative stress in rat pups. Neonatology (2008) 1.55
Impaired regulation of synaptic strength in hippocampal neurons from GluR1-deficient mice. J Physiol (2003) 1.55
Development of an acute and highly pathogenic nonhuman primate model of Nipah virus infection. PLoS One (2010) 1.54
The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules. J Neurosci Res (2008) 1.54
Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. J Alzheimers Dis (2010) 1.54
Chitin-like polysaccharides in Alzheimer's disease brains. Curr Alzheimer Res (2005) 1.51
Abnormal mitochondrial dynamics and neurodegenerative diseases. Biochim Biophys Acta (2009) 1.49
Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease. Ann N Y Acad Sci (2004) 1.49
Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. FASEB J (2002) 1.47
Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle. J Alzheimers Dis (2002) 1.47
Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability. Proc Natl Acad Sci U S A (2003) 1.46
Inherited motor neuron disease in domestic cats: a model of spinal muscular atrophy. Pediatr Res (2005) 1.46
4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal. Chem Res Toxicol (2005) 1.46
Oxidative stress in Alzheimer disease: a possibility for prevention. Neuropharmacology (2010) 1.46
Nucleic acid oxidation in Alzheimer disease. Free Radic Biol Med (2008) 1.45
Alzheimer disease pathology as a host response. J Neuropathol Exp Neurol (2008) 1.45
Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice. J Nucl Med (2002) 1.44
The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha. J Neurochem (2009) 1.43