Published in J Immunol on March 01, 2008
TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol (2009) 2.44
High expression of IL-17 and IL-17RE associate with poor prognosis of hepatocellular carcinoma. J Exp Clin Cancer Res (2013) 1.24
TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance. PLoS Pathog (2014) 1.10
Vitamin D-mediated induction of innate immunity in gingival epithelial cells. Infect Immun (2011) 0.99
Pleiotropic functions of EAPII/TTRAP/TDP2: cancer development, chemoresistance and beyond. Cell Cycle (2011) 0.99
Genetic and epigenetic aspects of initiation and progression of hepatocellular carcinoma. World J Gastroenterol (2015) 0.97
Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes. Immunology (2009) 0.97
Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells. PLoS Pathog (2009) 0.94
HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling. Nat Commun (2015) 0.91
Induction of triggering receptor expressed on myeloid cells (TREM-1) in airway epithelial cells by 1,25(OH)₂ vitamin D₃. Innate Immun (2011) 0.90
Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution. Cell Rep (2014) 0.90
IL-23 in infections, inflammation, autoimmunity and cancer: possible role in HIV-1 and AIDS. J Neuroimmune Pharmacol (2011) 0.88
Genomic characterization of remission in juvenile idiopathic arthritis. Arthritis Res Ther (2013) 0.87
Ischemic transient neurological events identified by immune response to cerebral ischemia. Stroke (2012) 0.87
Triggering receptor expressed on myeloid cells receptor family modulators: a patent review. Expert Opin Ther Pat (2014) 0.86
A novel ligand-independent peptide inhibitor of TREM-1 suppresses tumor growth in human lung cancer xenografts and prolongs survival of mice with lipopolysaccharide-induced septic shock. Int Immunopharmacol (2014) 0.85
Triggering receptor expressed on myeloid cells 1 (TREM-1)-mediated Bcl-2 induction prolongs macrophage survival. J Biol Chem (2014) 0.85
Activin, neutrophils, and inflammation: just coincidence? Semin Immunopathol (2013) 0.85
Cytosolic phospholipase A(2)α and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation. PLoS One (2013) 0.85
TREM-1 is induced in tumor associated macrophages by cyclo-oxygenase pathway in human non-small cell lung cancer. PLoS One (2014) 0.84
Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control. Am J Respir Crit Care Med (2016) 0.82
Triggering receptor expressed on myeloid cells-1 as a new therapeutic target during inflammatory diseases. Self Nonself (2010) 0.81
Combinatorial code governing cellular responses to complex stimuli. Nat Commun (2015) 0.79
Perioperative Dynamics of TLR2, TLR4, and TREM-1 Expression in Monocyte Subpopulations in the Setting of On-Pump Coronary Artery Bypass Surgery. ISRN Inflamm (2013) 0.79
Expression of triggering receptor-1 in myeloid cells of mice with acute lung injury. World J Emerg Med (2010) 0.79
Phenylbutyrate Is Bacteriostatic against Mycobacterium tuberculosis and Regulates the Macrophage Response to Infection, Synergistically with 25-Hydroxy-Vitamin D3. PLoS Pathog (2015) 0.79
A compendium of monocyte transcriptome datasets to foster biomedical knowledge discovery. F1000Res (2016) 0.78
Transcriptome of American oysters, Crassostrea virginica, in response to bacterial challenge: insights into potential mechanisms of disease resistance. PLoS One (2014) 0.78
TREM-1 signaling promotes host defense during the early stage of infection with highly pathogenic Streptococcus suis. Infect Immun (2015) 0.77
Contextualization procedure and modeling of monocyte specific TLR signaling. PLoS One (2012) 0.77
TGF-β1 Upregulates the Expression of Triggering Receptor Expressed on Myeloid Cells 1 in Murine Lungs. Sci Rep (2016) 0.77
A curated compendium of monocyte transcriptome datasets of relevance to human monocyte immunobiology research. F1000Res (2016) 0.77
Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system. Cell Death Dis (2016) 0.76
Early changes of the kinetics of monocyte trem-1 reflect final outcome in human sepsis. BMC Immunol (2014) 0.76
Conserved gene regulation during acute inflammation between zebrafish and mammals. Sci Rep (2017) 0.75
Targeting TREM-1 Signaling in the Presence of Antibiotics is Effective Against Streptococcal Toxic-Shock-Like Syndrome (STSLS) Caused by Streptococcus suis. Front Cell Infect Microbiol (2015) 0.75
LPS independent activation of the pro-inflammatory receptor Trem1 by C/EBPε in granulocytes. Sci Rep (2017) 0.75
Silencing Triggering Receptors Expressed on Myeloid Cells-1 Impaired the Inflammatory Response to Oxidized Low-Density Lipoprotein in Macrophages. Inflammation (2016) 0.75
Blocking triggering receptor expressed on myeloid cells-1 attenuates lipopolysaccharide-induced acute lung injury via inhibiting NLRP3 inflammasome activation. Sci Rep (2016) 0.75
TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis. Nat Commun (2016) 0.75
Rationally designed ligand-independent peptide inhibitors of TREM-1 ameliorate collagen-induced arthritis. J Cell Mol Med (2017) 0.75
Distinct cellular functions of MK2. Mol Cell Biol (2002) 2.12
Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme. Structure (2003) 1.84
The mouse epididymal transcriptome: transcriptional profiling of segmental gene expression in the epididymis. Biol Reprod (2005) 1.65
MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis. J Immunol (2006) 1.45
Risk factors associated with beta-amyloid(1-42) immunotherapy in preimmunization gene expression patterns of blood cells. Arch Neurol (2005) 1.44
Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis. J Biol Chem (2003) 1.29
Stage-specific gene expression is a fundamental characteristic of rat spermatogenic cells and Sertoli cells. Proc Natl Acad Sci U S A (2008) 1.25
Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized. Mol Cancer (2007) 1.24
Comparison of human and rat uterine leiomyomata: identification of a dysregulated mammalian target of rapamycin pathway. Cancer Res (2009) 1.17
Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem (2007) 1.11
Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood. PLoS One (2011) 1.05
The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls. Genome Med (2012) 1.03
Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality. J Leukoc Biol (2010) 1.01
Proteomic characterization of the dynamic KSR-2 interactome, a signaling scaffold complex in MAPK pathway. Biochim Biophys Acta (2009) 1.00
TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines. Rheumatology (Oxford) (2009) 1.00
Identification of epididymis-specific transcripts in the mouse and rat by transcriptional profiling. Asian J Androl (2007) 0.99
Differential gene expression among the proximal segments of the rat epididymis is lost after efferent duct ligation. Biol Reprod (2007) 0.98
Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett (2006) 0.97
Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. J Med Chem (2008) 0.97
Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity. J Biol Chem (2004) 0.97
Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett (2005) 0.97
TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain. J Immunol (2009) 0.96
Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. J Biol Chem (2003) 0.95
Segment boundaries of the adult rat epididymis limit interstitial signaling by potential paracrine factors and segments lose differential gene expression after efferent duct ligation. Asian J Androl (2007) 0.93
Characterization of (2R, 3S)-2-([[4-(2-butynyloxy)phenyl]sulfonyl]amino)-N,3-dihydroxybutanamide, a potent and selective inhibitor of TNF-alpha converting enzyme. Int Immunopharmacol (2004) 0.92
Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities. Growth Factors (2011) 0.90
Distinct protein degradation profiles are induced by different disuse models of skeletal muscle atrophy. Physiol Genomics (2011) 0.90
Liver X receptor is a therapeutic target for photoaging and chronological skin aging. Mol Endocrinol (2008) 0.90
Stem Leydig cell differentiation: gene expression during development of the adult rat population of Leydig cells. Biol Reprod (2011) 0.89
Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells. J Steroid Biochem Mol Biol (2005) 0.88
hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation. Biochem Biophys Res Commun (2005) 0.88
Gene expression during development of fetal and adult Leydig cells. Ann N Y Acad Sci (2007) 0.87
Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis. J Pharmacol Exp Ther (2004) 0.87
The molecular basis of the cooperation between EGF, FGF and eCB receptors in the regulation of neural stem cell function. Mol Cell Neurosci (2012) 0.86
Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett (2009) 0.86
Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles. Bioorg Med Chem (2007) 0.85
The NMR structure of the TRADD death domain, a key protein in the TNF signaling pathway. J Biomol NMR (2007) 0.84
Identification of testis-specific male contraceptive targets: insights from transcriptional profiling of the cycle of the rat seminiferous epithelium and purified testicular cells. Ann N Y Acad Sci (2007) 0.84
Sonic Hedgehog signaling in astrocytes is dependent on p38 mitogen-activated protein kinase and G-protein receptor kinase 2. J Neurochem (2009) 0.83
NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach. J Biol Chem (2004) 0.83
A study of 17beta-estradiol-regulated genes in the vagina of postmenopausal women with vaginal atrophy. Maturitas (2007) 0.83
P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity. FEBS Lett (2004) 0.83
Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner. J Biol Chem (2014) 0.82
Discovery of indazoles as inhibitors of Tpl2 kinase. Bioorg Med Chem Lett (2011) 0.82
Identification of rat cysteine-rich secretory protein 4 (Crisp4) as the ortholog to human CRISP1 and mouse Crisp4. Biol Reprod (2006) 0.82
Molecular analysis of the vaginal response to estrogens in the ovariectomized rat and postmenopausal woman. BMC Med Genomics (2008) 0.81
Novel progesterone receptor modulators with gene selective and context-dependent partial agonism. Biochem Pharmacol (2008) 0.79
Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors. Bioorg Med Chem Lett (2011) 0.79
Assignment of 1H, 13C and 15N resonances of the death domain of TRADD. J Biomol NMR (2004) 0.77
A rat pharmacokinetic/pharmacodynamic model for assessment of lipopolysaccharide-induced tumor necrosis factor-alpha production. J Pharmacol Toxicol Methods (2007) 0.77
Development of an early biomarker for the ovarian liability of selective estrogen receptor modulators in rats. J Steroid Biochem Mol Biol (2008) 0.76
Discovery of a novel mechanism of steroid receptor antagonism: WAY-255348 modulates progesterone receptor cellular localization and promoter interactions. Biochem Pharmacol (2011) 0.75
Complex responses to a diverse environment. Genome Biol (2008) 0.75