Published in Blood on May 15, 2003
HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev (2006) 5.15
A gain-of-function mutation in the HIF2A gene in familial erythrocytosis. N Engl J Med (2008) 5.11
Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A (2007) 3.51
A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. Proc Natl Acad Sci U S A (2006) 2.90
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. Blood (2007) 2.40
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev (2012) 2.24
Biology of hypoxia-inducible factor-2alpha in development and disease. Cell Death Differ (2008) 2.08
Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood (2009) 1.81
Hypoxic regulation of erythropoiesis and iron metabolism. Am J Physiol Renal Physiol (2010) 1.76
Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. J Clin Invest (2016) 1.49
Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev (2013) 1.47
Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells. Blood (2012) 1.45
The EPAS1 gene influences the aerobic-anaerobic contribution in elite endurance athletes. Hum Genet (2005) 1.29
Autophagy in mineralizing tissues: microenvironmental perspectives. Cell Cycle (2009) 1.14
Noninvasive stool-based detection of infant gastrointestinal development using gene expression profiles from exfoliated epithelial cells. Am J Physiol Gastrointest Liver Physiol (2010) 1.14
Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. J Biol Chem (2011) 1.13
Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells. Cell Cycle (2012) 1.13
Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells. J Hematol Oncol (2013) 1.05
Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. PLoS One (2010) 1.04
Anaemia in kidney disease: harnessing hypoxia responses for therapy. Nat Rev Nephrol (2015) 0.97
Transcriptional regulation by hypoxia inducible factors. Crit Rev Biochem Mol Biol (2013) 0.94
Dysregulated angiogenesis in B-chronic lymphocytic leukemia: morphologic, immunohistochemical, and flow cytometric evidence. Diagn Pathol (2008) 0.94
Oxygen and Cell Fate Decisions. Gene Regul Syst Bio (2008) 0.91
An acetate switch regulates stress erythropoiesis. Nat Med (2014) 0.91
Bone marrow endosteal mesenchymal progenitors depend on HIF factors for maintenance and regulation of hematopoiesis. Stem Cell Reports (2014) 0.90
The aryl hydrocarbon receptor nuclear translocator is an essential regulator of murine hematopoietic stem cell viability. Blood (2015) 0.90
Hypoxia-inducible factor as an angiogenic master switch. Front Pediatr (2015) 0.88
Integrity of the prolyl hydroxylase domain protein 2:erythropoietin pathway in aging mice. Blood Cells Mol Dis (2010) 0.88
Inconsistent effects of acidosis on HIF-alpha protein and its target genes. Pflugers Arch (2005) 0.87
A 3.4-kb Copy-Number Deletion near EPAS1 Is Significantly Enriched in High-Altitude Tibetans but Absent from the Denisovan Sequence. Am J Hum Genet (2015) 0.86
Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics (2008) 0.85
Oxygen-Dependent Gene Expression in Development and Cancer: Lessons Learned from the Wilms' Tumor Gene, WT1. Front Mol Neurosci (2011) 0.85
Hypoxia-inducible factors link iron homeostasis and erythropoiesis. Gastroenterology (2013) 0.84
Hypoxia and HIFs in regulating the development of the hematopoietic system. Blood Cells Mol Dis (2013) 0.84
Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. Blood (2012) 0.84
The Human Blood Metabolome-Transcriptome Interface. PLoS Genet (2015) 0.82
The erythroblastic island as an emerging paradigm in the anemia of inflammation. Immunol Res (2015) 0.80
Intermittent exposure to xenon protects against gentamicin-induced nephrotoxicity. PLoS One (2013) 0.80
Role of hypoxia and HIF2α in development of the sympathoadrenal cell lineage and chromaffin cell tumors with distinct catecholamine phenotypic features. Adv Pharmacol (2013) 0.80
Two functional loci in the promoter of EPAS1 gene involved in high-altitude adaptation of Tibetans. Sci Rep (2014) 0.79
EPAS1 gene variants are associated with sprint/power athletic performance in two cohorts of European athletes. BMC Genomics (2014) 0.79
Energy status and HIF signalling in chorionic villi show no evidence of hypoxic stress during human early placental development. Mol Hum Reprod (2014) 0.79
Role of Intestinal HIF-2α in Health and Disease. Annu Rev Physiol (2015) 0.76
Modulation of membrane lipid composition and homeostasis in salmon hepatocytes exposed to hypoxia and perfluorooctane sulfonamide, given singly or in combination. PLoS One (2014) 0.75
Inducible glomerular erythropoietin production in the adult kidney. Kidney Int (2015) 0.75
Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β. Hypoxia (Auckl) (2014) 0.75
Expression of HIF-2α and VEGF in Cervical Squamous Cell Carcinoma and Its Clinical Significance. Biomed Res Int (2016) 0.75
Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2. Nat Commun (2016) 0.75
Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes. Blood (2016) 0.75
Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations. Sci Rep (2017) 0.75
Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options. N Engl J Med (2013) 8.49
Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity (2005) 6.71
NeuPSIG guidelines on neuropathic pain assessment. Pain (2010) 4.04
All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis C virus genotype 3 infection: ALLY-3 phase III study. Hepatology (2015) 3.96
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat Genet (2003) 3.78
Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science (2009) 3.64
Targeted access to the genomes of low-abundance organisms in complex microbial communities. Appl Environ Microbiol (2007) 3.55
Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study. Crit Care (2007) 3.29
Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric cardiopulmonary bypass. J Am Coll Cardiol (2011) 3.17
NGAL is an early predictive biomarker of contrast-induced nephropathy in children. Pediatr Nephrol (2007) 2.99
Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med (2009) 2.94
Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung. J Clin Invest (2006) 2.76
The predictive performance of plasma neutrophil gelatinase-associated lipocalin (NGAL) increases with grade of acute kidney injury. Nephrol Dial Transplant (2009) 2.73
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med (2006) 2.67
PNPASE regulates RNA import into mitochondria. Cell (2010) 2.54
UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J (2011) 2.36
Environmental whole-genome amplification to access microbial populations in contaminated sediments. Appl Environ Microbiol (2006) 2.24
Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane. J Cell Biol (2008) 2.18
Maladaptive role of IL-6 in ischemic acute renal failure. J Am Soc Nephrol (2005) 2.07
HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner. Blood (2004) 1.99
Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. Diabetes (2007) 1.96
The primary defect in experimental ileitis originates from a nonhematopoietic source. J Exp Med (2006) 1.96
The Mouse Limb Anatomy Atlas: an interactive 3D tool for studying embryonic limb patterning. BMC Dev Biol (2008) 1.89
2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells. J Exp Med (2004) 1.88
Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. J Biol Chem (2005) 1.84
Tolerance of the human kidney to isolated controlled ischemia. J Am Soc Nephrol (2013) 1.82
Does an acute care surgical model improve the management and outcome of acute cholecystitis? ANZ J Surg (2010) 1.82
Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. Circ Res (2006) 1.81
Acute-care surgical service: a change in culture. ANZ J Surg (2009) 1.74
Rapid high resolution three dimensional reconstruction of embryos with episcopic fluorescence image capture. Birth Defects Res C Embryo Today (2004) 1.74
Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities. Proc Natl Acad Sci U S A (2009) 1.63
Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4. Kidney Int (2011) 1.63
Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells. Circ Res (2008) 1.62
Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum (2009) 1.56
Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol (2013) 1.55
Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease. J Clin Invest (2004) 1.50
ICAM-1 and LFA-1 play critical roles in LPS-induced neutrophil recruitment into the alveolar space. Am J Physiol Lung Cell Mol Physiol (2006) 1.41
Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells. J Immunol (2005) 1.41
Plasma NGAL for the diagnosis of AKI in patients admitted from the emergency department setting. Clin J Am Soc Nephrol (2013) 1.31
NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease. Kidney Int (2012) 1.30
Retinal disease in mice lacking hypoxia-inducible transcription factor-2alpha. Invest Ophthalmol Vis Sci (2005) 1.30
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A (2011) 1.28
Molecular characterization of influenza B viruses circulating in northern Italy during the 2001-2002 epidemic season. J Med Virol (2003) 1.27
Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr (2007) 1.26
Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia. J Mol Med (Berl) (2007) 1.25
Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis. J Cell Biol (2009) 1.23
Tbx4 and tbx5 acting in connective tissue are required for limb muscle and tendon patterning. Dev Cell (2010) 1.22
Aberrant DAP12 signaling in the 129 strain of mice: implications for the analysis of gene-targeted mice. J Immunol (2002) 1.20
CS1, a novel member of the CD2 family, is homophilic and regulates NK cell function. Mol Immunol (2002) 1.19
Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor. J Biol Chem (2005) 1.19
Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism. PLoS Biol (2013) 1.18
Severe vitamin B12 deficiency in an infant associated with a maternal deficiency and a strict vegetarian diet. J Pediatr Hematol Oncol (2004) 1.15
HIF-2alpha-haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery. Invest Ophthalmol Vis Sci (2008) 1.14
Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis. Proc Natl Acad Sci U S A (2013) 1.14
Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. J Biol Chem (2011) 1.13
Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis. J Exp Med (2006) 1.12
Human infection with highly pathogenic A(H7N7) avian influenza virus, Italy, 2013. Emerg Infect Dis (2014) 1.09
Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin. J Biol Chem (2007) 1.09
Changes in the hemagglutinins and neuraminidases of human influenza B viruses isolated in Italy during the 2001-02, 2002-03, and 2003-04 seasons. J Med Virol (2004) 1.09
Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient mice. PLoS One (2009) 1.08
Urinary biomarkers to detect acute kidney injury in the pediatric emergency center. Pediatr Nephrol (2010) 1.08
A prospective evaluation of urine microscopy in septic and non-septic acute kidney injury. Nephrol Dial Transplant (2011) 1.07
Urine biochemistry in septic and non-septic acute kidney injury: a prospective observational study. J Crit Care (2012) 1.04
Identification of a urinary proteomic signature for lupus nephritis in children. Pediatr Nephrol (2007) 1.03
Islet inflammation: a unifying target for diabetes treatment? Trends Endocrinol Metab (2013) 1.02
Urinary markers of kidney injury and kidney function decline in HIV-infected women. J Acquir Immune Defic Syndr (2012) 1.01
Transmembrane helices of membrane proteins may flex to satisfy hydrophobic mismatch. Biochim Biophys Acta (2006) 1.01
Increased bone marrow allograft rejection by depletion of NK cells expressing inhibitory Ly49 NK receptors for donor class I antigens. Blood (2002) 1.00
Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a. J Transl Med (2009) 1.00
Clarification of the identity of the mammalian fifth pharyngeal arch artery. Clin Anat (2012) 0.97
IRF-1 promotes inflammation early after ischemic acute kidney injury. J Am Soc Nephrol (2009) 0.96
Transcriptional regulation during development of the ductus arteriosus. Circ Res (2008) 0.96
Biomechanical properties of raw meshes used in pelvic floor reconstruction. Int Urogynecol J Pelvic Floor Dysfunct (2008) 0.96
Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet. Mediators Inflamm (2012) 0.95
[Linguistic adaptation and Spanish validation of the LANSS (Leeds Assessment of Neuropathic Symptoms and Signs) scale for the diagnosis of neuropathic pain]. Med Clin (Barc) (2006) 0.94
Transcervical intrauterine topical local anesthetic at hysterosalpingography: a prospective, randomized, double-blind, placebo-controlled trial. Fertil Steril (2002) 0.93
Mitochondrial respiratory chain disease discrimination by retrospective cohort analysis of blood metabolites. Mol Genet Metab (2013) 0.93
Biomarkers for early detection of sickle nephropathy. Am J Hematol (2011) 0.92
The murine NK receptor 2B4 (CD244) exhibits inhibitory function independent of signaling lymphocytic activation molecule-associated protein expression. J Immunol (2004) 0.92
Macular epiretinal brachytherapy in treated age-related macular degeneration: MERITAGE study: twelve-month safety and efficacy results. Ophthalmology (2012) 0.91
Regulated expression of hypoxia-inducible factors during postnatal and postpneumonectomy lung growth. Am J Physiol Lung Cell Mol Physiol (2005) 0.90
Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetes. J Clin Endocrinol Metab (2014) 0.89
Rituximab monotherapy for splenic marginal zone lymphoma. Haematologica (2005) 0.89
Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development. PLoS One (2013) 0.88
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling. J Biol Chem (2012) 0.88
E109K is a SEC23B founder mutation among Israeli Moroccan Jewish patients with congenital dyserythropoietic anemia type II. Acta Haematol (2011) 0.87
Alpha-tocopheryl succinate (alpha-TOS) modulates human prostate LNCaP xenograft growth and gene expression in BALB/c nude mice fed two levels of dietary soybean oil. Eur J Nutr (2006) 0.87
How to improve end of life care in acute hospitals. Nurs Older People (2009) 0.87
Macular epiretinal brachytherapy in treated age-related macular degeneration (MERITAGE): month 24 safety and efficacy results. Retina (2014) 0.87
Foxj3 transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. Dev Biol (2009) 0.87
Ophthalmodynamometry for ICP prediction and pilot test on Mt. Everest. BMC Neurol (2010) 0.86
Global framework for noncommunicable diseases: how can we monitor palliative care? J Palliat Med (2012) 0.86
Opinion: integration of diagnostic and management perspectives for placenta accreta. Aust N Z J Obstet Gynaecol (2009) 0.84
NK-cell purging of leukemia: superior antitumor effects of NK cells H2 allogeneic to the tumor and augmentation with inhibitory receptor blockade. Blood (2003) 0.84
Calorimetric studies of bovine rod outer segment disk membranes support a monomeric unit for both rhodopsin and opsin. Biophys J (2008) 0.83
Translation of the human angiotensin II type 1 receptor mRNA is mediated by a highly efficient internal ribosome entry site. Mol Cell Endocrinol (2003) 0.83