Published in J Comp Neurol on April 20, 2008
Gene copy-number alterations: a cost-benefit analysis. Cell (2013) 1.79
Massively parallel polymerase cloning and genome sequencing of single cells using nanoliter microwells. Nat Biotechnol (2013) 1.69
Chromosomal instability and aneuploidy in cancer: from yeast to man. EMBO Rep (2012) 1.51
The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning. Neuron (2016) 1.48
Frequent aneuploidy among normal human hepatocytes. Gastroenterology (2011) 1.30
Selective cell death of hyperploid neurons in Alzheimer's disease. Am J Pathol (2010) 1.15
Chromosome 7 and 19 trisomy in cultured human neural progenitor cells. PLoS One (2009) 1.13
The genomically mosaic brain: aneuploidy and more in neural diversity and disease. Semin Cell Dev Biol (2013) 1.05
Development and distribution of neuronal cilia in mouse neocortex. J Comp Neurol (2012) 1.01
Chromosome-specific accumulation of aneuploidy in the aging mouse brain. Hum Mol Genet (2012) 1.00
Neuronal DNA content variation (DCV) with regional and individual differences in the human brain. J Comp Neurol (2010) 1.00
Chromosomal aneuploidy in the aging brain. Mech Ageing Dev (2011) 0.95
Single cell genomics of the brain: focus on neuronal diversity and neuropsychiatric diseases. Curr Genomics (2012) 0.94
The DNA replication stress hypothesis of Alzheimer's disease. ScientificWorldJournal (2012) 0.93
Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains. Elife (2015) 0.93
A cell-based model system links chromothripsis with hyperploidy. Mol Syst Biol (2015) 0.92
Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development. J Neurosci (2012) 0.88
Liver repopulation and regeneration: new approaches to old questions. Curr Opin Organ Transplant (2013) 0.85
Brain tumor stem cells as therapeutic targets in models of glioma. Yonsei Med J (2010) 0.85
New approaches for modelling sporadic genetic disease in the mouse. Dis Model Mech (2009) 0.84
Sensitive and specific detection of mosaic chromosomal abnormalities using the Parent-of-Origin-based Detection (POD) method. BMC Genomics (2013) 0.84
Retinoic acid-treated pluripotent stem cells undergoing neurogenesis present increased aneuploidy and micronuclei formation. PLoS One (2011) 0.83
Different Facets of Copy Number Changes: Permanent, Transient, and Adaptive. Mol Cell Biol (2016) 0.80
Neuronal aneuploidy in health and disease: a cytomic approach to understand the molecular individuality of neurons. Int J Mol Sci (2009) 0.79
Implications of aneuploidy for stem cell biology and brain therapeutics. Front Cell Neurosci (2012) 0.77
Controlled somatic and germline copy number variation in the mouse model. Curr Genomics (2010) 0.76
Aneuploidy in stem cells. World J Stem Cells (2016) 0.75
Genomic Copy Number Variation Affecting Genes Involved in the Cell Cycle Pathway: Implications for Somatic Mosaicism. Int J Genomics (2015) 0.75
Investigating somatic aneuploidy in the brain: why we need a new model. Chromosoma (2016) 0.75
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med (2007) 5.06
LPA receptors: subtypes and biological actions. Annu Rev Pharmacol Toxicol (2010) 3.91
Lysophospholipid receptors: signaling and biology. Annu Rev Biochem (2004) 3.78
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem (2004) 3.57
LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature (2005) 3.35
Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature (2008) 3.14
Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis. Ann Neurol (2011) 2.85
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat Med (2004) 2.71
GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J Biol Chem (2006) 2.65
High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. Circulation (2006) 2.58
FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proc Natl Acad Sci U S A (2010) 2.49
Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A (2003) 2.44
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J Clin Invest (2004) 2.36
Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding. Nat Neurosci (2003) 2.36
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J Biol Chem (2003) 2.36
Constitutional aneuploidy in the normal human brain. J Neurosci (2005) 2.28
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. J Biol Chem (2004) 2.17
Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J (2006) 2.12
Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol Cell Biol (2002) 2.06
Emerging medicinal roles for lysophospholipid signaling. Trends Mol Med (2006) 2.01
Lysophospholipid G protein-coupled receptors. J Biol Chem (2004) 1.88
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med (2009) 1.86
Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance. Prostaglandins Other Lipid Mediat (2009) 1.81
Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor. Arterioscler Thromb Vasc Biol (2006) 1.80
Lysophosphatidic acid signaling may initiate fetal hydrocephalus. Sci Transl Med (2011) 1.76
Lysophosphatidic acid (LPA) and its receptors. Curr Opin Pharmacol (2008) 1.70
Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol (2007) 1.70
Massively parallel polymerase cloning and genome sequencing of single cells using nanoliter microwells. Nat Biotechnol (2013) 1.69
Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J Biol Chem (2002) 1.68
Retracted S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF. Proc Natl Acad Sci U S A (2005) 1.57
The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer. Gastroenterology (2009) 1.56
Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium. Cell Metab (2011) 1.52
Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy. J Neurol Sci (2013) 1.52
LPA1 receptor activation promotes renal interstitial fibrosis. J Am Soc Nephrol (2007) 1.51
Cell surface receptors in lysophospholipid signaling. Semin Cell Dev Biol (2004) 1.49
A reevaluation of tetraploidy in the Alzheimer's disease brain. Neurodegener Dis (2009) 1.47
Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J Biol Chem (2003) 1.47
Biological roles of lysophospholipid receptors revealed by genetic null mice: an update. Biochim Biophys Acta (2008) 1.43
Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development (2007) 1.40
The end of a Chilean institute. Science (2005) 1.39
The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. Mol Cell Biol (2005) 1.38
Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. J Neuroimmunol (2004) 1.37
Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2. Gastroenterology (2009) 1.33
Insights into the pharmacological relevance of lysophospholipid receptors. Br J Pharmacol (2012) 1.31
Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha. J Biol Chem (2004) 1.31
Lysophosphatidic acid as a novel cell survival/apoptotic factor. Biochim Biophys Acta (2002) 1.30
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell (2009) 1.29
LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation. J Biol Chem (2006) 1.28
Alteration of gene expression by chromosome loss in the postnatal mouse brain. J Neurosci (2003) 1.28
Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. Am J Respir Cell Mol Biol (2010) 1.27
The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. FASEB J (2007) 1.25
S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. Cardiovasc Res (2009) 1.25
The sphingosine-1-phosphate (S1P) lysophospholipid receptor S1P3 regulates MAdCAM-1+ endothelial cells in splenic marginal sinus organization. J Exp Med (2004) 1.24
Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells. J Neurosci (2003) 1.24
Lysophospholipids and their receptors in the central nervous system. Biochim Biophys Acta (2012) 1.21
Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol (2014) 1.21
Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure. Circ Res (2008) 1.20
Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis. FEBS Lett (2002) 1.20
Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2. J Neurosci (2007) 1.19
S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. J Biol Chem (2008) 1.18
Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. J Lipid Res (2008) 1.18
Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma. Arthritis Rheum (2011) 1.18
LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation. FASEB J (2013) 1.18
Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling. Am J Pathol (2007) 1.17
Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis. Cell Res (2011) 1.17
Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells. J Biol Chem (2005) 1.17
The lysophosphatidic acid receptor LPA1 promotes epithelial cell apoptosis after lung injury. Am J Respir Cell Mol Biol (2011) 1.16
Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation. Am J Respir Crit Care Med (2013) 1.15
Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3. Circ Res (2005) 1.14
Absence of LPA1 signaling results in defective cortical development. Cereb Cortex (2007) 1.14
The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. Neurology (2011) 1.14
Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2. J Biol Chem (2005) 1.13
Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain. Mol Pain (2008) 1.13
In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice. Biochim Biophys Acta (2002) 1.12
HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production. Arterioscler Thromb Vasc Biol (2008) 1.11
Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy. PLoS One (2011) 1.10
S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). FASEB J (2003) 1.08
Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons. Mol Cell Neurosci (2002) 1.08
Lysophospholipid activation of G protein-coupled receptors. Subcell Biochem (2008) 1.07
Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone. J Mol Med (Berl) (2009) 1.06
Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus. Mol Cell Neurosci (2008) 1.05
Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs. Am J Physiol Lung Cell Mol Physiol (2011) 1.05
The genomically mosaic brain: aneuploidy and more in neural diversity and disease. Semin Cell Dev Biol (2013) 1.05
Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain. Neurosurgery (2006) 1.05
Agricultural-related chemical exposures, season of conception, and risk of gastroschisis in Washington State. Am J Obstet Gynecol (2010) 1.05
Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma. Respir Res (2009) 1.04
LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA). J Leukoc Biol (2007) 1.02
Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. Brain Res (2003) 1.01
Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine. Mol Pain (2010) 1.00
Neuronal DNA content variation (DCV) with regional and individual differences in the human brain. J Comp Neurol (2010) 1.00