Published in Neurobiol Aging on February 06, 2008
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Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks. Behav Brain Res (2008) 1.51
Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice. Proc Natl Acad Sci U S A (2012) 1.17
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Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice. Pharmacol Biochem Behav (2009) 1.02
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Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice. Nutr Neurosci (2009) 0.98
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Cross-talk of membrane lipids and Alzheimer-related proteins. Mol Neurodegener (2013) 0.93
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Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice. Pharmacol Biochem Behav (2009) 0.88
Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model. Mol Brain (2014) 0.88
Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism. PLoS One (2012) 0.85
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Cytotoxic effects of G(M1) ganglioside and amyloid β-peptide on mouse embryonic neural stem cells. ASN Neuro (2010) 0.83
Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores. Yale J Biol Med (2016) 0.81
Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice. Behav Brain Res (2014) 0.81
Effects of amyloid β-peptides and gangliosides on mouse neural stem cells. Neurochem Res (2013) 0.81
Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics. Neurobiol Dis (2015) 0.79
Implications for the mammalian sialidases in the physiopathology of skeletal muscle. Skelet Muscle (2012) 0.78
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Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics. Genes Brain Behav (2014) 0.77
Brain gangliosides of a transgenic mouse model of Alzheimer's disease with deficiency in GD3-synthase: expression of elevated levels of a cholinergic-specific ganglioside, GT1aα. ASN Neuro (2013) 0.77
GD3 accumulation in cell surface lipid rafts prior to mitochondrial targeting contributes to amyloid-β-induced apoptosis. J Korean Med Sci (2010) 0.77
Imbalance in fatty-acid-chain length of gangliosides triggers Alzheimer amyloid deposition in the precuneus. PLoS One (2015) 0.77
APP Function and Lipids: A Bidirectional Link. Front Mol Neurosci (2017) 0.75
Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues. Clin Sci (Lond) (2012) 0.75
Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing. Sci Rep (2016) 0.75
Characterization of AD-like phenotype in aged APPSwe/PS1dE9 mice. Age (Dordr) (2016) 0.75
Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration. Genes Brain Behav (2017) 0.75
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Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections. Nat Genet (2007) 4.93
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol (2005) 4.91
Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep (2006) 4.06
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat Med (2009) 3.35
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene (2005) 3.17
Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci (2004) 3.09
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci (2009) 2.85
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain (2011) 2.76
Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease. Am J Hum Genet (2009) 2.50
Extracellular amyloid formation and associated pathology in neural grafts. Nat Neurosci (2003) 2.24
Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron (2003) 2.17
Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis (2007) 2.08
Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice. Exp Neurol (2007) 2.04
Quantification of F2-isoprostanes in biological fluids and tissues as a measure of oxidant stress. Methods Enzymol (2007) 1.98
Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nat Med (2009) 1.95
Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Ann Neurol (2004) 1.87
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest (2008) 1.79
Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci U S A (2009) 1.72
Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels. Circ Res (2005) 1.70
Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review. J Lipid Res (2008) 1.68
Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. J Biol Chem (2003) 1.60
DC isoketal-modified proteins activate T cells and promote hypertension. J Clin Invest (2014) 1.59
Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest (2015) 1.55
Familial thoracic aortic aneurysms and dissections: identification of a novel locus for stable aneurysms with a low risk for progression to aortic dissection. Circ Cardiovasc Genet (2010) 1.55
Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat Genet (2007) 1.53
In vivo reduction of amyloid-beta by a mutant copper transporter. Proc Natl Acad Sci U S A (2003) 1.52
Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science (2004) 1.52
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res (2008) 1.51
Genome sequence and comparative genome analysis of Lactobacillus casei: insights into their niche-associated evolution. Genome Biol Evol (2009) 1.51
The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nat Genet (2002) 1.51
Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains. J Neurochem (2007) 1.50
A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. Am J Pathol (2004) 1.50
The expression and functions of glycoconjugates in neural stem cells. Glycobiology (2007) 1.45
Isoprostane generation and function. Chem Rev (2011) 1.41
Biological significance of isoaspartate and its repair system. Biol Pharm Bull (2005) 1.39
The in vivo brain interactome of the amyloid precursor protein. Mol Cell Proteomics (2007) 1.38
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. J Neuropathol Exp Neurol (2004) 1.36
Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. J Neurosci (2003) 1.36
Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid. J Neurochem (2008) 1.35
Spatial and nonspatial escape strategies in the Barnes maze. Learn Mem (2006) 1.33
DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing. J Biol Chem (2006) 1.33
Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice. Neurobiol Dis (2003) 1.32
F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein. Mol Cell Biol (2005) 1.30
Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. J Neurosci (2008) 1.30
ELISA method for measurement of amyloid-beta levels. Methods Mol Biol (2005) 1.28
Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects. Am J Pathol (2008) 1.28
Tissue processing prior to protein analysis and amyloid-beta quantitation. Methods Mol Biol (2005) 1.28
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice. J Neurochem (2006) 1.27
Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation. Neurobiol Aging (2004) 1.27
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. J Biol Chem (2002) 1.26
The effects of amyloid precursor protein on postsynaptic composition and activity. J Biol Chem (2009) 1.25
Ganglioside molecular mimicry and its pathological roles in Guillain-Barré syndrome and related diseases. Infect Immun (2006) 1.24
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. J Biol Chem (2004) 1.23
Finding factors influencing risk: comparing Bayesian stochastic search and standard variable selection methods applied to logistic regression models of cases and controls. Stat Med (2008) 1.22
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 1.21
Antiganglioside antibodies and their pathophysiological effects on Guillain-Barré syndrome and related disorders--a review. Glycobiology (2009) 1.19
Characterization of glycoconjugate antigens in mouse embryonic neural precursor cells. J Neurochem (2005) 1.17
NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP). CNS Drug Rev (2005) 1.16
Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant. Biochem Biophys Res Commun (2004) 1.16
Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation. J Neurosci (2011) 1.16
Modification of proteins by isoketal-containing oxidized phospholipids. J Biol Chem (2004) 1.15
Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP. PLoS One (2006) 1.14
Functional roles of gangliosides in neurodevelopment: an overview of recent advances. Neurochem Res (2012) 1.14
Differentiation of radial glia-like cells from embryonic stem cells. Glia (2003) 1.14
Normalizing a large number of quantitative traits using empirical normal quantile transformation. BMC Proc (2007) 1.12
Structures, biosynthesis, and functions of gangliosides--an overview. J Oleo Sci (2011) 1.11
Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity. J Clin Invest (2014) 1.11
Isoketals form cytotoxic phosphatidylethanolamine adducts in cells. J Lipid Res (2009) 1.10
Aging, resting metabolic rate, and oxidative damage: results from the Louisiana Healthy Aging Study. J Gerontol A Biol Sci Med Sci (2007) 1.09
Synaptic autoregulation by metalloproteases and γ-secretase. J Neurosci (2011) 1.08
Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet. Neurobiol Aging (2006) 1.08
Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis. PLoS One (2013) 1.07
Genome-wide high-density SNP linkage search for glioma susceptibility loci: results from the Gliogene Consortium. Cancer Res (2011) 1.05
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proc Natl Acad Sci U S A (2005) 1.05
The biochemistry of the isoprostane, neuroprostane, and isofuran Pathways of lipid peroxidation. Brain Pathol (2005) 1.04
Tart cherry juice decreases oxidative stress in healthy older men and women. J Nutr (2009) 1.04
Oxidant stress modulates murine allergic airway responses. Free Radic Biol Med (2005) 1.03
Characterization of GD3 ganglioside as a novel biomarker of mouse neural stem cells. Glycobiology (2009) 1.03
Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. J Biol Chem (2007) 1.03
Isofurans: novel products of lipid peroxidation that define the occurrence of oxidant injury in settings of elevated oxygen tension. Antioxid Redox Signal (2005) 1.03
In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice. PLoS One (2009) 1.02
Role of proteoglycans and glycosaminoglycans in the pathogenesis of Alzheimer's disease and related disorders: amyloidogenesis and therapeutic strategies--a review. J Neurosci Res (2010) 1.02
Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein. J Neurochem (2004) 1.01
Arrestin serves as a molecular switch, linking endogenous alpha2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activation. J Biol Chem (2006) 1.01
Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. J Neurochem (2009) 1.01
Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis. Autophagy (2011) 1.00
mTOR/p70S6K signal transduction pathway contributes to osteosarcoma progression and patients' prognosis. Med Oncol (2009) 1.00
Histone acetylation-mediated glycosyltransferase gene regulation in mouse brain during development. J Neurochem (2011) 1.00
Down-regulation of WNK1 protein kinase in neural progenitor cells suppresses cell proliferation and migration. J Neurochem (2006) 0.99
Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation. J Biol Chem (2003) 0.99
Molecular mimicry: sensitization of Lewis rats with Campylobacter jejuni lipopolysaccharides induces formation of antibody toward GD3 ganglioside. J Neurosci Res (2006) 0.98