Published in N Engl J Med on February 21, 2008
Association of Intensive Care Unit Admission With Mortality Among Older Patients With Pneumonia. JAMA (2015) 3.18
Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy. Am J Cardiol (2010) 2.52
An IV for the RCT: using instrumental variables to adjust for treatment contamination in randomised controlled trials. BMJ (2010) 2.22
Comparative safety of anesthetic type for hip fracture surgery in adults: retrospective cohort study. BMJ (2014) 2.16
Patterns of second-line uterotonic use in a large sample of hospitalizations for childbirth in the United States: 2007-2011. Anesth Analg (2014) 2.04
Instrumental variable methods in comparative safety and effectiveness research. Pharmacoepidemiol Drug Saf (2010) 1.96
Longer dialysis session length is associated with better intermediate outcomes and survival among patients on in-center three times per week hemodialysis: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant (2012) 1.88
Healthy user and related biases in observational studies of preventive interventions: a primer for physicians. J Gen Intern Med (2011) 1.74
Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev (2011) 1.74
Angiotensin-converting enzyme inhibition or mineralocorticoid receptor blockade do not affect prevalence of atrial fibrillation in patients undergoing cardiac surgery. Crit Care Med (2012) 1.58
Type of stress ulcer prophylaxis and risk of nosocomial pneumonia in cardiac surgical patients: cohort study. BMJ (2013) 1.58
Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg (2014) 1.43
The differential impact of delivery hospital on the outcomes of premature infants. Pediatrics (2012) 1.42
Increased perioperative mortality following aprotinin withdrawal: a real-world analysis of blood management strategies in adult cardiac surgery. Intensive Care Med (2013) 1.37
Early postoperative outcomes and blood product utilization in adult cardiac surgery: the post-aprotinin era. Circulation (2011) 1.24
Modifiable practices associated with sudden death among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study. Clin J Am Soc Nephrol (2012) 1.24
Effect of a medical toxicology admitting service on length of stay, cost, and mortality among inpatients discharged with poisoning-related diagnoses. J Med Toxicol (2015) 1.16
The safety of aprotinin and lysine-derived antifibrinolytic drugs in cardiac surgery: a meta-analysis. CMAJ (2008) 1.12
Trends in acute kidney injury, associated use of dialysis, and mortality after cardiac surgery, 1999 to 2008. Ann Thorac Surg (2012) 1.10
Variations in the Use of Perioperative Multimodal Analgesic Therapy. Anesthesiology (2016) 1.08
Analyzing Propensity Matched Zero-Inflated Count Outcomes in Observational Studies. J Appl Stat (2014) 1.07
Risks of harms using antifibrinolytics in cardiac surgery: systematic review and network meta-analysis of randomised and observational studies. BMJ (2012) 1.07
Use of instrumental variable in prescription drug research with observational data: a systematic review. J Clin Epidemiol (2010) 1.03
Physicians' prescribing preferences were a potential instrument for patients' actual prescriptions of antidepressants. J Clin Epidemiol (2013) 1.02
Is delayed graft function causally associated with long-term outcomes after kidney transplantation? Instrumental variable analysis. Transplantation (2013) 1.00
Signal detection and monitoring based on longitudinal healthcare data. Pharmaceutics (2012) 1.00
Adherence with single-pill amlodipine/atorvastatin vs a two-pill regimen. Vasc Health Risk Manag (2008) 1.00
Reducing bias in the assessment of treatment effectiveness: androgen deprivation therapy for prostate cancer. Med Care (2012) 0.98
Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: a retrospective analysis. Crit Care (2010) 0.96
The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: a single-surgeon experience. J Child Orthop (2013) 0.93
Sports and exercise-related tendinopathies: a review of selected topical issues by participants of the second International Scientific Tendinopathy Symposium (ISTS) Vancouver 2012. Br J Sports Med (2013) 0.93
Safety and effectiveness of bivalirudin in routine care of patients undergoing percutaneous coronary intervention. Eur Heart J (2009) 0.89
Adjuvant vancomycin for antibiotic prophylaxis and risk of Clostridium difficile infection after coronary artery bypass graft surgery. J Thorac Cardiovasc Surg (2013) 0.87
Blockade of endogenous tissue kallikrein aggravates renal injury by enhancing oxidative stress and inhibiting matrix degradation. Am J Physiol Renal Physiol (2010) 0.87
Methylergonovine maleate and the risk of myocardial ischemia and infarction. Am J Obstet Gynecol (2013) 0.86
Efficacy of phototherapy for newborns with hyperbilirubinemia: a cautionary example of an instrumental variable analysis. Med Decis Making (2011) 0.86
Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature. PLoS One (2011) 0.85
Misclassification in administrative claims data: quantifying the impact on treatment effect estimates. Curr Epidemiol Rep (2014) 0.84
Blood transfusions in total hip and knee arthroplasty: an analysis of outcomes. ScientificWorldJournal (2014) 0.83
Learning from aprotinin--mandatory trials of comparative efficacy and safety needed. N Engl J Med (2008) 0.83
Effects of aprotinin or tranexamic acid on proteolytic/cytokine profiles in infants after cardiac surgery. Ann Thorac Surg (2010) 0.81
Utilization and comparative effectiveness of caspofungin and voriconazole early after market approval in the U.S. PLoS One (2014) 0.81
Neurological complications of cardiac surgery. Semin Neurol (2008) 0.79
Perioperative management of antiplatelet-drugs in cardiac surgery. Curr Cardiol Rev (2009) 0.78
Regulatory decisions pertaining to aprotinin may be putting patients at risk. CMAJ (2014) 0.76
The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS One (2013) 0.76
Strategies for blood conservation in pediatric cardiac surgery. Ann Card Anaesth (2016) 0.75
Aprotinin and classic wound drainage are unnecessary in total hip replacement - a prospective randomized trial. Eur J Med Res (2011) 0.75
Application of long-acting VLHL PAI-1 during sutureless partial nephrectomy in mice reduces bleeding. Biomed Res Int (2015) 0.75
The aprotinin saga and the risks of conducting meta-analyses on small randomised controlled trials - a critique of a Cochrane review. BMC Health Serv Res (2009) 0.75
A randomized clinical trial investigating the relationship between aprotinin and hypercoagulability in off-pump coronary surgery. Anesth Analg (2009) 0.75
Incorporating linked healthcare claims to improve confounding control in a study of in-hospital medication use. Drug Saf (2015) 0.75
External adjustment sensitivity analysis for unmeasured confounding: an application to coronary stent outcomes, Pennsylvania 2004-2008. Health Serv Res (2012) 0.75
Aprotinin exacerbates left ventricular dysfunction after ischemia/reperfusion in mice lacking tumor necrosis factor receptor I. J Cardiovasc Pharmacol (2008) 0.75
Operative time, blood loss, hemoglobin drop, blood transfusion, and hospital stay in orthognathic surgery. Oral Maxillofac Surg (2017) 0.75
Adverse Events Associated with Antipsychotic Use in Hospitalized Older Adults After Cardiac Surgery. J Am Geriatr Soc (2017) 0.75
Intensive Care Unit Admission and Survival among Older Patients with Chronic Obstructive Pulmonary Disease, Heart Failure, or Myocardial Infarction. Ann Am Thorac Soc (2017) 0.75
Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study. Lancet (2002) 9.66
Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect. Am J Epidemiol (2005) 6.20
Sensitivity analysis and external adjustment for unmeasured confounders in epidemiologic database studies of therapeutics. Pharmacoepidemiol Drug Saf (2006) 4.64
Outcomes of reference pricing for angiotensin-converting-enzyme inhibitors. N Engl J Med (2002) 4.07
Long-term effectiveness of highly active antiretroviral therapy on the survival of children and adolescents with HIV infection: a 10-year follow-up study. Clin Infect Dis (2008) 3.09
Outcomes of neonates undergoing extracorporeal membrane oxygenation support using centrifugal versus roller blood pumps. Ann Thorac Surg (2012) 2.97
Inhibition of clinical benefits of aspirin on first myocardial infarction by nonsteroidal antiinflammatory drugs. Circulation (2003) 2.73
Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide. Curr Med Res Opin (2009) 2.68
Persistence and adherence with topical glaucoma therapy. Am J Ophthalmol (2005) 2.31
An application of propensity score matching using claims data. Pharmacoepidemiol Drug Saf (2005) 2.15
Paroxetine in the first trimester and the prevalence of congenital malformations. Pharmacoepidemiol Drug Saf (2007) 2.04
The risk of nonvertebral fracture related to inhaled corticosteroid exposure among adults with chronic respiratory disease. Chest (2005) 2.04
Impact of reference-based pricing for angiotensin-converting enzyme inhibitors on drug utilization. CMAJ (2002) 1.99
Venous thromboembolism, myocardial infarction, and stroke among transdermal contraceptive system users. Obstet Gynecol (2007) 1.99
Statin use and risk of prostate cancer in the California Men's Health Study cohort. Cancer Epidemiol Biomarkers Prev (2007) 1.94
Risk of thromboembolism in women taking ethinylestradiol/drospirenone and other oral contraceptives. Obstet Gynecol (2007) 1.87
Benzodiazepine use and hip fractures in the elderly: who is at greatest risk? Arch Intern Med (2004) 1.86
Coronary heart disease outcomes in patients receiving antidiabetic agents in the PharMetrics database 2000-2007. Pharmacoepidemiol Drug Saf (2008) 1.76
The risk of coronary heart disease in type 2 diabetic patients exposed to thiazolidinediones compared to metformin and sulfonylurea therapy. Pharmacoepidemiol Drug Saf (2007) 1.64
Impact of baseline heart failure burden on post-implantable cardioverter-defibrillator mortality among medicare beneficiaries. J Am Coll Cardiol (2013) 1.62
The effectiveness of varenicline medication guide for conveying safety information to patients: a REMS assessment survey. Pharmacoepidemiol Drug Saf (2013) 1.61
Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting. Clin Infect Dis (2008) 1.60
Clinical and economic consequences of reference pricing for dihydropyridine calcium channel blockers. Clin Pharmacol Ther (2003) 1.49
Risk of Guillain-Barré syndrome after meningococcal conjugate vaccination. Pharmacoepidemiol Drug Saf (2012) 1.46
Use of propensity score technique to account for exposure-related covariates: an example and lesson. Med Care (2007) 1.44
Drug copayment and adherence in chronic heart failure: effect on cost and outcomes. Pharmacotherapy (2006) 1.41
Effect of aprotinin on renal dysfunction. Lancet (2008) 1.39
The impact of wording in "Dear doctor" letters and in black box labels. Clin Pharmacol Ther (2002) 1.38
Analgesic use and change in kidney function in apparently healthy men. Am J Kidney Dis (2003) 1.37
Serious cardiovascular events and mortality among patients with schizophrenia. J Nerv Ment Dis (2004) 1.32
A propensity score-matched cohort study of the effect of statins, mainly fluvastatin, on the occurrence of acute myocardial infarction. Am J Cardiol (2003) 1.29
Effectiveness of the pentavalent rotavirus vaccine in preventing gastroenteritis in the United States. Pediatrics (2010) 1.29
Occurrence of colon ischemia in relation to irritable bowel syndrome. Am J Gastroenterol (2004) 1.25
Coronary heart disease outcomes in patients receiving antidiabetic agents. Pharmacoepidemiol Drug Saf (2007) 1.25
Patterns of opioid utilization in pregnancy in a large cohort of commercial insurance beneficiaries in the United States. Anesthesiology (2014) 1.24
Bupropion in pregnancy and the prevalence of congenital malformations. Pharmacoepidemiol Drug Saf (2007) 1.23
The urban spread of visceral leishmaniasis: clues from spatial analysis. Epidemiology (2002) 1.20
The comparative safety of rosuvastatin: a retrospective matched cohort study in over 48,000 initiators of statin therapy. Pharmacoepidemiol Drug Saf (2006) 1.20
Incidence of allergic reactions associated with antibacterial use in a large, managed care organisation. Drug Saf (2007) 1.18
Serious ventricular arrhythmias among users of cisapride and other QT-prolonging agents in the United States. Pharmacoepidemiol Drug Saf (2002) 1.16
Lipid profiles among US elderly with untreated rheumatoid arthritis--the Third National Health and Nutrition Examination Survey. J Rheumatol (2005) 1.16
Estimation using all available covariate information versus a fixed look-back window for dichotomous covariates. Pharmacoepidemiol Drug Saf (2013) 1.15
Tegaserod and the risk of cardiovascular ischemic events: an observational cohort study. J Cardiovasc Pharmacol Ther (2010) 1.14
Achilles tendon rupture and its association with fluoroquinolone antibiotics and other potential risk factors in a managed care population. Pharmacoepidemiol Drug Saf (2006) 1.09
A distributed research network model for post-marketing safety studies: the Meningococcal Vaccine Study. Pharmacoepidemiol Drug Saf (2008) 1.09
Quasi-experimental longitudinal designs to evaluate drug benefit policy changes with low policy compliance. J Clin Epidemiol (2002) 1.07
Atomoxetine and cerebrovascular outcomes in adults. J Clin Psychopharmacol (2009) 1.06
Compliance with a statin treatment in a usual-care setting: retrospective database analysis over 3 years after treatment initiation in health maintenance organization enrollees with dyslipidemia. Clin Ther (2005) 1.05
Severe vascular events in migraine patients. Headache (2004) 1.04
Dopamine antagonists and the development of breast cancer. Arch Gen Psychiatry (2002) 1.01
The incidence of abdominal and pelvic surgery among patients with irritable bowel syndrome. Dig Dis Sci (2005) 1.01
Topical treatments with pimecrolimus, tacrolimus and medium- to high-potency corticosteroids, and risk of lymphoma. Dermatology (2009) 0.98
Pediatric ECMO outcomes: comparison of centrifugal versus roller blood pumps using propensity score matching. ASAIO J (2013) 0.98
Stratum-specific positive predictive values of claims for acute pancreatitis among commercial health insurance plan enrollees with diabetes mellitus. Pharmacoepidemiol Drug Saf (2010) 0.97
Identification of abacavir hypersensitivity reaction in health care claims data. Pharmacoepidemiol Drug Saf (2007) 0.95
Glucocorticoid use and serum lipid levels in US adults: the Third National Health and Nutrition Examination Survey. Arthritis Rheum (2005) 0.94
The thiazolidinediones rosiglitazone and pioglitazone and the risk of coronary heart disease: a retrospective cohort study using a US health insurance database. Clin Ther (2009) 0.93
Effectiveness of an incomplete RotaTeq (RV5) vaccination regimen in preventing rotavirus gastroenteritis in the United States. Pediatr Infect Dis J (2013) 0.92
Incidence of colonic ischemia, hospitalized complications of constipation, and bowel surgery in relation to use of alosetron hydrochloride. Am J Gastroenterol (2003) 0.92
The effect of pharmacotherapy for attention deficit hyperactivity disorder on risk of seizures in pediatric patients as assessed in an insurance claims database. Curr Drug Saf (2008) 0.92
The incidence of first provoked and unprovoked seizure in pediatric patients with and without psychiatric diagnoses. Epilepsia (2007) 0.92
Extended case-control study results on thromboembolic outcomes among transdermal contraceptive users. Contraception (2010) 0.92
Incidence of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome. Epidemiology (2004) 0.92
Educational attainment and response to HAART during initial therapy for HIV-1 infection. J Psychosom Res (2007) 0.91
Active safety monitoring of new medical products using electronic healthcare data: selecting alerting rules. Epidemiology (2012) 0.91
High-dimensional propensity score algorithm in comparative effectiveness research with time-varying interventions. Stat Med (2014) 0.91
Cardiovascular risk of selective cyclooxygenase-2 inhibitors and other non-aspirin non-steroidal anti-inflammatory medications. Pharmacoepidemiol Drug Saf (2006) 0.90
Risk of hyperkalemia in women taking ethinylestradiol/drospirenone and other oral contraceptives. Contraception (2008) 0.90
Trends in insulin initiation and treatment intensification among patients with type 2 diabetes. J Gen Intern Med (2013) 0.89
Studies of diabetes, thiazolidinediones, and coronary heart disease. Pharmacoepidemiol Drug Saf (2007) 0.88
A matched cohort study of the risk of cancer in users of becaplermin. Adv Skin Wound Care (2011) 0.88
Algorithms to identify colonic ischemia, complications of constipation and irritable bowel syndrome in medical claims data: development and validation. Pharmacoepidemiol Drug Saf (2006) 0.88
Effects of rofecoxib and naproxen on life expectancy among patients with rheumatoid arthritis: a decision analysis. Am J Med (2004) 0.87
Active influenza vaccine safety surveillance: potential within a healthcare claims environment. Med Care (2009) 0.86
Statin use and risk of colorectal cancer in a cohort of middle-aged men in the US: a prospective cohort study. Drugs (2009) 0.86
The effect of zanamivir treatment on influenza complications: a retrospective cohort study. Clin Ther (2002) 0.86
Clinical and economic benefits observed when follow-up triglyceride levels are less than 500 mg/dL in patients with severe hypertriglyceridemia. J Clin Lipidol (2012) 0.85
Incidence of hospitalized rhabdomyolysis with statin and fibrate use in an insured US population. Ann Pharmacother (2011) 0.85
Acute nonarteritic anterior ischemic optic neuropathy and exposure to phosphodiesterase type 5 inhibitors. J Sex Med (2014) 0.85
An event-based approach for comparing the performance of methods for prospective medical product monitoring. Pharmacoepidemiol Drug Saf (2012) 0.83
A pooled analysis of exenatide use and risk of acute pancreatitis. Curr Med Res Opin (2013) 0.83
Postmarketing evaluation of the short-term safety of the pentavalent rotavirus vaccine. Pediatr Infect Dis J (2012) 0.83
Observational studies of the association between glucose-lowering medications and cardiovascular outcomes: addressing methodological limitations. Diabetologia (2014) 0.82
Rationale and design of the multinational observational study assessing insulin use: the MOSAIc study. BMC Endocr Disord (2012) 0.82
Drug safety in the digital age. N Engl J Med (2014) 0.81
Health care resource utilization in patients with active epilepsy. Epilepsia (2009) 0.81
Transarticular facet screw stabilization and dorsal laminectomy in 26 dogs with degenerative lumbosacral stenosis with instability. Vet Surg (2012) 0.81
Lung cancer and mesothelioma among male automobile mechanics: a review. Rev Environ Health (2004) 0.81
Comparison of resource utilization by patients treated with transdermal fentanyl and long-acting oral opioids for nonmalignant pain. Pain Med (2002) 0.81
Methodological approaches to evaluate the impact of FDA drug safety communications. Drug Saf (2015) 0.81
Barriers to insulin progression among patients with type 2 diabetes: a systematic review. Diabetes Educ (2012) 0.80
Methods and objectives of a large US multicenter case-control study of post-transplant lymphoproliferative disorder in renal transplant patients. Recent Results Cancer Res (2002) 0.80
Hospitalization for peptic ulcer and bleeding in users of selective COX-2 inhibitors and nonselective NSAIDs with special reference to celecoxib. Pharmacoepidemiol Drug Saf (2008) 0.79
Methods for comparative effectiveness research/patient-centered outcomes research: from efficacy to effectiveness. J Clin Epidemiol (2013) 0.79
Duloxetine for depression and the incidence of hepatic events in adults. J Clin Psychopharmacol (2011) 0.79