Published in Free Radic Biol Med on February 07, 2008
Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med (2010) 7.31
Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells. Cancer Res (2009) 1.10
Manganese superoxide dismutase: beyond life and death. Amino Acids (2010) 1.06
Enhanced expression of mitochondrial superoxide dismutase leads to prolonged in vivo cell cycle progression and up-regulation of mitochondrial thioredoxin. Free Radic Biol Med (2010) 0.94
Heavy ions, radioprotectors and genomic instability: implications for human space exploration. Radiat Environ Biophys (2009) 0.91
WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. Free Radic Biol Med (2008) 0.91
Hydrogen peroxide signaling is required for glucocorticoid-induced apoptosis in lymphoma cells. Free Radic Biol Med (2011) 0.88
Tumorigenic polyploid cells contain elevated ROS and ARE selectively targeted by antioxidant treatment. J Cell Physiol (2012) 0.83
The functional role of MnSOD as a biomarker of human diseases and therapeutic potential of a new isoform of a human recombinant MnSOD. Biomed Res Int (2014) 0.81
Caspase inhibition blocks cell death and enhances mitophagy but fails to promote T-cell lymphoma. PLoS One (2011) 0.79
Manganese superoxide dismutase in cancer prevention. Antioxid Redox Signal (2013) 0.77
Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender. Radiat Res (2013) 0.75
Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma. Dis Markers (2016) 0.75
The hallmarks of cancer. Cell (2000) 113.05
Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell (1993) 10.83
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell (1991) 8.13
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (1997) 7.31
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell (1985) 7.29
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell (1993) 7.25
Dissecting p53 tumor suppressor functions in vivo. Cancer Cell (2002) 6.24
A mutator phenotype in cancer. Cancer Res (2001) 4.41
Persistent oxidative stress in cancer. FEBS Lett (1995) 3.85
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics (2003) 3.84
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature (2003) 3.77
Role of superoxide dismutase in cancer: a review. Cancer Res (1979) 3.34
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene (2005) 3.17
An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal Biochem (1989) 3.02
Reactive oxygen species in tumor progression. Front Biosci (2005) 2.72
Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc Natl Acad Sci U S A (2001) 2.63
The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutat Res (2001) 2.52
Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability. Cancer Res (2006) 2.27
Bcl-2 is a prognostic marker in breast cancer independently of the Nottingham Prognostic Index. Clin Cancer Res (2006) 2.16
Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. Proc Natl Acad Sci U S A (1993) 2.08
Oxidative stress inactivates the human DNA mismatch repair system. Am J Physiol Cell Physiol (2002) 1.71
Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis. Am J Physiol Heart Circ Physiol (2001) 1.71
Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. Blood (1998) 1.61
Mechanism of the tumor suppressive effect of MnSOD overexpression. Biomed Pharmacother (2005) 1.58
Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model. Cancer Res (2001) 1.48
Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase. Mol Cancer Ther (2003) 1.45
Bax alpha perturbs T cell development and affects cell cycle entry of T cells. EMBO J (1996) 1.43
Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells. Oncogene (2005) 1.30
Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts. Aging Cell (2003) 1.19
Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2. Antioxid Redox Signal (2006) 1.14
Bax accelerates tumorigenesis in p53-deficient mice. Cancer Res (2001) 1.13
Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress. Cancer Res (1998) 1.11
Synthesis and processing of the precursor for human mangano-superoxide dismutase. Biochim Biophys Acta (1989) 1.07
Paradoxical inhibition of c-myc-induced carcinogenesis by Bcl-2 in transgenic mice. Cancer Res (1999) 1.01
Tumor suppressive effects of MnSOD overexpression may involve imbalance in peroxide generation versus peroxide removal. Antioxid Redox Signal (2004) 1.01
Enforced expression of superoxide dismutase 2/manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosis. Cancer Res (2005) 0.99
Antioxidant enzymes and apoptosis. Drug Metab Rev (2004) 0.96
Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia. Blood (1999) 0.95
Paradoxical role of apoptosis in tumor progression. J Cell Biochem (2003) 0.91
Bax affects production of reactive oxygen by the mitochondria of non-apoptotic neurons. Exp Neurol (2006) 0.89
Bax-induced cell death in yeast depends on mitochondrial lipid oxidation. Eur J Biochem (2002) 0.88
Relationship between changes in ploidy and stable cellular resistance to hydrogen peroxide. J Cell Physiol (1989) 0.83
Lymphoma development in Bax transgenic mice is inhibited by Bcl-2 and associated with chromosomal instability. Cell Death Differ (2003) 0.83
Evidence of allelic imbalance of chromosome 6 in human astrocytomas. Neurology (1994) 0.82
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell (2005) 13.59
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell (2008) 6.16
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell (2010) 5.40
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell (2010) 4.19
Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc Natl Acad Sci U S A (2007) 3.41
Superoxide mediates the actions of angiotensin II in the central nervous system. Circ Res (2002) 3.29
Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J Neurosci (2006) 3.06
A newly discovered protein export machine in malaria parasites. Nature (2009) 2.79
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. Cell (2013) 2.75
Attitudes of doctors and nurses towards incident reporting: a qualitative analysis. Med J Aust (2004) 2.62
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci U S A (2006) 2.59
How insulin engages its primary binding site on the insulin receptor. Nature (2013) 2.52
Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels. Cell (2010) 2.50
Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem J (2009) 2.35
Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability. Cancer Res (2006) 2.27
The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity (2012) 2.15
SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci (2008) 2.12
Randomized controlled trial of unflued gas heater replacement on respiratory health of asthmatic schoolchildren. Int J Epidemiol (2004) 2.05
2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer Res (2007) 2.03
Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells. J Biol Chem (2004) 1.94
Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways. Radiology (2010) 1.84
Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT. Int J Radiat Oncol Biol Phys (2009) 1.83
Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2. J Biol Chem (2002) 1.82
Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Res (2002) 1.80
Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Mol Cell Biol (2003) 1.80
Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab. Blood (2006) 1.79
Cell of origin strongly influences genetic selection in a mouse model of T-ALL. Blood (2011) 1.78
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med (2011) 1.74
Boson sampling on a photonic chip. Science (2012) 1.71
Phase I clinical trial of CpG oligonucleotide 7909 (PF-03512676) in patients with previously treated chronic lymphocytic leukemia. Leuk Lymphoma (2011) 1.71
Structure-guided design of a selective BCL-X(L) inhibitor. Nat Chem Biol (2013) 1.68
Meta-analysis of the relationship between non-high-density lipoprotein cholesterol reduction and coronary heart disease risk. J Am Coll Cardiol (2009) 1.67
Redox regulation of the G1 to S phase transition in the mouse embryo fibroblast cell cycle. Cancer Res (2003) 1.62
Physical training for asthma. Cochrane Database Syst Rev (2013) 1.62
Non-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbations of asthma. Cochrane Database Syst Rev (2012) 1.60
Glucose as a prognostic factor in ovarian carcinoma. Cancer (2009) 1.59
Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry. EMBO J (2003) 1.59
Training health professionals in smoking cessation. Cochrane Database Syst Rev (2012) 1.59
The HSV-1 Us3 protein kinase is sufficient to block apoptosis induced by overexpression of a variety of Bcl-2 family members. Virology (2004) 1.57
Tissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke. Stroke (2004) 1.55
Consequences of two different amino-acid substitutions at the same codon in KRT14 indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis. J Invest Dermatol (2011) 1.53
Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity. ACS Chem Biol (2012) 1.50
Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain. J Am Chem Soc (2011) 1.49
Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem (2007) 1.48
18-Fluoro-deoxyglucose positron emission tomography report interpretation as predictor of outcome in diffuse large B-cell lymphoma including analysis of 'indeterminate' reports. Leuk Lymphoma (2010) 1.47
HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clin Cancer Res (2012) 1.47
Physical training for asthma. Cochrane Database Syst Rev (2012) 1.47
Geocoding accuracy and the recovery of relationships between environmental exposures and health. Int J Health Geogr (2008) 1.44
Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair. J Biol Chem (2006) 1.43
Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction. Circulation (2005) 1.42
Final results from a national multicenter phase II trial of combination bacillus Calmette-Guérin plus interferon alpha-2B for reducing recurrence of superficial bladder cancer. Urol Oncol (2006) 1.42
Mass media interventions for preventing smoking in young people. Cochrane Database Syst Rev (2010) 1.41
Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress. Aging (Albany NY) (2011) 1.40
2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer. Free Radic Biol Med (2007) 1.40
2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism. Cancer Res (2003) 1.34
High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angew Chem Int Ed Engl (2009) 1.34
Redox signaling in cancer biology. Antioxid Redox Signal (2006) 1.32
Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels. Biochemistry (2005) 1.31
Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity. J Immunol (2008) 1.30
Nuclear factor-kappaB and manganese superoxide dismutase mediate adaptive radioresistance in low-dose irradiated mouse skin epithelial cells. Cancer Res (2007) 1.27
Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation. J Biol Chem (2011) 1.27
A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion. Cell Host Microbe (2008) 1.27
Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses. J Med Virol (2005) 1.26
Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Oncogene (2005) 1.26
Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose. Cancer Res (2006) 1.25
The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo. Development (2003) 1.25
Sunburns and risk of cutaneous melanoma: does age matter? A comprehensive meta-analysis. Ann Epidemiol (2008) 1.22
Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance. Nucleic Acids Res (2005) 1.19
Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation. Oncogene (2002) 1.18
Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis. Biol Reprod (2002) 1.18
Modulation of reactive oxygen species in pancreatic cancer. Clin Cancer Res (2007) 1.18
The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues. Nat Struct Mol Biol (2005) 1.18
Anonymity or transparency in reporting of medical error: a community-based survey in South Australia. Med J Aust (2004) 1.17
Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth. Free Radic Biol Med (2006) 1.16
Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts. Cancer Biol Ther (2009) 1.15
Multiphoton quantum interference in a multiport integrated photonic device. Nat Commun (2013) 1.15
Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation. Am J Respir Crit Care Med (2008) 1.14
Thioredoxin reductase as a novel molecular target for cancer therapy. Cancer Lett (2005) 1.14
Community interventions for preventing smoking in young people. Cochrane Database Syst Rev (2011) 1.14
Glucose deprivation-induced metabolic oxidative stress and cancer therapy. J Cancer Res Ther (2009) 1.13
Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radic Biol Med (2010) 1.13
Heralded generation of ultrafast single photons in pure quantum States. Phys Rev Lett (2008) 1.13
Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex. PLoS Pathog (2011) 1.12
Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress. Free Radic Biol Med (2011) 1.12
Enhanced response of human head and neck cancer xenograft tumors to cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as determined by PET imaging. Int J Radiat Oncol Biol Phys (2007) 1.11
Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism. Clin Cancer Res (2011) 1.10
Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands. J Biol Chem (2009) 1.09
Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure. Free Radic Biol Med (2009) 1.09
Insight into the self-association of key enzymes from pathogenic species. Eur Biophys J (2005) 1.09
Acute toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: effects on hepatic oxidative stress, glutathione and metals status. Environ Int (2009) 1.09
Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers. Mol Cancer Ther (2013) 1.08
Adaptive responses to low-dose/low-dose-rate gamma rays in normal human fibroblasts: the role of growth architecture and oxidative metabolism. Radiat Res (2006) 1.08
Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells. Cancer Biol Ther (2009) 1.07