Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways.

PubWeight™: 1.84‹?› | Rank: Top 3%

🔗 View Article (PMC 2843831)

Published in Radiology on February 16, 2010

Authors

Stephanie A Solazzo1, Muneeb Ahmed, Rachel Schor-Bardach, Wei Yang, Geoffrey D Girnun, Syed Rahmanuddin, Tatyana Levchenko, Sabina Signoretti, Douglas R Spitz, Vladimir Torchilin, S Nahum Goldberg

Author Affiliations

1: Laboratory for Minimally Invasive Tumor Therapies, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA.

Articles citing this

More than just tumor destruction: immunomodulation by thermal ablation of cancer. Clin Dev Immunol (2011) 1.56

Do liposomal apoptotic enhancers increase tumor coagulation and end-point survival in percutaneous radiofrequency ablation of tumors in a rat tumor model? Radiology (2010) 1.07

Radiofrequency ablation combined with liposomal quercetin to increase tumour destruction by modulation of heat shock protein production in a small animal model. Int J Hyperthermia (2011) 1.05

Thermosensitive liposomes for localized delivery and triggered release of chemotherapy. J Control Release (2013) 0.98

Chemoradionuclide therapy with 186Re-labeled liposomal doxorubicin in combination with radiofrequency ablation for effective treatment of head and neck cancer in a nude rat tumor xenograft model. Radiology (2011) 0.98

Synergy in cancer treatment between liposomal chemotherapeutics and thermal ablation. Chem Phys Lipids (2011) 0.93

Combination radiofrequency (RF) ablation and IV liposomal heat shock protein suppression: reduced tumor growth and increased animal endpoint survival in a small animal tumor model. J Control Release (2011) 0.93

Therapeutic efficacy of combining pegylated liposomal doxorubicin and radiofrequency (RF) ablation: comparison between slow-drug-releasing, non-thermosensitive and fast-drug-releasing, thermosensitive nano-liposomes. PLoS One (2014) 0.85

Hepatic Radiofrequency Ablation-induced Stimulation of Distant Tumor Growth Is Suppressed by c-Met Inhibition. Radiology (2015) 0.85

Image-guided interventional therapy for cancer with radiotherapeutic nanoparticles. Adv Drug Deliv Rev (2014) 0.84

Radiofrequency ablation-induced upregulation of hypoxia-inducible factor-1α can be suppressed with adjuvant bortezomib or liposomal chemotherapy. J Vasc Interv Radiol (2014) 0.82

Role of Pluronic block copolymers in modulation of heat shock protein 70 expression. Int J Hyperthermia (2011) 0.82

Systemic siRNA Nanoparticle-Based Drugs Combined with Radiofrequency Ablation for Cancer Therapy. PLoS One (2015) 0.81

Adjuvant liposomal doxorubicin markedly affects radiofrequency ablation-induced effects on periablational microvasculature. J Vasc Interv Radiol (2013) 0.81

Development of a research agenda for the management of metastatic colorectal cancer: proceedings from a multidisciplinary research consensus panel. J Vasc Interv Radiol (2012) 0.80

Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation. Cell Stress Chaperones (2011) 0.80

Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes. Surg Oncol Clin N Am (2013) 0.79

Heat shock protein inhibitor, quercetin, as a novel adjuvant agent to improve radiofrequency ablation-induced tumor destruction and its molecular mechanism. Chin J Cancer Res (2016) 0.79

Nanodrug-enhanced radiofrequency tumor ablation: effect of micellar or liposomal carrier on drug delivery and treatment efficacy. PLoS One (2014) 0.77

Molecular bioluminescence imaging as a noninvasive tool for monitoring tumor growth and therapeutic response to MRI-guided laser ablation in a rat model of hepatocellular carcinoma. Invest Radiol (2013) 0.76

CD133(+) cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma. Sci Rep (2017) 0.76

Heat stress induced cell death mechanisms in hepatocytes and hepatocellular carcinoma: in vitro and in vivo study. Lasers Surg Med (2014) 0.76

Debulking treatment with CT-guided percutaneous radiofrequency ablation and hepatic artery infusion of floxuridine improves survival of patients with unresectable pulmonary and hepatic metastases of colorectal cancer. Chin J Cancer (2014) 0.75

DDMC-p53 gene therapy with or without cisplatin and microwave ablation. Onco Targets Ther (2015) 0.75

Effect of thermal dose on heat shock protein expression after radio-frequency ablation with and without adjuvant nanoparticle chemotherapies. Int J Hyperthermia (2016) 0.75

Science to practice: will randomized prospective clinical trials be necessary for RF ablation of large liver tumors with liposomal doxorubicin? Radiology (2010) 0.75

Heat shock protein 27 promotes cell proliferation through activator protein-1 in lung cancer. Oncol Lett (2015) 0.75

Targeted near infrared hyperthermia combined with immune stimulation for optimized therapeutic efficacy in thyroid cancer treatment. Oncotarget (2016) 0.75

Thermal Ablative Therapies and Immune Checkpoint Modulation: Can Locoregional Approaches Effect a Systemic Response? Gastroenterol Res Pract (2016) 0.75

Enhancement of Intratumoral Chemotherapy with Cisplatin with or without Microwave Ablation and Lipiodol. Future Concept for Local Treatment in Lung Cancer. J Cancer (2015) 0.75

Hepatic radiofrequency ablation: markedly reduced systemic effects by modulating periablational inflammation via cyclooxygenase-2 inhibition. Eur Radiol (2016) 0.75

Articles cited by this

Hepatocellular carcinoma: radio-frequency ablation of medium and large lesions. Radiology (2000) 4.83

Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance. J Appl Physiol (1985) (2002) 3.85

Early-stage hepatocellular carcinoma in patients with cirrhosis: long-term results of percutaneous image-guided radiofrequency ablation. Radiology (2005) 3.63

Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation. Cancer (2000) 2.59

Radiofrequency ablation of renal cell carcinoma: part 1, Indications, results, and role in patient management over a 6-year period and ablation of 100 tumors. AJR Am J Roentgenol (2005) 2.53

Effect of vessel size on creation of hepatic radiofrequency lesions in pigs: assessment of the "heat sink" effect. AJR Am J Roentgenol (2002) 2.31

Five-year survival in 309 patients with colorectal liver metastases treated with radiofrequency ablation. Eur Radiol (2009) 2.17

Saline-enhanced radio-frequency tissue ablation in the treatment of liver metastases. Radiology (1997) 2.15

Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol (2005) 1.89

Early-stage hepatocellular carcinoma: radiofrequency ablation combined with chemoembolization versus hepatectomy. Radiology (2008) 1.86

New insights on cell death from radiation exposure. Lancet Oncol (2005) 1.72

Tissue ablation with radiofrequency: effect of probe size, gauge, duration, and temperature on lesion volume. Acad Radiol (1995) 1.71

Radiofrequency ablation followed by conventional radiotherapy for medically inoperable stage I non-small cell lung cancer. Chest (2006) 1.64

Radio-frequency thermal ablation with NaCl solution injection: effect of electrical conductivity on tissue heating and coagulation-phantom and porcine liver study. Radiology (2001) 1.53

Heat shock proteins: stress proteins with Janus-like properties in cancer. Int J Hyperthermia (2008) 1.40

Oxidative stress, redox, and the tumor microenvironment. Semin Radiat Oncol (2004) 1.38

Thermally induced injury and heat-shock protein expression in cells and tissues. Ann N Y Acad Sci (2005) 1.35

How do cells respond to their thermal environment? Int J Hyperthermia (2005) 1.33

Radiofrequency ablation in the treatment of osteoid osteoma-5-year experience. Eur J Radiol (2009) 1.28

Cell biological effects of hyperthermia alone or combined with radiation or drugs: a short introduction to newcomers in the field. Int J Hyperthermia (2006) 1.25

Radiofrequency ablation of hepatic tumors: increased tumor destruction with adjuvant liposomal doxorubicin therapy. AJR Am J Roentgenol (2002) 1.25

Radiofrequency thermal ablation sharply increases intratumoral liposomal doxorubicin accumulation and tumor coagulation. Cancer Res (2003) 1.19

Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents. Oncogene (2005) 1.18

Combined radiofrequency ablation and adjuvant liposomal chemotherapy: effect of chemotherapeutic agent, nanoparticle size, and circulation time. J Vasc Interv Radiol (2005) 1.16

Combination radiofrequency thermal ablation and adjuvant IV liposomal doxorubicin increases tissue coagulation and intratumoural drug accumulation. Int J Hyperthermia (2004) 1.16

Percutaneous tumor ablation: increased necrosis with combined radio-frequency ablation and intravenous liposomal doxorubicin in a rat breast tumor model. Radiology (2002) 1.14

Improved tumor destruction with arsenic trioxide and radiofrequency ablation in three animal models. Radiology (2006) 1.13

Radio-frequency ablation increases intratumoral liposomal doxorubicin accumulation in a rat breast tumor model. Radiology (2002) 1.11

DNA breakage associated with targeted gene alteration directed by DNA oligonucleotides. Mutat Res (2009) 1.08

The immunopharmacology of paclitaxel (Taxol), docetaxel (Taxotere), and related agents. Int Immunopharmacol (2003) 1.07

Detection of apoptosis in vivo using antibodies against caspase-induced neo-epitopes. Methods (2008) 1.04

Radiofrequency ablation combined with chemoembolization for the treatment of hepatocellular carcinomas larger than 5 cm. J Vasc Interv Radiol (2008) 1.02

Combination radiofrequency ablation with intratumoral liposomal doxorubicin: effect on drug accumulation and coagulation in multiple tissues and tumor types in animals. Radiology (2005) 1.02

Doxorubicin-eluting bead-enhanced radiofrequency ablation of hepatocellular carcinoma: a pilot clinical study. J Hepatol (2008) 1.00

Patterns of heat shock protein (HSP70) expression and Kupffer cell activity following thermal ablation of liver and colorectal liver metastases. Int J Hyperthermia (2005) 0.96

Radiofrequency ablation: variability in heat sensitivity in tumors and tissues. J Vasc Interv Radiol (2007) 0.95

Reduced tumor growth with combined radiofrequency ablation and radiation therapy in a rat breast tumor model. Radiology (2005) 0.95

Radiofrequency ablation: the effect of distance and baseline temperature on thermal dose required for coagulation. Int J Hyperthermia (2008) 0.94

Paclitaxel-induced microtubule stabilization causes mitotic block and apoptotic-like cell death in a paclitaxel-sensitive strain of Saccharomyces cerevisiae. Yeast (2005) 0.93

Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives. J Med Chem (2009) 0.92

Pathomorphologic evaluation of pulmonary radiofrequency ablation: proof of cell death is characterized by DNA fragmentation and apoptotic bodies. Cancer (2008) 0.91

Thermal sensitization through ROS modulation: a strategy to improve the efficacy of hyperthermic intraperitoneal chemotherapy. Surgery (2007) 0.91

CT mapping of the distribution of saline during radiofrequency ablation with perfusion electrodes. Cardiovasc Intervent Radiol (2005) 0.89

Percutaneous radiofrequency ablation of small hepatocellular carcinoma invisible on both ultrasonography and unenhanced CT: a preliminary study of combined treatment with transarterial chemoembolisation. Br J Radiol (2009) 0.88

Modeling doxorubicin transport to improve intratumoral drug delivery to RF ablated tumors. J Control Release (2007) 0.86

Synergistic antiglioma action of hyperthermia and nitric oxide. Eur J Pharmacol (2008) 0.84

In vivo amelioration of adriamycin induced oxidative stress in plasma by gamma-glutamylcysteine ethyl ester (GCEE). Cancer Lett (2009) 0.84

Thiol supplementation in aged animals alters antioxidant enzyme activity after heat stress. J Appl Physiol (1985) (2005) 0.83

Enhancement of apoptosis by nitric oxide released from alpha-phenyl-tert-butyl nitrone under hyperthermic conditions. J Cell Physiol (2006) 0.81

Hyperthermia switches glucose depletion-induced necrosis to apoptosis in A549 lung adenocarcinoma cells. Int J Oncol (2008) 0.80

Thermal injury induces heat shock protein in the optic nerve head in vivo. Invest Ophthalmol Vis Sci (2006) 0.80

Urinary 8-hydroxy-2'-deoxyguanosine excretion as a biomarker for estimating DNA oxidation in patients undergoing external radiotherapy and/or brachytherapy. Oncol Rep (2005) 0.79

RF ablation with adjuvant therapy: comparison of external beam radiation and liposomal doxorubicin on ablation efficacy in an animal tumor model. Int J Hyperthermia (2008) 0.79

Temperature dependence of adriamycin-induced DNA damage in L1210 cells. Cancer Res (1989) 0.78

Articles by these authors

The landscape of somatic copy-number alteration across human cancers. Nature (2010) 31.88

High-throughput oncogene mutation profiling in human cancer. Nat Genet (2007) 12.68

H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science (2008) 7.89

Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. Cancer Res (2005) 6.66

A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell (2008) 6.16

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature (2002) 6.10

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature (2008) 6.04

Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease. JAMA (2011) 5.86

Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis. Cell (2005) 5.43

Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study. Radiology (2003) 5.42

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell (2010) 5.40

A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer. JAMA (2011) 4.63

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature (2011) 4.57

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature (2007) 4.35

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell (2010) 4.19

Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer. Clin Cancer Res (2005) 3.74

Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature (2005) 3.67

UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke. Cell (2006) 3.65

Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene. Cancer Discov (2011) 3.45

Superoxide mediates the actions of angiotensin II in the central nervous system. Circ Res (2002) 3.29

Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Res (2009) 3.17

Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma. Clin Genitourin Cancer (2007) 3.00

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. Nat Cell Biol (2008) 2.93

The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell (2013) 2.87

Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J Virol (2008) 2.84

Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib. Cancer Discov (2014) 2.79

Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription. Mol Cell (2007) 2.71

Structure and mechanism of human DNA polymerase eta. Nature (2010) 2.69

Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. J Biol Chem (2010) 2.59

Random walk in orthogonal space to achieve efficient free-energy simulation of complex systems. Proc Natl Acad Sci U S A (2008) 2.56

Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment. Radiology (2009) 2.55

The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc Natl Acad Sci U S A (2007) 2.53

Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. J Natl Cancer Inst (2009) 2.53

Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol (2004) 2.49

The requirement for cyclin D function in tumor maintenance. Cancer Cell (2012) 2.49

A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer Cell (2008) 2.48

Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease. Kidney Int (2013) 2.48

Inflammatory breast cancer: the disease, the biology, the treatment. CA Cancer J Clin (2010) 2.45

Single nucleotide polymorphisms and risk of recurrence of renal-cell carcinoma: a cohort study. Lancet Oncol (2012) 2.44

Principles of and advances in percutaneous ablation. Radiology (2011) 2.44

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. Mol Cancer Ther (2009) 2.43

Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis (2012) 2.42

Use of abdominopelvic computed tomography in emergency departments and rates of urgent diagnoses in Crohn's disease. Clin Gastroenterol Hepatol (2011) 2.40

Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis. EMBO J (2005) 2.37

Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem J (2009) 2.35

Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other. Immunity (2003) 2.34

Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. Cancer Res (2004) 2.32

Gamma-secretase gene mutations in familial acne inversa. Science (2010) 2.30

A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. Nat Genet (2013) 2.29

Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability. Cancer Res (2006) 2.27

The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. Cancer Cell (2004) 2.27

Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study. Am J Kidney Dis (2011) 2.25

Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release. EMBO J (2006) 2.23

Percutaneous radiofrequency ablation of liver metastases in potential candidates for resection: the "test-of-time approach". Cancer (2003) 2.22

The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2. J Cell Biol (2004) 2.22

Small liver colorectal metastases treated with percutaneous radiofrequency ablation: local response rate and long-term survival with up to 10-year follow-up. Radiology (2012) 2.16

Delays in primary surgical treatment are not associated with significant tumor size progression in breast cancer patients. Ann Surg (2011) 2.16

SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci (2008) 2.12

Gene transfer to plants by diverse species of bacteria. Nature (2005) 2.11

Snapshots of replication through an abasic lesion; structural basis for base substitutions and frameshifts. Mol Cell (2004) 2.10

Association of serum bicarbonate with risk of renal and cardiovascular outcomes in CKD: a report from the Chronic Renal Insufficiency Cohort (CRIC) study. Am J Kidney Dis (2013) 2.09

Replication of a cis-syn thymine dimer at atomic resolution. Nature (2003) 2.07

Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease. Cancer Res (2009) 2.07

Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability. J Clin Invest (2003) 2.06

The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma. Clin Cancer Res (2010) 2.03

2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer Res (2007) 2.03

Chimpanzee adenovirus antibodies in humans, sub-Saharan Africa. Emerg Infect Dis (2006) 1.99

Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc Natl Acad Sci U S A (2010) 1.96

Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells. J Biol Chem (2004) 1.94

Black soot and the survival of Tibetan glaciers. Proc Natl Acad Sci U S A (2009) 1.93

Multidisciplinary considerations in the implementation of the findings from the American College of Surgeons Oncology Group (ACOSOG) Z0011 study: a practice-changing trial. Ann Surg Oncol (2011) 1.93

Radiofrequency thermal ablation of abdominal tumors: lessons learned from complications. Radiographics (2004) 1.92

Watching DNA polymerase η make a phosphodiester bond. Nature (2012) 1.92

Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis. Cancer Prev Res (Phila) (2012) 1.90

Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell (2013) 1.85

Percutaneous radiofrequency ablation for inoperable non-small cell lung cancer and metastases: preliminary report. Radiology (2003) 1.85

Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT. Int J Radiat Oncol Biol Phys (2009) 1.83

Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2. J Biol Chem (2002) 1.82

Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Res (2002) 1.80

Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Mol Cell Biol (2003) 1.80

Fibroblast growth factor-23 and cardiovascular events in CKD. J Am Soc Nephrol (2013) 1.78

Image-guided tumor ablation: standardization of terminology and reporting criteria--a 10-year update. Radiology (2014) 1.78

Brain tissue oxygen and outcome after severe traumatic brain injury: a systematic review. Crit Care Med (2009) 1.75

Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol (2012) 1.75

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med (2011) 1.74

118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects. BMC Med Genet (2009) 1.74

Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A (2005) 1.73

Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev (2005) 1.73

Reduced risks of neural tube defects and orofacial clefts with higher diet quality. Arch Pediatr Adolesc Med (2011) 1.73

Reciprocal effects of STAT5 and STAT3 in breast cancer. Mol Cancer Res (2009) 1.72

A multilevel adaptive finite element algorithm for bioluminescence tomography. Opt Express (2006) 1.71

Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line. Cancer Res (2002) 1.69

Irreversible electroporation ablation: is all the damage nonthermal? Radiology (2012) 1.68

Association of cardiac troponin T with left ventricular structure and function in CKD. Am J Kidney Dis (2013) 1.67

Colonic perforation at CT colonography: assessment of risk in a multicenter large cohort. Radiology (2006) 1.67

Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase. Proc Natl Acad Sci U S A (2004) 1.66

Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee. Cancer Res (2013) 1.66