Published in Diabetologia on February 13, 2008
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Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion. PLoS Genet (2014) 1.94
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One (2010) 1.93
A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue. PLoS Genet (2013) 1.89
The role of epigenetics in the pathology of diabetic complications. Am J Physiol Renal Physiol (2010) 1.83
Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One (2010) 1.68
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Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes. Diabetes (2012) 1.54
Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylation. Diabetes (2014) 1.52
Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets. Diabetologia (2010) 1.52
Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets. Cell Metab (2013) 1.49
AGE restriction in diabetes mellitus: a paradigm shift. Nat Rev Endocrinol (2011) 1.46
Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia. Cardiovasc Res (2011) 1.46
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Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets. Diabetologia (2013) 1.39
Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes. PLoS One (2012) 1.38
PGC-1 coactivators in the control of energy metabolism. Acta Biochim Biophys Sin (Shanghai) (2011) 1.35
Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats. J Lipid Res (2010) 1.29
Global DNA methylation is associated with insulin resistance: a monozygotic twin study. Diabetes (2011) 1.24
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Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets. PLoS Genet (2014) 1.06
Global DNA methylation in old subjects is correlated with frailty. Age (Dordr) (2011) 1.05
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Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes. Eur J Endocrinol (2011) 0.93
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Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes. Cell Mol Life Sci (2013) 0.91
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β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab (2014) 0.90
DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets. BMC Med Genet (2013) 0.89
Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a Northern European family population. BMC Med Genomics (2013) 0.89
Epigenetic and microRNA-mediated regulation in diabetes. Nephrol Dial Transplant (2009) 0.88
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Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo. Eur J Endocrinol (2011) 0.88
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Differential expression and role of hyperglycemia induced oxidative stress in epigenetic regulation of β1, β2 and β3-adrenergic receptors in retinal endothelial cells. BMC Med Genomics (2014) 0.87
Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J mice. PLoS One (2014) 0.87
Genetic effects on DNA methylation and its potential relevance for obesity in Mexican Americans. PLoS One (2013) 0.86
A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits. PLoS One (2016) 0.85
Type 2 diabetes mellitus in relation to global LINE-1 DNA methylation in peripheral blood: a cohort study. Epigenetics (2014) 0.85
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The possible role of epigenetics in gestational diabetes: cause, consequence, or both. Obstet Gynecol Int (2010) 0.84
The Ups and Downs of Insulin Resistance and Type 2 Diabetes: Lessons from Genomic Analyses in Humans. Curr Cardiovasc Risk Rep (2012) 0.84
The emerging role of epigenetics in cardiovascular disease. Ther Adv Chronic Dis (2014) 0.83
Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins. PLoS One (2009) 0.83
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Epigenetic associations of type 2 diabetes and BMI in an Arab population. Clin Epigenetics (2016) 0.82
Epigenetic changes predisposing to type 2 diabetes in intrauterine growth retardation. Front Endocrinol (Lausanne) (2010) 0.81
Epigenetic analyses of the insulin-like growth factor binding protein 1 gene in type 1 diabetes and diabetic nephropathy. Clin Epigenetics (2014) 0.80
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Epigenetics of diabetic complications. Expert Rev Endocrinol Metab (2010) 0.80
Metabolic response to 36 hours of fasting in young men born small vs appropriate for gestational age. Diabetologia (2014) 0.80
Aberrant DNA methylation patterns in diabetic nephropathy. J Diabetes Metab Disord (2014) 0.80
Hypermethylation of the PRKCZ Gene in Type 2 Diabetes Mellitus. J Diabetes Res (2013) 0.79
Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes. PLoS One (2009) 0.79
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The potential use of DNA methylation biomarkers to identify risk and progression of type 2 diabetes. Front Endocrinol (Lausanne) (2015) 0.78
PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids. Mol Metab (2015) 0.78
Remodeling is at the heart of chromatin: the heartaches of chromatin. Epigenetics (2011) 0.78
Mitochondrial regulation of β-cell function: maintaining the momentum for insulin release. Mol Aspects Med (2015) 0.77
Complex disease interventions from a network model for type 2 diabetes. PLoS One (2013) 0.77
A systems view of epigenetic networks regulating pancreas development and β-cell function. Wiley Interdiscip Rev Syst Biol Med (2015) 0.76
Glutathione peroxidase mimic ebselen improves glucose-stimulated insulin secretion in murine islets. Antioxid Redox Signal (2013) 0.76
Epigenetic modifications and diabetic nephropathy. Kidney Res Clin Pract (2012) 0.76
PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns. Clin Epigenetics (2016) 0.76
Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells. PLoS One (2017) 0.75
Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins. J Diabetes Res (2015) 0.75
The Expression Level of mRNA, Protein, and DNA Methylation Status of FOSL2 of Uyghur in XinJiang in Type 2 Diabetes. J Diabetes Res (2016) 0.75
Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass. Diabetol Metab Syndr (2017) 0.75
DNA methylation and its role in the pathogenesis of diabetes. Pediatr Diabetes (2017) 0.75
From genotype to human β cell phenotype and beyond. Islets (2012) 0.75
Impact of the PPARGC1A Gly482Ser polymorphism on left ventricular structural and functional abnormalities in patients with hypertension. J Hum Hypertens (2014) 0.75
Hypermethylation of Cox5a promoter is associated with mitochondrial dysfunction in skeletal muscle of high fat diet-induced insulin resistant rats. PLoS One (2014) 0.75
Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene. Front Genet (2017) 0.75
Epigenetic effects of the pregnancy Mediterranean diet adherence on the offspring metabolic syndrome markers. J Physiol Biochem (2017) 0.75
DNA methylation of candidate genes in peripheral blood from patients with type 2 diabetes or the metabolic syndrome. PLoS One (2017) 0.75
Equine skeletal muscle adaptations to exercise and training: evidence of differential regulation of autophagosomal and mitochondrial components. BMC Genomics (2017) 0.75
Epigenetics in formation, function, and failure of the endocrine pancreas. Mol Metab (2017) 0.75
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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
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