Published in Curr Mol Med on February 01, 2008
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer (2009) 18.53
The morphological and molecular features of the epithelial-to-mesenchymal transition. Nat Protoc (2009) 1.60
Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer. Breast Cancer Res (2012) 1.55
Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response. Breast Cancer Res (2013) 1.33
In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer. Cancer Res (2010) 1.31
The complexities of obesity and diabetes with the development and progression of pancreatic cancer. Biochim Biophys Acta (2010) 1.29
COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion. J Clin Invest (2010) 1.28
Molecular pathways: linking tumor microenvironment to epithelial-mesenchymal transition in metastasis. Clin Cancer Res (2014) 1.17
The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells. BMC Cancer (2012) 1.09
Tumor cell metabolism: an integral view. Cancer Biol Ther (2011) 1.04
Hypoxia inducible factor 1α-mediated LOX expression correlates with migration and invasion in epithelial ovarian cancer. Int J Oncol (2013) 0.97
Tissue dynamics spectroscopy for phenotypic profiling of drug effects in three-dimensional culture. Biomed Opt Express (2012) 0.96
An emerging role for long non-coding RNAs in cancer metastasis. Front Genet (2014) 0.95
Intraoperative imaging in ovarian cancer: fact or fiction? Mol Imaging (2011) 0.94
Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy. Oncotarget (2015) 0.93
Contribution of acidic melanoma cells undergoing epithelial-to-mesenchymal transition to aggressiveness of non-acidic melanoma cells. Clin Exp Metastasis (2014) 0.89
A simplified synthesis of the hypoxia imaging agent 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-[(18)F]pentafluoropropyl)-acetamide ([18F]EF5). Nucl Med Biol (2012) 0.86
Recently identified biomarkers that promote lymph node metastasis in head and neck squamous cell carcinoma. Cancers (Basel) (2011) 0.86
Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancer. PLoS One (2009) 0.83
Targeting Notch to overcome radiation resistance. Oncotarget (2016) 0.82
Hypoxia-inducible factor-1 as a therapeutic target in endometrial cancer management. Obstet Gynecol Int (2010) 0.82
Co-expression of CXCL8 and HIF-1α is associated with metastasis and poor prognosis in hepatocellular carcinoma. Oncotarget (2015) 0.81
Regulation of cancer cell migration and invasion by sphingosine-1-phosphate. World J Biol Chem (2010) 0.81
Subcellular FIH-1 expression patterns in invasive breast cancer in relation to HIF-1α expression. Cell Oncol (Dordr) (2011) 0.78
Direct visualization of the phenotype of hypoxic tumor cells at single cell resolution in vivo using a new hypoxia probe. Intravital (2016) 0.76
Expression of proteins associated with hypoxia and Wnt pathway activation is of prognostic significance in hepatocellular carcinoma. Virchows Arch (2015) 0.76
Modulation of p75 neurotrophin receptor under hypoxic conditions induces migration and invasion of C6 glioma cells. Clin Exp Metastasis (2014) 0.76
Acidic pH-Triggered Drug-Eluting Nanocomposites for Magnetic Resonance Imaging-Monitored Intra-arterial Drug Delivery to Hepatocellular Carcinoma. ACS Appl Mater Interfaces (2016) 0.75
Expression of HIF-1α and HIF-2α correlates to biological and clinical significance in papillary thyroid carcinoma. World J Surg Oncol (2016) 0.75
Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cells. Cancer Sci (2016) 0.75
Glucose deprivation elicits phenotypic plasticity via ZEB1-mediated expression of NNMT. Oncotarget (2017) 0.75
Oxygen-Related Differences in Cellular and Vesicular Phenotypes Observed for Ovarian Cell Cancer Lines. J Circ Biomark (2016) 0.75
Micrometastases or isolated tumor cells and the outcome of breast cancer. N Engl J Med (2009) 5.36
Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer (2003) 3.47
Obesity and cancer: the role of dysfunctional adipose tissue. Cancer Epidemiol Biomarkers Prev (2009) 3.25
Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. J Clin Oncol (2002) 2.56
Fallopian tube intraluminal tumor spread from noninvasive precursor lesions: a novel metastatic route in early pelvic carcinogenesis. Am J Surg Pathol (2013) 2.19
Fatigue and relating factors in high-risk breast cancer patients treated with adjuvant standard or high-dose chemotherapy: a longitudinal study. J Clin Oncol (2005) 2.14
Cytogenetic alterations and cytokeratin expression patterns in breast cancer: integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesis. Lab Invest (2002) 2.06
Brief fixation does not affect assessment of hormone receptor expression in invasive breast carcinoma biopsies: paving the road for same-day tissue diagnostics. Am J Surg Pathol (2014) 1.95
Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene. Neoplasia (2004) 1.92
Receptor conversion in distant breast cancer metastases. Breast Cancer Res (2010) 1.85
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. J Biol Chem (2009) 1.83
Alternatives for randomization in lifestyle intervention studies in cancer patients were not better than conventional randomization. J Clin Epidemiol (2012) 1.71
HER-2/neu amplification testing in breast cancer by multiplex ligation-dependent probe amplification in comparison with immunohistochemistry and in situ hybridization. Cell Oncol (2009) 1.70
Going fully digital: Perspective of a Dutch academic pathology lab. J Pathol Inform (2013) 1.67
Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment. Clin Cancer Res (2011) 1.64
Serum CA-125 in relation to adnexal dysplasia and cancer in women at hereditary high risk of ovarian cancer. J Clin Oncol (2007) 1.58
The sentinel node in cervical cancer: scintigraphy and laparoscopic gamma probe-guided biopsy. Eur J Nucl Med Mol Imaging (2004) 1.56
Safety of avoiding routine use of axillary dissection in early stage breast cancer: a systematic review. Breast Cancer Res Treat (2010) 1.53
Genome-wide-array-based comparative genomic hybridization reveals genetic homogeneity and frequent copy number increases encompassing CCNE1 in fallopian tube carcinoma. Oncogene (2003) 1.52
Chemotherapy-induced nausea and vomiting in daily clinical practice: a community hospital-based study. Support Care Cancer (2011) 1.52
Creation of a fully digital pathology slide archive by high-volume tissue slide scanning. Hum Pathol (2010) 1.52
Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective. Histopathology (2009) 1.51
Breast cancer histopathology image analysis: a review. IEEE Trans Biomed Eng (2014) 1.47
Cultures of ovarian surface epithelium from women with and without a hereditary predisposition to develop female adnexal carcinoma. Gynecol Oncol (2004) 1.45
Sentinel node biopsy for nonpalpable breast tumors requires a preoperative diagnosis of invasive breast cancer. Breast J (2003) 1.44
Automatic nuclei segmentation in H&E stained breast cancer histopathology images. PLoS One (2013) 1.43
Promoter hypermethylation patterns in fallopian tube epithelium of BRCA1 and BRCA2 germ line mutation carriers. Endocr Relat Cancer (2012) 1.40
The 3-layered ductal epithelium in gynecomastia. Am J Surg Pathol (2012) 1.40
Confocal 3D DNA cytometry: assessment of required coefficient of variation by computer simulation. Cell Oncol (2004) 1.39
Ischemia/reperfusion accelerates the outgrowth of hepatic micrometastases in a highly standardized murine model. Hepatology (2005) 1.37
Rapid visualization of human tumor xenografts through optical imaging with a near-infrared fluorescent anti-epidermal growth factor receptor nanobody. Mol Imaging (2012) 1.33
Frequent promoter hypermethylation of BRCA2, CDH13, MSH6, PAX5, PAX6 and WT1 in ductal carcinoma in situ and invasive breast cancer. J Pathol (2011) 1.32
Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice. Mol Cell Biol (2007) 1.32
BRCA1/2-related ovarian cancers are of tubal origin: a hypothesis. Gynecol Oncol (2003) 1.31
c-Jun activation is associated with proliferation and angiogenesis in invasive breast cancer. Hum Pathol (2006) 1.30
Pathology of hereditary breast cancer. Cell Oncol (Dordr) (2011) 1.28
COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion. J Clin Invest (2010) 1.28
Accelerated perinecrotic outgrowth of colorectal liver metastases following radiofrequency ablation is a hypoxia-driven phenomenon. Ann Surg (2009) 1.24
Methylation of the TWIST1 promoter, TWIST1 mRNA levels, and immunohistochemical expression of TWIST1 in breast cancer. Cancer Epidemiol Biomarkers Prev (2008) 1.22
Whole slide images for primary diagnostics in dermatopathology: a feasibility study. J Clin Pathol (2011) 1.21
Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization. J Pathol (2003) 1.21
Whole slide images for primary diagnostics of gastrointestinal tract pathology: a feasibility study. Hum Pathol (2011) 1.21
Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1alpha (HIF-1alpha). Oncogene (2003) 1.20
The role of hypoxia inducible factor-1alpha in gynecological cancer. Crit Rev Oncol Hematol (2010) 1.19
Prognostic value of estrogen receptor α and progesterone receptor conversion in distant breast cancer metastases. Cancer (2012) 1.18
Molecular subtyping of male breast cancer by immunohistochemistry. Mod Pathol (2011) 1.17
High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer. Breast Cancer Res Treat (2007) 1.16
Do we see what we think we see? The complexities of morphological assessment. J Pathol (2009) 1.16
Molecular profiling of invasive breast cancer by multiplex ligation-dependent probe amplification-based copy number analysis of tumor suppressor and oncogenes. Mod Pathol (2010) 1.16
Comparative molecular and histological grading of epithelial dysplasia of the oral cavity and the oropharynx. J Pathol (2003) 1.13
Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance. J Clin Invest (2011) 1.13
Absence of chromosome 17 polysomy in breast cancer: analysis by CEP17 chromogenic in situ hybridization and multiplex ligation-dependent probe amplification. Breast Cancer Res Treat (2009) 1.13
HIF1-alpha overexpression indicates a good prognosis in early stage squamous cell carcinomas of the oral floor. BMC Cancer (2005) 1.12
Measuring [(18)F]FDG uptake in breast cancer during chemotherapy: comparison of analytical methods. Eur J Nucl Med Mol Imaging (2003) 1.11
COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70. PLoS One (2009) 1.11
Ovarian carcinogenesis: an alternative hypothesis. Adv Exp Med Biol (2008) 1.09
Reliable and controllable antibody fragment selections from Camelid non-immune libraries for target validation. Biochim Biophys Acta (2006) 1.08
Radiofrequency ablation of colorectal liver metastases induces an inflammatory response in distant hepatic metastases but not in local accelerated outgrowth. J Surg Oncol (2010) 1.08
Prospective multicenter validation of the independent prognostic value of the mitotic activity index in lymph node-negative breast cancer patients younger than 55 years. J Clin Oncol (2005) 1.08
Non-sentinel lymph node metastases associated with isolated breast cancer cells in the sentinel node. J Natl Cancer Inst (2008) 1.07
Histopathological characteristics of BRCA1- and BRCA2-associated intraperitoneal cancer: a clinic-based study. Fam Cancer (2003) 1.07
Prognostic factors in adult soft tissue sarcomas of the head and neck: a single-centre experience. Oral Oncol (2006) 1.06
Expression of hypoxia-inducible factor-1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor related. Breast Cancer Res (2004) 1.06
Differential Notch and TGFbeta signaling in primary colorectal tumors and their corresponding metastases. Cell Oncol (2008) 1.06
Oncogene amplification in male breast cancer: analysis by multiplex ligation-dependent probe amplification. Breast Cancer Res Treat (2012) 1.06
Atypical MEN type 2B associated with two germline RET mutations on the same allele not involving codon 918. J Clin Endocrinol Metab (2002) 1.05
Her-2/neu testing and therapy in gastroesophageal adenocarcinoma. Patholog Res Int (2010) 1.05
Molecular markers predict outcome in squamous cell carcinoma of the head and neck after concomitant cisplatin-based chemoradiation. Int J Cancer (2009) 1.04
HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages. Atherosclerosis (2007) 1.04
Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. J Biol Chem (2002) 1.04
18F-2-fluoro-2-deoxy-d-glucose positron emission tomography in staging of locally advanced breast cancer. J Clin Oncol (2004) 1.04
Gene dosage PCR and fluorescence in situ hybridization reveal low frequency of egfr amplifications despite protein overexpression in invasive breast carcinoma. Lab Invest (2004) 1.03
p300 and p53 levels determine activation of HIF-1 downstream targets in invasive breast cancer. Hum Pathol (2006) 1.02
Low frequency of HER2 amplification and overexpression in early onset gastric cancer. Cell Oncol (Dordr) (2011) 1.02
Tales of how great drugs were brought down by a flawed rationale--letter. Clin Cancer Res (2013) 1.02
Prognostic value of automatically extracted nuclear morphometric features in whole slide images of male breast cancer. Mod Pathol (2012) 1.02
Formaldehyde substitute fixatives: effects on nucleic acid preservation. J Clin Pathol (2011) 1.02
Confocal DNA cytometry: a contour-based segmentation algorithm for automated three-dimensional image segmentation. Cytometry (2002) 1.01
Accuracy of sentinel node biopsy after neoadjuvant chemotherapy in breast cancer patients: a systematic review. Eur J Cancer (2009) 1.01