Published in Invest Ophthalmol Vis Sci on February 15, 2008
Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 7.20
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling. Cardiovasc Res (2010) 2.30
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev (2012) 2.24
Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc Natl Acad Sci U S A (2009) 1.43
HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells. PLoS One (2016) 1.40
Vascular responses to hypoxia and ischemia. Arterioscler Thromb Vasc Biol (2009) 1.34
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia (2010) 1.31
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A (2011) 1.28
HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia. PLoS One (2010) 1.24
Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. J Biol Chem (2011) 1.13
Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue. Blood (2011) 1.09
Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice. Am J Pathol (2011) 0.93
Conditional hypoxia inducible factor-1α induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol (2011) 0.92
Adenoviral targeting of gene expression to tumors. Cancer Gene Ther (2010) 0.89
Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy. Doc Ophthalmol (2009) 0.86
Hypoxic signaling during tissue repair and regenerative medicine. Int J Mol Sci (2014) 0.84
Rapid and dynamic alterations of gene expression profiles of adult porcine bone marrow-derived stem cell in response to hypoxia. Stem Cell Res (2010) 0.83
Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress. Neuroscience (2015) 0.82
MicroRNA silencing improves the tumor specificity of adenoviral transgene expression. Cancer Gene Ther (2012) 0.81
Involvement of estrogen receptor β5 in the progression of glioma. Brain Res (2013) 0.81
Gene expression microarray analysis of early oxygen-induced retinopathy in the rat. J Ocul Biol Dis Infor (2009) 0.81
Molecular mechanisms of action and therapeutic uses of pharmacological inhibitors of HIF-prolyl 4-hydroxylases for treatment of ischemic diseases. Antioxid Redox Signal (2013) 0.78
Hypoxia inducible factor-2α regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors. PLoS One (2014) 0.76
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun (2017) 0.75
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab (2005) 9.14
Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab (2006) 4.02
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat Genet (2003) 3.78
Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science (2009) 3.64
Targeted access to the genomes of low-abundance organisms in complex microbial communities. Appl Environ Microbiol (2007) 3.55
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A (2006) 3.05
Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse. Proc Natl Acad Sci U S A (2009) 2.88
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med (2006) 2.67
Math5 determines the competence state of retinal ganglion cell progenitors. Dev Biol (2003) 2.36
The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem (2006) 2.31
Environmental whole-genome amplification to access microbial populations in contaminated sediments. Appl Environ Microbiol (2006) 2.24
The power of real-time PCR. Adv Physiol Educ (2005) 2.21
HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner. Blood (2004) 1.99
Genetic variations and treatments that affect the lifespan of the NPC1 mouse. J Lipid Res (2007) 1.99
DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. J Biol Chem (2002) 1.90
Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid. J Lipid Res (2009) 1.87
Differential regulation and properties of angiopoietin-like proteins 3 and 4. J Lipid Res (2005) 1.80
Diffusion tensor tractography of traumatic diffuse axonal injury. Arch Neurol (2008) 1.76
The HIF family member EPAS1/HIF-2alpha is required for normal hematopoiesis in mice. Blood (2003) 1.70
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proc Natl Acad Sci U S A (2008) 1.68
Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities. Proc Natl Acad Sci U S A (2009) 1.63
Quantitative real-time polymerase chain reaction measurement of regulators of G-protein signaling mRNA levels in mouse tissues. Methods Enzymol (2004) 1.63
Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells. Circ Res (2008) 1.62
The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. Mol Cell (2004) 1.61
Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick type C1 mouse and markedly prolongs life. Pediatr Res (2010) 1.59
Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. J Biol Chem (2004) 1.57
Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum (2009) 1.56
Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol (2013) 1.55
The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet (2006) 1.47
Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease. J Neuropathol Exp Neurol (2005) 1.39
Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment. J Neurosci (2011) 1.33
Retinal disease in mice lacking hypoxia-inducible transcription factor-2alpha. Invest Ophthalmol Vis Sci (2005) 1.30
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Proc Natl Acad Sci U S A (2002) 1.28
Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function. Mol Cell Endocrinol (2003) 1.28
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A (2011) 1.28
Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia. J Mol Med (Berl) (2007) 1.25
The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. J Clin Invest (2012) 1.23
Dietary supplementation with dried plum prevents ovariectomy-induced bone loss while modulating the immune response in C57BL/6J mice. J Nutr Biochem (2011) 1.21
Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor. J Biol Chem (2005) 1.19
Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis. Proc Natl Acad Sci U S A (2013) 1.14
Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivital role for nitrosothiol-derived nitric oxide. J Biol Chem (2003) 1.14
Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. J Biol Chem (2011) 1.13
Ghrelin directly stimulates glucagon secretion from pancreatic alpha-cells. Mol Endocrinol (2011) 1.13
Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse. J Lipid Res (2007) 1.11
Distribution of sphingosine kinase activity and mRNA in rodent brain. J Neurochem (2007) 1.11
Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin. J Biol Chem (2007) 1.09
Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations. J Lipid Res (2011) 1.09
Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation. J Biol Chem (2008) 1.09
Research resource: nuclear hormone receptor expression in the endocrine pancreas. Mol Endocrinol (2008) 1.08
Cyclodextrin mediates rapid changes in lipid balance in Npc1-/- mice without carrying cholesterol through the bloodstream. J Lipid Res (2012) 1.07
Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters. Am J Physiol Gastrointest Liver Physiol (2008) 1.06
Chronic social defeat stress disrupts regulation of lipid synthesis. J Lipid Res (2010) 1.04
Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1. Am J Physiol Gastrointest Liver Physiol (2010) 1.02
WSS45, a sulfated alpha-D-glucan, strongly interferes with Dengue 2 virus infection in vitro. Acta Pharmacol Sin (2010) 1.01
Heparin impairs angiogenesis through inhibition of microRNA-10b. J Biol Chem (2011) 1.01
Caveolin-1 is not required for murine intestinal cholesterol transport. J Biol Chem (2005) 0.99
Differential effects of shiitake- and white button mushroom-supplemented diets on hepatic steatosis in C57BL/6 mice. Food Chem Toxicol (2011) 0.97
Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. Mol Endocrinol (2004) 0.97
Nitric oxide-dependent processing of heparan sulfate in recycling S-nitrosylated glypican-1 takes place in caveolin-1-containing endosomes. J Biol Chem (2002) 0.97
Transcriptional regulation during development of the ductus arteriosus. Circ Res (2008) 0.96
Dried plum's unique capacity to reverse bone loss and alter bone metabolism in postmenopausal osteoporosis model. PLoS One (2013) 0.92
Heparanase enhances nerve-growth-factor-induced PC12 cell neuritogenesis via the p38 MAPK pathway. Biochem J (2011) 0.92
Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling. J Biol Chem (2009) 0.92
Structure elucidation and sulfated derivatives preparation of two alpha-D-glucans from Gastrodia elata Bl. and their anti-dengue virus bioactivities. Carbohydr Res (2007) 0.92
A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart. Glycobiology (2009) 0.91
GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice. J Lipid Res (2008) 0.91
Regulated expression of hypoxia-inducible factors during postnatal and postpneumonectomy lung growth. Am J Physiol Lung Cell Mol Physiol (2005) 0.90
Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711. Proc Natl Acad Sci U S A (2004) 0.89
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling. J Biol Chem (2012) 0.88
Niemann-Pick C1 expression is not regulated by the amount of cholesterol flowing through cells in the mouse. J Lipid Res (2005) 0.87
Foxj3 transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. Dev Biol (2009) 0.87
Enhanced expression of lipogenic genes may contribute to hyperglycemia and alterations in plasma lipids in response to dietary iron deficiency. Genes Nutr (2012) 0.86
A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance. J Biol Chem (2013) 0.86
Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Mol Endocrinol (2004) 0.85
Mango modulates body fat and plasma glucose and lipids in mice fed a high-fat diet. Br J Nutr (2011) 0.85
Carboxylesterases are uniquely expressed among tissues and regulated by nuclear hormone receptors in the mouse. Drug Metab Dispos (2012) 0.84
Isolation and structural characterization of the water-extractable polysaccharides from Cassia obtusifolia seeds. Carbohydr Polym (2012) 0.83
WSS25 inhibits growth of xenografted hepatocellular cancer cells in nude mice by disrupting angiogenesis via blocking bone morphogenetic protein (BMP)/Smad/Id1 signaling. J Biol Chem (2010) 0.83
Translation of the human angiotensin II type 1 receptor mRNA is mediated by a highly efficient internal ribosome entry site. Mol Cell Endocrinol (2003) 0.83
Microbial transformations of diosgenin by the white-rot basidiomycete Coriolus versicolor. J Nat Prod (2011) 0.81
A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-κB signaling and improves survival in mouse models of sepsis. Acta Pharmacol Sin (2012) 0.81
Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acid. Am J Physiol Gastrointest Liver Physiol (2012) 0.81
Endothelial progenitor cell response to antiproliferative drug exposure. Atherosclerosis (2012) 0.81
Silencing of hHS6ST2 inhibits progression of pancreatic cancer through inhibition of Notch signalling. Biochem J (2011) 0.81
Structural characterization and immunological activity of two cold-water extractable polysaccharides from Cistanche deserticola Y. C. Ma. Carbohydr Res (2007) 0.81
A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat. Bone (2013) 0.81
The hypoxic epicardial and subepicardial microenvironment. J Cardiovasc Transl Res (2012) 0.81
Hypoxia inducible factor-2 α is translationally repressed in response to dietary iron deficiency in Sprague-Dawley rats. J Nutr (2011) 0.80
Antiangiogenic effects of GFP08, an agaran-type polysaccharide isolated from Grateloupia filicina. Glycobiology (2012) 0.80
Structure of a β-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-κB signaling. Glycoconj J (2012) 0.79
Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues. Org Biomol Chem (2011) 0.79
Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo. Cancer Lett (2009) 0.79
WSS25 inhibits Dicer, downregulating microRNA-210, which targets Ephrin-A3, to suppress human microvascular endothelial cell (HMEC-1) tube formation. Glycobiology (2013) 0.79
Role of calcium and EPAC in norepinephrine-induced ghrelin secretion. Endocrinology (2013) 0.78
Subtypes of post-traumatic epilepsy: clinical, electrophysiological, and imaging features. J Neurotrauma (2014) 0.78